{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:00:41Z","timestamp":1791518441311,"version":"4.3.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-LABX-0030-INRT"],"award-info":[{"award-number":["ANR-10-LABX-0030-INRT"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-IDEX-0002-02"],"award-info":[{"award-number":["ANR-10-IDEX-0002-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["SNF 31003A-169-316"],"award-info":[{"award-number":["SNF 31003A-169-316"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation Recherche M\u00e9dicale","doi-asserted-by":"crossref","award":["PLP20170939073"],"award-info":[{"award-number":["PLP20170939073"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013465","name":"Association Fran\u00e7aise contre les Myopathies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014865","name":"Fondation Maladies Rares","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014865","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,15]]},"DOI":"10.1093\/hmg\/ddy446","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T20:16:07Z","timestamp":1545336967000},"page":"1579-1593","source":"Crossref","is-referenced-by-count":53,"title":["STIM1 over-activation generates a multi-systemic phenotype affecting the skeletal muscle, spleen, eye, skin, bones and immune system in mice"],"prefix":"10.1093","volume":"28","author":[{"given":"Roberto","family":"Silva-Rojas","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), Inserm, CNRS, Universit\u00e9 de Strasbourg, Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Treves","sequence":"additional","affiliation":[{"name":"Departments of Biomedicine and Anaesthesia, Basel University Hospital, Basel University, Basel, Switzerland"},{"name":"Department of Life Sciences, General Pathology section, University of Ferrara, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), Inserm, CNRS, Universit\u00e9 de Strasbourg, Illkirch, France"},{"name":"Institut Clinique de la Souris (ICS), Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Kessler","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), Inserm, CNRS, Universit\u00e9 de Strasbourg, Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Messaddeq","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), Inserm, CNRS, Universit\u00e9 de Strasbourg, Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Laporte","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), Inserm, CNRS, Universit\u00e9 de Strasbourg, Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), Inserm, CNRS, Universit\u00e9 de Strasbourg, Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"2019050123034788700_ref1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/nyas.12938","article-title":"Diseases caused by mutations in ORAI1 and STIM1","volume":"1356","author":"Lacruz","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2019050123034788700_ref2","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.cell.2009.02.014","article-title":"STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1","volume":"136","author":"Park","year":"2009","journal-title":"Cell"},{"key":"2019050123034788700_ref3","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1083\/jcb.200604015","article-title":"The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions","volume":"174","author":"Luik","year":"2006","journal-title":"J. Cell Biol."},{"key":"2019050123034788700_ref4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cell.2008.08.006","article-title":"Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry","volume":"135","author":"Stathopulos","year":"2008","journal-title":"Cell"},{"key":"2019050123034788700_ref5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature04702","article-title":"A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function","volume":"441","author":"Feske","year":"2006","journal-title":"Nature"},{"key":"2019050123034788700_ref6","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1056\/NEJMoa0900082","article-title":"STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity","volume":"360","author":"Picard","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2019050123034788700_ref7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ajhg.2012.12.007","article-title":"Constitutive activation of the calcium sensor STIM1 causes tubular-aggregate myopathy","volume":"92","author":"Bohm","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"2019050123034788700_ref8","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/humu.22544","article-title":"A dominant STIM1 mutation causes Stormorken syndrome","volume":"35","author":"Misceo","year":"2014","journal-title":"Hum. Mutat."},{"key":"2019050123034788700_ref9","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/humu.22621","article-title":"Gain-of-function mutation in STIM1 (P.R304W) is associated with Stormorken syndrome","volume":"35","author":"Morin","year":"2014","journal-title":"Hum. Mutat."},{"key":"2019050123034788700_ref10","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1073\/pnas.1312520111","article-title":"Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis","volume":"111","author":"Nesin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2019050123034788700_ref11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/path.1832","article-title":"The origin of tubular aggregates in human myopathies","volume":"207","author":"Chevessier","year":"2005","journal-title":"J. Pathol."},{"key":"2019050123034788700_ref12","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/humu.23172","article-title":"ORAI1 mutations with distinct channel gating defects in tubular aggregate myopathy","volume":"38","author":"Bohm","year":"2017","journal-title":"Hum. Mutat."},{"key":"2019050123034788700_ref13","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/hmg\/ddu477","article-title":"Dominant mutations in ORAI1 cause tubular aggregate myopathy with hypocalcemia via constitutive activation of store-operated Ca(2)(+) channels","volume":"24","author":"Endo","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"2019050123034788700_ref14","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ymgme.2014.12.307","article-title":"York platelet syndrome is a CRAC channelopathy due to gain-of-function mutations in STIM1","volume":"114","author":"Markello","year":"2015","journal-title":"Mol. Genet. Metab."