{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:51:07Z","timestamp":1790247067862,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH116582"],"award-info":[{"award-number":["R01MH116582"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS105200"],"award-info":[{"award-number":["R01NS105200"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH078972"],"award-info":[{"award-number":["R01MH078972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56MH113146"],"award-info":[{"award-number":["R56MH113146"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21NS095632"],"award-info":[{"award-number":["R21NS095632"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007925","name":"Waisman Center","doi-asserted-by":"publisher","award":["U54HD090256"],"award-info":[{"award-number":["U54HD090256"]}],"id":[{"id":"10.13039\/100007925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001819","name":"International Rett Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000882","name":"Brain Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000882","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UW Vilas Trust"},{"DOI":"10.13039\/100001395","name":"Wisconsin Alumni Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001395","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jenni and Kyle Professorship"},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,15]]},"DOI":"10.1093\/hmg\/ddy338","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T16:16:47Z","timestamp":1537373807000},"page":"245-257","source":"Crossref","is-referenced-by-count":42,"title":["Loss of MeCP2 in immature neurons leads to impaired network integration"],"prefix":"10.1093","volume":"28","author":[{"given":"Yi","family":"Sun","sequence":"first","affiliation":[{"name":"National Key Research Laboratory of Natural and Biomimetic Drugs"},{"name":"Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, PR China"},{"name":"Waisman Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[{"name":"Waisman Center"},{"name":"Department of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J","family":"Tidei","sequence":"additional","affiliation":[{"name":"Waisman Center"},{"name":"Department of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Shen","sequence":"additional","affiliation":[{"name":"Waisman Center"},{"name":"Department of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnson T","family":"Hoang","sequence":"additional","affiliation":[{"name":"Waisman Center"},{"name":"Department of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F","family":"Wagner","sequence":"additional","affiliation":[{"name":"Waisman Center"},{"name":"Department of Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5128-4424","authenticated-orcid":false,"given":"Xinyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Waisman Center"},{"name":"Department of Neuroscience"},{"name":"Cellular and Molecular Biology Program, University of Wisconsin\u2013Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,1]]},"reference":[{"key":"key\n\t\t\t\t2019010704223013600_ref1","first-page":"37","article-title":"Clinical and biological progress over 50 years in Rett syndrome","volume":"13","author":"Leonard","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"key\n\t\t\t\t2019010704223013600_ref2","first-page":"5","article-title":"DNA methylation and adult neurogenesis","volume":"3","author":"Jobe","year":"2017","journal-title":"Brain Plast."},{"key":"key\n\t\t\t\t2019010704223013600_ref3","first-page":"537","article-title":"Delayed maturation of neuronal architecture and synaptogenesis in cerebral cortex of Mecp2-deficient mice","volume":"64","author":"Fukuda","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"key\n\t\t\t\t2019010704223013600_ref4","first-page":"77","article-title":"Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons","volume":"27","author":"Smrt","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t2019010704223013600_ref5","first-page":"794","article-title":"MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively","volume":"37","author":"Palmer","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"key\n\t\t\t\t2019010704223013600_ref6","first-page":"219","article-title":"Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations","volume":"35","author":"Chapleau","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t2019010704223013600_ref7","first-page":"51","article-title":"MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons","volume":"222","author":"Kishi","year":"2010","journal-title":"Exp. Neurol."},{"key":"key\n\t\t\t\t2019010704223013600_ref8","first-page":"255","article-title":"Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation","volume":"52","author":"Zhou","year":"2006","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2019010704223013600_ref9","first-page":"477","article-title":"Rescue of methyl-CpG binding protein 2 dysfunction-induced defects in newborn neurons by pentobarbital","volume":"12","author":"Ma","year":"2015","journal-title":"Neurotherapeutics"},{"key":"key\n\t\t\t\t2019010704223013600_ref10","first-page":"428","article-title":"The neural circuit basis of Rett syndrome","volume":"7","author":"Goffin","year":"2012","journal-title":"Front. Biol."},{"key":"key\n\t\t\t\t2019010704223013600_ref11","first-page":"246","article-title":"The role of the perirhinal cortex and hippocampus in learning, memory and perception","volume":"58","author":"Buckley","year":"2005","journal-title":"Q. J. Exp. Psychol."},{"key":"key\n\t\t\t\t2019010704223013600_ref12","first-page":"217","article-title":"Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome","volume":"21","author":"Asaka","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t2019010704223013600_ref13","first-page":"1768","article-title":"Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging","volume":"105","author":"Calfa","year":"2011","journal-title":"J. Neurophysiol."