{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:19:41Z","timestamp":1769505581443,"version":"3.49.0"},"reference-count":219,"publisher":"Oxford University Press (OUP)","issue":"21","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["96012574"],"award-info":[{"award-number":["96012574"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glaucoma is a leading cause of blindness. We aimed in this study to identify genes that may make subtle and cumulative contributions to glaucoma pathogenesis. To this end, we identified molecular interactions and pathways that include transcription factors (TFs) FOXC1, PITX2, PAX6 and NFKB1 and various microRNAs including miR-204 known to have relevance to trabecular meshwork (TM) functions and\/or glaucoma. TM tissue is involved in glaucoma pathogenesis. In-house microarray transcriptome results and data sources were used to identify target genes of the regulatory molecules. Bioinformatics analyses were done to filter TM and glaucoma relevant genes. These were submitted to network-creating softwares to define interactions, pathways and a network that would include the genes. The network was stringently scrutinized and minimized, then expanded by addition of microarray data and data on TF and microRNA-binding sites. Selected features of the network were confirmed by empirical studies such as dual luciferase assays, real-time PCR and western blot experiments and apoptosis assays. MYOC, WDR36, LTPBP2, RHOA, CYP1B1, OPA1, SPARC, MEIS2, PLEKHG5, RGS5, BBS5, ALDH1A1, NOMO2, CXCL6, FMNL2, ADAMTS5, CLOCK and DKK1 were among the genes included in the final network. Pathways identified included those that affect ECM properties, IOP, ciliary body functions, retinal ganglion cell viability, apoptosis, focal adhesion and oxidative stress response. The identification of many genes potentially involved in glaucoma pathology is consistent with its being a complex disease. The inclusion of several known glaucoma-related genes validates the approach used.<\/jats:p>","DOI":"10.1093\/hmg\/ddz222","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T11:37:15Z","timestamp":1567769835000},"page":"3637-3663","source":"Crossref","is-referenced-by-count":15,"title":["Identification of genes involved in glaucoma pathogenesis using combined network analysis and empirical studies"],"prefix":"10.1093","volume":"28","author":[{"given":"Hamidreza","family":"Moazzeni","sequence":"first","affiliation":[{"name":"School of Biology, College of Science, University of Tehran, Tehran, Iran"},{"name":"Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehraban","family":"Mirrahimi","sequence":"additional","affiliation":[{"name":"School of Biology, College of Science, University of Tehran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abolfazl","family":"Moghadam","sequence":"additional","affiliation":[{"name":"School of Biology, College of Science, University of Tehran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Banaei-Esfahani","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahin","family":"Yazdani","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6897-2223","authenticated-orcid":false,"given":"Elahe","family":"Elahi","sequence":"additional","affiliation":[{"name":"School of Biology, College of Science, University of Tehran, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"2019122311035782900_ref1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"2019122311035782900_ref2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1755-3768.1994.tb02763.x","article-title":"Diffuse visual field loss and glaucoma","volume":"72","author":"Asman","year":"1994","journal-title":"Acta. Ophthalmol (Copenh)."},{"key":"2019122311035782900_ref3","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/bjo.86.2.238","article-title":"The definition and classification of glaucoma in prevalence surveys","volume":"86","author":"Foster","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"2019122311035782900_ref4","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1136\/bjo.82.10.1118","article-title":"Vertical cup\/disc ratio in relation to optic disc size: its value in the assessment of the glaucoma suspect","volume":"82","author":"Garway-Heath","year":"1998","journal-title":"Br. J. Ophthalmol."},{"key":"2019122311035782900_ref5","first-page":"149","article-title":"Target intraocular pressure in the management of glaucoma","volume":"29","author":"Popovic-Suic","year":"2005","journal-title":"Coll. Antropol."},{"key":"2019122311035782900_ref6","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/bjo.50.10.570","article-title":"Intra-ocular pressure, glaucoma, and glaucoma suspects in a defined population","volume":"50","author":"Hollows","year":"1966","journal-title":"Br. J. Ophthalmol."},{"key":"2019122311035782900_ref7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.matbio.2014.03.007","article-title":"The role of matricellular proteins in glaucoma","volume":"37","author":"Wallace","year":"2014","journal-title":"Matrix. Biol."},{"key":"2019122311035782900_ref8","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.ajhg.2009.03.017","article-title":"Null mutations in LTBP2 cause primary congenital glaucoma","volume":"84","author":"Ali","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"2019122311035782900_ref9","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0002-9394(03)00577-4","article-title":"Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma","volume":"136","author":"Alward","year":"2003","journal-title":"Am. J. Ophthalmol."},{"key":"2019122311035782900_ref10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/eye.2011.97","article-title":"Primary open-angle glaucoma genes","volume":"25","author":"Fingert","year":"2011","journal-title":"Eye (Lond)"},{"key":"2019122311035782900_ref11","first-page":"T6","article-title":"Tank-binding kinase 1 (TBK1) gene and open-angle glaucomas (an American Ophthalmological Society thesis)","volume":"114","author":"Fingert","year":"2016","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"2019122311035782900_ref12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.gene.2015.11.032","article-title":"Candidate genes involved in the susceptibility of primary open angle glaucoma","volume":"577","author":"Kumar","year":"2016","journal-title":"Gene"},{"key":"2019122311035782900_ref13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/hmg\/ddi068","article-title":"Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1","volume":"14","author":"Monemi","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref14","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1172\/JCI85830","article-title":"Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity","volume":"126","author":"Souma","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2019122311035782900_ref15","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/hmg\/6.4.641","article-title":"Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21","volume":"6","author":"Stoilov","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref16","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0896-1549(03)00062-2","article-title":"Genetics and biochemistry of primary congenital glaucoma","volume":"16","author":"Sarfarazi","year":"2003","journal-title":"Ophthalmol. Clin. North. Am."},{"key":"2019122311035782900_ref17","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddy256","article-title":"COL18A1 is a candidate eye iridocorneal angle closure gene in humans","author":"Suri","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref18","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/eye.2015.124","article-title":"The genetic mechanisms of primary angle closure glaucoma","volume":"29","author":"Ahram","year":"2015","journal-title":"Eye (Lond)"},{"key":"2019122311035782900_ref19","first-page":"5035","article-title":"Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos","volume":"25","author":"Gao","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref20","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/ng.3540","article-title":"Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma","volume":"48","author":"Khor","year":"2016","journal-title":"Nat. Genet."