},{"key":"2019050123034788700_ref15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.nmd.2016.10.006","article-title":"Tubular aggregate myopathy with features of Stormorken disease due to a new STIM1 mutation","volume":"27","author":"Noury","year":"2017","journal-title":"Neuromuscul. Disord."},{"key":"2019050123034788700_ref16","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.nmd.2015.04.005","article-title":"50 years to diagnosis: autosomal dominant tubular aggregate myopathy caused by a novel STIM1 mutation","volume":"25","author":"Walter","year":"2015","journal-title":"Neuromuscul. Disord."},{"key":"2019050123034788700_ref17","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/cge.12888","article-title":"A novel gain-of-function mutation in ORAI1 causes late-onset tubular aggregate myopathy and congenital miosis","volume":"91","author":"Garibaldi","year":"2017","journal-title":"Clin. Genet."},{"key":"2019050123034788700_ref18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2018.07.008","article-title":"Gain-of-function mutations in STIM1 and ORAI1 causing tubular aggregate myopathy and Stormorken syndrome","volume":"76","author":"Bohm","year":"2018","journal-title":"Cell Calcium"},{"key":"2019050123034788700_ref19","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.nmd.2017.05.002","article-title":"Complex phenotypes associated with STIM1 mutations in both coiled coil and EF-hand domains","volume":"27","author":"Harris","year":"2017","journal-title":"Neuromuscul. Disord."},{"key":"2019050123034788700_ref20","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1111\/ene.13545","article-title":"Corpus callosum agenesis, myopathy and pinpoint pupils: consider Stormorken syndrome","volume":"25","author":"Alonso-Jimenez","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"2019050123034788700_ref21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/s41467-018-03062-w","article-title":"A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state","volume":"9","author":"Fahrner","year":"2018","journal-title":"Nat. Commun."},{"key":"2019050123034788700_ref22","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1182\/blood-2008-07-171611","article-title":"Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation","volume":"113","author":"Braun","year":"2009","journal-title":"Blood"},{"key":"2019050123034788700_ref23","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1084\/jem.20080302","article-title":"The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction","volume":"205","author":"Varga-Szabo","year":"2008","journal-title":"J. Exp. Med."},{"key":"2019050123034788700_ref24","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/ncb1731","article-title":"STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle","volume":"10","author":"Stiber","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"2019050123034788700_ref25","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.4049\/jimmunol.1001796","article-title":"Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection","volume":"185","author":"McCarl","year":"2010","journal-title":"J. Immunol."},{"key":"2019050123034788700_ref26","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/ni1574","article-title":"Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance","volume":"9","author":"Oh-Hora","year":"2008","journal-title":"Nat. Immunol."},{"key":"2019050123034788700_ref27","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1111\/j.1538-7836.2011.04474.x","article-title":"Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis","volume":"9","author":"Ahmad","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"2019050123034788700_ref28","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1172\/JCI32312","article-title":"An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice","volume":"117","author":"Grosse","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2019050123034788700_ref29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1399-0004.1985.tb02209.x","article-title":"A new syndrome: thrombocytopathia, muscle fatigue, asplenia, miosis, migraine, dyslexia and ichthyosis","volume":"28","author":"Stormorken","year":"1985","journal-title":"Clin. Genet."},{"key":"2019050123034788700_ref30","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.nmd.2003.11.007","article-title":"Tubular aggregates are from whole sarcoplasmic reticulum origin: alterations in calcium binding protein expression in mouse skeletal muscle during aging","volume":"14","author":"Chevessier","year":"2004","journal-title":"Neuromuscul. Disord."},{"key":"2019050123034788700_ref31","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1136\/jmedgenet-2014-102623","article-title":"Clinical, histological and genetic characterisation of patients with tubular aggregate myopathy caused by mutations in STIM1","volume":"51","author":"Bohm","year":"2014","journal-title":"J. Med. Genet."},{"key":"2019050123034788700_ref32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00401-017-1775-x","article-title":"CASQ1 mutations impair calsequestrin polymerization and cause tubular aggregate myopathy","volume":"135","author":"Bohm","year":"2018","journal-title":"Acta Neuropathol."},{"key":"2019050123034788700_ref33","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1007\/s00415-014-7287-x","article-title":"Childhood onset tubular aggregate myopathy associated with de novo STIM1 mutations","volume":"261","author":"Hedberg","year":"2014","journal-title":"J. Neurol."},{"key":"2019050123034788700_ref34","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29968","article-title":"Defective STIM-mediated store operated Ca(2+) entry in hepatocytes leads to metabolic dysfunction in obesity","volume":"6","author":"Arruda","year":"2017","journal-title":"Elife"},{"key":"2019050123034788700_ref35","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.2337\/db17-1351","article-title":"Impaired store-operated calcium entry and STIM1 loss lead to reduced insulin secretion and increased endoplasmic reticulum stress in the diabetic beta-cell","volume":"67","author":"Kono","year":"2018","journal-title":"Diabetes"},{"key":"2019050123034788700_ref36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ceca.2018.10.001","article-title":"STIM1 R304W causes muscle degeneration and impaired platelet activation in mice","volume":"76","author":"Gamage","year":"2018","journal-title":"Cell Calcium"},{"key":"2019050123034788700_ref37","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1152\/physrev.00031.2010","article-title":"Fiber types in mammalian skeletal muscles","volume":"91","author":"Schiaffino","year":"2011","journal-title":"Physiol. Rev."