{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:30:14Z","timestamp":1781173814695,"version":"3.54.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":328,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Patient-Centered Clinical Research Coordinating Center"},{"name":"Ministry of Health & Welfare","award":["HC21C0123"],"award-info":[{"award-number":["HC21C0123"]}]},{"name":"Bio&Medical Technology Development Program of the National Research Foundation"},{"name":"Korean Government","award":["RS-2024-00440881"],"award-info":[{"award-number":["RS-2024-00440881"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>STUDY QUESTION<\/jats:title>\n                    <jats:p>Is maternal pre-existing atherosclerotic cardiovascular disease (ASCVD) associated with neonatal and long-term offspring outcomes?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUMMARY ANSWER<\/jats:title>\n                    <jats:p>Maternal pre-existing ASCVD is independently associated with consistent increases in neonatal and early childhood adverse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                    <jats:p>Maternal cardiovascular health may influence offspring development through intrauterine and early-life mechanisms. However, the impact of maternal pre-existing ASCVD on neonatal and long-term offspring\u2019s neurodevelopmental outcomes remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                    <jats:p>We conducted a nationwide cohort study linking maternal and child health data from the Korean National Health Insurance Service between 2005 and 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                    <jats:p>Pre-existing ASCVD was defined by diagnostic codes for myocardial infarction, ischemic stroke, or angina prior to conception. Offspring outcomes included neonatal complications (congenital malformations, sepsis, neonatal intensive care unit admission) and neurodevelopmental disorders (developmental delay, seizure, or attention-deficit hyperactivity disorder), with follow-up through 2020. Among 5\u00a0461\u00a0222 live births (3\u00a0640\u00a0815 unique mothers), 145\u00a0315 (2.7%) were delivered by women with pre-existing ASCVD before pregnancy. Propensity score matching (1:4) was used to adjust for baseline maternal characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                    <jats:p>Offspring of mothers with ASCVD had increased risk of congenital malformations (adjusted odds ratio [aOR] 1.09, 95% CI: 1.07\u20131.12), neonatal intensive care unit admission (aOR 1.19, 95% CI: 1.16\u20131.22), and neonatal sepsis (aOR 1.11, 95% CI: 1.07\u20131.15). The risk of neurodevelopmental disorders was also elevated (adjusted hazard ratio 1.08, 95% CI: 1.07\u20131.10). The absolute risk differences were consistent regardless of the presence of adverse pregnancy outcomes during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LIMITATIONS, REASON FOR CAUTION<\/jats:title>\n                    <jats:p>As with all observational studies, residual confounding could not be ruled out. Only live births are included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                    <jats:p>Maternal pre-existing ASCVD was associated with modest but consistent increases in neonatal and early childhood adverse outcomes. These associations appeared to persist regardless of the presence of adverse pregnancy outcomes, suggesting a possible independent contribution of maternal ASCVD on offspring development. Our findings suggest the importance of identifying and monitoring pregnancies of women with cardiovascular disease and indicate that early neurodevelopmental surveillance may be considered in affected children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                    <jats:p>This study was supported by the Patient-Centered Clinical Research Coordinating Center (PACEN) funded by the Ministry of Health &amp; Welfare, Republic of Korea (grant number: HC21C0123) and supported by the Bio&amp;Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (No. RS-2024-00440881). No competing interests are reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                    <jats:p>ClinicalTrials.gov, NCT06406998.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/hropen\/hoaf074","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:33:57Z","timestamp":1763987637000},"source":"Crossref","is-referenced-by-count":1,"title":["Association of maternal pre-existing atherosclerotic cardiovascular disease and neonatal and long-term offspring outcomes: a nationwide mother\u2013child paired cohort"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0244-7714","authenticated-orcid":false,"given":"Danbee","family":"Kang","sequence":"first","affiliation":[{"name":"Center for Clinical Epidemiology, Samsung Medical Center, Sungkyunkwan University School of Medicine , 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