},{"key":"2019122311035782900_ref21","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ophtha.2013.09.012","article-title":"Association of CAV1\/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss","volume":"121","author":"Loomis","year":"2014","journal-title":"Ophthalmology"},{"key":"2019122311035782900_ref22","first-page":"1209","article-title":"Effect of PITX2 knockdown on transcriptome of primary human trabecular meshwork cell cultures","volume":"17","author":"Paylakhi","year":"2011","journal-title":"Mol. Vis."},{"key":"2019122311035782900_ref23","first-page":"241","article-title":"Non-housekeeping genes expressed in human trabecular meshwork cell cultures","volume":"18","author":"Paylakhi","year":"2012","journal-title":"Mol. Vis."},{"key":"2019122311035782900_ref24","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.exer.2013.03.009","article-title":"FOXC1 in human trabecular meshwork cells is involved in regulatory pathway that includes miR-204, MEIS2, and ITGbeta1","volume":"111","author":"Paylakhi","year":"2013","journal-title":"Exp. Eye. Res."},{"key":"2019122311035782900_ref25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.gene.2016.08.019","article-title":"Expression of CXCL6 and BBS5 that may be glaucoma relevant genes is regulated by PITX2","volume":"593","author":"Moazzeni","year":"2016","journal-title":"Gene"},{"key":"2019122311035782900_ref26","first-page":"108","article-title":"MicroRNAs that target RGS5","volume":"18","author":"Banaei-Esfahani","year":"2015","journal-title":"Iran. J. Basic. Med. Sci."},{"key":"2019122311035782900_ref27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4103\/jovr.jovr_8_17","article-title":"FMNL2 with functions related to the cytoskeleton is partially regulated by PAX6","volume":"12","author":"Ghorbanpour","year":"2017","journal-title":"J. Ophthalmic. Vis. Res."},{"key":"2019122311035782900_ref28","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/hmg\/ddl008","article-title":"Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis","volume":"15","author":"Berry","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref29","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1167\/iovs.05-0691","article-title":"Fate maps of neural crest and mesoderm in the mammalian eye","volume":"46","author":"Gage","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref30","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1242\/dev.126.20.4643","article-title":"Dosage requirement of Pitx2 for development of multiple organs","volume":"126","author":"Gage","year":"1999","journal-title":"Development"},{"key":"2019122311035782900_ref31","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1006\/dbio.1999.9314","article-title":"The forkhead\/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye","volume":"211","author":"Kidson","year":"1999","journal-title":"Dev. Biol."},{"key":"2019122311035782900_ref32","doi-asserted-by":"crossref","first-page":"5749","DOI":"10.1242\/dev.126.24.5749","article-title":"Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism","volume":"126","author":"Kitamura","year":"1999","journal-title":"Development"},{"key":"2019122311035782900_ref33","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/45797","article-title":"Function of Rieger syndrome gene in left-right asymmetry and craniofacial development","volume":"401","author":"Lu","year":"1999","journal-title":"Nature"},{"key":"2019122311035782900_ref34","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1167\/iovs.06-0472","article-title":"Genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma patients with FOXC1 and PITX2 mutations","volume":"48","author":"Strungaru","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1167\/iovs.08-2253","article-title":"The transcription factor gene FOXC1 exhibits a limited role in primary congenital glaucoma","volume":"50","author":"Chakrabarti","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref36","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/ng0493-299","article-title":"A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells","volume":"3","author":"Matsuo","year":"1993","journal-title":"Nat. Genet."},{"key":"2019122311035782900_ref37","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.1073\/pnas.1610614114","article-title":"Drosophila Pax6 promotes development of the entire eye-antennal disc, thereby ensuring proper adult head formation","volume":"114","author":"Zhu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2019122311035782900_ref38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1242\/dev.103.Supplement.115","article-title":"Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities","volume":"103","author":"Hogan","year":"1988","journal-title":"Development"},{"key":"2019122311035782900_ref39","first-page":"95","article-title":"Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse","volume":"97","author":"Hogan","year":"1986","journal-title":"J. Embryol. Exp. Morphol."},{"key":"2019122311035782900_ref40","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/ng0294-168","article-title":"Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters\u2019 anomaly","volume":"6","author":"Hanson","year":"1994","journal-title":"Nat. Genet."},{"key":"2019122311035782900_ref41","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1167\/iovs.13-12128","article-title":"Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma","volume":"54","author":"Liu","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0006-8993(00)02886-9","article-title":"Failure to activate NF-kappaB promotes apoptosis of retinal ganglion cells following optic nerve transection","volume":"883","author":"Choi","year":"2000","journal-title":"Brain. Res."},{"key":"2019122311035782900_ref43","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jtos.2012.04.001","article-title":"Nuclear factor-kappaB: central regulator in ocular surface inflammation and diseases","volume":"10","author":"Lan","year":"2012","journal-title":"Ocul. Surf."},{"key":"2019122311035782900_ref44","first-page":"2282","article-title":"Sustained stress response after oxidative stress in trabecular meshwork cells","volume":"13","author":"Li","year":"2007","journal-title":"Mol. Vis."},{"key":"2019122311035782900_ref45","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/(SICI)1097-4652(199908)180:2<182::AID-JCP6>3.0.CO;2-X","article-title":"Oxidative stress affects cytoskeletal structure and cell-matrix interactions in cells from an ocular tissue: the trabecular meshwork","volume":"180","author":"Zhou","year":"1999","journal-title":"J. Cell. Physiol."},{"key":"2019122311035782900_ref46","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1878-5085-4-14","article-title":"The primary vascular dysregulation syndrome: implications for eye diseases","volume":"4","author":"Flammer","year":"2013","journal-title":"EPMA. J."},{"key":"2019122311035782900_ref47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.optom.2017.06.002","article-title":"Reactive oxygen species, oxidative stress, glaucoma and hyperbaric oxygen therapy","volume":"11","author":"McMonnies","year":"2018","journal-title":"J. Optom."},{"key":"2019122311035782900_ref48","doi-asserted-by":"crossref","first-page":"671","DOI":"10.15537\/smj.2015.6.10697","article-title":"Association of total antioxidants level with glaucoma type and severity","volume":"36","author":"Mousa","year":"2015","journal-title":"Saudi. Med. J."