{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:12:46Z","timestamp":1776089566334,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["17-04-00288"],"award-info":[{"award-number":["17-04-00288"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>WAGR syndrome (OMIM #194072) is a rare genetic disorder that consists of development of Wilms\u2019 tumor (nephroblastoma), aniridia, genitourinary anomalies and intellectual disability (mental retardation). It is associated with WAGR-region deletions in the 11p13 chromosome region. Our previous study of congenital aniridia patients revealed a noticeable number of aniridia patients with WAGR-region deletions but without Wilms\u2019 tumor in their medical history. We assessed the involvement of other neighboring genes from affected chromosome regions in the patients with and without Wilms\u2019 tumor. Reliable confidence was obtained for the LMO2 gene, which is significantly more often deleted in patients with nephroblastoma. Thus, our study presents genetic evidence that the development of Wilms tumors in WAGR syndrome patients should be attributed to the deletion of WT1 and LMO2 rather than WT1 only.<\/jats:p>","DOI":"10.1093\/hmg\/ddz168","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T19:10:12Z","timestamp":1562699412000},"page":"3323-3326","source":"Crossref","is-referenced-by-count":18,"title":["LMO2 gene deletions significantly worsen the prognosis of Wilms\u2019 tumor development in patients with WAGR syndrome"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-5118","authenticated-orcid":false,"given":"Andrey V","family":"Marakhonov","sequence":"first","affiliation":[{"name":"Research Center for Medical Genetics, Moscow 115522, Russia"},{"name":"Far Eastern Federal University, Vladivostok 690090, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana A","family":"Vasilyeva","sequence":"additional","affiliation":[{"name":"Research Center for Medical Genetics, Moscow 115522, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna A","family":"Voskresenskaya","sequence":"additional","affiliation":[{"name":"Cheboksary Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Cheboksary 428028, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natella V","family":"Sukhanova","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Children\u2019s Health, Moscow 119296, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaly V","family":"Kadyshev","sequence":"additional","affiliation":[{"name":"Research Center for Medical Genetics, Moscow 115522, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey I","family":"Kutsev","sequence":"additional","affiliation":[{"name":"Research Center for Medical Genetics, Moscow 115522, Russia"},{"name":"Pirogov Russian National Research Medical University, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rena A","family":"Zinchenko","sequence":"additional","affiliation":[{"name":"Research Center for Medical Genetics, Moscow 115522, Russia"},{"name":"Pirogov Russian National Research Medical University, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"2019111805402638700_ref1","volume-title":"Orphanet Report Series","author":"Rath","year":"2019"},{"key":"2019111805402638700_ref2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000172086","article-title":"Characterization of 11p14-p12 deletion in WAGR syndrome by array CGH for identifying genes contributing to mental retardation and autism","volume":"122","author":"Xu","year":"2008","journal-title":"Cytogenet. 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