{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:09:20Z","timestamp":1790813360614,"version":"4.1.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the High-level Key Discipline Construction Project of the National Administration of Traditional Chinese Medicine","award":["zyyzdxk-2023202"],"award-info":[{"award-number":["zyyzdxk-2023202"]}]},{"name":"the Joint supported by Hubei Provincial Natural Science Foundation and Shiyan City of China","award":["2025AFD180"],"award-info":[{"award-number":["2025AFD180"]}]},{"name":"the CACMS Innovation Fund","award":["CI2025G00-06"],"award-info":[{"award-number":["CI2025G00-06"]}]},{"name":"Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences","award":["CI2024C007YN"],"award-info":[{"award-number":["CI2024C007YN"]}],"id":[{"id":"https:\/\/ror.org\/042pgcv68","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Fundamental Research Funds for the Central public welfare research institutes","award":["ZZ13-YQ-093, ZZXT202508"],"award-info":[{"award-number":["ZZ13-YQ-093, ZZXT202508"]}]},{"name":"Key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources","award":["2060302-2501-02, 2060302-2401-08"],"award-info":[{"award-number":["2060302-2501-02, 2060302-2401-08"]}]},{"name":"the National Natural Science Foundation of China","award":["82373987"],"award-info":[{"award-number":["82373987"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The triterpenoid-rich Panax spp. possess notable allelopathic capabilities, yet current knowledge lacks comprehensive understanding of the biological mechanisms underlying these inhibitory effects. Here, we show that zingibroside R1 (ZR1), a newly identified allelochemical from Panax spp., inhibits the adventitious root growth in ginseng and primary root elongation in Arabidopsis. Mechanistic analyses revealed that ZR1 disrupts auxin transport, as evidenced by monitoring DR5::GFP and PINs markers. The effect of ZR1 on auxin transport was further elucidated through synergistic effects observed with the auxin transport inhibitor NPA and in the auxin transport mutants aux1 and pin2. Additionally, ZR1 downregulates key root development regulators, including stem cell maintenance regulators PLT1\/2, WOX5, SHR, and SCR. Transcriptomic and biochemical data indicate that ZR1 triggers an ROS response in plants, which disrupts ROS scavenging\u2014via altered peroxidase activities and reduced glutathione\/oxidized glutathione balance\u2014thereby impairing detoxification function and resulting in root shortening by regulation of auxin distribution and stem cell gene expression. Our results establish a mechanistic framework for understanding how ginsenosides mediate allelopathic effects on root development.<\/jats:p>","DOI":"10.1093\/hr\/uhag185","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:28:54Z","timestamp":1778250534000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Panax<\/i>\n                    -derived Zingibroside R1 exerts allelopathic effects on root architecture by modulating the auxin transport pathway and oxidative stress responses"],"prefix":"10.1093","volume":"13","author":[{"given":"Xinjie","family":"Yang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine , Xianyang, Shaanxi 712046 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine , Xianyang, Shaanxi 712046 ,","place":["China"]},{"name":"Shiyan Key Laboratory of Medicinal Plants and Evolutionary Genetics, Hubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medicine, Hubei University of Medicine , Shiyan 442000 ,","place":["China"]},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing 100700 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weipeng","family":"Lian","sequence":"additional","affiliation":[{"name":"Shiyan Key Laboratory of Medicinal Plants and Evolutionary Genetics, Hubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medicine, Hubei University of Medicine , Shiyan 442000 ,","place":["China"]},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical 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