},{"key":"2019122311035782900_ref49","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1167\/iovs.16-19153","article-title":"Antioxidant treatment limits neuroinflammation in experimental glaucoma","volume":"57","author":"Yang","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref50","doi-asserted-by":"crossref","first-page":"8442","DOI":"10.1167\/iovs.11-8152","article-title":"Neurodegenerative and inflammatory pathway components linked to TNF-alpha\/TNFR1 signaling in the glaucomatous human retina","volume":"52","author":"Yang","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref51","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1055\/s-0029-1245132","article-title":"Importance of the nuclear factor kappaB for the primary open angle glaucoma--a hypothesis","volume":"227","author":"Erb","year":"2010","journal-title":"Klin. Monbl. Augenheilkd."},{"key":"2019122311035782900_ref52","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/j.1460-2075.1991.tb07761.x","article-title":"Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1","volume":"10","author":"Schreck","year":"1991","journal-title":"EMBO. J."},{"key":"2019122311035782900_ref53","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/85446","article-title":"Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype","volume":"7","author":"Wang","year":"2001","journal-title":"Nat. Med."},{"key":"2019122311035782900_ref54","doi-asserted-by":"crossref","first-page":"15491","DOI":"10.1073\/pnas.0914785107","article-title":"miR-204 is required for lens and retinal development via Meis2 targeting","volume":"107","author":"Conte","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2019122311035782900_ref55","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1167\/iovs.06-0866","article-title":"Identification and characterization of microRNAs expressed in the mouse eye","volume":"48","author":"Karali","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref56","doi-asserted-by":"crossref","first-page":"25053","DOI":"10.1074\/jbc.M700501200","article-title":"MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster","volume":"282","author":"Xu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2019122311035782900_ref57","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1089\/jop.2013.0191","article-title":"Role of microRNAs in the trabecular meshwork","volume":"30","author":"Gonzalez","year":"2014","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"2019122311035782900_ref58","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1167\/iovs.10-6708","article-title":"Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells","volume":"52","author":"Li","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref59","doi-asserted-by":"crossref","first-page":"e37361","DOI":"10.1371\/journal.pone.0037361","article-title":"Identification of microRNAs inhibiting TGF-beta-induced IL-11 production in bone metastatic breast cancer cells","volume":"7","author":"Pollari","year":"2012","journal-title":"PLoS One"},{"key":"2019122311035782900_ref60","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/ijc.26060","article-title":"Dysregulation of microRNA-204 mediates migration and invasion of endometrial cancer by regulating FOXC1","volume":"130","author":"Chung","year":"2012","journal-title":"Int. J. Cancer."},{"key":"2019122311035782900_ref61","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1093\/hmg\/ddr038","article-title":"A complex regulatory network of transcription factors critical for ocular development and disease","volume":"20","author":"Acharya","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref62","doi-asserted-by":"crossref","first-page":"34829","DOI":"10.1074\/jbc.M109.006684","article-title":"Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells","volume":"284","author":"Acharya","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2019122311035782900_ref63","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/hmg\/ddm326","article-title":"FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A","volume":"17","author":"Berry","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref64","doi-asserted-by":"crossref","first-page":"e1003949","DOI":"10.1371\/journal.pgen.1003949","article-title":"Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of syngnathia","volume":"9","author":"Inman","year":"2013","journal-title":"PLoS. Genet."},{"key":"2019122311035782900_ref65","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1242\/dev.127.9.1857","article-title":"The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer","volume":"127","author":"Adams","year":"2000","journal-title":"Development"},{"key":"2019122311035782900_ref66","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0042-6989(02)00416-9","article-title":"The roles of hedgehogs and fibroblast growth factors in eye development and retinal cell rescue","volume":"43","author":"Russell","year":"2003","journal-title":"Vision. Res."},{"key":"2019122311035782900_ref67","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1038\/s41467-018-04555-4","article-title":"A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci","volume":"9","author":"Choquet","year":"2018","journal-title":"Nat. Commun."},{"key":"2019122311035782900_ref68","doi-asserted-by":"crossref","first-page":"e1004359","DOI":"10.1371\/journal.pgen.1004359","article-title":"A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected]","volume":"10","author":"Cross","year":"2014","journal-title":"PLoS. Genet."},{"key":"2019122311035782900_ref69","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1136\/bjo.2006.092619","article-title":"Nail-patella syndrome and its association with glaucoma: a review of eight families","volume":"90","author":"Mimiwati","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"2019122311035782900_ref70","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/sj.ejhg.5201405","article-title":"Interaction of the LMX1B and PAX2 gene products suggests possible molecular basis of differential phenotypes in Nail-Patella syndrome","volume":"13","author":"Marini","year":"2005","journal-title":"Eur. J. Hum. Genet."},{"key":"2019122311035782900_ref71","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.devcel.2015.01.033","article-title":"The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis","volume":"33","author":"Eisner","year":"2015","journal-title":"Dev. Cell."},{"key":"2019122311035782900_ref72","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.modgep.2005.04.010","article-title":"Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction","volume":"6","author":"Purcell","year":"2005","journal-title":"Gene. Expr. Patterns."},{"key":"2019122311035782900_ref73","doi-asserted-by":"crossref","first-page":"e0178518","DOI":"10.1371\/journal.pone.0178518","article-title":"FOXC1 modulates MYOC secretion through regulation of the exocytic proteins RAB3GAP1, RAB3GAP2 and SNAP25","volume":"12","author":"Rasnitsyn","year":"2017","journal-title":"PLoS One"},{"key":"2019122311035782900_ref74","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.2353\/ajpath.2010.090853","article-title":"Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesis","volume":"176","author":"Joe","year":"2010","journal-title":"Am. J. Pathol."