{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:13:40Z","timestamp":1789708420247,"version":"4.0.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"Project for Development of Innovative Research on Cancer Therapeutics"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004696","name":"National Bioscience Database Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004696","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004696","name":"NBDC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004696","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001695","name":"JST","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"KAKENHI","award":["16K11020"],"award-info":[{"award-number":["16K11020"]}]},{"name":"KAKENHI","award":["15604475"],"award-info":[{"award-number":["15604475"]}]},{"name":"KAKENHI","award":["15551829"],"award-info":[{"award-number":["15551829"]}]},{"name":"KAKENHI","award":["15K10600"],"award-info":[{"award-number":["15K10600"]}]},{"name":"Intramural Research Program"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Cancer Research"},{"DOI":"10.13039\/100012728","name":"Frederick National Laboratory for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HHSN261200800001E"],"award-info":[{"award-number":["HHSN261200800001E"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Health and Human Services"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"DOI":"10.1093\/hmg\/ddy181","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T11:07:58Z","timestamp":1525864078000},"page":"2712-2724","source":"Crossref","is-referenced-by-count":22,"title":["BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-8835","authenticated-orcid":false,"given":"Hisashi","family":"Hasumi","sequence":"first","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"},{"name":"Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuko","family":"Furuya","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tatsuno","sequence":"additional","affiliation":[{"name":"Genome Science Division, Research Center for Advanced Science and Technology, The University Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Genome Science Division, Research Center for Advanced Science and Technology, The University Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Baba","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"},{"name":"International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Hasumi","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"},{"name":"Department of Ophthalmology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Isono","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Jikuya","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Otake","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Muraoka","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimito","family":"Osaka","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narihiko","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Makiyama","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Nakaigawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Teranishi","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Yumura","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroji","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam R","family":"Metwalli","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"},{"name":"Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Aburatani","sequence":"additional","affiliation":[{"name":"Genome Science Division, Research Center for Advanced Science and Technology, The University Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Marston","family":"Linehan","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Urology, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"key\n\t\t\t\t20180717055120_ddy181-B1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/iju.13015","article-title":"Birt\u2013Hogg\u2013Dube syndrome: clinical and molecular aspects of recently identified kidney cancer syndrome","volume":"23","author":"Hasumi","year":"2016","journal-title":"Int. J. Urol"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/cge.12807","article-title":"Genetic, epidemiologic and clinicopathologic studies of Japanese Asian patients with Birt\u2013Hogg\u2013Dube syndrome","volume":"90","author":"Furuya","year":"2016","journal-title":"Clin. Genet"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1535-6108(02)00104-6","article-title":"Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt\u2013Hogg\u2013Dube syndrome","volume":"2","author":"Nickerson","year":"2002","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B4","first-page":"354","article-title":"H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation","volume":"26","author":"Hasumi","year":"2017","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/jnci\/dji154","article-title":"High frequency of somatic frameshift BHD gene mutations in Birt\u2013Hogg\u2013Dube-associated renal tumors","volume":"97","author":"Vocke","year":"2005","journal-title":"J. Natl. Cancer Inst"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B6","doi-asserted-by":"crossref","first-page":"e1005520","DOI":"10.1371\/journal.pgen.1005520","article-title":"FLCN and AMPK confer resistance to hyperosmotic stress via remodeling of glycogen stores","volume":"11","author":"Possik","year":"2015","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B7","doi-asserted-by":"crossref","first-page":"e1004273","DOI":"10.1371\/journal.pgen.1004273","article-title":"Folliculin regulates AMPK-dependent autophagy and metabolic stress survival","volume":"10","author":"Possik","year":"2014","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B8","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/onc.2009.14","article-title":"The role of the Birt\u2013Hogg\u2013Dube protein in mTOR activation and renal tumorigenesis","volume":"28","author":"Hartman","year":"2009","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B9","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1093\/hmg\/ddu286","article-title":"Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation","volume":"23","author":"Hasumi","year":"2014","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B10","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1093\/jnci\/djs418","article-title":"Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN","volume":"104","author":"Hasumi","year":"2012","journal-title":"J. Natl. Cancer Inst"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B11","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1172\/JCI71749","article-title":"The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation","volume":"124","author":"Yan","year":"2014","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B12","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/stem.2293","article-title":"Loss of folliculin disrupts hematopoietic stem cell quiescence and homeostasis resulting in bone marrow failure","volume":"34","author":"Baba","year":"2016","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B13","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1101\/gad.287953.116","article-title":"The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue","volume":"30","author":"Wada","year":"2016","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B14","doi-asserted-by":"crossref","first-page":"e12107","DOI":"10.14814\/phy2.12107","article-title":"Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells","volume":"2","author":"Khabibullin","year":"2014","journal-title":"Physiol Rep"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B15","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1182\/blood-2012-02-410407","article-title":"The