{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:23:08Z","timestamp":1790022188522,"version":"4.0.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012615","name":"University of Texas Health Science Center at Houston","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,15]]},"DOI":"10.1093\/hmg\/ddz001","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T04:14:00Z","timestamp":1546488840000},"page":"1608-1619","source":"Crossref","is-referenced-by-count":6,"title":["TIPE2 gene transfer with adeno-associated virus 9 ameliorates dystrophic pathology in mdx mice"],"prefix":"10.1093","volume":"28","author":[{"given":"Shanshan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA"},{"name":"Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Amra","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA"},{"name":"Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Huard","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA"},{"name":"Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"2019050123033009200_ref1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/00019052-199704000-00016","article-title":"Muscular dystrophies and the dystrophin-glycoprotein complex","volume":"10","author":"Straub","year":"1997","journal-title":"Curr. Opin. Neurol."},{"key":"2019050123033009200_ref2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.pmrj.2009.04.010","article-title":"Immune-mediated mechanisms potentially regulate the disease time-course of duchenne muscular dystrophy and provide targets for therapeutic intervention","volume":"1","author":"Evans","year":"2009","journal-title":"PM R"},{"key":"2019050123033009200_ref3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.200105110","article-title":"A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice","volume":"155","author":"Wehling","year":"2001","journal-title":"J. Cell Biol."},{"key":"2019050123033009200_ref4","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J. Immunol."},{"key":"2019050123033009200_ref5","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/hmg\/ddn376","article-title":"Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy","volume":"18","author":"Villalta","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"2019050123033009200_ref6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/path.2287","article-title":"TNF-mediated inflammatory disease","volume":"214","author":"Bradley","year":"2008","journal-title":"J. Pathol."},{"key":"2019050123033009200_ref7","doi-asserted-by":"crossref","first-page":"C1179","DOI":"10.1152\/ajpcell.00062.2005","article-title":"Role of TNF-alpha signaling in regeneration of cardiotoxin-injured muscle","volume":"289","author":"Chen","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2019050123033009200_ref8","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1177\/002215540104900807","article-title":"The role of tumor necrosis factor-alpha (TNF-alpha) in skeletal muscle regeneration. Studies in TNF-alpha(-\/-) and TNF-alpha(-\/-)\/LT-alpha(-\/-) mice","volume":"49","author":"Collins","year":"2001","journal-title":"J. Histochem. Cytochem."},{"key":"2019050123033009200_ref9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","article-title":"Tumor necrosis factor-alpha signaling in macrophages","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"2019050123033009200_ref10","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1006\/jmcc.2001.1385","article-title":"Effect of NF-kappa B Inhibition on TNF-alpha-induced apoptosis and downstream pathways in cardiomyocytes","volume":"33","author":"Bergmann","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2019050123033009200_ref11","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/sj.bjc.6605530","article-title":"TNF-alpha\/NF-kappaB\/Snail pathway in cancer cell migration and invasion","volume":"102","author":"Wu","year":"2010","journal-title":"Br. J. Cancer"},{"key":"2019050123033009200_ref12","first-page":"2259","article-title":"Role of inflammatory cytokines in peripheral nerve injury","volume":"7","author":"Fregnan","year":"2012","journal-title":"Neural Regen. Res."},{"key":"2019050123033009200_ref13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jneuroim.2010.10.032","article-title":"Eicosapentaenoic acid decreases TNF-alpha and protects dystrophic muscles of mdx mice from degeneration","volume":"232","author":"Machado","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"2019050123033009200_ref14","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.2147\/DDDT.S110163","article-title":"Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors","volume":"10","author":"Miyatake","year":"2016","journal-title":"Drug Des. Devel. Ther."},{"key":"2019050123033009200_ref15","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/embor.2012.142","article-title":"The inflammation theory of disease. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment","volume":"13","author":"Hunter","year":"2012","journal-title":"EMBO Rep."},{"key":"2019050123033009200_ref16","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.pmr.2012.08.003","article-title":"Novel approaches to corticosteroid treatment in Duchenne muscular dystrophy","volume":"23","author":"Hoffman","year":"2012","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"2019050123033009200_ref17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cell.2008.03.026","article-title":"TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis","volume":"133","author":"Sun","year":"2008","journal-title":"Cell"},{"key":"2019050123033009200_ref18","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.molimm.2010.06.016","article-title":"Tissue-specific expression of TIPE2 provides insights into its function","volume":"47","author":"Zhang","year":"2010","journal-title":"Mol. Immunol."