{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:01:29Z","timestamp":1790704889925,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CRI 88413"],"award-info":[{"award-number":["CRI 88413"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FND-148425"],"award-info":[{"award-number":["FND-148425"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["418734\u20132012"],"award-info":[{"award-number":["418734\u20132012"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mount Sinai Department of Obstetrics and Gynaecology\u2019s Research Fund"},{"name":"Canadian Centre for Computational Genomics"},{"DOI":"10.13039\/100006135","name":"Geothermal Technologies Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000092","name":"Ontario Genomics Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"DOI":"10.1093\/hmg\/ddy321","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T07:14:34Z","timestamp":1537168474000},"page":"372-385","source":"Crossref","is-referenced-by-count":81,"title":["Impact of assisted reproduction, infertility, sex and paternal factors on the placental DNA methylome"],"prefix":"10.1093","volume":"28","author":[{"given":"Sanaa","family":"Choufani","sequence":"first","affiliation":[{"name":"Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei L","family":"Turinsky","sequence":"additional","affiliation":[{"name":"Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Centre for Computational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Melamed","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynaecology Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Greenblatt","sequence":"additional","affiliation":[{"name":"Mount Sinai Centre for Fertility and Reproductive Health, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brudno","sequence":"additional","affiliation":[{"name":"Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Centre for Computational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Department of Computer Science, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anick","family":"B\u00e9rard","sequence":"additional","affiliation":[{"name":"Research Unit on Medications and Pregnancy, Research Centre, CHU Sainte-Justine, and Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Fraser","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e9 de Sherbrooke and Centre de Recherche du CHUS, Sherbrooke, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-4150","authenticated-orcid":false,"given":"Rosanna","family":"Weksberg","sequence":"additional","affiliation":[{"name":"Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Department of Pediatrics and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquetta","family":"Trasler","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Human Genetics and Pharmacology & Therapeutics, and The Montreal Children\u2019s Hospital and Research Institute of the McGill University Health Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Monnier","sequence":"additional","affiliation":[{"name":"MUHC Reproductive Centre, Department of Obstetrics and Gynecology, Royal Victoria Hospital and Research Institute of McGill University Health Centre, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"3D cohort study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Audibert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Dubois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Julien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Cheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Michaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Moutquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Muckle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"S\u00e9guin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquetta","family":"Trasler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Ernest","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Abenhaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jos\u00e9e","family":"B\u00e9dard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anick","family":"B\u00e9rard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Bujold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoha","family":"Kibar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Marc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Monnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Noelle","family":"Simard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Pasquier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Welt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"key\n\t\t\t\t2019011805582085000_ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humupd\/dmh002","article-title":"Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology","volume":"10","author":"Lucifero","year":"2004","journal-title":"Hum. Reprod. Update"},{"key":"key\n\t\t\t\t2019011805582085000_ref2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1086\/341096","article-title":"Intracytoplasmic sperm injection may increase the risk of imprinting defects","volume":"71","author":"Cox","year":"2002","journal-title":"Am. J. Human Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1086\/346031","article-title":"Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19","volume":"72","author":"DeBaun","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref4","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1086\/374824","article-title":"In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene","volume":"72","author":"Gicquel","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/jmg.40.1.62","article-title":"Beckwith-Wiedemann syndrome and assisted reproduction technology (ART)","volume":"40","author":"Maher","year":"2003","journal-title":"J. Med. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref6","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1086\/346030","article-title":"Another case of imprinting defect in a girl with Angelman syndrome who was conceived by intracytoplasmic semen injection","volume":"72","author":"Orstavik","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref7","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0140-6736(03)13592-1","article-title":"Rare congenital disorders, imprinted genes, and assisted reproductive technology","volume":"361","author":"Gosden","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019011805582085000_ref8","doi-asserted-by":"crossref","first-page":"e1289","DOI":"10.1371\/journal.pone.0001289","article-title":"Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm","volume":"2","author":"Houshdaran","year":"2007","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019011805582085000_ref9","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/hmg\/ddm187","article-title":"Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients","volume":"16","author":"Kobayashi","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/molehr\/gam093","article-title":"Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia","volume":"14","author":"Marques","year":"2008","journal-title":"Mol. Hum. Reprod."