{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:13:51Z","timestamp":1787505231798,"version":"build-2736575974"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M023605\/1"],"award-info":[{"award-number":["MR\/M023605\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011699","name":"BRACE","doi-asserted-by":"publisher","award":["BR17\/04"],"award-info":[{"award-number":["BR17\/04"]}],"id":[{"id":"10.13039\/100011699","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Newton Advanced Fellowship","award":["NAF\\R1\\191045"],"award-info":[{"award-number":["NAF\\R1\\191045"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Huntington\u2019s disease (HD) is a neurodegenerative disorder caused by an expanded polyglutamine tract in the huntingtin (HTT) protein. Mutant HTT (mHTT) toxicity is caused by its aggregation\/oligomerization. The striatum is the most vulnerable region, although all brain regions undergo neuronal degeneration in the disease. Here we show that the levels of Bim, a BH3-only protein, are significantly increased in HD human post-mortem and HD mouse striata, correlating with neuronal death. Bim reduction ameliorates mHTT neurotoxicity in HD cells. In the HD mouse model, heterozygous Bim knockout significantly mitigates mHTT accumulation and neuronal death, ameliorating disease-associated phenotypes and lifespan. Therefore, Bim could contribute to the progression of HD.<\/jats:p>","DOI":"10.1093\/hmg\/ddz275","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T15:12:37Z","timestamp":1573485157000},"page":"216-227","source":"Crossref","is-referenced-by-count":6,"title":["Bim contributes to the progression of Huntington\u2019s disease-associated phenotypes"],"prefix":"10.1093","volume":"29","author":[{"given":"Sheridan L","family":"Roberts","sequence":"first","affiliation":[{"name":"Peninsula Schools of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth, Plymouth PL6 8BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Evans","sequence":"additional","affiliation":[{"name":"Peninsula Schools of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth, Plymouth PL6 8BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Peninsula Schools of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth, Plymouth PL6 8BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Neurobiology, School of Life Sciences, Fudan University, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W","family":"Button","sequence":"additional","affiliation":[{"name":"Peninsula Schools of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth, Plymouth PL6 8BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J","family":"Sipthorpe","sequence":"additional","affiliation":[{"name":"Peninsula Schools of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth, Plymouth PL6 8BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Cowan","sequence":"additional","affiliation":[{"name":"Peninsula Schools of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth, Plymouth PL6 8BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Valionyte","sequence":"additional","affiliation":[{"name":"Peninsula Schools of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth, Plymouth PL6 8BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Anichtchik","sequence":"additional","affiliation":[{"name":"Peninsula Schools of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth, Plymouth PL6 8BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiliang","family":"Li","sequence":"additional","affiliation":[{"name":"Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxun","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Neurobiology, School of Life Sciences, Fudan University, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouqing","family":"Luo","sequence":"additional","affiliation":[{"name":"Peninsula Schools of Medicine and Dentistry, Institute of Translational and Stratified Medicine, University of Plymouth, Plymouth PL6 8BU, 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