{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:21:43Z","timestamp":1787008903177,"version":"build-2736575974"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T00:00:00Z","timestamp":1519430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"ERC","doi-asserted-by":"publisher","award":["309742"],"award-info":[{"award-number":["309742"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UP_1501\/1"],"award-info":[{"award-number":["MC_UP_1501\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"DOI":"10.1093\/hmg\/ddy069","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T15:15:33Z","timestamp":1519398933000},"page":"1618-1629","source":"Crossref","is-referenced-by-count":32,"title":["Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss"],"prefix":"10.1093","volume":"27","author":[{"given":"Alice","family":"Biosa","sequence":"first","affiliation":[{"name":"Molecular Physiology and Biophysics Unit, Department of Biology, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Sanchez-Martinez","sequence":"additional","affiliation":[{"name":"MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Filograna","sequence":"additional","affiliation":[{"name":"Molecular Physiology and Biophysics Unit, Department of Biology, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Terriente-Felix","sequence":"additional","affiliation":[{"name":"MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M","family":"Alam","sequence":"additional","affiliation":[{"name":"MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Beltramini","sequence":"additional","affiliation":[{"name":"Molecular Physiology and Biophysics Unit, Department of Biology, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Bubacco","sequence":"additional","affiliation":[{"name":"Molecular Physiology and Biophysics Unit, Department of Biology, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bisaglia","sequence":"additional","affiliation":[{"name":"Molecular Physiology and Biophysics Unit, Department of Biology, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1154-6629","authenticated-orcid":false,"given":"Alexander J","family":"Whitworth","sequence":"additional","affiliation":[{"name":"MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,24]]},"reference":[{"key":"key\n\t\t\t\t20180626055859_ddy069-B1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pneurobio.2013.04.004","article-title":"Mitochondrial dysfunction and oxidative stress in Parkinson's disease","volume":"106\u2013107","author":"Subramaniam","year":"2013","journal-title":"Prog. Neurobiol"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B2","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nrm3013","article-title":"Mitochondrial fusion and fission in cell life and death","volume":"11","author":"Westermann","year":"2010","journal-title":"Nat. Rev. Mol. Cell. Biol"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cmet.2015.06.006","article-title":"Redox homeostasis and mitochondrial dynamics","volume":"22","author":"Willems","year":"2015","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B4","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/humu.21277","article-title":"Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update","volume":"31","author":"Nuytemans","year":"2010","journal-title":"Hum. Mutat"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nbd.2012.10.011","article-title":"Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism","volume":"51","author":"Hauser","year":"2013","journal-title":"Neurobiol. Dis"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-380860-8.00001-X","article-title":"Drosophila models of Parkinson's disease","volume":"73","author":"Whitworth","year":"2011","journal-title":"Adv. Genet"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B7","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nature04779","article-title":"Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin","volume":"441","author":"Clark","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/hmg\/ddi074","article-title":"Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis","volume":"14","author":"Greene","year":"2005","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B9","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1242\/dev.01095","article-title":"Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress","volume":"131","author":"Pesah","year":"2004","journal-title":"Development"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B10","doi-asserted-by":"crossref","first-page":"18614","DOI":"10.1074\/jbc.M401135200","article-title":"Mitochondrial dysfunction and oxidative damage in parkin-deficient mice","volume":"279","author":"Palacino","year":"2004","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B11","doi-asserted-by":"crossref","first-page":"11364","DOI":"10.1073\/pnas.0802076105","article-title":"Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress","volume":"105","author":"Gautier","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B12","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/ana.21492","article-title":"Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts","volume":"64","author":"Mortiboys","year":"2008","journal-title":"Ann. Neurol"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B13","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/brain\/awp108","article-title":"Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio)","volume":"132","author":"Flinn","year":"2009","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1460-9568.2010.07091.x","article-title":"Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of pink1 function","volume":"31","author":"Xi","year":"2010","journal-title":"Eur. J. Neurosci"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B15","doi-asserted-by":"crossref","first-page":"e25622.","DOI":"10.1371\/journal.pone.0025622","article-title":"Bioenergetic consequences of PINK1 mutations in Parkinson disease","volume":"6","author":"Abramov","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B17","doi-asserted-by":"crossref","first-page":"9257","DOI":"10.1074\/jbc.M115.708057","article-title":"Superoxide dismutase (SOD)-mimetic M40403 is protective in cell and fly models of paraquat toxicity: implications for Parkinson disease","volume":"291","author":"Filograna","year":"2016","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B18","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B19","doi-asserted-by":"crossref","first-page":"12022","DOI":"10.1073\/pnas.0802814105","article-title":"The kinase domain of mitochondrial PINK1 faces the cytoplasm","volume":"105","author":"Zhou","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.200910140","article-title":"PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy","volume":"189","author":"Matsuda","year":"2010","journal-title":"J. Cell. Biol"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B21","doi-asserted-by":"crossref","first-page":"e1000298.","DOI":"10.1371\/journal.pbio.1000298","article-title":"PINK1 is selectively stabilized on impaired mitochondria to activate Parkin","volume":"8","author":"Narendra","year":"2010","journal-title":"PLoS