},{"key":"key\n\t\t\t\t2019011805582085000_ref11","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.fertnstert.2009.09.010","article-title":"Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility","volume":"94","author":"Hammoud","year":"2010","journal-title":"Fertility and sterility"},{"key":"key\n\t\t\t\t2019011805582085000_ref12","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1365-2605.2009.01000.x","article-title":"Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2\/H19 ICR1","volume":"33","author":"Poplinski","year":"2010","journal-title":"Int. J. Androl."},{"key":"key\n\t\t\t\t2019011805582085000_ref13","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1242\/dev.01241","article-title":"Selective loss of imprinting in the placenta following preimplantation development in culture","volume":"131","author":"Mann","year":"2004","journal-title":"Development"},{"key":"key\n\t\t\t\t2019011805582085000_ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/hmg\/ddm280","article-title":"Manipulations of mouse embryos prior to implantation result in aberrant expression of imprinted genes on day 9.5 of development","volume":"17","author":"Rivera","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref15","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/hmg\/ddn055","article-title":"Superovulation alters the expression of imprinted genes in the midgestation mouse placenta","volume":"17","author":"Fortier","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref16","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1095\/biolreprod.110.085480","article-title":"Side-by-side comparison of five commercial media systems in a mouse model: suboptimal in vitro culture interferes with imprint maintenance","volume":"83","author":"Market-Velker","year":"2010","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t2019011805582085000_ref17","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1093\/hmg\/dds287","article-title":"Gonadotropin stimulation contributes to an increased incidence of epimutations in ICSI-derived mice","volume":"21","author":"Waal","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref18","doi-asserted-by":"crossref","first-page":"591","DOI":"10.4161\/epi.24655","article-title":"Large offspring syndrome: a bovine model for the human loss-of-imprinting overgrowth syndrome Beckwith-Wiedemann","volume":"8","author":"Chen","year":"2013","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t2019011805582085000_ref19","first-page":"6975","article-title":"The cumulative effect of assisted reproduction procedures on placental development and epigenetic perturbations in a mouse model","volume":"24","author":"Waal","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref20","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1093\/humupd\/dmu033","article-title":"A systematic review and meta-analysis of DNA methylation levels and imprinting disorders in children conceived by IVF\/ICSI compared with children conceived spontaneously","volume":"20","author":"Lazaraviciute","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"key\n\t\t\t\t2019011805582085000_ref21","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1093\/hmg\/ddp319","article-title":"DNA methylation and gene expression differences in children conceived in vitro or in vivo","volume":"18","author":"Katari","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref22","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4161\/15592294.2014.988041","article-title":"Comparison of genome-wide and gene-specific DNA methylation between ART and naturally conceived pregnancies","volume":"10","author":"Melamed","year":"2015","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t2019011805582085000_ref23","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.fertnstert.2016.05.006","article-title":"Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants","volume":"106","author":"Estill","year":"2016","journal-title":"Fertil. Steril."},{"key":"key\n\t\t\t\t2019011805582085000_ref24","first-page":"4649","article-title":"Compromised oocyte quality and assisted reproduction contribute to sex-specific effects on offspring outcomes and epigenetic patterning","volume":"25","author":"Whidden","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13073-017-0413-5","article-title":"DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation","volume":"9","author":"Castillo-Fernandez","year":"2017","journal-title":"Genome Med."},{"key":"key\n\t\t\t\t2019011805582085000_ref26","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1093\/humrep\/dex209","article-title":"DNA methylation signatures in cord blood of ICSI children","volume":"32","author":"El Hajj","year":"2017","journal-title":"Hum. Reprod."},{"key":"key\n\t\t\t\t2019011805582085000_ref27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/hmg\/ddv458","article-title":"Outlier DNA methylation levels as an indicator of environmental exposure and risk of undesirable birth outcome","volume":"25","author":"Ghosh","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref28","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1073\/pnas.1523538113","article-title":"Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization","volume":"113","author":"Tan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t2019011805582085000_ref29","first-page":"22","article-title":"In vitro culture increases the frequency of stochastic epigenetic errors at imprinted genes in placental tissues from mouse concepti produced through assisted reproductive technologies","volume":"90","author":"Waal","year":"2014","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t2019011805582085000_ref30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/ppe.12320","article-title":"3D Cohort Study: the integrated research network in perinatology of Quebec and Eastern Ontario","volume":"30","author":"Fraser","year":"2016","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"key\n\t\t\t\t2019011805582085000_ref31","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/humrep\/deu067","article-title":"Universal coverage of IVF pays off","volume":"29","author":"Velez","year":"2014","journal-title":"Hum. Reprod."},{"key":"key\n\t\t\t\t2019011805582085000_ref32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.4161\/epi.27648","article-title":"Improved reporting of DNA methylation data derived from studies of the human placenta","volume":"9","author":"Hogg","year":"2014","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t2019011805582085000_ref33","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1093\/humrep\/des151","article-title":"Methylation levels at imprinting control regions are not altered with ovulation induction or in vitro fertilization in a birth cohort","volume":"27","author":"Rancourt","year":"2012","journal-title":"Hum. Reprod."