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Several molecular studies have suggested impaired endometrial receptivity in women with endometriosis, while others have detected no dysregulation of endometrial receptivity. Nevertheless, the previous endometrial transcriptome studies comparing women with and without endometriosis have been performed in small sample size with limited statistical power. We set out to systematically search and compile data of endometrial gene expression signatures at the receptive phase in women with endometriosis versus control women. Based on the obtained data, we conducted a meta-analysis of differentially expressed genes in order to raise the power of the analysis for identifying the molecular profiles of receptive phase endometria in endometriosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>A systematic literature search was conducted up to February 2022 following PRISMA criteria and included PubMed, Cochrane and Web of Science databases. For the systematic search, the term \u2018endometriosis\u2019 was paired with the terms \u2018transcriptomics\u2019, \u2018transcriptome\u2019, \u2018gene expression\u2019, \u2018RNA-seq\u2019, \u2018sequencing\u2019 and \u2018array\u2019, by using the Boolean operator \u2018AND\u2019 to connect them. Articles written in English were screened and interrogated for data extraction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>A meta-analysis was performed on the selected studies to extract the differentially expressed genes described at the mid-secretory phase in women with endometriosis versus women without endometriosis in natural cycles, using the robust rank aggregation method. In total, transcriptome data of 125 women (78 patients and 47 controls) were meta-analysed, with a special focus on endometrial receptivity-specific genes based on commercial endometrial receptivity tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>In total, 8 studies were eligible for the quantitative meta-analysis, gathering transcriptome data from the mid-secretory phase endometria of 125 women. A total of 7779 differentially expressed transcripts between the study groups were retrieved (3496 up-regulated and 4283 down-regulated) and were meta-analysed. After stringent multiple correction, there was no differential expression of any single molecule in the endometrium of women with endometriosis versus controls, while enrichment analysis detected that the pathways of chemotaxis and locomotion are dysregulated in endometriosis. Further analysis of endometrial receptivity-specific genes highlighted dysregulation of C4BPA, MAOA and PAEP and enrichment of immune and defence pathways in women with endometriosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>Most of the studies included into the meta-analysis were relatively small and had different study designs, which might have contributed to a bias.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>The current meta-analysis supports the hypothesis that endometrial receptivity is altered in women with endometriosis, although the changes are small. The molecules and pathways identified could serve as future biomarkers and therapeutical targets in detecting and treating endometriosis-associated infertility.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>The authors declare no competing interests. This work was supported by the Spanish Ministry of Education, Culture and Sport [grant FPU15\/01193] and the Margarita Salas program for the Requalification of the Spanish University system [grant UJAR01MS]; Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and European Regional Development Fund (FEDER): grants RYC-2016-21199 and ENDORE SAF2017-87526-R; Programa Operativo FEDER Andaluc\u00eda (B-CTS-500-UGR18; A-CTS-614-UGR20); the Junta de Andaluc\u00eda [BIO-302; and PAIDI P20_00158]; the University of Ja\u00e9n [PAIUJA-EI_CTS02_2017]; the University of Granada, Plan Propio de Investigaci\u00f3n 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES), and by the Junta de Andaluc\u00eda, Consejer\u00eda de Conocimiento, Investigaci\u00f3n y Universidades and European Regional Development Fund (ERDF), ref. SOMM17\/6107\/UGR; the Estonian Research Council (grant PRG1076); Horizon 2020 innovation (ERIN, grant no. EU952516) of the European Commission and Enterprise Estonia (grant EU48695).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>The systematic review was registered at PROSPERO (identifier: CRD42020122054).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/hropen\/hoac016","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T13:14:43Z","timestamp":1649078083000},"source":"Crossref","is-referenced-by-count":23,"title":["The mid-secretory endometrial transcriptomic landscape in endometriosis: a meta-analysis"],"prefix":"10.1093","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-8518","authenticated-orcid":false,"given":"E","family":"Vargas","sequence":"first","affiliation":[{"name":"Systems Biology Unit, Department of Experimental Biology, Faculty of Experimental Sciences, University of Ja\u00e9n, Ja\u00e9n, Spain"},{"name":"Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Garc\u00eda-Moreno","sequence":"additional","affiliation":[{"name":"Immunology Unit, Hospital Universitario Puerta del Mar, C\u00e1diz, C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Aghajanova","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford School of Medicine, Sunnyvale, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Salumets","sequence":"additional","affiliation":[{"name":"Competence Centre on Health Technologies, Tartu, Estonia"},{"name":"Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Obstetrics and Gyneaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Horcajadas","sequence":"additional","affiliation":[{"name":"Department of Genetics, University Pablo de Olavide, Sevilla, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-2973","authenticated-orcid":false,"given":"F J","family":"Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-1865","authenticated-orcid":false,"given":"S","family":"Altm\u00e4e","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"},{"name":"Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"2022042110520619800_hoac016-B1","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.fertnstert.2016.07.005","article-title":"Immune-inflammation gene signatures in endometriosis patients","volume":"106","author":"Ahn","year":"2016","journal-title":"Fertil Steril"},{"key":"2022042110520619800_hoac016-B2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.rbmo.2015.09.008","article-title":"What do we know about endometrial receptivity in women with endometriosis? 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