{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:34:16Z","timestamp":1758126856261},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1093\/humrep\/14.12.2969","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T22:22:29Z","timestamp":1027722149000},"page":"2969-2973","source":"Crossref","is-referenced-by-count":11,"title":["Ovulation induction with low dose alternate day recombinant follicle stimulating hormone (Puregon)"],"prefix":"10.1093","volume":"14","author":[{"given":"H.M.","family":"Buckler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.R.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vickers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,12]]},"reference":[{"key":"key\n\t\t\t\t20170410032425_ADAMS-ETAL-1986","doi-asserted-by":"crossref","unstructured":"Adams, J., Polson, D.W. and Franks, S. (1986) Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br. Med. J., 293, 355\u2013359.","DOI":"10.1136\/bmj.293.6543.355"},{"key":"key\n\t\t\t\t20170410032425_ANOBILE-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Anobile, C.J., Talbot, J.A., McCann, S.J. et al. (1998) Glycoform composition of serum gonadotrophins through the normal menstrual cycle and in the post-menopausal state. Mol. Hum. Reprod., 4, 631\u2013639.","DOI":"10.1093\/molehr\/4.7.631"},{"key":"key\n\t\t\t\t20170410032425_BROWN-1987","doi-asserted-by":"crossref","unstructured":"Brown, J.B. (1987) Pituitary control of ovarian function \u2013 concepts derived from gonadotropin therapy. Aust. N.Z. Obstet. Gynaecol., 18, 47\u201355.","DOI":"10.1111\/j.1479-828X.1978.tb00011.x"},{"key":"key\n\t\t\t\t20170410032425_BUCKLER-ETAL-1998A","unstructured":"Buckler, H.M., Lambert, A., Anderson, A. et al. (1998a) Low dose alternate day recombinant FSH in an ovulation induction programme. Hum. Reprod., 13 (Abstract Bk.1), P-138."},{"key":"key\n\t\t\t\t20170410032425_BUCKLER-ETAL-1998B","unstructured":"Buckler, H.M., Lambert, A., Anderson, A. et al. (1998b) Ovulation induction with low dose alternate day recombinant FSH (Puregon). IFFS '98 Program Supplement. Fertil. Steril., Abs P-1129, S-475."},{"key":"key\n\t\t\t\t20170410032425_CHRISTINMAITRE-ETAL-1996","unstructured":"ChristinMaitre, S., Taylor, A.E., Khoury, R.H. et al. (1996) Homologous in-vitro bioassay for follicle-stimulating-hormone (FSH) reveals increased FSH biological signal during the mid-phase to late luteal-phase of the human menstrual-cycle. J. Clin. Endocrinol. Metab., 81, 2080\u20132088."},{"key":"key\n\t\t\t\t20170410032425_COELINGH-BENNINK-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Coelingh Bennink, H.J.T., Fauser, B.C.J.M. and Out, H.J. (1998) Recombinant follicle-stimulating hormone (FSH; Puregon) is more efficient than urinary FSH (Metrodin) in women with clomiphene citrate-resistant, normogonadotrophic, chronic anovulation: a prospective, multicenter, assessor-blind, randomized, clinical trial. Fertil. Steril., 69, 19\u201325.","DOI":"10.1016\/S0015-0282(97)00423-8"},{"key":"key\n\t\t\t\t20170410032425_CONWAY-ETAL-1989","doi-asserted-by":"crossref","unstructured":"Conway, G.S., Honour, J.W., Jacobs H.S. (1989) Heterogeneity of the polycystic ovary syndrome: clinical, endocrine and ultrasound features in 556 patients. Clin. Endocrinol., 30, 459\u2013470.","DOI":"10.1111\/j.1365-2265.1989.tb00446.x"},{"key":"key\n\t\t\t\t20170410032425_DEVROEY-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Devroey, P., Tournaye, H., Van Steirteghem, A. et al. (1998) The use of a 100 IU starting dose of recombinant follicle stimulating hormone (Puregon) in in-vitro fertilization. Hum. Reprod., 13, 565\u2013566.","DOI":"10.1093\/humrep\/13.3.565"},{"key":"key\n\t\t\t\t20170410032425_DING-AND-HUHTANIEMI-1991","doi-asserted-by":"crossref","unstructured":"Ding, Y. and Huhtaniemi, I. (1991) Preponderance of basic isoforms of serum luteinizing hormone (LH) is associated with the high bio\/immuno ratio of LH in healthy women and in women with polycystic ovarian disease. Hum. Reprod., 6, 346\u2013350.","DOI":"10.1093\/oxfordjournals.humrep.a137336"},{"key":"key\n\t\t\t\t20170410032425_FAUSER-AND-VAN-HEUSDEN-1997","doi-asserted-by":"crossref","unstructured":"Fauser, B.C.J.M. and Van Heusden, A.M. (1997) Manipulation of human ovarian function: physiological concepts and clinical consequences. Endocr. Rev., 18, 71\u2013106.","DOI":"10.1210\/er.18.1.71"},{"key":"key\n\t\t\t\t20170410032425_FRANKS-1989","doi-asserted-by":"crossref","unstructured":"Franks, S. (1989) Polycystic ovary syndrome: a changing perspective. Clin. Endocrinol., 31, 187\u2013220.","DOI":"10.1111\/j.1365-2265.1989.tb00457.x"},{"key":"key\n\t\t\t\t20170410032425_GROOME-ETAL-1996","unstructured":"Groome, N.P., Illingworth, P.J., O'Brien, M. et al. (1996) Measurement of dimeric inhibin-B throughout the normal menstrual cycle. J. Clin. Endocrinol. Metab., 81, 1400\u20131405."