Biol"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B22","doi-asserted-by":"crossref","first-page":"48120","DOI":"10.1074\/jbc.M306889200","article-title":"Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age","volume":"278","author":"Pawlyk","year":"2003","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B23","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell. Biol"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B24","doi-asserted-by":"crossref","first-page":"10.","DOI":"10.1186\/s13024-017-0149-0","article-title":"The SH-SY5Y cell line in Parkinson's disease research: a systematic review","volume":"12","author":"Xicoy","year":"2017","journal-title":"Mol. Neurodegener"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B25","doi-asserted-by":"crossref","first-page":"22284","DOI":"10.1074\/jbc.M312847200","article-title":"Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators","volume":"279","author":"Dooley","year":"2004","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B26","doi-asserted-by":"crossref","first-page":"12413","DOI":"10.1523\/JNEUROSCI.0719-07.2007","article-title":"Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin","volume":"27","author":"Exner","year":"2007","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B27","doi-asserted-by":"crossref","first-page":"13843","DOI":"10.1074\/jbc.M808515200","article-title":"Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission","volume":"284","author":"Dagda","year":"2009","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B28","doi-asserted-by":"crossref","first-page":"11740","DOI":"10.1074\/jbc.M109.066662","article-title":"Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1","volume":"285","author":"Cui","year":"2010","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neuro.2014.04.007","article-title":"Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells","volume":"44","author":"Rojas-Charry","year":"2014","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B30","doi-asserted-by":"crossref","first-page":"22938","DOI":"10.1074\/jbc.M109.035774","article-title":"Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation","volume":"284","author":"Lutz","year":"2009","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbadis.2013.01.004","article-title":"Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca(2+) transfer to sustain cell bioenergetics","volume":"1832","author":"Cali","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B32","doi-asserted-by":"crossref","first-page":"10190","DOI":"10.1073\/pnas.1107402108","article-title":"Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation","volume":"108","author":"Rambold","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B33","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1073\/pnas.0737556100","article-title":"Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants","volume":"100","author":"Greene","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B34","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nature04788","article-title":"Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin","volume":"441","author":"Park","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B35","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial dynamics\u2013mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N. Engl. J. Med"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B36","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2174\/1570159X13666151030102718","article-title":"Anti-oxidants in Parkinson's disease therapy: a critical point of view","volume":"14","author":"Filograna","year":"2016","journal-title":"Curr. Neuropharmacol"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B38","doi-asserted-by":"crossref","first-page":"300","DOI":"10.15252\/embr.201541486","article-title":"The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation","volume":"17","author":"Yamano","year":"2016","journal-title":"EMBO Rep"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B39","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ncpneuro0924","article-title":"Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis","volume":"4","author":"Henchcliffe","year":"2008","journal-title":"Nat. Clin. Pract. Neurol"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B40","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF03033137","article-title":"Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease","volume":"5","author":"Asanuma","year":"2003","journal-title":"Neurotox. Res"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B41","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0026-895X(25)13535-9","article-title":"Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones","volume":"14","author":"Graham","year":"1978","journal-title":"Mol. Pharmacol"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B42","doi-asserted-by":"crossref","first-page":"18738","DOI":"10.1074\/jbc.M111.311589","article-title":"Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53","volume":"287","author":"Girotto","year":"2012","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B43","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.bbrc.2010.03.044","article-title":"Dopamine quinones interact with alpha-synuclein to form unstructured adducts","volume":"394","author":"Bisaglia","year":"2010","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B44","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/nm1314","article-title":"Dopamine covalently modifies and functionally inactivates parkin","volume":"11","author":"LaVoie","year":"2005","journal-title":"Nat. Med"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B45","doi-asserted-by":"crossref","first-page":"e38026.","DOI":"10.1371\/journal.pone.0038026","article-title":"Human SOD2 modification by dopamine quinones affects enzymatic activity by promoting its aggregation: possible implications for Parkinson's disease","volume":"7","author":"Belluzzi","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B46","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00401-017-1726-6","article-title":"Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brain","volume":"134","author":"Trist","year":"2017","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B47","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.neurobiolaging.2013.09.034","article-title":"Copper pathology in vulnerable brain regions in Parkinson's disease","volume":"35","author":"Davies","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B48","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.cmet.2011.10.010","article-title":"In vivo mapping of hydrogen peroxide and oxidized glutathione reveals chemical and regional specificity of redox homeostasis","volume":"14","author":"Albrecht","year":"2011","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180626055859_ddy069-B49","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.cmet.2016.03.009","article-title":"Mitochondrial ROS produced via reverse electron transport extend animal lifespan","volume":"23","author":"Scial\u00f2","year":"2016","journal-title":"Cell Metab"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/27\/9\/1618\/25087288\/ddy069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T20:24:27Z","timestamp":1751401467000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/27\/9\/1618\/4908668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,24]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,2,24]]},"published-print":{"date-parts":[[2018,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy069","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,5,1]]},"published":{"date-parts":[[2018,2,24]]}}}