{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:02:40Z","timestamp":1791810160883,"version":"4.3.4"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["093077"],"award-info":[{"award-number":["093077"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000346","name":"Ataxia UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000346","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RS MacDonald Charitable Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"DOI":"10.1093\/hmg\/ddy169","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T19:38:10Z","timestamp":1525376290000},"page":"2614-2627","source":"Crossref","is-referenced-by-count":39,"title":["Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells"],"prefix":"10.1093","volume":"27","author":[{"given":"Emma M","family":"Perkins","sequence":"first","affiliation":[{"name":"The Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne L","family":"Clarkson","sequence":"additional","affiliation":[{"name":"The Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daumante","family":"Suminaite","sequence":"additional","affiliation":[{"name":"The Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair R","family":"Lyndon","sequence":"additional","affiliation":[{"name":"School of Energy, Geoscience, Infrastructure and Society, Heriot-Watt University, John Muir Building, Riccarton, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-Ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D","family":"Rothstein","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Skehel","sequence":"additional","affiliation":[{"name":"The Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J A","family":"Wyllie","sequence":"additional","affiliation":[{"name":"The Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, Edinburgh, UK"},{"name":"Centre for Brain Development and Repair, Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Jackson","sequence":"additional","affiliation":[{"name":"The Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"key":"key\n\t\t\t\t20180717055103_ddy169-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2001","journal-title":"Prog. Neurobiol"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s12311-008-0063-7","article-title":"The cerebellum, cerebellar disorders, and cerebellar research \u2013 two centuries of discoveries","volume":"7","author":"Manto","year":"2008","journal-title":"Cerebellum"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/72101","article-title":"Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1","volume":"3","author":"Lin","year":"2000","journal-title":"Nat. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s12311-014-0605-0","article-title":"Decreased expression of glutamate transporter GLAST in Bergmann glia is associated with the loss of Purkinje neurons in the spinocerebellar ataxia type 1","volume":"14","author":"Cvetanovic","year":"2015","journal-title":"Cerebellum"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B5","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1523\/JNEUROSCI.6065-09.2010","article-title":"Loss of \u03b2-III spectrin leads to Purkinje cell dysfunction recapitulating the behaviour and neuropathology of spinocerebellar ataxia type 5 in humans","volume":"30","author":"Perkins","year":"2010","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B6","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.1073\/pnas.1001522107","article-title":"Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes","volume":"107","author":"Stankewich","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B7","first-page":"4448","article-title":"Posterior cerebellar Purkinje cells in an SCA5\/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of \u03b2-III spectrin and GLAST","volume":"25","author":"Perkins","year":"2016","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B8","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/nn1750","article-title":"Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport","volume":"9","author":"Custer","year":"2006","journal-title":"Nat. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B9","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1212\/01.WNL.0000172638.58172.5a","article-title":"Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures","volume":"65","author":"Jen","year":"2005","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/archneurol.2008.535","article-title":"Episodic ataxia associated with EAAT1 mutation C186S affecting glutamate reuptake","volume":"66","author":"de Vries","year":"2009","journal-title":"Arch. Neurol"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/jhg.2016.137","article-title":"Late-onset episodic ataxia associated with SLC1A3 mutation","volume":"62","author":"Choi","year":"2017","journal-title":"J. Hum. Genet"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B12","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0387-7604(02)00103-1","article-title":"Oxidative stress and disturbed glutamate transport in spinal muscular atrophy","volume":"24","author":"Hayashi","year":"2002","journal-title":"Brain Dev"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B13","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.neurobiolaging.2013.11.009","article-title":"Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor\/ataxia syndrome","volume":"35","author":"Pretto","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B14","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.biopsych.2008.05.001","article-title":"Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2\/3 agonist","volume":"64","author":"Karlsson","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1126\/science.1155174","article-title":"Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia","volume":"320","author":"Walsh","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000051260","article-title":"Alzheimer\u2019s disease and the cerebellum: a morphologic study on neuronal and glial changes","volume":"12","author":"Sj\u00f6beck","year":"2001","journal-title":"Dement. Geriatr. Cogn. Disord"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B17","first-page":"221","article-title":"Dendritic