{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:49:26Z","timestamp":1773042566753,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","funder":[{"name":"Intramural Research Program of National Institutes of Health"},{"DOI":"10.13039\/100011541","name":"National Cancer Institute, Division of Cancer Epidemiology and Genetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C588\/A19167"],"award-info":[{"award-number":["C588\/A19167"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","award":["RO1-CA-083115-06"],"award-info":[{"award-number":["RO1-CA-083115-06"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001320","name":"Roswell Park Comprehensive Cancer Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001320","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016056"],"award-info":[{"award-number":["P30CA016056"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/hmg\/ddy282","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T15:30:01Z","timestamp":1532619001000},"source":"Crossref","is-referenced-by-count":12,"title":["Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma"],"prefix":"10.1093","author":[{"given":"Fangyi","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA"},{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Huei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, Laval University, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth M","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Concetta","family":"Fargnoli","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donato","family":"Calista","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Maurizio Bufalini Hospital, Cesena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Ghiorzo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, University of Genoa and Genetics of Rare Cancers, Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketty","family":"Peris","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Catholic University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Puig","sequence":"additional","affiliation":[{"name":"Dermatology Department, Melanoma Unit, Hospital Cl\u00ednic de Barcelona, IDIBAPS, Universitat de Barcelona, Barcelona, Spain and Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras (CIBERER), Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Menin","sequence":"additional","affiliation":[{"name":"Department of Immunology and Molecular Oncology, Veneto Institute of Oncology IOV\u2013IRCCS, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arcangela","family":"De Nicolo","sequence":"additional","affiliation":[{"name":"Cancer Genomics Program, Veneto Institute of Oncology IOV\u2013IRCCS, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Rodolfo","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenza","family":"Pastorino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, University of Genoa and Genetics of Rare Cancers, Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelos","family":"Evangelou","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece"},{"name":"Department of Epidemiology and Biostatistics, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongwu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Hua","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curt T","family":"DellaValle","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Timothy Bishop","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"MacGregor","sequence":"additional","affiliation":[{"name":"Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark I","family":"Iles","sequence":"additional","affiliation":[{"name":"Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew H","family":"Law","sequence":"additional","affiliation":[{"name":"Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Cust","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, and Melanoma Institute Australia, The University of Sydney, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J","family":"Stratigos","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology\u2013Venereology, National and Kapodistrian University of Athens School of Medicine, Andreas Sygros Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Nagore","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Instituto Valenciano de Oncolog\u00eda, Val\u00e8ncia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Chanock","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Shi","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanoma Meta-Analysis","family":"Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MelaNostrum","family":"Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Landi","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"key\n\t\t\t\t20180831050349_ref1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1001\/jama.294.6.681","article-title":"Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years","volume":"294","author":"Christenson","year":"2005","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180831050349_ref2","first-page":"24","author":"Cancer Facts & Figures","year":"2017"},{"key":"key\n\t\t\t\t20180831050349_ref3","first-page":"234","article-title":"Epidemiology, etiology, and control of melanoma","volume":"84","author":"Weinstock","year":"2001","journal-title":"Med. Health R. I."},{"key":"key\n\t\t\t\t20180831050349_ref4","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMoa1708539","article-title":"Adjuvant dabrafenib plus trametinib in stage III BRAF-mutated melanoma","volume":"377","author":"Long","year":"2017","journal-title":"New Engl. J. Med."},{"key":"key\n\t\t\t\t20180831050349_ref5","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1056\/NEJMoa1709030","article-title":"Adjuvant nivolumab versus ipilimumab in resected stage III or IV melanoma","volume":"377","author":"Weber","year":"2017","journal-title":"New Engl. J. Med."},{"key":"key\n\t\t\t\t20180831050349_ref6","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1056\/NEJMoa1709684","article-title":"Overall survival with combined nivolumab and ipilimumab in advanced melanoma","volume":"377","author":"Wolchok","year":"2017","journal-title":"New Engl. J. Med."