},{"key":"2019122311035782900_ref75","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1167\/iovs.09-4866","article-title":"Interaction of recombinant myocilin with the matricellular protein SPARC: functional implications","volume":"52","author":"Aroca-Aguilar","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref76","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1093\/hmg\/11.11.1291","article-title":"Optimedin: a novel olfactomedin-related protein that interacts with myocilin","volume":"11","author":"Torrado","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref77","doi-asserted-by":"crossref","first-page":"8196","DOI":"10.1074\/jbc.M109.025684","article-title":"SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin","volume":"285","author":"Chang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2019122311035782900_ref78","doi-asserted-by":"crossref","first-page":"e138","DOI":"10.1111\/j.1755-3768.2011.02283.x","article-title":"SPARC modulates expression of extracellular matrix genes in human trabecular meshwork cells","volume":"90","author":"Wei","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"2019122311035782900_ref79","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1074\/jbc.M708250200","article-title":"Rho GTPase and cAMP\/protein kinase A signaling mediates myocilin-induced alterations in cultured human trabecular meshwork cells","volume":"283","author":"Shen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2019122311035782900_ref80","doi-asserted-by":"crossref","first-page":"5712341","DOI":"10.1155\/2017\/5712341","article-title":"Epigenetics and signaling pathways in glaucoma","volume":"2017","author":"Gauthier","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"2019122311035782900_ref81","doi-asserted-by":"crossref","first-page":"e12409","DOI":"10.1371\/journal.pone.0012409","article-title":"The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain","volume":"5","author":"Goh","year":"2010","journal-title":"PLoS One"},{"key":"2019122311035782900_ref82","doi-asserted-by":"crossref","first-page":"31311","DOI":"10.1074\/jbc.M111.327056","article-title":"The GTPase-deficient Rnd proteins are stabilized by their effectors","volume":"287","author":"Goh","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2019122311035782900_ref83","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1167\/iovs.12-9681","article-title":"Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow","volume":"53","author":"Iyer","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref84","doi-asserted-by":"crossref","first-page":"26618","DOI":"10.1074\/jbc.M109.073155","article-title":"Smad3 regulates Rho signaling via NET1 in the transforming growth factor-beta-induced epithelial-mesenchymal transition of human retinal pigment epithelial cells","volume":"285","author":"Lee","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2019122311035782900_ref85","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1091\/mbc.e16-04-0262","article-title":"ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens","volume":"28","author":"Priya","year":"2017","journal-title":"Mol. Biol. Cell."},{"key":"2019122311035782900_ref86","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/sj.emboj.7600612","article-title":"RhoE function is regulated by ROCK I-mediated phosphorylation","volume":"24","author":"Riento","year":"2005","journal-title":"EMBO. J."},{"key":"2019122311035782900_ref87","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaf0791","article-title":"RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms","author":"Yang","year":"2016"},{"key":"2019122311035782900_ref88","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/IJG.0b013e318241b83c","article-title":"Elevated levels of RhoA in the optic nerve head of human eyes with glaucoma","volume":"21","author":"Goldhagen","year":"2012","journal-title":"J. Glaucoma."},{"key":"2019122311035782900_ref89","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1089\/omi.2016.0031","article-title":"Toward novel diagnostics for primary open-angle glaucoma? An association study of polymorphic variation in Ras homolog family member (A, B, C, D) genes RHOA, RHOB, RHOC, and RHOD","volume":"20","author":"Saracaloglu","year":"2016","journal-title":"OMICS"},{"key":"2019122311035782900_ref90","doi-asserted-by":"crossref","first-page":"C1057","DOI":"10.1152\/ajpcell.00481.2007","article-title":"Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork","volume":"295","author":"Zhang","year":"2008","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"2019122311035782900_ref91","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2174\/156652412802480907","article-title":"siRNA silencing of gene expression in trabecular meshwork: RhoA siRNA reduces IOP in mice","volume":"12","author":"Liu","year":"2012","journal-title":"Curr. Mol. Med."},{"key":"2019122311035782900_ref92","first-page":"951","article-title":"Pax6 interacts with SPARC and TGF-beta in murine eyes","volume":"18","author":"Shubham","year":"2012","journal-title":"Mol. Vis."},{"key":"2019122311035782900_ref93","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1053\/j.gastro.2005.01.004","article-title":"Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure","volume":"128","author":"Russo","year":"2005","journal-title":"Gastroenterology"},{"key":"2019122311035782900_ref94","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.cellsig.2009.12.001","article-title":"RhoA\/ROCK1 signaling regulates stress granule formation and apoptosis","volume":"22","author":"Tsai","year":"2010","journal-title":"Cell. Signal."},{"key":"2019122311035782900_ref95","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.gene.2018.06.038","article-title":"LTBP2 knockdown and oxidative stress affect glaucoma features including TGFbeta pathways, ECM genes expression and apoptosis in trabecular meshwork cells","volume":"673","author":"Suri","year":"2018","journal-title":"Gene"},{"key":"2019122311035782900_ref96","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1091\/mbc.01-07-0358","article-title":"Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signaling","volume":"13","author":"Wei","year":"2002","journal-title":"Mol. Biol. Cell."},{"key":"2019122311035782900_ref97","doi-asserted-by":"crossref","first-page":"e53846","DOI":"10.1371\/journal.pone.0053846","article-title":"Copy number variations in alternative splicing gene networks impact lifespan","volume":"8","author":"Glessner","year":"2013","journal-title":"PLoS One"},{"key":"2019122311035782900_ref98","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1086\/518900","article-title":"The nuclear factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive lower motor neuron disease with childhood onset","volume":"81","author":"Maystadt","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"2019122311035782900_ref99","doi-asserted-by":"crossref","first-page":"C1170","DOI":"10.1152\/ajpcell.00139.2013","article-title":"Cyp1B1 expression promotes angiogenesis by suppressing NF-kappaB activity","volume":"305","author":"Palenski","year":"2013","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"2019122311035782900_ref100","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/jnc.12326","article-title":"Optineurin suppression causes neuronal cell death via NF-kappaB pathway","volume":"126","author":"Akizuki","year":"2013","journal-title":"J. Neurochem"},{"key":"2019122311035782900_ref101","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1016\/j.yexcr.2008.06.006","article-title":"TGF-beta coordinately activates TAK1\/MEK\/AKT\/NFkB and SMAD pathways to promote osteoclast survival","volume":"314","author":"Gingery","year":"2008","journal-title":"Exp. Cell. Res."},{"key":"2019122311035782900_ref102","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1158\/1940-6207.CAPR-07-0002","article-title":"Cyclic AMP-responsive element binding protein- and nuclear factor-kappaB-regulated CXC chemokine gene expression in lung carcinogenesis","volume":"1","author":"Sun","year":"2008","journal-title":"Cancer. Prev. Res (Phila)."},{"key":"2019122311035782900_ref103","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1016\/S0039-6257(99)00029-6","article-title":"Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death","volume":"43","author":"Nickells","year":"1999","journal-title":"Surv. Ophthalmol."