{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:59:24Z","timestamp":1781071164576,"version":"3.54.1"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":130,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>STUDY QUESTION<\/jats:title>\n                    <jats:p>Could the miRNA cargo of extracellular vesicles (EVs) secreted by eutopic endometrium from women with endometriosis be involved in the pregnancy complications related to endometriosis?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUMMARY ANSWER<\/jats:title>\n                    <jats:p>EVs secreted by eutopic endometrium from women with endometriosis present altered miRNA that modulates biological processes related to pregnancy disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                    <jats:p>Communication between endometrial cells, immune cells, endothelial cells, and the embryo is essential for the correct establishment and development of pregnancy, and EVs have been proposed as key mediators of this dialogue. This study aimed to elucidate whether EV-mediated communication is altered in endometriosis, by analysing the miRNA cargo of EVs secreted by eutopic endometrium from women with endometriosis, after differentiation to the gestational phase, compared with the miRNA cargo of EVs secreted by eutopic endometrium from healthy women, also after differentiation to the gestational phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                    <jats:p>This was a prospective experimental comparative study in which endometrial organoids were derived from eutopic endometrium of patients with endometriosis (n\u2009=\u200916) and healthy women (n\u2009=\u200915).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                    <jats:p>Organoids were differentiated to mimic the gestational phase through supplementation with pregnancy hormones. EVs were then isolated from the culture medium, characterized, and their miRNA cargo was profiled by sequencing. Target genes of the significantly differentially expressed miRNAs were identified, and functional enrichment analysis was subsequently performed. Finally, the organoids were co-cultured with human endometrial stromal cells (hESCs) and human placental choriocarcinoma JAR cells, and the effects of EV-derived miRNAs were assessed by qPCR using representative target genes selected based on their roles in endometrium\u2013embryo communication and epithelial\u2013mesenchymal and mesenchymal\u2013epithelial transitions (EMT\u2013MET) in organoids, EMT in stromal (hESC) cells, and endometrium\u2013embryo communication in JAR cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                    <jats:p>EVs were successfully isolated. miRNA-seq showed eight significantly differentially expressed miRNAs (false discovery rate [FDR] &amp;lt; 0.05); six were downregulated: miR-1290, miR-1246, miR-320d, miR-4516, miR-12136, and miR-3065-5p; and two were upregulated: miR-191-5p, and miR-335-5p. These miRNAs target 3964 genes and GO enrichment analysis identified 789 biological processes (FDR &amp;lt; 0.05), mainly involved in embryo development and developmental growth, immune system function, angiogenesis, and epithelial\u2013mesenchymal transition. KEGG pathway analysis revealed 32 deregulated pathways (FDR &amp;lt; 0.05), including the PI3K\u2013Akt pathway commonly related to the pathogenesis of preeclampsia. Validation in gestational epithelial endometriosis organoids showed upregulation of IGF2 and NR2F2, and downregulation of LIF. Within the EMT\u2013MET group, PTK2B was downregulated, whereas WASF3 and RAC1 were upregulated. In hESC cells co-cultured with gestational epithelial endometriosis organoids, SFRP1, CDC42, RAC1, and WASF3 were upregulated, while PTK2B was downregulated, reflecting the miRNA cargo of ENDO-GEST-derived EVs. Similarly, in JAR cells co-cultured with gestational epithelial endometriosis, NR2F2 and IGF2 were upregulated, whereas MDFI, SP3, and RDH10 were downregulated. All results were consistent with the inverse expression patterns of their regulatory miRNAs in secreted EVs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LARGE SCALE DATA<\/jats:title>\n                    <jats:p>All raw sequencing data are available through the Gene Expression Omnibus (GEO) under accession number GSE302961.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                    <jats:p>This was an in vitro study in which the conditions of the endometrial organoid culture could not fully replicate the intrauterine environment. In addition, due to the limited amount of RNA obtained from EVs, sample pooling was required for downstream analyses, which may have reduced our ability to assess inter-sample variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                    <jats:p>EVs secreted by eutopic endometrium from women with endometriosis present altered miRNA that modulates processes essential for a successful pregnancy and could serve as potential diagnostic biomarkers for endometriosis and pregnancy disorders. These results also open avenues for further research about potential targets to promote pregnancy success in women with endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                    <jats:p>This study was supported by the Spanish Ministry of Education through FPU (FPU21\/00988 awarded to A.M.-P.), the Carlos III Health Institute, and cofounded by the European Social Fund (ESF) \u2018Investing in your future\u2019 through PI21\/00184 and PI24\/00961 (awarded to H.F.) and F122\/00102 (awarded to A.B.-R.), a Sara Borrell Contract (CD23\/00157 awarded to A.C. and CD24\/00184 awarded to A.V.), and Miguel Servet Programme grants (CP20\/00120 awarded to H.F. and CP19\/00149 awarded to I.C.). This study was also supported by Fundaci\u00f3 La Marat\u00f3 de TV3 (12\/C\/2024). The authors have no conflicts of interest to disclose.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/hropen\/hoag040","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:16:52Z","timestamp":1777893412000},"source":"Crossref","is-referenced-by-count":0,"title":["Altered miRNA cargo of endometrial extracellular vesicles in patients with endometriosis: potential implications for pregnancy outcomes"],"prefix":"10.1093","volume":"2026","author":[{"given":"Alba","family":"Bas-Rivas","sequence":"first","affiliation":[{"name":"Fetal and Reproductive Medicine Department, Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe)\/IVI-RMA Global Research Alliance, IVI Foundation , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Villalba","sequence":"additional","affiliation":[{"name":"Fetal and Reproductive Medicine Department, Instituto de Investigaci\u00f3n Sanitaria La Fe 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