{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:47:18Z","timestamp":1789505238271,"version":"build-2803163510"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-12-EMMA-0013"],"award-info":[{"award-number":["ANR-12-EMMA-0013"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-14-CE13-0035"],"award-info":[{"award-number":["ANR-14-CE13-0035"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1093\/hmg\/ddy207","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T15:10:54Z","timestamp":1527174654000},"page":"3012-3028","source":"Crossref","is-referenced-by-count":23,"title":["Improvement of BDNF signalling by P42 peptide in Huntington's disease"],"prefix":"10.1093","volume":"27","author":[{"given":"Simon","family":"Couly","sequence":"first","affiliation":[{"name":"MMDN, Univ-Montpellier, EPHE, INSERM, UMR-S1198, Montpellier F-34095, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Paucard","sequence":"additional","affiliation":[{"name":"MMDN, Univ-Montpellier, EPHE, INSERM, UMR-S1198, Montpellier F-34095, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bonneaud","sequence":"additional","affiliation":[{"name":"MMDN, Univ-Montpellier, EPHE, INSERM, UMR-S1198, Montpellier F-34095, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangui","family":"Maurice","sequence":"additional","affiliation":[{"name":"MMDN, Univ-Montpellier, EPHE, INSERM, UMR-S1198, Montpellier F-34095, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Benigno","sequence":"additional","affiliation":[{"name":"Medesis Pharma, Baillargues F-34670, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Jourdan","sequence":"additional","affiliation":[{"name":"MMDN, Univ-Montpellier, EPHE, INSERM, UMR-S1198, Montpellier F-34095, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cohen-Solal","sequence":"additional","affiliation":[{"name":"IBMM-UMR5247, Univ-Montpellier, Montpellier F-34095, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Vignes","sequence":"additional","affiliation":[{"name":"IBMM-UMR5247, Univ-Montpellier, Montpellier F-34095, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Maschat","sequence":"additional","affiliation":[{"name":"MMDN, Univ-Montpellier, EPHE, INSERM, UMR-S1198, Montpellier F-34095, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"key\n\t\t\t\t20180817083354_ddy207-B1","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1136\/jnnp-2012-304636","article-title":"Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records","volume":"84","author":"Evans","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B2","doi-asserted-by":"crossref","first-page":"24.","DOI":"10.1186\/s13023-016-0405-3","article-title":"The P42 peptide and peptide-based therapies for Huntington's disease","volume":"11","author":"Marelli","year":"2016","journal-title":"Orphanet. J. Rare Dis"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000443738","article-title":"The prevalence of Huntington's disease","volume":"46","author":"Rawlins","year":"2016","journal-title":"Neuroepidemiology"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B4","doi-asserted-by":"crossref","first-page":"12784","DOI":"10.1073\/pnas.221451398","article-title":"Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis","volume":"98","author":"Kim","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B5","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1523\/JNEUROSCI.22-18-07862.2002","article-title":"Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease","volume":"22","author":"Wellington","year":"2002","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1097-2765(02)00602-0","article-title":"Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions","volume":"10","author":"Lunkes","year":"2002","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B7","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1073\/pnas.1221891110","article-title":"Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease","volume":"110","author":"Sathasivam","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B8","doi-asserted-by":"crossref","first-page":"e60012.","DOI":"10.1371\/journal.pone.0060012","article-title":"Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6\/2 mouse model of HD","volume":"8","author":"Rattray","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B9","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999","article-title":"Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation","volume":"19","author":"Carter","year":"1999","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1601-183X.2012.00858.x","article-title":"Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6\/2 mouse model of Huntington's disease","volume":"12","author":"Samadi","year":"2013","journal-title":"Genes Brain Behav"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1750-3639.2007.00111.x","article-title":"Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease","volume":"18","author":"Zuccato","year":"2007","journal-title":"Brain Pathol"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B13","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","article-title":"Dysregulation of gene expression in the R6\/2 model of polyglutamine disease: parallel changes in muscle and brain","volume":"11","author":"Luthi-Carter","year":"2002","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pneurobio.2007.01.003","article-title":"Role of brain-derived neurotrophic factor in Huntington's disease","volume":"81","author":"Zuccato","year":"2007","journal-title":"Progr. Neurobiol"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B16","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1460-9568.2006.04590.x","article-title":"Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain","volume":"23","author":"Gines","year":"2006","journal-title":"Eur. J. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B17","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2005.07.003","article-title":"Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications","volume":"28","author":"Nagappan","year":"2005","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B18","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/81593","article-title":"Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice","volume":"26","author":"Dragatsis","year":"2000","journal-title":"Nat. Genet"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1086\/318207","article-title":"Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo","volume":"68","author":"Leavitt","year":"2001","journal-title":"Am. J. Hum. Genet"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B20","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/brain\/awg077","article-title":"Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course","volume":"126","author":"Squitieri","year":"2003","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B21","doi-asserted-by":"crossref","first-page":"80.","DOI":"10.1186\/1471-2202-7-80","article-title":"Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease","volume":"7","author":"Van Raamsdonk","year":"2006","journal-title":"BMC Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B22","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nrn1806","article-title":"Normal huntingtin function: an alternative approach to Huntington's disease","volume":"6","author":"Cattaneo","year":"2005","journal-title":"Nat. Rev. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B23","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1093\/hmg\/ddn255","article-title":"Protective role of engrailed in a Drosophila model of Huntington's disease","volume":"17","author":"Mugat","year":"2008","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B24","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00041.2009","article-title":"Molecular mechanisms and potential therapeutical targets in Huntington's disease","volume":"90","author":"Zuccato","year":"2010","journal-title":"Physiol. Rev"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B25","doi-asserted-by":"crossref","first-page":"e68775.","DOI":"10.1371\/journal.pone.0068775","article-title":"A huntingtin peptide inhibits polyQ-huntingtin associated defects","volume":"8","author":"Arribat","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B26","first-page":"86.","article-title":"Systemic delivery of P42 peptide: a new weapon to fight Huntington inverted question marks disease","volume":"2","author":"Arribat","year":"2014","journal-title":"Acta Neuropathol. Commun"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1602\/neurorx.2.3.447","article-title":"The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies","volume":"2","author":"Li","year":"2005","journal-title":"NeuroRx"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B28","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1523\/JNEUROSCI.2033-12.2013","article-title":"Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites","volume":"33","author":"Liot","year":"2013","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.1059581","article-title":"Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease","volume":"293","author":"Zuccato","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B30","doi-asserted-by":"crossref","first-page":"2031.","DOI":"10.1038\/ncomms3031","article-title":"BDNF-TrkB signaling in striatopallidal neurons controls inhibition of locomotor behavior","volume":"4","author":"Besusso","year":"2013","journal-title":"Nat. Commun"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuroscience.2012.05.043","article-title":"Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington's disease","volume":"251","author":"Nithianantharajah","year":"2013","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B32","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.neuroscience.2008.11.024","article-title":"Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression","volume":"158","author":"Giralt","year":"2009","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B33","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1523\/JNEUROSCI.5113-06.2007","article-title":"Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease","volume":"27","author":"Lynch","year":"2007","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B34","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1073\/pnas.0811228106","article-title":"Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice","volume":"106","author":"Simmons","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B35","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1523\/JNEUROSCI.20-13-05115.2000","article-title":"Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation","volume":"20","author":"Murphy","year":"2000","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B36","article-title":"Disturbance of metabotropic glutamate receptor-mediated long-term depression (mGlu-LTD) of excitatory synaptic transmission in the rat hippocampus after prenatal immune challenge","author":"Cavalier","year":"2018","journal-title":"Neurochem. Res"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/cns.12824","article-title":"Neurotrophin-3 restores synaptic plasticity in the striatum of a mouse model of Huntington's disease","volume":"4","author":"Gomez-Pineda","year":"2018","journal-title":"CNS Neurosci. Ther"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B38","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1523\/JNEUROSCI.3590-06.2007","article-title":"Endogenous brain-derived neurotrophic factor triggers fast calcium transients at synapses in developing dendrites","volume":"27","author":"Lang","year":"2007","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrneurol.2009.54","article-title":"Brain-derived neurotrophic factor in neurodegenerative diseases","volume":"5","author":"Zuccato","year":"2009","journal-title":"Nat. Rev. Neurol"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B40","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/gt.2012.84","article-title":"In vivo delivery of DN: rEST improves transcriptional changes of REST-regulated genes in HD mice","volume":"20","author":"Conforti","year":"2013","journal-title":"Gene Ther"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B41","doi-asserted-by":"crossref","first-page":"7727","DOI":"10.1523\/JNEUROSCI.1197-04.2004","article-title":"Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease","volume":"24","author":"Canals","year":"2004","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B42","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/39885","article-title":"Anterograde transport of brain-derived neurotrophic factor and its role in the brain","volume":"389","author":"Altar","year":"1997","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B43","doi-asserted-by":"crossref","first-page":"e64037.","DOI":"10.1371\/journal.pone.0064037","article-title":"Systemic delivery of recombinant brain derived neurotrophic factor (BDNF) in the R6\/2 mouse model of Huntington's disease","volume":"8","author":"Giampa","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B44","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1152\/jn.01140.2009","article-title":"Activity-dependent release of endogenous BDNF from mossy fibers evokes a TRPC3 current and Ca2+ elevations in CA3 pyramidal neurons","volume":"103","author":"Li","year":"2010","journal-title":"J. Neurophysiol"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B45","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1523\/JNEUROSCI.3310-10.2010","article-title":"Presynaptic BDNF promotes postsynaptic long-term potentiation in the dorsal striatum","volume":"30","author":"Jia","year":"2010","journal-title":"J. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B46","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1113\/jphysiol.2010.188466","article-title":"Distinct coincidence detectors govern the corticostriatal spike timing-dependent plasticity","volume":"588","author":"Fino","year":"2010","journal-title":"J. Physiol"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B47","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.celrep.2017.12.013","article-title":"Reconstituting corticostriatal network on-a-chip reveals the contribution of the presynaptic compartment to Huntington's disease","volume":"22","author":"Virlogeux","year":"2018","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B48","doi-asserted-by":"crossref","DOI":"10.1089\/hum.2017.069","article-title":"Design of a novel gene therapy construct to achieve sustained brain-derived neurotrophic factor signalling in neurons","author":"Osborne","year":"2018","journal-title":"Hum. Gene Ther"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B49","doi-asserted-by":"crossref","first-page":"254.","DOI":"10.3389\/fncel.2014.00254","article-title":"BDNF signaling and survival of striatal neurons","volume":"8","author":"Baydyuk","year":"2014","journal-title":"Front. Cell Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B50","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1172\/JCI27607","article-title":"Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase","volume":"116","author":"Borrell-Pages","year":"2006","journal-title":"J. Clin. Investig"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B51","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1093\/hmg\/ddw238","article-title":"Pridopidine activates neuroprotective pathways impaired in Huntington disease","volume":"25","author":"Geva","year":"2016","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1042\/CS20160044","article-title":"Neurotrophin signalling: novel insights into mechanisms and pathophysiology","volume":"131","author":"Mitre","year":"2017","journal-title":"Clin. Sci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4103\/1673-5374.198964","article-title":"Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury","volume":"12","author":"Wurzelmann","year":"2017","journal-title":"Neural Regen. Res"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B54","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jcis.2013.10.058","article-title":"Phase behavior of reverse microemulsions based on Peceol((R))","volume":"416","author":"Mouri","year":"2014","journal-title":"J. Colloid Interface Sci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B55","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jcis.2015.06.010","article-title":"Development of pharmaceutical clear gel based on Peceol(R), lecithin, ethanol and water: physicochemical characterization and stability study","volume":"457","author":"Mouri","year":"2015","journal-title":"J. Colloid Interface Sci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B56","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijpharm.2016.01.072","article-title":"Formulation, physicochemical characterization and stability study of lithium-loaded microemulsion system","volume":"502","author":"Mouri","year":"2016","journal-title":"Int. J. Pharm"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B57","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.bbr.2009.09.024","article-title":"Behavioral phenotyping of heterozygous acetylcholinesterase knockout (AChE+\/-) mice showed no memory enhancement but hyposensitivity to amnesic drugs","volume":"206","author":"Espallergues","year":"2010","journal-title":"Behav. Brain Res"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B58","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/npp.2013.70","article-title":"Blockade of Tau hyperphosphorylation and Abeta(1)(-)(4)(2) generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and sigma(1) receptor agonist, in a nontransgenic mouse model of Alzheimer's disease","volume":"38","author":"Lahmy","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B59","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1046\/j.1460-9568.1999.00759.x","article-title":"Potentiation of glutamatergic agonist-induced inositol phosphate formation by basic fibroblast growth factor is related to developmental features in hippocampal cultures: neuronal survival and glial cell proliferation","volume":"11","author":"Blanc","year":"1999","journal-title":"Eur. J. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B60","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.freeradbiomed.2005.05.021","article-title":"A transient treatment of hippocampal neurons with alpha-tocopherol induces a long-lasting protection against oxidative damage via a genomic action","volume":"39","author":"de Jesus Ferreira","year":"2005","journal-title":"Free Radic. Biol. Med"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B61","doi-asserted-by":"crossref","first-page":"e74667.","DOI":"10.1371\/journal.pone.0074667","article-title":"Area-specific alterations of synaptic plasticity in the 5XFAD mouse model of Alzheimer's disease: dissociation between somatosensory cortex and hippocampus","volume":"8","author":"Crouzin","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B62","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/hipo.20146","article-title":"Low-frequency stimulation induces a new form of LTP, metabotropic glutamate (mGlu5) receptor- and PKA-dependent, in the CA1 area of the rat hippocampus","volume":"16","author":"Lante","year":"2006","journal-title":"Hippocampus"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B63","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1111\/ejn.13013","article-title":"Involvement of PKA and ERK pathways in ghrelin-induced long-lasting potentiation of excitatory synaptic transmission in the CA1 area of rat hippocampus","volume":"42","author":"Cavalier","year":"2015","journal-title":"Eur. J. Neurosci"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B64","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.freeradbiomed.2007.01.032","article-title":"Alpha-tocopherol-mediated long-lasting protection against oxidative damage involves an attenuation of calcium entry through TRP-like channels in cultured hippocampal neurons","volume":"42","author":"Crouzin","year":"2007","journal-title":"Free Radic. Biol. Med"},{"key":"key\n\t\t\t\t20180817083354_ddy207-B65","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1271\/bbb.90637","article-title":"Complex formation of a brain-derived neurotrophic factor and glycosaminoglycans","volume":"73","author":"Kanato","year":"2009","journal-title":"Biosci. Biotechnol. Biochem"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/27\/17\/3012\/25505594\/ddy207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T09:37:22Z","timestamp":1571391442000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/27\/17\/3012\/5026425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,1]]},"references-count":65,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2018,6,1]]},"published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy207","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2018,6,1]]}}}