},{"key":"2019122311035782900_ref104","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/eye.2016.295","article-title":"Assessing retinal ganglion cell damage","volume":"31","author":"Smith","year":"2017","journal-title":"Eye (Lond)"},{"key":"2019122311035782900_ref105","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2013.02.064","article-title":"ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse","volume":"544","author":"Demircan","year":"2013","journal-title":"Neurosci. Lett."},{"key":"2019122311035782900_ref106","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1167\/iovs.09-3673","article-title":"Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork","volume":"50","author":"Keller","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref107","doi-asserted-by":"crossref","first-page":"e3931","DOI":"10.1371\/journal.pone.0003931","article-title":"Glaucoma alters the circadian timing system","volume":"3","author":"Drouyer","year":"2008","journal-title":"PLoS One"},{"key":"2019122311035782900_ref108","doi-asserted-by":"crossref","first-page":"35228","DOI":"10.1074\/jbc.M506195200","article-title":"The Optimedin gene is a downstream target of Pax6","volume":"280","author":"Grinchuk","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2019122311035782900_ref109","doi-asserted-by":"crossref","first-page":"e45077","DOI":"10.1371\/journal.pone.0045077","article-title":"Molecular basis for involvement of CYP1B1 in MYOC upregulation and its potential implication in glaucoma pathogenesis","volume":"7","author":"Mookherjee","year":"2012","journal-title":"PLoS One"},{"key":"2019122311035782900_ref110","doi-asserted-by":"crossref","first-page":"e4159","DOI":"10.1371\/journal.pone.0004159","article-title":"Identification of pax6-dependent gene regulatory networks in the mouse lens","volume":"4","author":"Wolf","year":"2009","journal-title":"PLoS One"},{"key":"2019122311035782900_ref111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2013.01.007","article-title":"Stimulation of mouse Cyp1b1 during adipogenesis: characterization of promoter activation by the transcription factor Pax6","volume":"532","author":"Zheng","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"key":"2019122311035782900_ref112","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/labinvest.2013.55","article-title":"Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells","volume":"93","author":"Palenski","year":"2013","journal-title":"Lab. Invest."},{"key":"2019122311035782900_ref113","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1128\/MCB.00856-13","article-title":"Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress","volume":"33","author":"Zhao","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"2019122311035782900_ref114","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.exer.2016.04.017","article-title":"PAX6: 25th anniversary and more to learn","volume":"156","author":"Cvekl","year":"2017","journal-title":"Exp. Eye. Res."},{"key":"2019122311035782900_ref115","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1432-0436.2007.00168.x","article-title":"Stage-dependent expression of Pax6 in optic vesicle\/cup regulates patterning genes through signaling molecules","volume":"75","author":"Reza","year":"2007","journal-title":"Differentiation"},{"key":"2019122311035782900_ref116","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s004170000241","article-title":"Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes","volume":"239","author":"Inatani","year":"2001","journal-title":"Graefes. Arch. Clin. Exp. Ophthalmol."},{"key":"2019122311035782900_ref117","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0079-6123(08)01127-8","article-title":"Oxidative stress and glaucoma: injury in the anterior segment of the eye","volume":"173","author":"Sacca","year":"2008","journal-title":"Prog. Brain. Res."},{"key":"2019122311035782900_ref118","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/j.ajpath.2012.03.011","article-title":"Primary open-angle glaucoma: a transforming growth factor-beta pathway-mediated disease","volume":"180","author":"Taylor","year":"2012","journal-title":"Am. J. Pathol."},{"key":"2019122311035782900_ref119","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.exer.2014.07.014","article-title":"Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma","volume":"133","author":"Vranka","year":"2015","journal-title":"Exp. Eye. Res."},{"key":"2019122311035782900_ref120","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1089\/jop.2013.0220","article-title":"The role of TGF-beta2 and bone morphogenetic proteins in the trabecular meshwork and glaucoma","volume":"30","author":"Wordinger","year":"2014","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"2019122311035782900_ref121","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1167\/iovs.07-1478","article-title":"Oxidative stress and TGF-beta2 increase heat shock protein 27 expression in human optic nerve head astrocytes","volume":"49","author":"Yu","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref122","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1242\/jcs.113.18.3173","article-title":"Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression","volume":"113","author":"Duncan","year":"2000","journal-title":"J. Cell. Sci."},{"key":"2019122311035782900_ref123","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1750-1326-6-45","article-title":"Microglial phagocytosis induced by fibrillar beta-amyloid is attenuated by oligomeric beta-amyloid: implications for Alzheimer\u2019s disease","volume":"6","author":"Pan","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"2019122311035782900_ref124","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1242\/jcs.042127","article-title":"The mechanical integrin cycle","volume":"122","author":"Puklin-Faucher","year":"2009","journal-title":"J. Cell. Sci."},{"key":"2019122311035782900_ref125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.preteyeres.2006.10.004","article-title":"Control of integrin genes expression in the eye","volume":"26","author":"Vigneault","year":"2007","journal-title":"Prog. Retin. Eye. Res."},{"key":"2019122311035782900_ref126","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1242\/dev.128.22.4425","article-title":"Fgf receptor signaling plays a role in lens induction","volume":"128","author":"Faber","year":"2001","journal-title":"Development"},{"key":"2019122311035782900_ref127","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/hmg\/10.3.231","article-title":"Mutations in the human forkhead transcription factor FOXE3 associated with anterior segment ocular dysgenesis and cataracts","volume":"10","author":"Semina","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref128","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0888-7543(05)80103-X","article-title":"Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14)","volume":"14","author":"Iozzo","year":"1992","journal-title":"Genomics"},{"key":"2019122311035782900_ref129","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.devcel.2011.12.006","article-title":"Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2","volume":"22","author":"Ahmed","year":"2012","journal-title":"Dev. Cell."},{"key":"2019122311035782900_ref130","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1101\/gad.887101","article-title":"Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development","volume":"15","author":"Kamachi","year":"2001","journal-title":"Genes. Dev."