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DMD patients exhibit progressive muscle degeneration and weakness, leading to loss of ambulation and premature death from cardiopulmonary failure. We previously reported that mouse Laminin-111 (msLam-111) protein could reduce muscle pathology and improve muscle function in the mdx mouse model for DMD. In this study, we examined the ability of msLam-111 to prevent muscle disease progression in the golden retriever muscular dystrophy (GRMD) dog model of DMD. The msLam-111 protein was injected into the cranial tibial muscle compartment of GRMD dogs and muscle strength and pathology were assessed. The results showed that msLam-111 treatment increased muscle fiber regeneration and repair with improved muscle strength and reduced muscle fibrosis in the GRMD model. Together, these findings support the idea that Laminin-111 could serve as a novel protein therapy for the treatment of DMD.<\/jats:p>","DOI":"10.1093\/hmg\/ddz086","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T19:15:22Z","timestamp":1555960522000},"page":"2686-2695","source":"Crossref","is-referenced-by-count":20,"title":["Laminin-111 protein therapy enhances muscle regeneration and repair in the GRMD dog model of Duchenne muscular dystrophy"],"prefix":"10.1093","volume":"28","author":[{"given":"Pamela","family":"Barraza-Flores","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana M","family":"Fontelonga","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan D","family":"Wuebbles","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey J","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia M","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe N","family":"Kornegay","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean J","family":"Burkin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"2019080901544386400_ref1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s11910-012-0332-1","article-title":"Update on the treatment of duchenne muscular dystrophy","volume":"13","author":"Rodino-Klapac","year":"2013","journal-title":"Curr. 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