{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:21Z","timestamp":1792785921105,"version":"4.5.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Furong Scholar Program (High-level Talent Introduction Plan, Flexible Recruitment) of Hunan Province","award":["2025RC4007"],"award-info":[{"award-number":["2025RC4007"]}]},{"name":"the Yuelushan Laboratory Talent Program","award":["2025RC3003"],"award-info":[{"award-number":["2025RC3003"]}]},{"name":"the Yunnan Xingdian Talent Support Plan","award":["XDYC-YLXZ-2022-0019"],"award-info":[{"award-number":["XDYC-YLXZ-2022-0019"]}]},{"name":"the China Agriculture Research System of MOF and MARA","award":["CARS-09"],"award-info":[{"award-number":["CARS-09"]}],"id":[{"id":"https:\/\/ror.org\/03p5eky76","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Yunnan Fundamental Research Projects","award":["202105AF150028, 202501AS070012, and 202501\u00a0BC070003"],"award-info":[{"award-number":["202105AF150028, 202501AS070012, and 202501\u00a0BC070003"]}]},{"name":"the National Natural Science Foundation of China","award":["32401838, 32360757, and 32361143517"],"award-info":[{"award-number":["32401838, 32360757, and 32361143517"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Joint Fund of the National Natural Science Foundation of China","award":["U2202206"],"award-info":[{"award-number":["U2202206"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Potato (Solanum tuberosum L.) is a globally important staple crop. Improving its nutritional quality without compromising yield\u2014a classic manifestation of the growth\u2013defense trade-off\u2014remains a major challenge in modern agriculture. Traditional breeding in potato is hindered by its highly heterozygous genome and tetrasomic inheritance, making it difficult and time-consuming to introduce and fix new traits. To address this, we applied a gene-editing approach to enhance vitamin C (Vc) content in tubers by mutating the upstream open reading frames of two potato GDP-l-galactose phosphorylase genes. New variants, with significantly elevated Vc levels, well-balanced nutrient profiles, and maintained yield, were created. The nutritionally enriched\u200b tubers retained high Vc content after culinary processing and exhibited substantially increased antioxidant activity. Importantly, we also found that excessive Vc enrichment can disrupt auxin activity, leading to developmental arrest and yield penalties. Thus, our study not only provides an effective strategy for multitrait improvement in potato, but also offers broader insights into the physiological mechanisms governing the balance between yield and nutritional quality in horticultural crops.<\/jats:p>","DOI":"10.1093\/hr\/uhag191","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:30:59Z","timestamp":1778585459000},"source":"Crossref","is-referenced-by-count":1,"title":["Balancing tuber vitamin C improvement with trade-off side effect by fine-tuning regulation of\n                    <i>StGGPs<\/i>"],"prefix":"10.1093","volume":"13","author":[{"given":"Bo","family":"Zhang","sequence":"first","affiliation":[{"name":"Engineering Research Center for Valorization of Unique Bio-Resources in Yunnan, Ministry of Education, Yunnan Normal University , Kunming ,","place":["China"]},{"name":"Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences , Shenzhen ,","place":["China"]},{"name":"Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences\/Key Laboratory of Biology and Genetic Improvement of Tuber and Root Crops\/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops, Ministry of Agriculture and Rural Affairs , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Huazhong Agricultural University , Wuhan ,","place":["China"]},{"name":"Southwest United Graduate School , Kunming ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saihang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Engineering Research Center for Valorization of Unique Bio-Resources in Yunnan, Ministry of Education, Yunnan Normal University , Kunming ,","place":["China"]},{"name":"Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Dehong Agricultural Technology Extension Center, Dehong Agricultural Science Institute , Yunnan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Hu","sequence":"additional","affiliation":[{"name":"Engineering Research Center for Valorization of Unique Bio-Resources in Yunnan, Ministry of Education, Yunnan Normal University , Kunming ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Xue","sequence":"additional","affiliation":[{"name":"Institute of Apicultural Research, Chinese Academy of Agricultural Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3127-4488","authenticated-orcid":false,"given":"Jinzhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences\/Key Laboratory of Biology and Genetic Improvement of Tuber and Root Crops\/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops, Ministry of Agriculture and Rural Affairs , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shang","sequence":"additional","affiliation":[{"name":"Engineering Research Center for Valorization of Unique Bio-Resources in Yunnan, Ministry of Education, Yunnan Normal University , Kunming ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences\/Key Laboratory of Biology and Genetic Improvement of Tuber and Root Crops\/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops, Ministry of Agriculture and Rural Affairs , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ma","sequence":"additional","affiliation":[{"name":"Engineering Research Center for Valorization of Unique 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