},{"key":"2019122311035782900_ref131","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1242\/dev.127.11.2357","article-title":"Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2","volume":"127","author":"Matsunaga","year":"2000","journal-title":"Development"},{"key":"2019122311035782900_ref132","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1242\/dev.055178","article-title":"Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6","volume":"138","author":"Matsushima","year":"2011","journal-title":"Development"},{"key":"2019122311035782900_ref133","doi-asserted-by":"crossref","first-page":"e1003357","DOI":"10.1371\/journal.pgen.1003357","article-title":"Pax6 regulates gene expression in the vertebrate lens through miR-204","volume":"9","author":"Shaham","year":"2013","journal-title":"PLoS. Genet."},{"key":"2019122311035782900_ref134","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1242\/dev.032888","article-title":"Pax6 is essential for lens fiber cell differentiation","volume":"136","author":"Shaham","year":"2009","journal-title":"Development"},{"key":"2019122311035782900_ref135","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12031-010-9334-0","article-title":"Interaction of Pax6 with SPARC and p53 in brain of mice indicates Smad3 dependent auto-regulation","volume":"41","author":"Tripathi","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"2019122311035782900_ref136","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/WNR.0b013e3282f64377","article-title":"Pax6 directly modulate Sox2 expression in the neural progenitor cells","volume":"19","author":"Wen","year":"2008","journal-title":"Neuroreport"},{"key":"2019122311035782900_ref137","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1093\/hmg\/ddn229","article-title":"Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear","volume":"17","author":"Zou","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref138","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1073\/pnas.1218145110","article-title":"Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye","volume":"110","author":"Zhou","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"2019122311035782900_ref139","doi-asserted-by":"crossref","first-page":"7043","DOI":"10.1167\/iovs.12-9664","article-title":"Existence of the canonical Wnt signaling pathway in the human trabecular meshwork","volume":"53","author":"Mao","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref140","first-page":"1056","article-title":"Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure","volume":"118","author":"Wang","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2019122311035782900_ref141","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/cas.12768","article-title":"Formin-like2 regulates rho\/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer","volume":"106","author":"Zeng","year":"2015","journal-title":"Cancer. Sci."},{"key":"2019122311035782900_ref142","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cub.2012.03.064","article-title":"FMNL2 drives actin-based protrusion and migration downstream of Cdc42","volume":"22","author":"Block","year":"2012","journal-title":"Curr. Biol."},{"key":"2019122311035782900_ref143","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1038\/s41467-017-01913-6","article-title":"A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure","volume":"8","author":"Choquet","year":"2017","journal-title":"Nat. Commun."},{"key":"2019122311035782900_ref144","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.tibs.2015.12.002","article-title":"Formins at the junction","volume":"41","author":"Grikscheit","year":"2016","journal-title":"Trends. Biochem. Sci."},{"key":"2019122311035782900_ref145","doi-asserted-by":"crossref","first-page":"14832","DOI":"10.1038\/ncomms14832","article-title":"FMNL formins boost lamellipodial force generation","volume":"8","author":"Kage","year":"2017","journal-title":"Nat. Commun."},{"key":"2019122311035782900_ref146","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1167\/iovs.11-9314","article-title":"Elastic modulus determination of normal and glaucomatous human trabecular meshwork","volume":"53","author":"Russell","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref147","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbamcr.2010.01.014","article-title":"Fifteen formins for an actin filament: a molecular view on the regulation of human formins","volume":"1803","author":"Schonichen","year":"2010","journal-title":"Biochim. Biophys. Acta."},{"key":"2019122311035782900_ref148","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.exer.2008.08.008","article-title":"The role of the actomyosin system in regulating trabecular fluid outflow","volume":"88","author":"Tian","year":"2009","journal-title":"Exp. Eye. Res."},{"key":"2019122311035782900_ref149","first-page":"619","article-title":"Cytoskeletal involvement in the regulation of aqueous humor outflow","volume":"41","author":"Tian","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref150","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1158\/1541-7786.MCR-10-0081","article-title":"FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition","volume":"8","author":"Li","year":"2010","journal-title":"Mol. Cancer. Res."},{"key":"2019122311035782900_ref151","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1152\/physiolgenomics.90261.2008","article-title":"Individual molecular response to elevated intraocular pressure in perfused postmortem human eyes","volume":"38","author":"Comes","year":"2009","journal-title":"Physiol. Genomics."},{"key":"2019122311035782900_ref152","first-page":"774","article-title":"Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue","volume":"12","author":"Liton","year":"2006","journal-title":"Mol. Vis."},{"key":"2019122311035782900_ref153","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1186\/gb-2008-9-7-r111","article-title":"Susceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors","volume":"9","author":"Lukas","year":"2008","journal-title":"Genome. Biol."},{"key":"2019122311035782900_ref154","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1001\/archophthalmol.2010.85","article-title":"Monocyte modulation of aqueous outflow and recruitment to the trabecular meshwork following selective laser trabeculoplasty","volume":"128","author":"Alvarado","year":"2010","journal-title":"Arch. Ophthalmol."},{"key":"2019122311035782900_ref155","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.preteyeres.2006.07.003","article-title":"Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences","volume":"25","author":"Tezel","year":"2006","journal-title":"Prog. Retin. Eye. Res."},{"key":"2019122311035782900_ref156","doi-asserted-by":"crossref","first-page":"26174","DOI":"10.1074\/jbc.M110.132548","article-title":"Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex","volume":"285","author":"Dettmer","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2019122311035782900_ref157","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1038\/sj.emboj.7600307","article-title":"Nicalin and its binding partner Nomo are novel nodal signaling antagonists","volume":"23","author":"Haffner","year":"2004","journal-title":"EMBO. J."},{"key":"2019122311035782900_ref158","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1146\/annurev.cellbio.19.041603.094522","article-title":"Nodal signaling in vertebrate development","volume":"19","author":"Schier","year":"2003","journal-title":"Annu. Rev. Cell. Dev. Biol."},{"key":"2019122311035782900_ref159","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1534-5807(01)00076-4","article-title":"Nodal signaling in early vertebrate embryos: themes and variations","volume":"1","author":"Whitman","year":"2001","journal-title":"Dev. Cell."