{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:26:34Z","timestamp":1790267194931,"version":"4.1.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":103,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This article summarises and contextualises the accumulated basic and clinical data on the ERA test and addresses specific comments and opinions presented by the opponent as part of an invited debate. Progress in medicine depends on new technologies and concepts that translate to practice to solve long-standing problems. In a key example, combining RNA sequencing data (transcriptomics) with artificial intelligence (AI) led to a clinical revolution in personalising disease diagnosis and fostered the concept of precision medicine. The reproductive field is no exception. Translation of endometrial transcriptomics to the clinic yielded an objective definition of the limited time period during which the maternal endometrium is receptive to an embryo, known as the window of implantation (WOI). The WOI is induced by the presence of exogenous and\/or endogenous progesterone (P) after proper oestradiol (E2) priming. The window lasts 30\u201336\u2009hours and, depending on the patient, occurs between LH\u2009+\u20096 and LH\u2009+\u20099 in natural cycles or between P\u2009+\u20094 and P\u2009+\u20097 in hormonal replacement therapy (HRT) cycles. In approximately 30% of IVF cycles in which embryo transfer is performed blindly, the WOI is displaced and embryo-endometrial synchrony is not achieved. Extending this application of endometrial transcriptomics, the endometrial receptivity analysis (ERA) test couples next-generation sequencing (NGS) to a computational predictor to identify transcriptomic signatures for each endometrial stage: proliferative (PRO), pre-receptive (PRE), receptive (R) and post-receptive (POST). In this way, personalised embryo transfer (pET) may be possible by synchronising embryo transfer with each patient\u2019s WOI. Data are the only way to confront arguments sustained in opinions and\/or misleading concepts; it is up to the reader to make their own conclusions regarding its clinical utility.<\/jats:p>","DOI":"10.1093\/hropen\/hoab011","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T07:22:23Z","timestamp":1614324143000},"source":"Crossref","is-referenced-by-count":81,"title":["Endometrial Receptivity Analysis (ERA): data versus opinions"],"prefix":"10.1093","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3938-3486","authenticated-orcid":false,"given":"Maria","family":"Ruiz-Alonso","sequence":"first","affiliation":[{"name":"Igenomix Foundation-INCLIVA, Valencia, Spain"},{"name":"Igenomix SL, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Valbuena","sequence":"additional","affiliation":[{"name":"Igenomix Foundation-INCLIVA, Valencia, Spain"},{"name":"Igenomix SL, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gomez","sequence":"additional","affiliation":[{"name":"Igenomix SL, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Cuzzi","sequence":"additional","affiliation":[{"name":"Igenomix USA & Canada, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-9531","authenticated-orcid":false,"given":"Carlos","family":"Simon","sequence":"additional","affiliation":[{"name":"Igenomix Foundation-INCLIVA, Valencia, Spain"},{"name":"Department of Pediatrics, Obstetrics & Gynecology, University of Valencia, Valencia, Spain"},{"name":"Department of Obstetrics and Gynecology, BIMDC, Harvard University, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"2021070823450685200_hoab011-B1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.fertnstert.2018.06.039","article-title":"International Committee for Monitoring Assisted Reproductive Technology: World Report on Assisted Reproductive Technology, 2011","volume":"110","author":"Adamson","year":"2018","journal-title":"Fertil Steril"},{"key":"2021070823450685200_hoab011-B2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/molehr\/gap102","article-title":"Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility","volume":"16","author":"Altm\u00e4e","year":"2010","journal-title":"Mol Hum Reprod"},{"key":"2021070823450685200_hoab011-B3","doi-asserted-by":"crossref","first-page":"10077","DOI":"10.1038\/s41598-017-10098-3","article-title":"Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers","volume":"7","author":"Altm\u00e4e","year":"2017","journal-title":"Sci Rep"},{"key":"2021070823450685200_hoab011-B4","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s10815-018-1190-9","article-title":"Does the endometrial receptivity array really provide personalized embryo transfer?","volume":"35","author":"Bassil","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"2021070823450685200_hoab011-B5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.fertnstert.2019.03.007","article-title":"Factors associated with early in vitro fertilization treatment discontinuation","volume":"112","author":"Bedrick","year":"2019","journal-title":"Fertil Steril"},{"key":"2021070823450685200_hoab011-B6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/GCO.0000000000000468","article-title":"Implantation failure of endometrial origin: what is new?","volume":"30","author":"Bellver","year":"2018","journal-title":"Curr Opin Obstet Gynecol"},{"key":"2021070823450685200_hoab011-B7","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1093\/humrep\/dep340","article-title":"When and why do subfertile couples discontinue their fertility care? 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