{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:22:11Z","timestamp":1790688131525,"version":"4.1.0"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,15]]},"DOI":"10.1093\/hmg\/ddy055","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T20:10:15Z","timestamp":1518120615000},"page":"1447-1459","source":"Crossref","is-referenced-by-count":44,"title":["The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T\/Brachyury and early vascular differentiation gene networks"],"prefix":"10.1093","volume":"27","author":[{"given":"Nolwenn","family":"Briand","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, Norway"},{"name":"Sorbonne Universit\u00e9, Inserm UMR S938, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Claire","family":"Gu\u00e9nantin","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm UMR S938, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition, 75012 Paris, France"},{"name":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Jeziorowska","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, UPMC Universit\u00e9 Paris 6, UMR-S1166 ICAN, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Mantecon","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm UMR S938, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Capel","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm UMR S938, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Garcia","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm UMR S938, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Sebastien","family":"Hulot","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, UPMC Universit\u00e9 Paris 6, UMR-S1166 ICAN, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Vigouroux","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm UMR S938, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition, 75012 Paris, France"},{"name":"AP-HP Saint-Antoine Hospital, Molecular Biology and Genetics Laboratory, Endocrinology Department, National Reference Center for Insulin Secretion and Insulin Sensitivity Rare Diseases, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Collas","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, Norway"},{"name":"Department of Immunology and Transfusion Medicine, Norwegian Center for Stem Cell Research, Oslo University Hospital, 0424 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"key\n\t\t\t\t20180403031345_ddy055-B1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/path.2999","article-title":"Nuclear lamins and laminopathies","volume":"226","author":"Worman","year":"2012","journal-title":"J. Pathol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B2","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1210\/jc.2007-0654","article-title":"New metabolic phenotypes in laminopathies: lMNA mutations in patients with severe metabolic syndrome","volume":"92","author":"Decaudain","year":"2007","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.semcdb.2013.12.015","article-title":"Nuclear envelope-related lipodystrophies","volume":"29","author":"Guenantin","year":"2014","journal-title":"Semin. Cell Dev. Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B4","first-page":"1776","article-title":"Gender differences in the prevalence of metabolic complications in familial partial lipodystrophy (Dunnigan variety)","volume":"85","author":"Garg","year":"2000","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B5","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1161\/01.CIR.103.18.2225","article-title":"Premature atherosclerosis associated with monogenic insulin resistance","volume":"103","author":"Hegele","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B6","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1161\/ATVBAHA.113.301933","article-title":"Lipodystrophy-linked LMNA p.R482W mutation induces clinical early atherosclerosis and in vitro endothelial dysfunction","volume":"33","author":"Bidault","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B7","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ. Res"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrm3488","article-title":"The nuclear lamins: flexibility in function","volume":"14","author":"Burke","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B9","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nature06947","article-title":"Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions","volume":"453","author":"Guelen","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B10","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1101\/gr.159400.113","article-title":"Lamin A\/C-promoter interactions specify chromatin state-dependent transcription outcomes","volume":"23","author":"Lund","year":"2013","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1101\/gr.196220.115","article-title":"A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha","volume":"26","author":"Gesson","year":"2016","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B12","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1083\/jcb.201701043","article-title":"A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus","volume":"216","author":"Oldenburg","year":"2017","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B13","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.4161\/cc.8.10.8499","article-title":"Lamin complexes in the nuclear interior control progenitor cell proliferation and tissue homeostasis","volume":"8","author":"Naetar","year":"2009","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B14","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/hmg\/ddt509","article-title":"Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A p.R482W mutation elicits a myogenic gene expression program in preadipocytes","volume":"23","author":"Oldenburg","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B15","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1242\/dev.024703","article-title":"Identification of direct T-box target genes in the developing zebrafish mesoderm","volume":"136","author":"Garnett","year":"2009","journal-title":"Development"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12915-014-0063-7","article-title":"Brachyury cooperates with Wnt\/beta-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells","volume":"12","author":"Turner","year":"2014","journal-title":"BMC Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B17","doi-asserted-by":"crossref","first-page":"118","DOI":"10.15252\/embr.201744201","article-title":"BRACHYURY directs histone acetylation to target loci during mesoderm development","volume":"19","author":"Beisaw","year":"2018","journal-title":"EMBO Rep"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B18","doi-asserted-by":"crossref","first-page":"e57891","DOI":"10.1371\/journal.pone.0057891","article-title":"Lamin A\/C haploinsufficiency modulates the differentiation potential of mouse embryonic stem