},{"key":"2019050123034788700_ref38","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1152\/physrev.1997.77.4.901","article-title":"Store depletion and calcium influx","volume":"77","author":"Parekh","year":"1997","journal-title":"Physiol. Rev."},{"key":"2019050123034788700_ref39","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1212\/01.WNL.0000138575.14424.5F","article-title":"Familial myopathy with tubular aggregates associated with abnormal pupils","volume":"63","author":"Shahrizaila","year":"2004","journal-title":"Neurology"},{"key":"2019050123034788700_ref40","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1212\/WNL.28.5.439","article-title":"Intracellular calcium accumulation in Duchenne dystrophy and other myopathies: a study of 567,000 muscle fibers in 114 biopsies","volume":"28","author":"Bodensteiner","year":"1978","journal-title":"Neurology"},{"key":"2019050123034788700_ref41","doi-asserted-by":"crossref","first-page":"D750","DOI":"10.2741\/A548","article-title":"Molecular mechanisms regulating myogenic determination and differentiation","volume":"5","author":"Perry","year":"2000","journal-title":"Front. Biosci."},{"key":"2019050123034788700_ref42","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s004180000211","article-title":"Age-related appearance of tubular aggregates in the skeletal muscle of almost all male inbred mice","volume":"114","author":"Agbulut","year":"2000","journal-title":"Histochem. Cell Biol."},{"key":"2019050123034788700_ref43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/0003319713492375","article-title":"Mean platelet volume in recurrent aphthous stomatitis and Behcet disease","volume":"65","author":"Ekiz","year":"2014","journal-title":"Angiology"},{"key":"2019050123034788700_ref44","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s10753-013-9716-x","article-title":"Mean platelet volume seems to be a valuable marker in patients with systemic sclerosis","volume":"37","author":"Soydinc","year":"2014","journal-title":"Inflammation"},{"key":"2019050123034788700_ref45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/09537104.2013.875137","article-title":"Mean platelet volume as an inflammatory marker in patients with severe periodontitis","volume":"26","author":"Wang","year":"2015","journal-title":"Platelets"},{"key":"2019050123034788700_ref46","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","article-title":"Th17 and regulatory T cell balance in autoimmune and inflammatory diseases","volume":"13","author":"Noack","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"2019050123034788700_ref47","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1096\/fj.11-194399","article-title":"Orai1-mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor NFATc1","volume":"26","author":"Hwang","year":"2012","journal-title":"FASEB J."},{"key":"2019050123034788700_ref48","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/labinvest.2012.72","article-title":"Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development","volume":"92","author":"Robinson","year":"2012","journal-title":"Lab. Invest."},{"key":"2019050123034788700_ref49","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1084\/jem.20101597","article-title":"Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma","volume":"207","author":"Byun","year":"2010","journal-title":"J. Exp. Med."},{"key":"2019050123034788700_ref50","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.4049\/jimmunol.1102507","article-title":"Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency","volume":"188","author":"Fuchs","year":"2012","journal-title":"J. Immunol."},{"key":"2019050123034788700_ref51","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jaci.2009.10.007","article-title":"ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia","volume":"124","author":"McCarl","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"issue":"479\u2013482","key":"2019050123034788700_ref52","article-title":"A novel mutation in ORAI1 presenting with combined immunodeficiency and residual T-cell function","volume":"136","author":"Chou","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"2019050123034788700_ref53","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jaci.2015.03.009","article-title":"A novel hypomorphic mutation in STIM1 results in a late-onset immunodeficiency","volume":"136","author":"Schaballie","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"2019050123034788700_ref54","doi-asserted-by":"crossref","first-page":"94S","DOI":"10.1177\/0022034514527971","article-title":"STIM1 and SLC24A4 are critical for enamel maturation","volume":"93","author":"Wang","year":"2014","journal-title":"J. Dent. Res."},{"key":"2019050123034788700_ref55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088653","article-title":"Evidence based selection of commonly used RT-qPCR reference genes for the analysis of mouse skeletal muscle","volume":"9","author":"Thomas","year":"2014","journal-title":"PLoS One"},{"key":"2019050123034788700_ref56","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1021\/pr500675e","article-title":"Muscle proteomics reveals novel insights into the pathophysiological mechanisms of collagen VI myopathies","volume":"13","author":"De Palma","year":"2014","journal-title":"J. Proteome Res."},{"key":"2019050123034788700_ref57","first-page":"320","article-title":"Cellular, biochemical and molecular changes in muscles from patients with X-linked myotubular myopathy due to MTM1 mutations","volume":"26","author":"Bachmann","year":"2017","journal-title":"Hum. Mol. Genet."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/28\/10\/1579\/28548676\/ddy446.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T21:21:51Z","timestamp":1605734511000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/28\/10\/1579\/5257096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,21]]},"references-count":57,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,12,21]]},"published-print":{"date-parts":[[2019,5,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddy446","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,5,15]]},"published":{"date-parts":[[2018,12,21]]}}}