{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:46:58Z","timestamp":1790279218502,"version":"4.1.0"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Key Project at Central Government level: the ability establishment of sustainable use for valuable Chinese medicine resources","award":["2060302"],"award-info":[{"award-number":["2060302"]}]},{"name":"the China Agriculture Research System of MOF and MARA","award":["CARS-21"],"award-info":[{"award-number":["CARS-21"]}]},{"name":"the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences","award":["CI2021A03903 and CI2021B013"],"award-info":[{"award-number":["CI2021A03903 and CI2021B013"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81891014"],"award-info":[{"award-number":["81891014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The formation of high-quality Chinese medicinal materials is a micro-evolutionary process of multiple genes involving quantitative inheritance under environmental stress. Atractylodes lancea is a traditionally used medicinal plant in China that is broadly distributed and possesses a considerable amount of essential oils. However, to date, limited research has been conducted to characterize the genetics and metabolites of A. lancea shaped by natural variation. Hence, we assembled a high-quality genome of A. lancea, featuring a contig N50 of 1.18\u00a0Mb. We further integrated population resequencing of A. lancea and conducted analyses to characterize its genetic diversity, population evolution, and rewiring of volatile metabolites. The natural variation effect exerted significant pressure on A. lancea from different geographic locations, resulting in genetic differentiation among three groups. Correlation analysis of metabolites in A. lancea revealed significant natural variations of terpenoids, heterocyclic compounds, ketones, and esters. We also found that 427 metabolites displayed noteworthy divergence due to directional selection. Additionally, our genome-wide association studies on the metabolome for medicinal quality traits identified several candidate genes, such as AlZFP706 and AlAAHY1, exhibiting significant correlations with atractylodin and hinesol levels, respectively. Overall, this study provides an intricate genomic resource for A. lancea, thereby expanding our understanding of the effect of natural variation on metabolites and facilitating the genetic improvement of its medicinal properties.<\/jats:p>","DOI":"10.1093\/hr\/uhae167","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T21:19:50Z","timestamp":1719004790000},"source":"Crossref","is-referenced-by-count":27,"title":["Genome resequencing reveals the genetic basis of population evolution, local adaptation, and rewiring of the rhizome metabolome in <i>Atractylodes lancea<\/i>"],"prefix":"10.1093","volume":"11","author":[{"given":"Chengcai","family":"Zhang","sequence":"first","affiliation":[{"name":"China Academy of Chinese Medical Sciences State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, , Beijing 100700, China"},{"name":"Ministry of Agriculture and Rural Affairs Key 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