},{"key":"key\n\t\t\t\t2019011805582085000_ref34","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/humrep\/des459","article-title":"Placentas from pregnancies conceived by IVF\/ICSI have a reduced DNA methylation level at the H19 and MEST differentially methylated regions","volume":"28","author":"Nelissen","year":"2013","journal-title":"Hum. Reprod."},{"key":"key\n\t\t\t\t2019011805582085000_ref35","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/humrep\/dex366","article-title":"The epigenetic control of transposable elements and imprinted genes in newborns is affected by the mode of conception: ART versus spontaneous conception without underlying infertility","volume":"33","author":"Choux","year":"2018","journal-title":"Hum. Reprod."},{"key":"key\n\t\t\t\t2019011805582085000_ref36","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.fertnstert.2014.01.041","article-title":"Effects of assisted reproductive technologies on human sex ratio at birth","volume":"101","author":"Maalouf","year":"2014","journal-title":"Fertil. Steril."},{"key":"key\n\t\t\t\t2019011805582085000_ref37","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1111\/j.1471-0528.2010.02731.x","article-title":"The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures\u2014an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002\u20132006","volume":"117","author":"Dean","year":"2010","journal-title":"BJOG"},{"key":"key\n\t\t\t\t2019011805582085000_ref38","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1016\/j.fertnstert.2008.03.066","article-title":"Impact of blastocyst transfer on offspring sex ratio and the monozygotic twinning rate: a systematic review and meta-analysis","volume":"91","author":"Chang","year":"2009","journal-title":"Fertil. Steril."},{"key":"key\n\t\t\t\t2019011805582085000_ref39","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1098\/rstb.2003.1323","article-title":"Imprinting errors and developmental asymmetry","volume":"358","author":"Bestor","year":"2003","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"key\n\t\t\t\t2019011805582085000_ref40","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/hmg\/11.11.1317","article-title":"Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome","volume":"11","author":"Weksberg","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref41","doi-asserted-by":"crossref","first-page":"e1003873","DOI":"10.1371\/journal.pgen.1003873","article-title":"Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females","volume":"9","author":"McGraw","year":"2013","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref42","doi-asserted-by":"crossref","first-page":"e1004458","DOI":"10.1371\/journal.pgen.1004458","article-title":"Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility","volume":"10","author":"Jenkins","year":"2014","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref43","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.fertnstert.2015.08.019","article-title":"Aberrant sperm DNA methylation predicts male fertility status and embryo quality","volume":"104","author":"Aston","year":"2015","journal-title":"Fertil. Steril."},{"key":"key\n\t\t\t\t2019011805582085000_ref44","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tins.2011.01.001","article-title":"Slitrks as emerging candidate genes involved in neuropsychiatric disorders","volume":"34","author":"Proenca","year":"2011","journal-title":"Trends Neurosci."},{"key":"key\n\t\t\t\t2019011805582085000_ref45","doi-asserted-by":"crossref","first-page":"e0169994","DOI":"10.1371\/journal.pone.0169994","article-title":"Rare synaptogenesis-impairing mutations in SLITRK5 are associated with obsessive compulsive disorder","volume":"12","author":"Song","year":"2017","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019011805582085000_ref46","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/2040-2392-5-40","article-title":"Serum microRNA profiles in children with autism","volume":"5","author":"Mundalil Vasu","year":"2014","journal-title":"Molecular autism"},{"key":"key\n\t\t\t\t2019011805582085000_ref47","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s12885-016-2350-x","article-title":"MicroRNA-663a is downregulated in non-small cell lung cancer and inhibits proliferation and invasion by targeting JunD","volume":"16","author":"Zhang","year":"2016","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t2019011805582085000_ref48","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1093\/hmg\/8.10.1947","article-title":"Williams-Beuren syndrome: genes and mechanisms","volume":"8","author":"Francke","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref49","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/ejhg.2016.153","article-title":"A genome-wide investigation into parent-of-origin effects in autism spectrum disorder identifies previously associated genes including SHANK3","volume":"25","author":"Connolly","year":"2017","journal-title":"Eur. J. Hum. Genet."},{"key":"key\n\t\t\t\t2019011805582085000_ref50","doi-asserted-by":"crossref","first-page":"46207","DOI":"10.1038\/srep46207","article-title":"Association between assisted reproductive technology and the risk of autism spectrum disorders in the offspring: a meta-analysis","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"key\n\t\t\t\t2019011805582085000_ref51","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2217\/epi.13.62","article-title":"How has the study of the human placenta aided our understanding of partially methylated genes?","volume":"5","author":"Schroeder","year":"2013","journal-title":"Epigenomics"},{"key":"key\n\t\t\t\t2019011805582085000_ref52","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1101\/gr.111922.110","article-title":"A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes","volume":"21","author":"Choufani","year":"2011","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t2019011805582085000_ref53","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4161\/epi.23470","article-title":"Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray","volume":"8","author":"Chen","year":"2013","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t2019011805582085000_ref54","first-page":"1","article-title":"(2014) changepoint: an R package for changepoint analysis","volume":"58","author":"Killick","journal-title":"J. Stat. Softw."},{"key":"key\n\t\t\t\t2019011805582085000_ref55","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/bmj.310.6973.170","article-title":"Multiple significance tests: the Bonferroni method","volume":"310","author":"Bland","year":"1995","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019011805582085000_ref56","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/28\/3\/372\/27520197\/ddy321.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T07:49:40Z","timestamp":1720597780000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/28\/3\/372\/5102486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":56,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,9,19]]},"published-print":{"date-parts":[[2019,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy321","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,2,1]]},"published":{"date-parts":[[2018,9,19]]}}}