{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:11:32Z","timestamp":1779887492405,"version":"3.53.1"},"reference-count":107,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL118305"],"award-info":[{"award-number":["R01HL118305"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene\u2013smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129\u2009913 individuals in stage 1 and follow-up analysis in 480\u2009178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and\/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and\/or diastolic BP through gene\u2013smoking interaction analysis and 38 were newly identified (P\u2009&lt;\u20095\u2009\u00d7\u200910\u22128, false discovery rate\u2009&lt;\u20090.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride\/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.<\/jats:p>","DOI":"10.1093\/hmg\/ddz070","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T20:13:04Z","timestamp":1553803984000},"page":"2615-2633","source":"Crossref","is-referenced-by-count":45,"title":["A multi-ancestry genome-wide study incorporating gene\u2013smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure"],"prefix":"10.1093","volume":"28","author":[{"given":"Yun Ju","family":"Sung","sequence":"first","affiliation":[{"name":"Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"de las Fuentes","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Washington University, St. Louis, MO, USA"},{"name":"Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel I","family":"Chasman","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R","family":"Bentley","sequence":"additional","affiliation":[{"name":"Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldi T","family":"Kraja","sequence":"additional","affiliation":[{"name":"Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Ntalla","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen R","family":"Warren","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK"},{"name":"NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqing","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Schwander","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa K","family":"Manning","sequence":"additional","affiliation":[{"name":"Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Brown","sequence":"additional","affiliation":[{"name":"Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Aschard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA"},{"name":"Centre de Bioinformatique, Biostatistique et Biologie Int\u00e9grative (C3BI), Institut Pasteur, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary F","family":"Feitosa","sequence":"additional","affiliation":[{"name":"Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchang","family":"Lu","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore"},{"name":"Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore"},{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Sim","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Vojinovic","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Marten","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon K","family":"Musani","sequence":"additional","affiliation":[{"name":"Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas O","family":"Kilpel\u00e4inen","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A","family":"Richard","sequence":"additional","affiliation":[{"name":"Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Aslibekyan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traci M","family":"Bartz","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Dorajoo","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwei","family":"Li","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomo","family":"Rankinen","sequence":"additional","affiliation":[{"name":"Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Vernon","family":"Smith","sequence":"additional","affiliation":[{"name":"Icelandic Heart Association, Kopavogur, Iceland"},{"name":"Faculty of Medicine, University of Iceland, Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman M","family":"Tajuddin","sequence":"additional","affiliation":[{"name":"Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bamidele O","family":"Tayo","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Biostatistics, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Matoba","sequence":"additional","affiliation":[{"name":"Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Sofer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, MA, USA"},{"name":"Division of Sleep and Circadian Disorders, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maris","family":"Alver","sequence":"additional","affiliation":[{"name":"Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzyeh","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen RB, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Boissel","sequence":"additional","affiliation":[{"name":"CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Fang","family":"Chai","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Divers","sequence":"additional","affiliation":[{"name":"Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Gandin","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Trieste, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Giulianini","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj","family":"Goel","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, UK"},{"name":"Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E","family":"Harris","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK"},{"name":"Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando P","family":"Hartwig","sequence":"additional","affiliation":[{"name":"Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil"},{"name":"Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meian","family":"He","sequence":"additional","affiliation":[{"name":"Lab Genetics and Molecular Cardiology, Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea R V R","family":"Horimoto","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Chi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne U","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace M","family":"Kammerer","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradhani","family":"Kasturiratne","sequence":"additional","affiliation":[{"name":"Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo","family":"Komulainen","sequence":"additional","affiliation":[{"name":"Research Unit of Molecular Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"K\u00fchnel","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Leander","sequence":"additional","affiliation":[{"name":"Medical Research, Taichung Veterans General Hospital, Department of Social Work, Tunghai University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jane","family":"Lee","sequence":"additional","affiliation":[{"name":"Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng-Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"MRC Epidemiology Unit, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2019an","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo-Pekka","family":"Lyytik\u00e4inen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Finnish Cardiovascular Research Center\u2014Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland"},{"name":"Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin A","family":"McKenzie","sequence":"additional","affiliation":[{"name":"School of Public Health, Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongi Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, Leicester, UK"},{"name":"NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Noordam","sequence":"additional","affiliation":[{"name":"Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne H H","family":"Sheu","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan"},{"name":"School of Medicine, National Yang-ming University, Taipei, Taiwan"},{"name":"School of