},{"key":"key\n\t\t\t\t20180831050349_ref7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3322\/caac.21409","article-title":"Melanoma staging: evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual","volume":"67","author":"Gershenwald","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"key\n\t\t\t\t20180831050349_ref8","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1200\/JCO.2005.11.108","article-title":"Risk factors and individual probabilities of melanoma for whites","volume":"23","author":"Cho","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"key\n\t\t\t\t20180831050349_ref9","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1158\/1055-9965.EPI-14-1062","article-title":"Development and validation of a melanoma risk score based on pooled data from 16 case-control studies","volume":"24","author":"Davies","year":"2015","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"key\n\t\t\t\t20180831050349_ref10","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1200\/JCO.2005.04.1277","article-title":"Identifying individuals at high risk of melanoma: a practical predictor of absolute risk","volume":"24","author":"Fears","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"key\n\t\t\t\t20180831050349_ref11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/CEJ.0b013e32833b492f","article-title":"Identifying individuals at high risk of melanoma: a simple tool","volume":"19","author":"Fortes","year":"2010","journal-title":"Eur. J. Cancer Prev."},{"key":"key\n\t\t\t\t20180831050349_ref12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1468-3083.2011.04014.x","article-title":"Development of a targeted risk-group model for skin cancer screening based on more than 100,000 total skin examinations","volume":"26","author":"Guther","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"key\n\t\t\t\t20180831050349_ref13","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0140-6736(89)92097-7","article-title":"Personal risk-factor chart for cutaneous melanoma","volume":"2","author":"MacKie","year":"1989","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180831050349_ref14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1440-0960.2010.00727.x","article-title":"Predicting melanoma risk for the Australian population","volume":"52","author":"Mar","year":"2011","journal-title":"Australas. J. Dermatol."},{"key":"key\n\t\t\t\t20180831050349_ref15","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/aje\/kwu356","article-title":"Indoor tanning and the MC1R genotype: risk prediction for basal cell carcinoma risk in young people","volume":"181","author":"Molinaro","year":"2015","journal-title":"Am. J. Epidemiol."},{"key":"key\n\t\t\t\t20180831050349_ref16","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/jid.2014.533","article-title":"Independent validation of six melanoma risk prediction models","volume":"135","author":"Olsen","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"key\n\t\t\t\t20180831050349_ref17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/CEJ.0b013e32834474ae","article-title":"Development of an individual score for melanoma risk","volume":"20","author":"Quereux","year":"2011","journal-title":"Eur. J. Cancer Prev."},{"key":"key\n\t\t\t\t20180831050349_ref18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.7326\/0003-4819-125-5-199609010-00003","article-title":"A prognostic model for predicting 10-year survival in patients with primary melanoma. The Pigmented Lesion Group","volume":"125","author":"Schuchter","year":"1996","journal-title":"Ann. Intern. Med."},{"key":"key\n\t\t\t\t20180831050349_ref19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1186\/1471-2407-14-359","article-title":"Individual risk of cutaneous melanoma in New Zealand: developing a clinical prediction aid","volume":"14","author":"Sneyd","year":"2014","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t20180831050349_ref20","article-title":"Identifying persons at highest risk of melanoma using self-assessed risk factors","volume":"2","author":"Williams","year":"2011","journal-title":"J. Clin. Exp. Dermatol. Res."},{"key":"key\n\t\t\t\t20180831050349_ref21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/jama.2015.17703","article-title":"Familial risk and heritability of cancer among twins in Nordic countries","volume":"315","author":"Mucci","year":"2016","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180831050349_ref22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/jmg.2006.043802","article-title":"Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents","volume":"44","author":"Goldstein","year":"2007","journal-title":"J. Med. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng0196-97","article-title":"Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma","volume":"12","author":"Zuo","year":"1996","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref24","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/ng.910","article-title":"Germline mutations in BAP1 predispose to melanocytic tumors","volume":"43","author":"Wiesner","year":"2011","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref25","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1230062","article-title":"TERT promoter mutations in familial and sporadic melanoma","volume":"339","author":"Horn","year":"2013","journal-title":"Science"},{"key":"key\n\t\t\t\t20180831050349_ref26","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/ng.2947","article-title":"POT1 loss-of-function variants predispose to familial melanoma","volume":"46","author":"Robles-Espinoza","year":"2014","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref27","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/ng.2941","article-title":"Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma","volume":"46","author":"Shi","year":"2014","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref28","article-title":"Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma","volume":"107","author":"Aoude","year":"2015","journal-title":"J. Natl. Cancer Ins."},{"key":"key\n\t\t\t\t20180831050349_ref29","article-title":"PARKIN inactivation links Parkinson's disease to melanoma","volume":"108","author":"Hu","year":"2016","journal-title":"J. Natl. Cancer Ins."