},{"key":"key\n\t\t\t\t2019010704223013600_ref14","first-page":"319","article-title":"Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome","volume":"26","author":"Moretti","year":"2006","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t2019010704223013600_ref15","first-page":"710","article-title":"MeCP2-dependent transcriptional repression regulates excitatory neurotransmission","volume":"16","author":"Nelson","year":"2006","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t2019010704223013600_ref16","first-page":"a018812","article-title":"Neurogenesis in the adult hippocampus","volume":"7","author":"Kempermann","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"key\n\t\t\t\t2019010704223013600_ref17","first-page":"387","article-title":"Adult neurogenesis and the future of the rejuvenating brain circuits","volume":"86","author":"Lepousez","year":"2015","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2019010704223013600_ref18","first-page":"5601","article-title":"Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway","volume":"5","author":"Li","year":"2014","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t2019010704223013600_ref19","first-page":"41701","article-title":"Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"key\n\t\t\t\t2019010704223013600_ref20","first-page":"1618","article-title":"Inhibition of miR-15a promotes BDNF expression and rescues dendritic maturation deficits in MeCP2-deficient neurons","volume":"33","author":"Gao","year":"2015","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t2019010704223013600_ref21","first-page":"450","article-title":"Insulin-like growth factor 1 and related compounds in the treatment of childhood-onset neurodevelopmental disorders","volume":"10","author":"Vahdatpour","year":"2016","journal-title":"Front. Neurosci."},{"key":"key\n\t\t\t\t2019010704223013600_ref22","first-page":"230","article-title":"Neurodevelopmental effects of insulin-like growth factor signaling","volume":"33","author":"O'Kusky","year":"2012","journal-title":"Front. Neuroendocrinol."},{"key":"key\n\t\t\t\t2019010704223013600_ref23","first-page":"43","article-title":"Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain","volume":"10","author":"Bach","year":"1991","journal-title":"Brain Res. Mol. Brain Res."},{"key":"key\n\t\t\t\t2019010704223013600_ref24","first-page":"52","article-title":"IGF-I: a key growth factor that regulates neurogenesis and synaptogenesis from embryonic to adult stages of the brain","volume":"10","author":"Nieto-Estevez","year":"2016","journal-title":"Front. Neurosci."},{"key":"key\n\t\t\t\t2019010704223013600_ref25","first-page":"91","article-title":"IGF-1 enhances cell proliferation and survival during early differentiation of mesenchymal stem cells to neural progenitor-like cells","volume":"15","author":"Huat","year":"2014","journal-title":"BMC Neurosci."},{"key":"key\n\t\t\t\t2019010704223013600_ref26","first-page":"660","article-title":"Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex","volume":"9","author":"Tropea","year":"2006","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t2019010704223013600_ref27","first-page":"23","article-title":"Is insulin growth factor-1 the future for treating autism spectrum disorder and\/or schizophrenia?","volume":"99","author":"Bou Khalil","year":"2017","journal-title":"Med. Hypotheses"},{"key":"key\n\t\t\t\t2019010704223013600_ref28","first-page":"527","article-title":"A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells","volume":"143","author":"Marchetto","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019010704223013600_ref29","first-page":"9941","article-title":"Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome","volume":"111","author":"Castro","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t2019010704223013600_ref30","first-page":"2029","article-title":"Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice","volume":"106","author":"Tropea","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t2019010704223013600_ref31","first-page":"1651","article-title":"Fragile X proteins FMRP and FXR2P control synaptic GluA1 expression and neuronal maturation via distinct mechanisms","volume":"11","author":"Guo","year":"2015","journal-title":"Cell Rep."},{"key":"key\n\t\t\t\t2019010704223013600_ref32","first-page":"29","article-title":"Running rewires the neuronal network of adult-born dentate granule cells","volume":"131","author":"Vivar","year":"2016","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t2019010704223013600_ref33","first-page":"47","article-title":"Retrograde neuronal tracing with a deletion-mutant rabies virus","volume":"4","author":"Wickersham","year":"2007","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t2019010704223013600_ref34","first-page":"E1152","article-title":"Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb","volume":"110","author":"Deshpande","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t2019010704223013600_ref35","first-page":"9106","article-title":"Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t2019010704223013600_ref36","first-page":"1107","article-title":"Monosynaptic inputs to new neurons in the dentate gyrus","volume":"3","author":"Vivar","year":"2012","journal-title":"Nat. Commun."