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Anthocyanin accumulation exhibits remarkable diversity among fruit species and cultivars, providing invaluable genetic resources for trait improvement. This review summarizes the multifaceted mechanisms underlying the differential anthocyanin accumulation in fruit between species and cultivars. There are diverse control mechanisms governing anthocyanin accumulation, including mutations in genes involved in biosynthesis, transport, and transcriptional regulation, as well as multilayered regulation through epigenetic, post-transcriptional, and post-translational processes. The discovery of these genetic variants affecting anthocyanin accumulation, along with an understanding of the underlying molecular mechanisms, provides potential targets for fruit color modification through molecular breeding or biotechnological approaches.<\/jats:p>","DOI":"10.1093\/hr\/uhag204","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:54:48Z","timestamp":1779450888000},"source":"Crossref","is-referenced-by-count":1,"title":["Multifaceted mechanisms underlying species- and cultivar-associated differential anthocyanin accumulation in fruits"],"prefix":"10.1093","volume":"13","author":[{"given":"Ling","family":"Liang","sequence":"first","affiliation":[{"name":"College of Agriculture and Biotechnology, Zhejiang University , Zijingang Campus, Hangzhou 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"New Zealand Institute for Bioeconomy Science Limited , Private Bag 92169, Auckland Mail Centre, Auckland 1142 ,","place":["New Zealand"]},{"name":"School of Biological Sciences, University of Auckland , Private Bag 92019, Auckland 1142 ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biotechnology, Zhejiang University , Zijingang Campus, Hangzhou 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Ai","sequence":"additional","affiliation":[{"name":"Cuisine Science Key Laboratory of Sichuan Province, Sichuan Tourism University , Chengdu 610100 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1177-1700","authenticated-orcid":false,"given":"Kui","family":"Lin-Wang","sequence":"additional","affiliation":[{"name":"New Zealand Institute for Bioeconomy Science Limited , Private Bag 92169, Auckland Mail Centre, Auckland 1142 ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C","family":"Allan","sequence":"additional","affiliation":[{"name":"New Zealand Institute for Bioeconomy Science Limited , Private Bag 92169, Auckland Mail Centre, Auckland 1142 ,","place":["New Zealand"]},{"name":"School of Biological Sciences, University of Auckland , Private Bag 92019, Auckland 1142 ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunsong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biotechnology, Zhejiang University , Zijingang Campus, Hangzhou 310058 ,","place":["China"]},{"name":"Zhejiang Key Laboratory of Horticultural Crop Quality Improvement, Zhejiang University , Zijingang Campus, Hangzhou 310058 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