Medicine, National Defense Medical Center, Taipei, Taiwan"},{"name":"Institute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Stan\u010d\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"van der Most","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen RB, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor V","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Waken","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, MA, USA"},{"name":"Division of Sleep and Circadian Disorders, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin B","family":"Ware","sequence":"additional","affiliation":[{"name":"Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Weiss","sequence":"additional","affiliation":[{"name":"Interfaculty Institute for Genetics and Functional Genomics, University Medicine Ernst Moritz Arndt University Greifswald, Greifswald, Germany"},{"name":"DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Wen","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R","family":"Yanek","sequence":"additional","affiliation":[{"name":"General Internal Medicine, GeneSTAR Research Program, Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK"},{"name":"Department of Cardiology, Ealing Hospital, Middlesex, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Afaq","sequence":"additional","affiliation":[{"name":"MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamuno","family":"Alfred","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najaf","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan E","family":"Arking","sequence":"additional","affiliation":[{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin","family":"Aung","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore"},{"name":"Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore"},{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Graham","family":"Barr","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence F","family":"Bielak","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boerwinkle","sequence":"additional","affiliation":[{"name":"Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA"},{"name":"Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin P","family":"Bottinger","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S","family":"Braund","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, Leicester, UK"},{"name":"NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Brody","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Broeckel","sequence":"additional","affiliation":[{"name":"Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Cade","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archie","family":"Campbell","sequence":"additional","affiliation":[{"name":"Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micka\u00ebl","family":"Canouil","sequence":"additional","affiliation":[{"name":"CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravinda","family":"Chakravarti","sequence":"additional","affiliation":[{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Cocca","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Trieste, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis S","family":"Collins","sequence":"additional","affiliation":[{"name":"Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"Connell","sequence":"additional","affiliation":[{"name":"Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e","family":"de Mutsert","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Janaka","family":"de Silva","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"D\u00f6rr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany"},{"name":"DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina, Chapel Hill, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B","family":"Eaton","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Ehret","sequence":"additional","affiliation":[{"name":"McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Evangelou","sequence":"additional","affiliation":[{"name":"MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK"},{"name":"Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica D","family":"Faul","sequence":"additional","affiliation":[{"name":"Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nita G","family":"Forouhi","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar H","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yechiel","family":"Friedlander","sequence":"additional","affiliation":[{"name":"Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Gao","sequence":"additional","affiliation":[{"name":"MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Gigante","sequence":"additional","affiliation":[{"name":"Medical Research, Taichung Veterans General Hospital, Department of Social Work, Tunghai University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Charles","family":"Gu","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Gupta","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia P","family":"Hagenaars","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK"},{"name":"Psychology, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara B","family":"Harris","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"He","sequence":"additional","affiliation":[{"name":"Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA"},{"name":"Medicine, Tulane University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Heikkinen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland"},{"name":"Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chew-Kiat","family":"Heng","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"},{"name":"Khoo Teck Puat\u2014National University Children\u2019s Medical Institute, National University Health System, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara V","family":"Howard","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute, Hyattsville, MD, USA"},{"name":"Center for Clinical and Translational Sciences and Department of Medicine, Georgetown\u2013Howard Universities, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C","family":"Hunt","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA"},{"name":"Department of Genetic Medicine, Weill Cornell Medicine, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite R","family":"Irvin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Jia","sequence":"additional","affiliation":[{"name":"Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Katsuya","sequence":"additional","affiliation":[{"name":"Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan"},{"name":"Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Epidemiology, Occupational and Environmental Medicine Program, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola D","family":"Kerrison","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiea Chuen","family":"Khor","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore"},{"name":"Department of Biochemistry, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon-Puay","family":"Koh","sequence":"additional","affiliation":[{"name":"Health Services and Systems Research, Duke\u2013NUS Medical School, Singapore, Singapore"},{"name":"Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki A","family":"Koistinen","sequence":"additional","affiliation":[{"name":"Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland"},{"name":"Department of Medicine and Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland"},{"name":"Minerva Foundation Institute for Medical Research, Biomedicum 2U, Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B","family":"Kooperberg","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose E","family":"Krieger","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Kubo","sequence":"additional","affiliation":[{"name":"RIKEN Center for Integrative Medical Sciences, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Kutalik","sequence":"additional","affiliation":[{"name":"Institute of Social Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland"},{"name":"Swiss