folliculin-FNIP1 pathway deleted in human Birt\u2013Hogg\u2013Dube syndrome is required for murine B-cell development","volume":"120","author":"Baba","year":"2012","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B16","doi-asserted-by":"crossref","first-page":"15552","DOI":"10.1073\/pnas.0603781103","article-title":"Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling","volume":"103","author":"Baba","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.gene.2008.02.022","article-title":"Identification and characterization of a novel folliculin-interacting protein FNIP2","volume":"415","author":"Hasumi","year":"2008","journal-title":"Gene"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B18","doi-asserted-by":"crossref","first-page":"E1624","DOI":"10.1073\/pnas.1419502112","article-title":"Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn","volume":"112","author":"Hasumi","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B19","doi-asserted-by":"crossref","first-page":"9947","DOI":"10.18632\/oncotarget.14221","article-title":"Nutrient-induced FNIP degradation by SCFbeta-TRCP regulates FLCN complex localization and promotes renal cancer progression","volume":"8","author":"Nagashima","year":"2017","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B20","doi-asserted-by":"crossref","first-page":"18722","DOI":"10.1073\/pnas.0908853106","article-title":"Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2","volume":"106","author":"Hasumi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B21","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/jnci\/djm288","article-title":"Kidney-targeted Birt\u2013Hogg\u2013Dube gene inactivation in a mouse model: Erk1\/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys","volume":"100","author":"Baba","year":"2008","journal-title":"J. Natl. Cancer Inst"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF00420947","article-title":"von Hippel-Lindau disease: identification of deletion mutations by pulsed-field gel electrophoresis","volume":"92","author":"Yao","year":"1993","journal-title":"Hum. Genet"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B23","author":"Ueda"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/ng.3146","article-title":"Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes","volume":"47","author":"Durinck","year":"2015","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ccr.2014.07.014","article-title":"The somatic genomic landscape of chromophobe renal cell carcinoma","volume":"26","author":"Davis","year":"2014","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B26","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/ng.2699","article-title":"Integrated molecular analysis of clear-cell renal cell carcinoma","volume":"45","author":"Sato","year":"2013","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature12222","article-title":"Comprehensive molecular characterization of clear cell renal cell carcinoma","volume":"499","author":"Cancer Genome Atlas Research Network","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1056\/NEJMoa1505917","article-title":"Comprehensive molecular characterization of papillary renal-cell carcinoma","volume":"374","author":"Linehan","year":"2016","journal-title":"N. Engl. J. Med"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B29","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1200\/JCO.2012.45.2003","article-title":"Molecular genetics of clear-cell renal cell carcinoma","volume":"32","author":"Brugarolas","year":"2014","journal-title":"J. Clin. Oncol"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B30","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/ng.2323","article-title":"BAP1 loss defines a new class of renal cell carcinoma","volume":"44","author":"Pena-Llopis","year":"2012","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B31","doi-asserted-by":"crossref","first-page":"16538","DOI":"10.1073\/pnas.1414789111","article-title":"Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B32","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1016\/j.celrep.2017.02.074","article-title":"The SWI\/SNF protein PBRM1 restrains VHL-loss-driven clear cell renal cell carcinoma","volume":"18","author":"Nargund","year":"2017","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/23808993.2017.1284557","article-title":"The role of epigenomics in personalized medicine","volume":"2","author":"Kronfol","year":"2017","journal-title":"Expert Rev. Precis Med. Drug Dev"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B34","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1172\/JCI7319","article-title":"Tsc2(+\/\u2212) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background","volume":"104","author":"Onda","year":"1999","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B35","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1093\/hmg\/ddu597","article-title":"A shower of second hit events as the cause of multifocal renal cell carcinoma in tuberous sclerosis complex","volume":"24","author":"Tyburczy","year":"2015","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B36","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.semcancer.2012.06.002","article-title":"The metabolic basis of kidney cancer","volume":"23","author":"Linehan","year":"2013","journal-title":"Semin. Cancer Biol"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B37","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1101\/gad.281410.116","article-title":"Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1alpha\/ERRalpha","volume":"30","author":"Yan","year":"2016","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B38","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/cas.12601","article-title":"Distinctive expression patterns of glycoprotein non-metastatic B and folliculin in renal tumors in patients with Birt\u2013Hogg\u2013Dube syndrome","volume":"106","author":"Furuya","year":"2015","journal-title":"Cancer Sci"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B39","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ajpath.2015.10.013","article-title":"Genome-wide uniparental disomy and copy number variations in renal cell carcinomas associated with Birt\u2013Hogg\u2013Dube syndrome","volume":"186","author":"Iribe","year":"2016","journal-title":"Am. J. Pathol"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B40","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/pin.12254","article-title":"Immunohistochemical characterization of renal tumors in patients with Birt\u2013Hogg\u2013Dube syndrome","volume":"65","author":"Iribe","year":"2015","journal-title":"Pathol. Int"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B41","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows\u2013Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B42","year":"2017"},{"key":"key\n\t\t\t\t20180717055120_ddy181-B43","doi-asserted-by":"crossref","first-page":"D18","DOI":"10.1093\/nar\/gku1120","article-title":"The DDBJ Japanese Genotype-phenotype Archive for genetic and phenotypic human data","volume":"43","author":"Kodama","year":"2015","journal-title":"Nucleic Acids Res"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/27\/15\/2712\/25170231\/ddy181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T12:39:20Z","timestamp":1589891960000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/27\/15\/2712\/4996218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,14]]},"references-count":43,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2018,5,14]]},"published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy181","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,8,1]]},"published":{"date-parts":[[2018,5,14]]}}}