},{"key":"2019122311035782900_ref160","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)81475-0","article-title":"Pitx2 participates in the late phase of the pathway controlling left-right asymmetry","volume":"94","author":"Piedra","year":"1998","journal-title":"Cell"},{"key":"2019122311035782900_ref161","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00427-018-0611-1","article-title":"Asymmetric pitx2 expression in medaka epithalamus is regulated by nodal signaling through an intronic enhancer","volume":"228","author":"Soukup","year":"2018","journal-title":"Dev. Genes. Evol."},{"key":"2019122311035782900_ref162","doi-asserted-by":"crossref","first-page":"e4268","DOI":"10.1371\/journal.pone.0004268","article-title":"Graded Smad2\/3 activation is converted directly into levels of target gene expression in embryonic stem cells","volume":"4","author":"Guzman-Ayala","year":"2009","journal-title":"PLoS One"},{"key":"2019122311035782900_ref163","first-page":"1997","article-title":"Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling","volume":"119","author":"Iwao","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2019122311035782900_ref164","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1074\/jbc.M111.280974","article-title":"Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor beta (TGFbeta) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis","volume":"287","author":"Iwata","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2019122311035782900_ref165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2045-3701-2-9","article-title":"Regulation of TGF-beta receptor activity","volume":"2","author":"Huang","year":"2012","journal-title":"Cell. Biosci."},{"key":"2019122311035782900_ref166","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1126\/science.1105718","article-title":"Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity","volume":"307","author":"Ozdamar","year":"2005","journal-title":"Science"},{"key":"2019122311035782900_ref167","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1126\/science.1090772","article-title":"Regulation of cell polarity and protrusion formation by targeting RhoA for degradation","volume":"302","author":"Wang","year":"2003","journal-title":"Science"},{"key":"2019122311035782900_ref168","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/cr.2008.328","article-title":"Non-Smad pathways in TGF-beta signaling","volume":"19","author":"Zhang","year":"2009","journal-title":"Cell. Res."},{"key":"2019122311035782900_ref169","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.exer.2016.07.012","article-title":"Smad-independent TGF-beta2 signaling pathways in human trabecular meshwork cells","volume":"158","author":"Pervan","year":"2017","journal-title":"Exp. Eye. Res."},{"key":"2019122311035782900_ref170","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1167\/iovs.05-1060","article-title":"TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure","volume":"47","author":"Fleenor","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref171","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.bbamcr.2011.03.013","article-title":"Interplay between FOXO, TOR, and Akt","volume":"1813","author":"Hay","year":"2011","journal-title":"Biochim. Biophys. Acta."},{"key":"2019122311035782900_ref172","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1242\/jcs.001222","article-title":"Dynamic FoxO transcription factors","volume":"120","author":"Huang","year":"2007","journal-title":"J. Cell. Sci."},{"key":"2019122311035782900_ref173","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1167\/iovs.11-7287","article-title":"Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells","volume":"52","author":"Sethi","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref174","first-page":"1657","article-title":"Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo","volume":"63","author":"Akiri","year":"2003","journal-title":"Cancer. Res."},{"key":"2019122311035782900_ref175","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00335.2010","article-title":"Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects","volume":"299","author":"Lopez","year":"2010","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"2019122311035782900_ref176","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1358\/dnp.2008.21.4.1213351","article-title":"Lysyl oxidase as a potential therapeutic target","volume":"21","author":"Rodriguez","year":"2008","journal-title":"Drug. News. Perspect."},{"key":"2019122311035782900_ref177","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1126\/science.1146554","article-title":"Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma","volume":"317","author":"Thorleifsson","year":"2007","journal-title":"Science"},{"key":"2019122311035782900_ref178","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jhep.2005.02.052","article-title":"Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2","volume":"43","author":"Vadasz","year":"2005","journal-title":"J. Hepatol."},{"key":"2019122311035782900_ref179","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-2443.2010.01483.x","article-title":"Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma","volume":"16","author":"Comes","year":"2011","journal-title":"Genes. Cells."},{"key":"2019122311035782900_ref180","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1167\/iovs.07-1347","article-title":"Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor","volume":"49","author":"Kuchtey","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref181","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1203\/00006450-199410000-00005","article-title":"Prenatal diagnosis of collagen disorders by direct biochemical analysis of chorionic villus biopsies","volume":"36","author":"Raghunath","year":"1994","journal-title":"Pediatr. Res."},{"key":"2019122311035782900_ref182","first-page":"2649","article-title":"Effect of matrix metalloproteinases activity on outflow in perfused human organ culture","volume":"39","author":"Bradley","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref183","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1096\/fj.04-3626fje","article-title":"Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism","volume":"19","author":"Hinz","year":"2005","journal-title":"FASEB. J."},{"key":"2019122311035782900_ref184","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1167\/iovs.09-4920","article-title":"Treatment of sheep steroid-induced ocular hypertension with a glucocorticoid-inducible MMP1 gene therapy virus","volume":"51","author":"Gerometta","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref185","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1002\/art.38122","article-title":"Deletion of the transforming growth factor beta receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice","volume":"65","author":"Shen","year":"2013","journal-title":"Arthritis. Rheum."},{"key":"2019122311035782900_ref186","first-page":"8","article-title":"Inhibition of RhoA\/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-beta in ARPE-19","volume":"6","author":"Zhu","year":"2013","journal-title":"Int. J. Ophthalmol."},{"key":"2019122311035782900_ref187","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1167\/iovs.12-11474","article-title":"Regulation of SPARC by transforming growth factor beta2 in human trabecular meshwork","volume":"54","author":"Kang","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref188","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1167\/iovs.10-5679","article-title":"TGF-{beta}2 induces senescence-associated changes in human trabecular meshwork cells","volume":"51","author":"Yu","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref189","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/hmg\/ddi468","article-title":"Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer\u2019s vesicle cilia function","volume":"15","author":"Yen","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref190","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1101\/gad.1194004","article-title":"Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport","volume":"18","author":"Blacque","year":"2004","journal-title":"Genes. Dev."