},{"key":"2019050123033009200_ref19","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3892\/ijo.2014.2725","article-title":"TIPE2 inhibits TNF-alpha-induced hepatocellular carcinoma cell metastasis via Erk1\/2 downregulation and NF-kappaB activation","volume":"46","author":"Zhang","year":"2015","journal-title":"Int. J. Oncol."},{"key":"2019050123033009200_ref20","doi-asserted-by":"crossref","first-page":"13319","DOI":"10.1038\/s41598-017-13825-y","article-title":"TIPE2 negatively regulates mycoplasma pneumonia-triggered immune response via MAPK signaling pathway","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"2019050123033009200_ref21","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.molcel.2012.01.006","article-title":"The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras","volume":"45","author":"Gus-Brautbar","year":"2012","journal-title":"Mol. Cell"},{"key":"2019050123033009200_ref22","first-page":"952","article-title":"TIPE2 governs macrophage polarization via negative regulation of mTORC1","volume":"17","author":"Jiang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"2019050123033009200_ref23","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1111\/j.1471-4159.1986.tb13078.x","article-title":"alpha-Bungarotoxin binds to low-affinity nicotine binding sites in rat brain","volume":"47","author":"Wonnacott","year":"1986","journal-title":"J. Neurochem."},{"key":"2019050123033009200_ref24","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1073\/pnas.74.8.3268","article-title":"Identification of synaptic acetylcholine receptor sites in retina with peroxidase-labeled alpha-bungarotoxin","volume":"74","author":"Vogel","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2019050123033009200_ref25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11068-006-8725-1","article-title":"Acetylcholine receptors and nerve terminal distribution at the neuromuscular junction of long-term regenerated muscle fibers","volume":"34","author":"Marques","year":"2005","journal-title":"J. Neurocytol."},{"key":"2019050123033009200_ref26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.molimm.2011.08.006","article-title":"The TIPE (TNFAIP8) family in inflammation, immunity, and cancer","volume":"49","author":"Lou","year":"2011","journal-title":"Mol. Immunol."},{"key":"2019050123033009200_ref27","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.4049\/jimmunol.1300053","article-title":"Enhanced atherosclerosis in TIPE2-deficient mice is associated with increased macrophage responses to oxidized low-density lipoprotein","volume":"191","author":"Lou","year":"2013","journal-title":"J. Immunol."},{"key":"2019050123033009200_ref28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.4161\/cc.23325","article-title":"TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation","volume":"12","author":"Zhang","year":"2013","journal-title":"Cell Cycle"},{"key":"2019050123033009200_ref29","doi-asserted-by":"crossref","first-page":"942","DOI":"10.3892\/etm.2017.4050","article-title":"Expression and roles of TIPE2 in autoimmune hepatitis","volume":"13","author":"Qian","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"2019050123033009200_ref30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12967-018-1383-0","article-title":"TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt\/beta-catenin pathway","volume":"16","author":"Zhu","year":"2018","journal-title":"J. Transl. Med."},{"key":"2019050123033009200_ref31","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/mt.2008.76","article-title":"Analysis of AAV serotypes 1\u20139 mediated gene expression and tropism in mice after systemic injection","volume":"16","author":"Zincarelli","year":"2008","journal-title":"Mol. Ther."},{"key":"2019050123033009200_ref32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2567.2000.00997.x","article-title":"Interleukin-16 stimulates the expression and production of pro-inflammatory cytokines by human monocytes","volume":"100","author":"Mathy","year":"2000","journal-title":"Immunology"},{"key":"2019050123033009200_ref33","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.4049\/jimmunol.160.12.5874","article-title":"IL-16 activates the SAPK signaling pathway in CD4+ macrophages","volume":"160","author":"Krautwald","year":"1998","journal-title":"J. Immunol."},{"key":"2019050123033009200_ref34","doi-asserted-by":"crossref","first-page":"693","DOI":"10.12965\/jer.1735094.547","article-title":"Low-intensity training provokes adaptive extracellular matrix turnover of a muscular dystrophy model","volume":"13","author":"Gaiad","year":"2017","journal-title":"J. Exerc. Rehabil."},{"key":"2019050123033009200_ref35","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1212\/WNL.0b013e3182518302","article-title":"Increased muscle expression of interleukin-17 in Duchenne muscular dystrophy","volume":"78","author":"De Pasquale","year":"2012","journal-title":"Neurology"},{"key":"2019050123033009200_ref36","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1128\/IAI.00845-10","article-title":"Interleukin-17 is not required for classical macrophage activation in a pulmonary mouse model of Cryptococcus neoformans infection","volume":"78","author":"Hardison","year":"2010","journal-title":"Infect. Immun."