cells","volume":"8","author":"Sehgal","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B19","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1128\/MCB.00521-10","article-title":"Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability","volume":"30","author":"Foster","year":"2010","journal-title":"Mol. Cell Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13059-016-1146-2","article-title":"Chrom3D: three-dimensional genome modeling from Hi-C and lamin-genome contacts","volume":"18","author":"Paulsen","year":"2017","journal-title":"Genome Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrd.2016.245","article-title":"Induced pluripotent stem cell technology: a decade of progress","volume":"16","author":"Shi","year":"2017","journal-title":"Nat. Rev. Drug Discov"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B22","doi-asserted-by":"crossref","first-page":"510","DOI":"10.5966\/sctm.2013-0168","article-title":"Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome","volume":"3","author":"Blondel","year":"2014","journal-title":"Stem Cells Transl. Med"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B23","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/acel.12621","article-title":"Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape","volume":"16","author":"Chen","year":"2017","journal-title":"Aging Cell"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B24","doi-asserted-by":"crossref","first-page":"380","DOI":"10.18632\/aging.100277","article-title":"Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A\/C","volume":"3","author":"Ho","year":"2011","journal-title":"Aging"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13287-016-0401-5","article-title":"Recent advances in animal and human pluripotent stem cell modeling of cardiac laminopathy","volume":"7","author":"Lee","year":"2016","journal-title":"Stem. Cell Res. Ther"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B26","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.stem.2011.04.019","article-title":"Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs","volume":"8","author":"Liu","year":"2011","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B27","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.stem.2013.11.006","article-title":"Human iPSC-based modeling of late-onset disease via progerin-induced aging","volume":"13","author":"Miller","year":"2013","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.molcel.2010.03.016","article-title":"Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation","volume":"38","author":"Peric-Hupkes","year":"2010","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B29","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.molcel.2016.04.035","article-title":"Tissue-specific gene repositioning by muscle nuclear membrane proteins enhances repression of critical developmental genes during myogenesis","volume":"62","author":"Robson","year":"2016","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B30","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1101\/gr.212308.116","article-title":"Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments","volume":"27","author":"Robson","year":"2017","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B31","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1101\/gr.193748.115","article-title":"Prepatterning of differentiation-driven nuclear lamin A\/C-associated chromatin domains by GlcNAcylated histone H2B","volume":"25","author":"R\u00f8nningen","year":"2015","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B32","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.cell.2014.11.021","article-title":"A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping","volume":"159","author":"Rao","year":"2014","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B33","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ncb1793","article-title":"Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation","volume":"10","author":"Naetar","year":"2008","journal-title":"Nat. Cell Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B34","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1242\/jcs.203430","article-title":"Lamins in the nuclear interior - life outside the lamina","volume":"130","author":"Naetar","year":"2017","journal-title":"J. Cell Sci"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B35","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1083\/jcb.201504035","article-title":"Lamin A\/C sustains PcG protein architecture, maintaining transcriptional repression at target genes","volume":"211","author":"Cesarini","year":"2015","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4161\/19491034.2014.990855","article-title":"Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin","volume":"6","author":"Lund","year":"2015","journal-title":"Nucleus"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/19491034.2016.1157675","article-title":"Nucleoplasmic Lamin A\/C and Polycomb group of proteins: an evolutionarily conserved interplay","volume":"7","author":"Marullo","year":"2016","journal-title":"Nucleus"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B38","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1242\/dev.117838","article-title":"Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells","volume":"142","author":"Faial","year":"2015","journal-title":"Development"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B39","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature14233","article-title":"Transcription factor binding dynamics during human ES cell differentiation","volume":"518","author":"Tsankov","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B40","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/ng.127","article-title":"An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors","volume":"40","author":"Ben-Porath","year":"2008","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.stem.2008.04.004","article-title":"Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs","volume":"3","author":"Lindsley","year":"2008","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4161\/nucl.23384","article-title":"Lamin A\/C is expressed in pluripotent mouse embryonic stem cells","volume":"4","author":"Eckersley-Maslin","year":"2013","journal-title":"Nucleus"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B43","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1101\/gr.141028.112","article-title":"Constitutive nuclear lamina-genome interactions are highly conserved and associated with A\/T-rich sequence","volume":"23","author":"Meuleman","year":"2013","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B44","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/hmg\/ddi480","article-title":"Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy","volume":"15","author":"Boguslavsky","year":"2006","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B45","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.ajpath.2011.07.049","article-title":"LMNA mutations induce a non-inflammatory fibrosis and a brown fat-like dystrophy of enlarged cervical adipose