},{"key":"key\n\t\t\t\t2019010704223013600_ref37","first-page":"684","article-title":"Efficient generation of CA3 neurons from human pluripotent stem cells enables modeling of hippocampal connectivity in vitro","volume":"22","author":"Sarkar","year":"2018","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t2019010704223013600_ref38","first-page":"3178","article-title":"Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro","volume":"142","author":"Kirwan","year":"2015","journal-title":"Development"},{"key":"key\n\t\t\t\t2019010704223013600_ref39","article-title":"Revealing neuronal circuitry using stem cell-derived neurons","author":"Garcia","year":"2013","journal-title":"Curr. Protoc. Stem Cell Biol."},{"key":"key\n\t\t\t\t2019010704223013600_ref40","first-page":"2140","article-title":"Tracing synaptic connectivity onto embryonic stem cell-derived neurons","volume":"30","author":"Garcia","year":"2012","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t2019010704223013600_ref41","first-page":"259","article-title":"Effects of copper on viability and functional properties of hippocampal neurons in vitro","volume":"69","author":"Kapkaeva","year":"2017","journal-title":"Exp. Toxicol. Pathol."},{"key":"key\n\t\t\t\t2019010704223013600_ref42","first-page":"288","article-title":"Bud extracts from Tilia tomentosa Moench inhibit hippocampal neuronal firing through GABAA and benzodiazepine receptors activation","volume":"172","author":"Allio","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"key\n\t\t\t\t2019010704223013600_ref43","first-page":"203","article-title":"The BDNF val-66-met polymorphism affects neuronal morphology and synaptic transmission in cultured hippocampal neurons from Rett syndrome mice","volume":"11","author":"Xu","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"key\n\t\t\t\t2019010704223013600_ref44","first-page":"15","article-title":"Functional circuits of new neurons in the dentate gyrus","volume":"7","author":"Vivar","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"key\n\t\t\t\t2019010704223013600_ref45","first-page":"739","article-title":"Loss and gain of MeCP2 cause similar hippocampal circuit dysfunction that is rescued by deep brain stimulation in a Rett syndrome mouse model","volume":"91","author":"Lu","year":"2016","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2019010704223013600_ref46","first-page":"159","article-title":"Excitation\/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice","volume":"25","author":"Calfa","year":"2015","journal-title":"Hippocampus"},{"key":"key\n\t\t\t\t2019010704223013600_ref47","first-page":"27","article-title":"Effectiveness and tolerability of antiepileptic drugs in 104 girls with Rett syndrome","volume":"66","author":"Vignoli","year":"2017","journal-title":"Epilepsy Behav."},{"key":"key\n\t\t\t\t2019010704223013600_ref48","first-page":"327","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"Chen","year":"2001","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2019010704223013600_ref49","first-page":"3","article-title":"Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus","volume":"26","author":"Zhao","year":"2006","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t2019010704223013600_ref50","first-page":"692","article-title":"Improved monosynaptic neural circuit tracing using engineered rabies virus glycoproteins","volume":"15","author":"Kim","year":"2016","journal-title":"Cell Rep."},{"key":"key\n\t\t\t\t2019010704223013600_ref51","first-page":"433","article-title":"Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation","volume":"6","author":"Liu","year":"2010","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t2019010704223013600_ref52","first-page":"1060","article-title":"MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1","volume":"28","author":"Smrt","year":"2010","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t2019010704223013600_ref53","first-page":"2064","article-title":"Integrative single-cell transcriptomics reveals molecular networks defining neuronal maturation during postnatal neurogenesis","volume":"27","author":"Gao","year":"2017","journal-title":"Cereb. Cortex"},{"key":"key\n\t\t\t\t2019010704223013600_ref54","first-page":"301","article-title":"Nuclear translocation of DJ-1 protects adult neuronal stem cells in an MPTP mouse model of Parkinson's disease","volume":"29","author":"Sun","year":"2018","journal-title":"Neuroreport"},{"key":"key\n\t\t\t\t2019010704223013600_ref55","first-page":"877","article-title":"FAIRE (formaldehyde-assisted isolation of regulatory elements) isolates active regulatory elements from human chromatin","volume":"17","author":"Giresi","year":"2007","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t2019010704223013600_ref56","first-page":"84","article-title":"Expression of the Parkinson's disease protein DJ-1 during the differentiation of neural stem cells","volume":"1468","author":"Li","year":"2012","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t2019010704223013600_ref57","first-page":"336ra361","article-title":"MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome","volume":"8","author":"Li","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"key\n\t\t\t\t2019010704223013600_ref58","first-page":"167","article-title":"Optogenetic stimulation effectively enhances intrinsically generated network synchrony","volume":"7","author":"El Hady","year":"2013","journal-title":"Front. Neural Circuits"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/28\/2\/245\/27215277\/ddy338.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T16:14:06Z","timestamp":1546964046000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/28\/2\/245\/5113227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,1]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,10,1]]},"published-print":{"date-parts":[[2019,1,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy338","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1,15]]},"published":{"date-parts":[[2018,10,1]]}}}