},{"key":"2019050123033009200_ref37","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1158\/1078-0432.CCR-13-0042","article-title":"IL-17-mediated M1\/M2 macrophage alteration contributes to pathogenesis of bisphosphonate-related osteonecrosis of the jaws","volume":"19","author":"Zhang","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"2019050123033009200_ref38","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1006\/bbrc.2000.3497","article-title":"TNF-alpha stimulation of MCP-1 expression is mediated by the Akt\/PKB signal transduction pathway in vascular endothelial cells","volume":"276","author":"Murao","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2019050123033009200_ref39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1742-2094-5-35","article-title":"MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult","volume":"5","author":"Thompson","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"2019050123033009200_ref40","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.15252\/emmm.201403967","article-title":"Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2","volume":"6","author":"Mojumdar","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"2019050123033009200_ref41","doi-asserted-by":"crossref","first-page":"32546","DOI":"10.1074\/jbc.M112.348755","article-title":"TIPE2, a novel regulator of immunity, protects against experimental stroke","volume":"287","author":"Zhang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2019050123033009200_ref42","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bbrc.2017.11.178","article-title":"TIPE2 attenuates liver fibrosis by reversing the activated hepatic stellate cells","volume":"498","author":"Xu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2019050123033009200_ref43","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1084\/jem.170.3.727","article-title":"Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation","volume":"170","author":"Khalil","year":"1989","journal-title":"J. Exp. Med."},{"key":"2019050123033009200_ref44","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1002\/j.1460-2075.1991.tb04950.x","article-title":"The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B","volume":"10","author":"Schmitz","year":"1991","journal-title":"EMBO J."},{"key":"2019050123033009200_ref45","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1172\/JCI30556","article-title":"Interplay of IKK\/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy","volume":"117","author":"Acharyya","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2019050123033009200_ref46","first-page":"16","article-title":"Activation of NF-kappaB pathway in Duchenne muscular dystrophy: relation to age","volume":"30","author":"Messina","year":"2011","journal-title":"Acta Myol."},{"key":"2019050123033009200_ref47","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1096\/fj.02-0542com","article-title":"Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy","volume":"17","author":"Kumar","year":"2003","journal-title":"FASEB J."},{"key":"2019050123033009200_ref48","doi-asserted-by":"crossref","first-page":"e90341","DOI":"10.1172\/jci.insight.90341","article-title":"Disease-modifying effects of orally bioavailable NF-kappaB inhibitors in dystrophin-deficient muscle","volume":"1","author":"Hammers","year":"2016","journal-title":"JCI Insight"},{"key":"2019050123033009200_ref49","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1359\/jbmr.1998.13.8.1290","article-title":"TNF-alpha increases expression of IL-6 and ICAM-1 genes through activation of NF-kappaB in osteoblast-like ROS17\/2.8 cells","volume":"13","author":"Kurokouchi","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"2019050123033009200_ref50","doi-asserted-by":"crossref","first-page":"36916","DOI":"10.1074\/jbc.M301598200","article-title":"Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway","volume":"278","author":"Sakurai","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2019050123033009200_ref51","doi-asserted-by":"crossref","first-page":"22650","DOI":"10.1074\/jbc.M116.733451","article-title":"TIPE2 (Tumor necrosis factor alpha-induced protein 8-like 2) Is a novel negative regulator of TAK1 signal","volume":"291","author":"Oho","year":"2016","journal-title":"J. Biol. Chem."},{"key":"2019050123033009200_ref52","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1074\/jbc.M109.064063","article-title":"Transforming growth factor-beta-activated kinase 1 is an essential regulator of myogenic differentiation","volume":"285","author":"Bhatnagar","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2019050123033009200_ref53","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jviromet.2012.04.004","article-title":"Rapid and simplified purification of recombinant adeno-associated virus","volume":"183","author":"Guo","year":"2012","journal-title":"J. Virol. Methods"},{"key":"2019050123033009200_ref54","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/28\/10\/1608\/28548719\/ddz001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T16:53:45Z","timestamp":1694537625000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/28\/10\/1608\/5272617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":54,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,1,4]]},"published-print":{"date-parts":[[2019,5,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddz001","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,5,15]]},"published":{"date-parts":[[2019,1,4]]}}}