},{"key":"key\n\t\t\t\t20180831050349_ref30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature10630","article-title":"A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma","volume":"480","author":"Yokoyama","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180831050349_ref31","doi-asserted-by":"crossref","first-page":"6112","DOI":"10.1093\/hmg\/ddu312","article-title":"Most common 'sporadic' cancers have a significant germline genetic component","volume":"23","author":"Lu","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref32","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ng.3373","article-title":"Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma","volume":"47","author":"Law","year":"2015","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref33","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1126\/science.1217849","article-title":"Melanesian blond hair is caused by an amino acid change in TYRP1","volume":"336","author":"Kenny","year":"2012","journal-title":"Science"},{"key":"key\n\t\t\t\t20180831050349_ref34","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00439-015-1559-0","article-title":"Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up","volume":"134","author":"Liu","year":"2015","journal-title":"Hum. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ajhg.2010.05.017","article-title":"IRF4 variants have age-specific effects on nevus count and predispose to melanoma","volume":"87","author":"Duffy","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref36","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ng.410","article-title":"Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi","volume":"41","author":"Falchi","year":"2009","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085642","article-title":"Joint effect of multiple common SNPs predicts melanoma susceptibility","volume":"8","author":"Fang","year":"2013","journal-title":"PloS One"},{"key":"key\n\t\t\t\t20180831050349_ref38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055712","article-title":"Replication and predictive value of SNPs associated with melanoma and pigmentation traits in a Southern European case-control study","volume":"8","author":"Stefanaki","year":"2013","journal-title":"PloS One"},{"key":"key\n\t\t\t\t20180831050349_ref39","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jid.2015.12.007","article-title":"Prediction of melanoma risk in a Southern European population based on a weighted genetic risk score","volume":"136","author":"Kypreou","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"key\n\t\t\t\t20180831050349_ref40","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/b91ba224-10be-409d-93f4-7423d502cba0","article-title":"Power and predictive accuracy of polygenic risk scores","volume":"9","author":"Dudbridge","year":"2013","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20180831050349_ref41","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/ijc.2910620403","article-title":"Risk of cutaneous melanoma associated with a family history of the disease. The International Melanoma Analysis Group (IMAGE)","volume":"62","author":"Ford","year":"1995","journal-title":"Int. J. Cancer"},{"issue":"400\u2013405","key":"key\n\t\t\t\t20180831050349_ref42","first-page":"405e401","article-title":"Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies","volume":"45","author":"Chatterjee","year":"2013","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006493","article-title":"Winner's curse correction and variable thresholding improve performance of polygenic risk modeling based on genome-wide association study summary-level data","volume":"12","author":"Shi","year":"2016","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20180831050349_ref44","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv036","article-title":"Prediction of breast cancer risk based on profiling with common genetic variants","author":"Mavaddat","year":"2015","journal-title":"J. Natl. Cancer Ins."},{"key":"key\n\t\t\t\t20180831050349_ref45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/biostatistics\/kxu034","article-title":"Testing calibration of risk models at extremes of disease risk","volume":"16","author":"Song","year":"2015","journal-title":"Biostatistics"},{"key":"key\n\t\t\t\t20180831050349_ref46","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature08185","article-title":"Common polygenic variation contributes to risk of schizophrenia and bipolar disorder","volume":"460","author":"Purcell","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180831050349_ref47","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref48","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ajhg.2015.09.001","article-title":"Modeling linkage disequilibrium increases accuracy of polygenic risk scores","volume":"97","author":"Vilhjalmsson","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20180831050349_ref49","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinform."},{"key":"key\n\t\t\t\t20180831050349_ref50","volume-title":"IVEWARE: Imputation and Variance Estimation Software","author":"Raghunathan","year":"2002"},{"key":"key\n\t\t\t\t20180831050349_ref51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev.publhealth.21.1.121","article-title":"Causal effects in clinical and epidemiological studies via potential outcomes: concepts and analytical approaches","volume":"21","author":"Little","year":"2000","journal-title":"Ann. Rev. Publ. Health"},{"key":"key\n\t\t\t\t20180831050349_ref52","volume-title":"Latent Variable Models and Factor Analysis","author":"Bartholomew","year":"1987"},{"key":"key\n\t\t\t\t20180831050349_ref53","doi-asserted-by":"crossref","DOI":"10.1201\/9781315117539","volume-title":"Absolute Risk: Methods and Applications in Clinical Management and Public Health","author":"Pfeiffer","year":"2017"},{"key":"key\n\t\t\t\t20180831050349_ref54","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/oxfordjournals.aje.a114174","article-title":"Estimating the population attributable risk for multiple risk factors using case-control data","volume":"122","author":"Bruzzi","year":"1985","journal-title":"Am. J. Epidemiol."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/advance-article-pdf\/doi\/10.1093\/hmg\/ddy282\/25632682\/ddy282.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T05:57:43Z","timestamp":1571637463000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/advance-article\/doi\/10.1093\/hmg\/ddy282\/5061268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,31]]},"references-count":54,"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy282","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,31]]}}}