},{"key":"2019122311035782900_ref191","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cell.2007.03.053","article-title":"A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis","volume":"129","author":"Nachury","year":"2007","journal-title":"Cell"},{"key":"2019122311035782900_ref192","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.preteyeres.2007.01.002","article-title":"New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland","volume":"26","author":"Coca-Prados","year":"2007","journal-title":"Prog. Retin. Eye. Res."},{"key":"2019122311035782900_ref193","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2010.08.001","article-title":"Ciliary blood flow and aqueous humor production","volume":"30","author":"Kiel","year":"2011","journal-title":"Prog. Retin. Eye. Res."},{"key":"2019122311035782900_ref194","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1089\/jop.2000.16.173","article-title":"Review: a case for corneal crystallins","volume":"16","author":"Piatigorsky","year":"2000","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"2019122311035782900_ref195","article-title":"Regulation of the primary open-angle glaucoma gene myocilin by PITX2","volume":"44","author":"Kozlowski","year":"2003","journal-title":"IOVS"},{"key":"2019122311035782900_ref196","doi-asserted-by":"crossref","first-page":"e38568","DOI":"10.1371\/journal.pone.0038568","article-title":"An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud","volume":"7","author":"Jumlongras","year":"2012","journal-title":"PLoS One"},{"key":"2019122311035782900_ref197","doi-asserted-by":"crossref","first-page":"e0169671","DOI":"10.1371\/journal.pone.0169671","article-title":"A comparison of gene expression profiles between glucocorticoid responder and non-responder bovine trabecular meshwork cells using RNA sequencing","volume":"12","author":"Bermudez","year":"2017","journal-title":"PLoS One"},{"key":"2019122311035782900_ref198","doi-asserted-by":"crossref","first-page":"15362","DOI":"10.18632\/oncotarget.3798","article-title":"The intrinsic stiffness of human trabecular meshwork cells increases with senescence","volume":"6","author":"Morgan","year":"2015","journal-title":"Oncotarget"},{"key":"2019122311035782900_ref199","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1167\/iovs.15-16739","article-title":"Dexamethasone stiffens trabecular meshwork, trabecular meshwork cells, and matrix","volume":"56","author":"Raghunathan","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref200","doi-asserted-by":"crossref","first-page":"7433","DOI":"10.1167\/iovs.13-12652","article-title":"Canonical wnt signaling regulates extracellular matrix expression in the trabecular meshwork","volume":"55","author":"Villarreal","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref201","first-page":"460","article-title":"Polymorphisms in OPA1 are associated with normal tension glaucoma","volume":"9","author":"Powell","year":"2003","journal-title":"Mol. Vis."},{"key":"2019122311035782900_ref202","first-page":"1074","article-title":"Down-regulation of OPA1 in patients with primary open angle glaucoma","volume":"17","author":"Bosley","year":"2011","journal-title":"Mol. Vis."},{"key":"2019122311035782900_ref203","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/hmg\/ddq478","article-title":"Lack of WDR36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro","volume":"20","author":"Gallenberger","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref204","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1167\/iovs.08-2499","article-title":"Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina","volume":"50","author":"Ju","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref205","first-page":"1331","article-title":"Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma","volume":"16","author":"Ju","year":"2010","journal-title":"Mol. Vis."},{"key":"2019122311035782900_ref206","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1167\/iovs.07-1661","article-title":"Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve","volume":"49","author":"Ju","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2019122311035782900_ref207","first-page":"120","article-title":"Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells","volume":"15","author":"Ju","year":"2009","journal-title":"Mol. Vis."},{"key":"2019122311035782900_ref208","first-page":"2629","article-title":"Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina","volume":"14","author":"Ju","year":"2008","journal-title":"Mol. Vis."},{"key":"2019122311035782900_ref209","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1074\/jbc.C200677200","article-title":"Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis","volume":"278","author":"Olichon","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2019122311035782900_ref210","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1093\/hmg\/ddn147","article-title":"The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway","volume":"17","author":"Skarie","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"2019122311035782900_ref211","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/0092-8674(89)90063-9","article-title":"DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9","volume":"57","author":"Hanes","year":"1989","journal-title":"Cell"},{"key":"2019122311035782900_ref212","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1128\/MCB.23.6.1968-1982.2003","article-title":"Dominant negative dimerization of a mutant homeodomain protein in Axenfeld-Rieger syndrome","volume":"23","author":"Saadi","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"2019122311035782900_ref213","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0092-8674(89)90038-X","article-title":"A single amino acid can determine the DNA binding specificity of homeodomain proteins","volume":"59","author":"Treisman","year":"1989","journal-title":"Cell"},{"key":"2019122311035782900_ref214","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.4103\/0301-4738.73695","article-title":"Normal-tension glaucoma (Low-tension glaucoma)","volume":"59","author":"Anderson","year":"2011","journal-title":"Indian. J. Ophthalmol."},{"key":"2019122311035782900_ref215","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.exer.2008.01.013","article-title":"Extracellular matrix in the trabecular meshwork","volume":"86","author":"Acott","year":"2008","journal-title":"Exp. Eye. Res."},{"key":"2019122311035782900_ref216","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1002\/jcp.22701","article-title":"Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine\/threonine kinase signaling pathway","volume":"226","author":"Kwon","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"2019122311035782900_ref217","first-page":"2978","article-title":"Elevated pressure downregulates ZO-1 expression and disrupts cytoskeleton and focal adhesion in human trabecular meshwork cells","volume":"17","author":"Yang","year":"2011","journal-title":"Mol. Vis."},{"key":"2019122311035782900_ref218","first-page":"827","article-title":"Apoptosis in the iris and trabecular meshwork of medically treated and untreated primary open angle glaucoma patients","volume":"6","author":"Aktas","year":"2013","journal-title":"Int. J. Ophthalmol."},{"key":"2019122311035782900_ref219","first-page":"1513","article-title":"Apoptosis in the trabecular meshwork of glaucomatous patients","volume":"14","author":"Baleriola","year":"2008","journal-title":"Mol. 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