and spinal pathology of the Purkinje cells from the human cerebellar vermis in Alzheimer\u2019s disease","volume":"25","author":"Mavroudis","year":"2013","journal-title":"Psychiatr. Danub"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0140-6736(94)90923-7","article-title":"Cerebellar hypoplasia and hyperplasia in infantile autism","volume":"343","author":"Courchesne","year":"1994","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B19","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1093\/brain\/awh287","article-title":"Neuropathological findings in autism","volume":"127","author":"Palmen","year":"2004","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B20","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s12311-008-0043-y","article-title":"Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k","volume":"7","author":"Whitney","year":"2008","journal-title":"Cerebellum"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B21","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/brain\/121.4.561","article-title":"The cerebellar cognitive affective syndrome","volume":"121","author":"Schmahmann","year":"1998","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B22","doi-asserted-by":"crossref","first-page":"e20035.","DOI":"10.1371\/journal.pone.0020035","article-title":"Altered cerebellar-cerebral functional connectivity in geriatric depression","volume":"6","author":"Alalade","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cortex.2009.10.005","article-title":"The cerebellum and dyslexia","volume":"47","author":"Stoodley","year":"2011","journal-title":"Cortex"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B24","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1097\/00001756-199608120-00032","article-title":"EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses","volume":"7","author":"Yamada","year":"1996","journal-title":"Neuroreport"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B25","doi-asserted-by":"crossref","first-page":"8751","DOI":"10.1523\/JNEUROSCI.18-21-08751.1998","article-title":"The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain","volume":"18","author":"Lehre","year":"1998","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B26","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neures.2005.11.002","article-title":"Roles of glial glutamate transporters in shaping EPSCs at the climbing fiber-Purkinje cell synapses","volume":"54","author":"Takatsuru","year":"2006","journal-title":"Neurosci. Res"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B27","first-page":"929","article-title":"EAAT4, a glutamate transporter with properties of a chloride channel, is predominantly localized in Purkinje cell dendrites, and forms parasagittal compartments in rat cerebellum","volume":"78","author":"Nagao","year":"1997","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B28","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1523\/JNEUROSCI.18-10-03606.1998","article-title":"The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia","volume":"18","author":"Dehnes","year":"1998","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B29","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1523\/JNEUROSCI.5232-11.2012","article-title":"Neuronal glutamate transporters regulate glial excitatory transmission","volume":"32","author":"Tsai","year":"2012","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B30","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/0896-6273(93)90086-7","article-title":"The metabotropic glutamate receptor (mGluR\u03b1) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction","volume":"11","author":"Baude","year":"1993","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B31","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/nn1539","article-title":"Patterned expression of Purkinje cell glutamate transporters controls synaptic plasticity","volume":"8","author":"Wadiche","year":"2005","journal-title":"Nat. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B32","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/0896-6273(95)90340-2","article-title":"Kinetics of a human glutamate transporter","volume":"14","author":"Wadiche","year":"1995","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B33","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1523\/JNEUROSCI.17-12-04672.1997","article-title":"Transporters buffer synaptically released glutamate on a submillisecond time scale","volume":"17","author":"Diamond","year":"1997","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0896-6273(00)80379-7","article-title":"Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration","volume":"19","author":"H\u00e4usser","year":"1997","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B35","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1523\/JNEUROSCI.17-12-04517.1997","article-title":"Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons","volume":"17","author":"Raman","year":"1997","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B36","doi-asserted-by":"crossref","first-page":"e105633.","DOI":"10.1371\/journal.pone.0105633","article-title":"Systematic regional variations in Purkinje cell spiking patterns","volume":"9","author":"Xiao","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B37","doi-asserted-by":"crossref","first-page":"e02536","DOI":"10.7554\/eLife.02536","article-title":"Cerebellar modules operate at different frequencies","volume":"3","author":"Zhou","year":"2014","journal-title":"Elife"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.expneurol.2006.08.016","article-title":"Analysis of cerebellar Purkinje cells using EAAT4 glutamate transporter promoter reporter in mice generated via bacterial artificial chromosome-mediated transgenesis","volume":"203","author":"Gincel","year":"2007","journal-title":"Exp. Neurol"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B39","doi-asserted-by":"crossref","first-page":"8733","DOI":"10.1073\/pnas.96.15.8733","article-title":"Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin","volume":"96","author":"Jabaudon","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1152\/jn.1997.78.1.63","article-title":"Metabotropic glutamate receptor agonists alter neuronal excitability and Ca2+ levels via the phospholipase C transduction pathway in cultured Purkinje neurons","volume":"78","author":"Netzeband","year":"1997","journal-title":"J. Neurophysiol"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B41","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nn1227","article-title":"Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapses","volume":"7","author":"Duguid","year":"2004","journal-title":"Nat. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B42","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1523\/JNEUROSCI.1338-04.2004","article-title":"Glial glutamate transporters limit spillover activation of presynaptic NMDA receptors and influence synaptic inhibition of Purkinje neurons","volume":"24","author":"Huang","year":"2004","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1469-7793.1997.077bo.x","article-title":"Dendritic and somatic glutamate receptor channels in rat cerebellar Purkinje cells","volume":"501","author":"H\u00e4ausser","year":"1997","journal-title":"J. Physiol"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B44","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1523\/JNEUROSCI.1020-05.2005","article-title":"Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses","volume":"25","author":"Takayasu","year":"2005","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B45","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neures.2007.07.006","article-title":"Facilitated activation of metabotropic glutamate receptors in cerebellar Purkinje cells in glutamate transporter EAAT4-deficient mice","volume":"59","author":"Nikkuni","year":"2007","journal-title":"Neurosci. Res"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1523\/JNEUROSCI.4473-03.2004","article-title":"Climbing fiber activation of EAAT4 transporters and kainite receptors in cerebellar Purkinje cells","volume":"24","author":"Huang","year":"2004","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B47","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neures.2006.03.007","article-title":"Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death: an in vivo study using a cardiac arrest model in mice lacking GLAST or EAAT4","volume":"55","author":"Yamashita","year":"2006","journal-title":"Neurosci. Res"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B48","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1126\/science.277.5331.1515","article-title":"Postsynaptic glutamate transport at the climbing fiber-Purkinje cell synapse","volume":"277","author":"Otis","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B49","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0896-6273(00)00132-X","article-title":"Fast removal of synaptic glutamate by postsynaptic transporters","volume":"28","author":"Auger","year":"2000","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B50","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1523\/JNEUROSCI.5118-09.2010","article-title":"Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum","volume":"30","author":"Paukert","year":"2010","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B51","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1523\/JNEUROSCI.3953-15.2016","article-title":"Prolonged type 1 metabotropic glutamate receptor dependent synaptic signaling contributes to spino-cerebellar ataxia type 1","volume":"36","author":"Power","year":"2016","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B52","doi-asserted-by":"crossref","first-page":"e26377","DOI":"10.7554\/eLife.26377","article-title":"A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2","volume":"6","author":"Meera","year":"2017","journal-title":"Elife"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B53","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1172\/JCI74770","article-title":"Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model","volume":"125","author":"Maltecca","year":"2015","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B54","doi-asserted-by":"crossref","first-page":"48.","DOI":"10.1186\/1756-6606-6-48","article-title":"Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1","volume":"6","author":"Notartomaso","year":"2013","journal-title":"Mol. Brain"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B55","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1152\/jn.00369.2016","article-title":"Purkinje cell intrinsic excitability increases after synaptic long term depression","volume":"116","author":"Yang","year":"2016","journal-title":"J. Neurophysiol"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B56","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0092-8674(94)90205-4","article-title":"Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice","volume":"79","author":"Aiba","year":"1994","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B57","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1152\/jn.00796.2009","article-title":"Synaptic activation of T-type Ca2+ channels via mGluR activation in the primary dendrite of mitral cells","volume":"103","author":"Johnston","year":"2010","journal-title":"J. Neurophysiol"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B58","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1113\/JP270453","article-title":"Protein kinase C bidirectionally modulates Ih and hyperpolarization-activated cyclic nucleotide-gated (HCN) channel surface expression in hippocampal pyramidal neurons","volume":"593","author":"Williams","year":"2015","journal-title":"J. Physiol"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B59","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nn1648","article-title":"Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia","volume":"9","author":"Walter","year":"2006","journal-title":"Nat. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B60","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/ng1758","article-title":"Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes","volume":"38","author":"Waters","year":"2006","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B61","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/ana.23700","article-title":"Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19","volume":"72","author":"Duarri","year":"2012","journal-title":"Ann. Neurol"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B62","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/ana.23701","article-title":"Mutations in KCND3 cause spinocerebellar ataxia type 22","volume":"72","author":"Lee","year":"2012","journal-title":"Ann. Neurol"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B63","first-page":"15","article-title":"Parasagittal compartmentalization of the metabotropic glutamate receptor mGluR1b in the cerebellar cortex","volume":"5","author":"Mateos","year":"2001","journal-title":"Eur. J. Anat"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B64","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/cne.20912","article-title":"Complementary stripes of phospholipase Cbeta3 and Cbeta4 expression by Purkinje cell subsets in the mouse cerebellum","volume":"496","author":"Sarna","year":"2006","journal-title":"J. Comp. Neurol"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B65","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1523\/JNEUROSCI.3542-13.2014","article-title":"The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function","volume":"34","author":"Ohtani","year":"2014","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B66","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1074\/jbc.273.1.425","article-title":"A cluster of basic residues in the carboxyl-terminal tail of the short metabotropic glutamate receptor 1 variants impairs their coupling to phospholipase C","volume":"273","author":"Mary","year":"1998","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B67","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1046\/j.1460-9568.1998.00108.x","article-title":"Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice","volume":"10","author":"Watase","year":"1998","journal-title":"Eur. J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B68","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1093\/brain\/aws255","article-title":"A point mutation associated with episodic ataxia 6 increases glutamate transporter anion currents","volume":"135","author":"Winter","year":"2012","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B69","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1523\/JNEUROSCI.0197-16.2016","article-title":"Disruption of an EAAT-mediated chloride channel in a Drosophila model of ataxia","volume":"36","author":"Parinejad","year":"2016","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B70","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.1073\/pnas.1617330114","article-title":"Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells","volume":"114","author":"Miyazaki","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B71","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0896-6273(94)90210-0","article-title":"Development and regional expression in the rat brain and properties of four NMDA receptors","volume":"12","author":"Monyer","year":"1994","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B72","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0168-0102(97)00087-4","article-title":"GABA(B) receptor activation of Purkinje cells in cerebellar slices","volume":"29","author":"Vigot","year":"1997","journal-title":"Neurosci. Res"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B73","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/YPG.0b013e328341a307","article-title":"Genetic and functional studies of a missense variant in a glutamate transporter, SLC1A3, in Tourette syndrome","volume":"21","author":"Adamczyk","year":"2011","journal-title":"Psychiatr. Genet"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B74","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ejmg.2016.06.003","article-title":"Duplications of SLC1A3: associated with ADHD and autism","volume":"59","author":"van Amen-Hellebrekers","year":"2016","journal-title":"Eur. J. Med. Genet"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B75","doi-asserted-by":"crossref","first-page":"12627.","DOI":"10.1038\/ncomms12627","article-title":"Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice","volume":"7","author":"Peter","year":"2016","journal-title":"Nat. Commun"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B76","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1093\/hmg\/ddu103","article-title":"III spectrin underpins ankyrin R function in Purkinje cell dendritic tress: protein complex critical for sodium channel activity is impaired by SCA5-associated mutations","volume":"23","author":"Clarkson","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B77","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1523\/JNEUROSCI.1069-16.2016","article-title":"Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to fragile X syndrome phenotypes in vivo","volume":"36","author":"Higashimori","year":"2016","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B78","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/npp.2015.26","article-title":"Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice","volume":"40","author":"Aida","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20180717055103_ddy169-B79","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1523\/JNEUROSCI.2170-14.2015","article-title":"Structure-function relationships between aldolase C\/Zebrin II expression and complex spike synchrony in the cerebellum","volume":"35","author":"Tsutsumi","year":"2015","journal-title":"J. Neurosci"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/27\/15\/2614\/25170168\/ddy169.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T08:59:43Z","timestamp":1571302783000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/27\/15\/2614\/4993965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,8]]},"references-count":79,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2018,5,8]]},"published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy169","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,8,1]]},"published":{"date-parts":[[2018,5,8]]}}}