Institute of Bioinformatics, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kuusisto","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo A","family":"Lakka","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland"},{"name":"Research Unit of Molecular Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl D","family":"Langefeld","sequence":"additional","affiliation":[{"name":"Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Langenberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore J","family":"Launer","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H","family":"Lee","sequence":"additional","affiliation":[{"name":"Sergievsky Center, College of Physicians and Surgeons, Columbia University Mailman School of Public Health, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Lehne","sequence":"additional","affiliation":[{"name":"MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Levy","sequence":"additional","affiliation":[{"name":"NHLBI Framingham Heart Study, Framingham, MA, USA"},{"name":"The Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora E","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yize","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Lifelines Cohort Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sing Hui","family":"Lim","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Ti","family":"Liu","sequence":"additional","affiliation":[{"name":"Biostatistics, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore"},{"name":"Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmin","family":"Liu","sequence":"additional","affiliation":[{"name":"WHI CCC, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Loh","sequence":"additional","affiliation":[{"name":"MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK"},{"name":"Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt K","family":"Lohman","sequence":"additional","affiliation":[{"name":"Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin","family":"Louie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reedik","family":"M\u00e4gi","sequence":"additional","affiliation":[{"name":"Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Laboratory for Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Minato-ku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Meitinger","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"Institute of Human Genetics, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Metspalu","sequence":"additional","affiliation":[{"name":"Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Milani","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Washington University, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihide","family":"Momozawa","sequence":"additional","affiliation":[{"name":"Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H","family":"Mosley, Jr","sequence":"additional","affiliation":[{"name":"Geriatrics, Medicine, University of Mississippi, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike A","family":"Nalls","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ubaydah","family":"Nasri","sequence":"additional","affiliation":[{"name":"Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff R","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA"},{"name":"Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adesola","family":"Ogunniyi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter R","family":"Palmas","sequence":"additional","affiliation":[{"name":"Internal Medicine, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholette D","family":"Palmer","sequence":"additional","affiliation":[{"name":"Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S","family":"Pankow","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Peters","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A","family":"Peyser","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozren","family":"Polasek","sequence":"additional","affiliation":[{"name":"Department of Public Health, Department of Medicine, University of Split, Split, Croatia"},{"name":"Psychiatric Hospital \u2018Sveti Ivan\u2019, Zagreb, Croatia"},{"name":"Gen-info Ltd, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Porteous","sequence":"additional","affiliation":[{"name":"Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli T","family":"Raitakari","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland"},{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frida","family":"Renstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"},{"name":"Department of Biobank Research, Ume\u00e5 University, Ume\u00e5, V\u00e4sterbotten, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Treva K","family":"Rice","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M","family":"Ridker","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Robino","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u2018Burlo Garofolo\u2019, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer G","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda M","family":"Rose","sequence":"additional","affiliation":[{"name":"Preventive Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Rudan","sequence":"additional","affiliation":[{"name":"Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charumathi","family":"Sabanayagam","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore"},{"name":"Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babatunde L","family":"Salako","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Sandow","sequence":"additional","affiliation":[{"name":"Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten O","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany"},{"name":"DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J","family":"Schreiner","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Scott","sequence":"additional","affiliation":[{"name":"MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sever","sequence":"additional","affiliation":[{"name":"International Centre for Circulatory Health, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Sims","sequence":"additional","affiliation":[{"name":"Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen M","family":"Sitlani","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair H","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA"},{"name":"Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Snieder","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen RB, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"Starr","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK"},{"name":"Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Strauch","sequence":"additional","affiliation":[{"name":"Institute of Genetic Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent D","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yik Ying","family":"Teo","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore"},{"name":"Life Sciences Institute, National University of Singapore, Singapore, Singapore"},{"name":"NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore"},{"name":"Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore"},{"name":"Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih Chung","family":"Tham","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 G","family":"Uitterlinden","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Waldenberger","sequence":"additional","affiliation":[{"name":"Research Unit of Molecular Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"MRC Epidemiology Unit, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Bin","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Wilson","sequence":"additional","affiliation":[{"name":"Jackson Heart Study, School of Public Health, Jackson State University, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K","family":"Wojczynski","sequence":"additional","affiliation":[{"name":"Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Bing","family":"Xiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yao","sequence":"additional","affiliation":[{"name":"Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Min","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan B","family":"Zonderman","sequence":"additional","affiliation":[{"name":"Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane M","family":"Becker","sequence":"additional","affiliation":[{"name":"General Internal Medicine, GeneSTAR Research Program, Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Boehnke","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W","family":"Bowden","sequence":"additional","affiliation":[{"name":"Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Chambers","sequence":"additional","affiliation":[{"name":"MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK"},{"name":"Department of Cardiology, Ealing Hospital, Middlesex, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yii-Der Ida","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Weir","sequence":"additional","affiliation":[{"name":"Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"de Faire","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J","family":"Deary","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK"},{"name":"Psychology, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00f5nu","family":"Esko","sequence":"additional","affiliation":[{"name":"Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia"},{"name":"Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Farrall","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, UK"},{"name":"Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence","family":"Forrester","sequence":"additional","affiliation":[{"name":"Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry I","family":"Freedman","sequence":"additional","affiliation":[{"name":"Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Froguel","sequence":"additional","affiliation":[{"name":"CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France"},{"name":"Department of Genomics of Common Disease, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gasparini","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Trieste, Trieste, Italy"},{"name":"Department of Genetic Medicine, Weill Cornell Medicine, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gieger","sequence":"additional","affiliation":[{"name":"Research Unit of Molecular Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo Lessa","family":"Horta","sequence":"additional","affiliation":[{"name":"Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jen","family":"Hung","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jost Bruno","family":"Jonas","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaspal S","family":"Kooner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ealing Hospital, Middlesex, UK"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Laakso","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terho","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland"},{"name":"Department of Clinical Chemistry, Finnish Cardiovascular Research Center\u2014Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae-Woei","family":"Liang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan"},{"name":"School of Medicine, National Yang-ming University, Taipei, Taiwan"},{"name":"Department of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik K E","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albertine J","family":"Oldehinkel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen RB, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre C","family":"Pereira","sequence":"additional","affiliation":[{"name":"Lab Genetics and Molecular Cardiology, Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, CA, USA"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Perls","sequence":"additional","affiliation":[{"name":"Geriatrics Section, Boston University Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Rauramaa","sequence":"additional","affiliation":[{"name":"Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Redline","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Rettig","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, Greifswald, Germany"},{"name":"Institute of Physiology, University of Medicine Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh J","family":"Samani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, Leicester, UK"},{"name":"NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Scott","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ou","family":"Shu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"van der Harst","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen RB, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne E","family":"Wagenknecht","sequence":"additional","affiliation":[{"name":"Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Wareham","sequence":"additional","affiliation":[{"name":"MRC Epidemiology Unit, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Watkins","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, UK"},{"name":"Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda R","family":"Wickremasinghe","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangchun","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health, Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongi Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Kamatani","sequence":"additional","affiliation":[{"name":"Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy C","family":"Laurie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele K","family":"Evans","sequence":"additional","affiliation":[{"name":"Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmundur","family":"Gudnason","sequence":"additional","affiliation":[{"name":"Icelandic Heart Association, Kopavogur, Iceland"},{"name":"Faculty of Medicine, University of Iceland, Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hixson","sequence":"additional","affiliation":[{"name":"Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L R","family":"Kardia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B","family":"Kritchevsky","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M","family":"Psaty","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, USA"},{"name":"Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob M","family":"van Dam","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore"},{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna K","family":"Arnett","sequence":"additional","affiliation":[{"name":"Dean\u2019s Office, University of Kentucky College of Public Health, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis O","family":"Mook-Kanamori","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Fornage","sequence":"additional","affiliation":[{"name":"Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ervin R","family":"Fox","sequence":"additional","affiliation":[{"name":"Cardiology, Medicine, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Hayward","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia M","family":"van Duijn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Shyong","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"},{"name":"Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore"},{"name":"Health Services and Systems Research, Duke\u2013NUS Medical School, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien Yin","family":"Wong","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore"},{"name":"Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore"},{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth J F","family":"Loos","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA"},{"name":"Icahn School of Medicine at Mount Sinai, The Mindich Child Health and Development Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex P","family":"Reiner","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N","family":"Rotimi","sequence":"additional","affiliation":[{"name":"Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J","family":"Bierut","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Adrienne","family":"Cupples","sequence":"additional","affiliation":[{"name":"Biostatistics, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Province","sequence":"additional","affiliation":[{"name":"Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome I","family":"Rotter","sequence":"additional","affiliation":[{"name":"Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W","family":"Franks","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"},{"name":"Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, MA, USA"},{"name":"Department of Public Health & Clinical Medicine, Ume\u00e5 University, Ume\u00e5, V\u00e4sterbotten, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Elliott","sequence":"additional","affiliation":[{"name":"MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Caulfield","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK"},{"name":"NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W James","family":"Gauderman","sequence":"additional","affiliation":[{"name":"Biostatistics, Preventive Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia B","family":"Munroe","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK"},{"name":"NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dabeeru C","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna C","family":"Morrison","sequence":"additional","affiliation":[{"name":"Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"2019072208295993600_ref1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/ng.361","article-title":"Genome-wide association study identifies eight loci associated with blood pressure","volume":"41","author":"Newton-Cheh","year":"2009","journal-title":"Nat. Genet."},{"key":"2019072208295993600_ref2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/ng.384","article-title":"Genome-wide association study of blood pressure and hypertension","volume":"41","author":"Levy","year":"2009","journal-title":"Nat. Genet."},{"key":"2019072208295993600_ref3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature10405","article-title":"Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk","volume":"478","author":"Ehret","year":"2011","journal-title":"Nature"},{"key":"2019072208295993600_ref4","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/ng.3667","article-title":"The genetics of blood pressure regulation and its target organs from association studies in 342\u2009415 individuals","volume":"48","author":"Ehret","year":"2016","journal-title":"Nat. Genet."},{"key":"2019072208295993600_ref5","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/ng.3660","article-title":"Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci","volume":"48","author":"Liu","year":"2016","journal-title":"Nat. Genet."},{"key":"2019072208295993600_ref6","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/ng.3654","article-title":"Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension","volume":"48","author":"Surendran","year":"2016","journal-title":"Nat. Genet."},{"key":"2019072208295993600_ref7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/ng.3715","article-title":"Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation","volume":"49","author":"Hoffmann","year":"2016","journal-title":"Nat. Genet."},{"key":"2019072208295993600_ref8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/ng.3768","article-title":"Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk","volume":"49","author":"Warren","year":"2017","journal-title":"Nat. Genet."},{"key":"2019072208295993600_ref9","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/s41588-018-0205-x","article-title":"Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits","volume":"50","author":"Evangelou","year":"2018","journal-title":"Nat. Genet."},{"key":"2019072208295993600_ref10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41588-018-0303-9","article-title":"Trans-ethnic association study of blood pressure determinants in over 750\u2009000 individuals","volume":"51","author":"Giri","year":"2019","journal-title":"Nat. Genet."},{"key":"2019072208295993600_ref11","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/ng.2274","article-title":"A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance","volume":"44","author":"Manning","year":"2012","journal-title":"Nat. Genet."},{"key":"2019072208295993600_ref12","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGENETICS.117.001764","article-title":"Genes, environment, and the heart: putting the pieces together","volume":"10","author":"Kirk","year":"2017","journal-title":"Circ. Cardiovasc. Genet."},{"key":"2019072208295993600_ref13","doi-asserted-by":"crossref","first-page":"e001649","DOI":"10.1161\/CIRCGENETICS.116.001649","article-title":"A multi-ancestry study of gene\u2013lifestyle interactions for cardiovascular traits in 610\u2009475 individuals from 124 cohorts: design and rationale","volume":"10","author":"Rao","year":"2017","journal-title":"Circ. Cardiovasc. Genet."},{"key":"2019072208295993600_ref14","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1001\/jama.1991.03460170080037","article-title":"Elevation of ambulatory systolic blood pressure in hypertensive smokers. A case\u2013control study","volume":"265","author":"Mann","year":"1991","journal-title":"JAMA"},{"key":"2019072208295993600_ref15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/01.HYP.37.2.187","article-title":"Association between smoking and blood pressure: evidence from the health survey for England","volume":"37","author":"Primatesta","year":"2001","journal-title":"Hypertension"},{"key":"2019072208295993600_ref16","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ajhg.2018.01.015","article-title":"A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure","volume":"102","author":"Sung","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"2019072208295993600_ref17","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/01.CIR.96.1.308","article-title":"Hemodynamic patterns of age-related changes in blood pressure. The Framingham heart study","volume":"96","author":"Franklin","year":"1997","journal-title":"Circulation"},{"key":"2019072208295993600_ref18","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"Lewington","year":"2002","journal-title":"Lancet"},{"key":"2019072208295993600_ref19","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/01.HYP.36.5.801","article-title":"Systolic and diastolic blood pressure, pulse pressure, and mean arterial pressure as predictors of cardiovascular disease risk in men","volume":"36","author":"Sesso","year":"2000","journal-title":"Hypertension"},{"key":"2019072208295993600_ref20","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0735-1097(01)01108-1","article-title":"Pulse pressure\u2014a review of mechanisms and clinical relevance","volume":"37","author":"Dart","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"2019072208295993600_ref21","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/01.CIR.100.4.354","article-title":"Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham heart study","volume":"100","author":"Franklin","year":"1999","journal-title":"Circulation"},{"key":"2019072208295993600_ref22","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1097\/00004872-199917080-00004","article-title":"Pulse pressure as a risk factor for cardiovascular events in the MRC mild hypertension trial","volume":"17","author":"Millar","year":"1999","journal-title":"J. Hypertens."},{"key":"2019072208295993600_ref23","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1016\/j.jacc.2017.11.006","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"2019072208295993600_ref24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/gepi.20546","article-title":"Meta-analysis of gene\u2013environment interaction: joint estimation of SNP and SNP \u00d7 environment regression coefficients","volume":"35","author":"Manning","year":"2011","journal-title":"Genet. Epidemiol."