{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:03:01Z","timestamp":1784854981770,"version":"3.55.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"TYLCV infectious clone was kindly provided by Prof. Xueping Zhou from Chinese Academy of Agricultural Sciences, China"},{"name":"Green Prevention and Control Technologies for Insect-transmitted Viral Diseases in Sichuan Province","award":["SCYC202605"],"award-info":[{"award-number":["SCYC202605"]}]},{"name":"Research and Management of Major Non-Infectious Leaf Spot Diseases","award":["SCYC202513"],"award-info":[{"award-number":["SCYC202513"]}]},{"name":"Enterprise Doctoral Innovation and Entrepreneurship Program of Yingkou City","award":["YKSCJH2024-020"],"award-info":[{"award-number":["YKSCJH2024-020"]}]},{"name":"the Foundation of Liaoning Provincial Department of Education","award":["JYTYB2024001"],"award-info":[{"award-number":["JYTYB2024001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tomato yellow leaf curl virus (TYLCV) poses a serious threat to global tomato production. Current management strategies remain limited, highlighting the need for novel antiviral agents. In this study, we evaluated the efficacy of a newly synthesized pyrimidine\u2013guanidine derivative, YYH-6, against TYLCV in tomato (Solanum lycopersicum cv. Micro-Tom) and investigated its underlying mechanisms. Foliar application of YYH-6 significantly reduced viral accumulation and alleviated disease symptoms. Transcriptomic analysis revealed that YYH-6 treatment upregulates defense-related pathways such as plant\u2013pathogen interaction, MAPK signaling, and phenylpropanoid biosynthesis. Results of TRV-based virus-induced gene silencing (VIGS) further indicate that RPP13 and ALS2 function as important resistance genes induced by YYH-6. Activity-based protein profiling, LC\u2013MS\/MS, and reverse genetic verification by VIGS indicate that serine hydroxymethyltransferase and STI1 domain-containing proteins are potential target proteins of YYH-6 for TYLCV inhibition. Our findings demonstrate that YYH-6 suppresses TYLCV infection through multitarget modulation of host defense pathways, making it a promising candidate for sustainable management of tomato viral diseases.<\/jats:p>","DOI":"10.1093\/hr\/uhag120","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:45:32Z","timestamp":1775043932000},"source":"Crossref","is-referenced-by-count":0,"title":["A novel pyrimidine\u2013guanidine derivative YYH-6 confers tomato resistance to TYLCV via multitarget regulation of host defense genes and proteins"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-8592","authenticated-orcid":false,"given":"Miao","family":"Yu","sequence":"first","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University , Shenyang, Liaoning 110866 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Agriculture and Horticulture, Liaoning Agricultural Vocational and Technical College , Yingkou, Liaoning 115000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shu","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University , Shenyang, Liaoning 110866 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University , Shenyang, Liaoning 110866 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University , Shenyang, Liaoning 110866 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Liangshan Prefecture Branch of Sichuan Tobacco Company , Liangshan, Sichuan 615000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Liangshan Prefecture Branch of Sichuan Tobacco Company , Liangshan, Sichuan 615000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqiang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Liangshan Prefecture Branch of Sichuan Tobacco Company , Liangshan, Sichuan 615000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University , Shenyang, Liaoning 110866 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University , Shenyang, Liaoning 110866 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"An","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University , Shenyang, Liaoning 110866 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghai","family":"Li","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University , Shenyang, Liaoning 110866 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhua","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University , Shenyang, Liaoning 110866 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"2026072320364348700_ref1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00705-025-06345-y","article-title":"Tomato yellow leaf curl Reunion virus: a novel tomato-infecting monopartite begomovirus from Reunion Island","volume":"170","author":"Leclair","year":"2025","journal-title":"Arch Virol"},{"key":"2026072320364348700_ref2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-4238(96)00945-4","article-title":"Viral diseases causing the greatest economic losses to the tomato crop. 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