tissue","volume":"179","author":"Bereziat","year":"2011","journal-title":"Am. J. Pathol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B46","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1093\/hmg\/ddu728","article-title":"The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy","volume":"24","author":"Vadrot","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1194\/jlr.M071381","article-title":"Extracellular Matrix Remodeling and Transforming Growth Factor-beta Signaling Abnormalities Induced by Lamin A\/C Variants that Cause Lipodystrophy","volume":"58","author":"Le Dour","year":"2017","journal-title":"J. Lipid Res"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B48","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1158\/0008-5472.CAN-13-1894","article-title":"WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition","volume":"74","author":"Hamilton","year":"2014","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B49","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.200904124","article-title":"Role of A-type lamins in signaling, transcription, and chromatin organization","volume":"187","author":"Andres","year":"2009","journal-title":"J. Cell Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B50","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/ncb1792","article-title":"Tethering by lamin A stabilizes and targets the ING1 tumour suppressor","volume":"10","author":"Han","year":"2008","journal-title":"Nat. Cell Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B51","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/sj.embor.7401075","article-title":"The inner nuclear envelope as a transcription factor resting place","volume":"8","author":"Heessen","year":"2007","journal-title":"EMBO Rep"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B52","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1101\/gad.349506","article-title":"A mechanism of AP-1 suppression through interaction of c-Fos with lamin A\/C","volume":"20","author":"Ivorra","year":"2006","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B53","doi-asserted-by":"crossref","first-page":"a000554","DOI":"10.1101\/cshperspect.a000554","article-title":"Lamin-binding Proteins","volume":"2","author":"Wilson","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B54","doi-asserted-by":"crossref","first-page":"1240104","DOI":"10.1126\/science.1240104","article-title":"Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation","volume":"341","author":"Swift","year":"2013","journal-title":"Science"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B55","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.4049\/jimmunol.1203403","article-title":"Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet","volume":"190","author":"Jang","year":"2013","journal-title":"J. Immunol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B56","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.stemcr.2017.07.016","article-title":"Inhibition of EZH2 promotes human embryonic stem cell differentiation into mesoderm by reducing H3K27me3","volume":"9","author":"Yu","year":"2017","journal-title":"Stem Cell Rep"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B57","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1074\/jbc.M116.766949","article-title":"Activin\/Smad2-induced histone H3 Lys-27 trimethylation (H3K27me3) reduction is crucial to initiate mesendoderm differentiation of human embryonic stem cells","volume":"292","author":"Wang","year":"2017","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B58","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/stem.1573","article-title":"EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification","volume":"32","author":"Hemming","year":"2014","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B59","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0092-8674(03)00437-9","article-title":"Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration","volume":"113","author":"Polesskaya","year":"2003","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B60","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nature06192","article-title":"A histone H3 lysine 27 demethylase regulates animal posterior development","volume":"449","author":"Lan","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B61","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/cr.2007.83","article-title":"JMJD3 is a histone H3K27 demethylase","volume":"17","author":"Xiang","year":"2007","journal-title":"Cell Res"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B62","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.biocel.2015.07.006","article-title":"JMJD3 as an epigenetic regulator in development and disease","volume":"67","author":"Burchfield","year":"2015","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B63","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/ncb2411","article-title":"Programming human pluripotent stem cells into white and brown adipocytes","volume":"14","author":"Ahfeldt","year":"2012","journal-title":"Nat. Cell Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B64","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1101\/gr.361602","article-title":"The Bioperl toolkit: perl modules for the life sciences","volume":"12","author":"Stajich","year":"2002","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B65","author":"Team, R.C.","year":"2015"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B66","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B67","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1093\/nar\/gku324","article-title":"enriched domain detector: a program for detection of wide genomic enrichment domains robust against local variations","volume":"42","author":"Lund","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B68","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B69","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B70","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B71","article-title":"cummeRbund: analysis, exploration, manipulation, and visualization of Cufllinks high-throughput sequencing data","author":"Goff","year":"2012","journal-title":"R Package"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B72","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-10-48","article-title":"GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists","volume":"10","author":"Eden","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B73","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem"},{"key":"key\n\t\t\t\t20180403031345_ddy055-B74","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/27\/8\/1447\/24527126\/ddy055.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T23:16:10Z","timestamp":1603840570000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/27\/8\/1447\/4847145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":74,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,2,9]]},"published-print":{"date-parts":[[2018,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy055","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,4,15]]},"published":{"date-parts":[[2018,2,9]]}}}