},{"key":"2019072208295993600_ref25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/gepi.20582","article-title":"Novel method to estimate the phenotypic variation explained by genome-wide association studies reveals large fraction of the missing heritability","volume":"35","author":"Kutalik","year":"2011","journal-title":"Genet. Epidemiol."},{"key":"2019072208295993600_ref26","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"Ward","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2019072208295993600_ref27","doi-asserted-by":"crossref","first-page":"e1001025","DOI":"10.1371\/journal.pcbi.1001025","article-title":"Identifying a high fraction of the human genome to be under selective constraint using GERP++","volume":"6","author":"Davydov","year":"2010","journal-title":"PLoS Comput. Biol."},{"key":"2019072208295993600_ref28","doi-asserted-by":"crossref","first-page":"i54","DOI":"10.1093\/bioinformatics\/btp190","article-title":"Identifying novel constrained elements by exploiting biased substitution patterns","volume":"25","author":"Garber","year":"2009","journal-title":"Bioinformatics"},{"key":"2019072208295993600_ref29","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"Human genomics. The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"Consortium","year":"2015","journal-title":"Science"},{"key":"2019072208295993600_ref30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13059-016-1142-6","article-title":"Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies","volume":"18","author":"Joehanes","year":"2017","journal-title":"Genome Biol."},{"key":"2019072208295993600_ref31","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cardfail.2015.02.005","article-title":"Right ventricular myocardial biomarkers in human heart failure","volume":"21","author":"di Salvo","year":"2015","journal-title":"J. Card. Fail."},{"key":"2019072208295993600_ref32","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1161\/CIRCRESAHA.111.256743","article-title":"Thrombospondin-4 is required for stretch-mediated contractility augmentation in cardiac muscle","volume":"109","author":"Cingolani","year":"2011","journal-title":"Circ. Res."},{"key":"2019072208295993600_ref33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/01.RES.0000237387.05259.a5","article-title":"Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition","volume":"99","author":"Han","year":"2006","journal-title":"Circ. Res."},{"key":"2019072208295993600_ref34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.5535\/arm.2017.41.2.197","article-title":"Association between a polymorphism in CASP3 and CASP9 genes and ischemic stroke","volume":"41","author":"Lee","year":"2017","journal-title":"Ann. Rehabil. Med."},{"key":"2019072208295993600_ref35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1868-7083-6-4","article-title":"Differences in smoking associated DNA methylation patterns in South Asians and Europeans","volume":"6","author":"Elliott","year":"2014","journal-title":"Clin. Epigenetics"},{"key":"2019072208295993600_ref36","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1289\/ehp.1307892","article-title":"Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy","volume":"122","author":"Markunas","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"2019072208295993600_ref37","doi-asserted-by":"crossref","first-page":"26238","DOI":"10.1074\/jbc.M110.214155","article-title":"Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCs) via inhibition of mitogen-activated protein kinase (MAPK) signaling and alterations in critical cell cycle regulatory proteins","volume":"286","author":"Begum","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2019072208295993600_ref38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ng.3302","article-title":"PDE3A mutations cause autosomal dominant hypertension with brachydactyly","volume":"47","author":"Maass","year":"2015","journal-title":"Nat. Genet."},{"key":"2019072208295993600_ref39","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1161\/HYPERTENSIONAHA.115.06000","article-title":"Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly","volume":"66","author":"Toka","year":"2015","journal-title":"Hypertension"},{"key":"2019072208295993600_ref40","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/jama.2009.978-a","article-title":"Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data","volume":"302","author":"Vasan","year":"2009","journal-title":"JAMA"},{"key":"2019072208295993600_ref41","doi-asserted-by":"crossref","first-page":"e001398","DOI":"10.1161\/JAHA.114.001398","article-title":"Large-scale gene-centric analysis identifies polymorphisms for resistant hypertension","volume":"3","author":"Fontana","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"2019072208295993600_ref42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fgene.2013.00277","article-title":"Gene\u2013alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9","volume":"4","author":"Simino","year":"2013","journal-title":"Front. Genet."},{"key":"2019072208295993600_ref43","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1242\/dmm.026716","article-title":"Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat","volume":"10","author":"Coan","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"2019072208295993600_ref44","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/jhh.2009.86","article-title":"Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and\/or hypertension in two Korean cohorts","volume":"24","author":"Hong","year":"2010","journal-title":"J. Hum. Hypertens."},{"key":"2019072208295993600_ref45","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.5551\/jat.4291","article-title":"Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population","volume":"17","author":"Koriyama","year":"2010","journal-title":"J. Atheroscler. Thromb."},{"key":"2019072208295993600_ref46","doi-asserted-by":"crossref","first-page":"e1003681","DOI":"10.1371\/journal.pgen.1003681","article-title":"Genome-wide association of body fat distribution in African ancestry populations suggests new loci","volume":"9","author":"Liu","year":"2013","journal-title":"PLoS Genet."},{"key":"2019072208295993600_ref47","doi-asserted-by":"crossref","first-page":"e24052","DOI":"10.1371\/journal.pone.0024052","article-title":"Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study","volume":"6","author":"Irvin","year":"2011","journal-title":"PLoS One"},{"key":"2019072208295993600_ref48","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1196\/annals.1441.018","article-title":"Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify \u2018connectivity constellation\u2019 and drug target genes with pleiotropic effects","volume":"1141","author":"Uhl","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2019072208295993600_ref49","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5808\/GI.2011.9.4.152","article-title":"Genome-wide survey of copy number variants associated with blood pressure and body mass index in a Korean population","volume":"9","author":"Moon","year":"2011","journal-title":"Genomics Informatics"},{"key":"2019072208295993600_ref50","doi-asserted-by":"crossref","first-page":"F161","DOI":"10.1152\/ajprenal.00219.2003","article-title":"SLC26A7: a basolateral cl-\/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct","volume":"286","author":"Petrovic","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2019072208295993600_ref51","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1161\/CIRCRESAHA.107.150474","article-title":"Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage","volume":"101","author":"Henke","year":"2007","journal-title":"Circ. Res."},{"key":"2019072208295993600_ref52","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1161\/CIRCULATIONAHA.108.804294","article-title":"Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight\/obese middle-aged and older humans","volume":"119","author":"Pierce","year":"2009","journal-title":"Circulation"},{"key":"2019072208295993600_ref53","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/jhh.2015.13","article-title":"Association of gene polymorphisms in RANKL\/RANK\/OPG system with hypertension and blood pressure in Chinese women","volume":"29","author":"Duan","year":"2015","journal-title":"J. Hum. Hypertens."},{"key":"2019072208295993600_ref54","first-page":"F615","article-title":"Contribution of vasopressin to the maintenance of blood pressure during dehydration","volume":"245","author":"Woods","year":"1983","journal-title":"Am. J. Physiol."},{"key":"2019072208295993600_ref55","doi-asserted-by":"crossref","first-page":"F100","DOI":"10.1152\/ajprenal.00088.2008","article-title":"Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells","volume":"295","author":"Aoyagi","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2019072208295993600_ref56","doi-asserted-by":"crossref","first-page":"7807","DOI":"10.1073\/pnas.0600875103","article-title":"V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity","volume":"103","author":"Koshimizu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2019072208295993600_ref57","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1161\/01.HYP.26.5.828","article-title":"Attenuation of genetic hypertension after short-term vasopressin V1A receptor antagonism","volume":"26","author":"Burrell","year":"1995","journal-title":"Hypertension"},{"key":"2019072208295993600_ref58","first-page":"657","article-title":"Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension","volume":"123","author":"Ronzaud","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2019072208295993600_ref59","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1093\/emboj\/20.24.7052","article-title":"Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression","volume":"20","author":"Debonneville","year":"2001","journal-title":"EMBO J."},{"key":"2019072208295993600_ref60","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ajh.2010.222","article-title":"Association between NEDD4L gene and sodium lithium countertransport","volume":"24","author":"Zheng","year":"2011","journal-title":"Am. J. Hypertens."},{"key":"2019072208295993600_ref61","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1161\/HYPERTENSIONAHA.109.135103","article-title":"A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension","volume":"54","author":"Luo","year":"2009","journal-title":"Hypertension"},{"key":"2019072208295993600_ref62","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/HJH.0b013e3283410390","article-title":"A functional variant of the NEDD4L gene is associated with beneficial treatment response with beta-blockers and diuretics in hypertensive patients","volume":"29","author":"Svensson-Farbom","year":"2011","journal-title":"J. Hypertens."},{"key":"2019072208295993600_ref63","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/HJH.0b013e32835e2a71","article-title":"Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics","volume":"31","author":"McDonough","year":"2013","journal-title":"J. Hypertens."},{"key":"2019072208295993600_ref64","article-title":"Cardiovascular and renal actions of dopamine: potential clinical applications","volume":"24","author":"Goldberg","year":"1972","journal-title":"Pharmacol. Rev."},{"key":"2019072208295993600_ref65","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1161\/01.HYP.38.3.303","article-title":"Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice","volume":"38","author":"Li","year":"2001","journal-title":"Hypertension"},{"key":"2019072208295993600_ref66","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1161\/01.HYP.0000254486.00883.3d","article-title":"Reactive oxygen species-dependent hypertension in dopamine D2 receptor-deficient mice","volume":"49","author":"Armando","year":"2007","journal-title":"Hypertension"},{"key":"2019072208295993600_ref67","doi-asserted-by":"crossref","first-page":"F128","DOI":"10.1152\/ajprenal.00453.2014","article-title":"Dopamine D2 receptors\u2019 effects on renal inflammation are mediated by regulation of PP2A function","volume":"310","author":"Zhang","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2019072208295993600_ref68","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1161\/HYPERTENSIONAHA.114.03840","article-title":"Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production","volume":"64","author":"Yang","year":"2014","journal-title":"Hypertension"},{"key":"2019072208295993600_ref69","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10565-014-9276-3","article-title":"Upregulation of sestrin-2 expression protects against endothelial toxicity of angiotensin II","volume":"30","author":"Yi","year":"2014","journal-title":"Cell Biol. Toxicol."},{"key":"2019072208295993600_ref70","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/mds.23221","article-title":"Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations","volume":"25","author":"Paisan-Ruiz","year":"2010","journal-title":"Mov. Disord."},{"key":"2019072208295993600_ref71","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1523\/JNEUROSCI.09-03-00865.1989","article-title":"ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Immunocytochemical localization in rat brain","volume":"9","author":"Ouimet","year":"1989","journal-title":"J. Neurosci."},{"key":"2019072208295993600_ref72","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neubiorev.2005.04.016","article-title":"The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse?","volume":"30","author":"Pierce","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"2019072208295993600_ref73","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mce.2013.07.032","article-title":"Familial pheochromocytomas and paragangliomas","volume":"386","author":"King","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"2019072208295993600_ref74","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1471-2350-11-92","article-title":"Low penetrance of a SDHB mutation in a large Dutch paraganglioma family","volume":"11","author":"Hes","year":"2010","journal-title":"BMC Med. Genet."},{"key":"2019072208295993600_ref75","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCGENETICS.115.001190","article-title":"International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents","volume":"9","author":"Parmar","year":"2016","journal-title":"Circ. Cardiovasc. Genet."},{"key":"2019072208295993600_ref76","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1755-148X.2010.00762.x","article-title":"The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis","volume":"23","author":"Luecke","year":"2010","journal-title":"Pigment Cell Melanoma Res."},{"key":"2019072208295993600_ref77","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/ajh\/hpu049","article-title":"Common genetic variations in the vitamin D pathway in relation to blood pressure","volume":"27","author":"Wang","year":"2014","journal-title":"Am. J. Hypertens."},{"key":"2019072208295993600_ref78","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1001\/archinte.160.8.1085","article-title":"Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients","volume":"160","author":"Blacher","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"2019072208295993600_ref79","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/00004872-200201000-00021","article-title":"Pulsatile blood pressure component as predictor of mortality in hypertension: a meta-analysis of clinical trial control groups","volume":"20","author":"Gasowski","year":"2002","journal-title":"J. Hypertens."},{"key":"2019072208295993600_ref80","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1097\/01.hjh.0000249697.26983.aa","article-title":"Interaction between CYP1A1 T3801C and AHR G1661A polymorphisms according to smoking status on blood pressure in the Stanislas cohort","volume":"24","author":"Gambier","year":"2006","journal-title":"J. Hypertens."},{"key":"2019072208295993600_ref81","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.taap.2005.07.005","article-title":"Characterizing the role of endothelin-1 in the progression of cardiac hypertrophy in aryl hydrocarbon receptor (AhR) null mice","volume":"212","author":"Lund","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2019072208295993600_ref82","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0006-291X(02)02970-4","article-title":"Aryl hydrocarbon receptor ligands repress T-cadherin expression in vascular smooth muscle cells","volume":"300","author":"Niermann","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2019072208295993600_ref83","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0014-5793(98)00977-6","article-title":"Density- and proliferation status-dependent expression of T-cadherin, a novel lipoprotein-binding glycoprotein: a function in negative regulation of smooth muscle cell growth?","volume":"434","author":"Kuzmenko","year":"1998","journal-title":"FEBS Lett."},{"key":"2019072208295993600_ref84","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1093\/hmg\/ddp135","article-title":"Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations","volume":"18","author":"Org","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"2019072208295993600_ref85","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1021\/tx7001965","article-title":"The search for endogenous activators of the aryl hydrocarbon receptor","volume":"21","author":"Nguyen","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"2019072208295993600_ref86","doi-asserted-by":"crossref","first-page":"L391","DOI":"10.1152\/ajplung.00062.2005","article-title":"The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts","volume":"289","author":"Martey","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2019072208295993600_ref87","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/ncpcardio0307","article-title":"Large-artery stiffness, hypertension and cardiovascular risk in older patients","volume":"2","author":"Blacher","year":"2005","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"2019072208295993600_ref88","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1086\/512821","article-title":"Overcoming the winner's curse: estimating penetrance parameters from case-control data","volume":"80","author":"Zollner","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"2019072208295993600_ref89","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/s41588-019-0378-y","article-title":"Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.","volume":"51","author":"Bentley","year":"2019","journal-title":"Nature genetics"},{"key":"2019072208295993600_ref90","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biopsych.2013.09.006","article-title":"Gene \u00d7 environment interaction studies have not properly controlled for potential confounders: the problem and the (simple) solution","volume":"75","author":"Keller","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"2019072208295993600_ref91","first-page":"559","article-title":"Gene-obesogenic environment interactions in the UK biobank study","volume":"46","author":"Tyrrell","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"2019072208295993600_ref92","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1092 human genomes","volume":"491","author":"1000 Genomes Project Consortium","year":"2012","journal-title":"Nature"},{"key":"2019072208295993600_ref93","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000099183","article-title":"Exploiting gene\u2013environment interaction to detect genetic associations","volume":"63","author":"Kraft","year":"2007","journal-title":"Hum. Hered."},{"key":"2019072208295993600_ref94","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v016.i09","article-title":"Object-oriented computation of sandwich estimators","volume":"16","author":"Zeileis","year":"2006","journal-title":"J. Stat. Softw."},{"key":"2019072208295993600_ref95","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-11-134","article-title":"ProbABEL package for genome-wide association analysis of imputed data","volume":"11","author":"Aulchenko","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2019072208295993600_ref96","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/EDE.0b013e31820877c5","article-title":"On the robustness of tests of genetic associations incorporating gene\u2013environment interaction when the environmental exposure is misspecified","volume":"22","author":"Tchetgen Tchetgen","year":"2011","journal-title":"Epidemiology"},{"key":"2019072208295993600_ref97","doi-asserted-by":"crossref","first-page":"e19416","DOI":"10.1371\/journal.pone.0019416","article-title":"Behavior of QQ-plots and genomic control in studies of gene\u2013environment interaction","volume":"6","author":"Voorman","year":"2011","journal-title":"PLoS One"},{"key":"2019072208295993600_ref98","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/nprot.2014.071","article-title":"Quality control and conduct of genome-wide association meta-analyses","volume":"9","author":"Winkler","year":"2014","journal-title":"Nat. Protoc."},{"key":"2019072208295993600_ref99","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/gepi.21978","article-title":"An empirical comparison of joint and stratified frameworks for studying G \u00d7 E interactions: systolic blood pressure and smoking in the CHARGE gene\u2013lifestyle interactions working group","volume":"40","author":"Sung","year":"2016","journal-title":"Genet. Epidemiol."},{"key":"2019072208295993600_ref100","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"2019072208295993600_ref101","doi-asserted-by":"crossref","first-page":"e1003500","DOI":"10.1371\/journal.pgen.1003500","article-title":"Sex-stratified genome-wide association studies including 270\u2009000 individuals show sexual dimorphism in genetic loci for anthropometric traits","volume":"9","author":"Randall","year":"2013","journal-title":"PLoS Genet."},{"key":"2019072208295993600_ref102","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1159\/000323318","article-title":"Genome-wide meta-analysis of joint tests for genetic and gene\u2013environment interaction effects","volume":"70","author":"Aschard","year":"2010","journal-title":"Hum. Hered."},{"key":"2019072208295993600_ref103","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/bioinformatics\/btu621","article-title":"EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data","volume":"31","author":"Winkler","year":"2015","journal-title":"Bioinformatics"},{"key":"2019072208295993600_ref104","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies","volume":"55","author":"Devlin","year":"1999","journal-title":"Biometrics"},{"key":"2019072208295993600_ref105","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate\u2014a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Series B Stat. Methodol."},{"key":"2019072208295993600_ref106","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","author":"Genomes Project","year":"2010","journal-title":"Nature"},{"key":"2019072208295993600_ref107","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1038\/ncomms6890","article-title":"Biological interpretation of genome-wide association studies using predicted gene functions","volume":"6","author":"Pers","year":"2015","journal-title":"Nat. Commun."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/advance-article-pdf\/doi\/10.1093\/hmg\/ddz070\/28646779\/ddz070.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/28\/15\/2615\/28936234\/ddz070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T07:51:13Z","timestamp":1721116273000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/28\/15\/2615\/5439584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":107,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2019,4,10]]},"published-print":{"date-parts":[[2019,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddz070","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,8,1]]},"published":{"date-parts":[[2019,4,10]]}}}