},{"key":"key\n\t\t\t\t20170410032425_HARRIS-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Harris, S.D., Anobile, C.J., McLoughlin, J. et al. (1996) Internal carbohydrate complexity of the oligosaccharide chains of recombinant human follicle stimulating hormone (Puregon, ORG 32489); comparison with Metrodin and Metrodin HP. Molec. Hum. Reprod., 2, 807\u2013811.","DOI":"10.1093\/molehr\/2.10.807"},{"key":"key\n\t\t\t\t20170410032425_HAYDEN-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Hayden, C.J., Rutherford, A.J. and Balen, A. (1999) Induction of ovulation with a starting dose of 50 units of recombinant human follicle-stimulating hormone (Puregon). Fertil. Steril., 71,106\u2013108.","DOI":"10.1016\/S0015-0282(98)00408-7"},{"key":"key\n\t\t\t\t20170410032425_HORSMAN-ETAL-1998","unstructured":"Horsman, G., Talbot, J.A., McLoughlin, J.D. et al. (1998) A biological, immunological, and physico-chemical comparison of Gonal-F and Puregon. Hum. Reprod., 13 (Abstract Bk.1), O-100."},{"key":"key\n\t\t\t\t20170410032425_LAMBERT-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Lambert, A., Rodgers, M., Mitchell, R. et al. (1995). In-vitro biopotency and glycoform distribution of recombinant human FSH (ORG32489), Metrodin and Metrodin-HP. Hum. Reprod., 10, 1928\u20131935.","DOI":"10.1093\/oxfordjournals.humrep.a136208"},{"key":"key\n\t\t\t\t20170410032425_LOCKWOOD-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Lockwood, G.M., Muttukrishna, S., Groome, N.P. et al. (1996) Circulating inhibins and activin-A during GnRH-analogue down-regulation and ovarian hyperstimulation with recombinant FSH for in-vitro fertilization\u2013embryo transfer. Clin. Endocrinol., 45, 741\u2013748.","DOI":"10.1046\/j.1365-2265.1996.8510861.x"},{"key":"key\n\t\t\t\t20170410032425_LOCKWOOD-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Lockwood, G.M., Muttukrishna, S., Groome, N.P. et al. (1998) Mid-follicular phase pulses of inhibin B are absent in polycystic ovarian syndrome and are initiated by successful laparoscopic ovarian diathermy: a possible mechanism regulating emergence of the dominant follicle. J. Clin. Endocrinol. Metab., 83, 1730\u20131735.","DOI":"10.1210\/jcem.83.5.4756"},{"key":"key\n\t\t\t\t20170410032425_MANNAERTS-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Mannaerts, B.M.J.L., Rombout, F., Out, H.J. et al. (1996) Clinical profiling of recombinant follicle stimulating hormone: (rFSH; Puregon): relationship between serum FSH and efficacy. Hum. Reprod. Update, 2, 153\u2013161.","DOI":"10.1093\/humupd\/2.2.153"},{"key":"key\n\t\t\t\t20170410032425_MUTTUKRISHNA-ETAL-1996","unstructured":"Muttukrishna, S., Fowler, P.A., George, L. et al. (1996) Changes in peripheral serum concentrations of total activin-A during the human menstrual cycle and pregnancy. J. Clin. Endocrinol. Metab., 81, 3328\u20133334."},{"key":"key\n\t\t\t\t20170410032425_OUT-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Out, H.J., Mannaerts, B.M., Driessen, S.G. et al. (1995) A prospective, randomized, assessor-blind, multicentre study comparing recombinant and urinary follicle stimulating hormone (Puregon versus Metrodin) in in-vitro fertilization. Hum. Reprod., 10, 2534\u20132540.","DOI":"10.1093\/oxfordjournals.humrep.a135740"},{"key":"key\n\t\t\t\t20170410032425_PACHE-ETAL-1992","doi-asserted-by":"crossref","unstructured":"Pache, T.D., Hop, W.C., De Yong, F.H. et al. (1992) 17 beta-oestradiol, androstenedione and inhibin levels in fluid from individual follicles of normal and polycystic ovaries, and in ovaries from androgen treated female to male transsexuals. Clin. Endocrinol., 36, 565\u2013571.","DOI":"10.1111\/j.1365-2265.1992.tb02266.x"},{"key":"key\n\t\t\t\t20170410032425_RECOMBINANT-HUMAN-FSH-STUDY-GROUP-1995","unstructured":"Recombinant Human FSH Study Group (1995) Clinical assessment of recombinant human follicle-stimulating hormone in stimulating ovarian follicular development before in vitro fertilization. Fertil. Steril., 63, 77\u201386."},{"key":"key\n\t\t\t\t20170410032425_RECOMBINANT-HUMAN-FSH-STUDY-GROUP-1998","unstructured":"Recombinant Human FSH Study Group (1998) A compilation of previously published papers. Fertil. Steril., 69 (Suppl.1), 1S\u201344S."},{"key":"key\n\t\t\t\t20170410032425_RODGERS-ETAL-1992","doi-asserted-by":"crossref","unstructured":"Rodgers, M., Mitchell, R., Lambert A. et al. (1992) Human chorionic gonadotrophin contributes to the bioactivity of Pergonal. Clin. Endocrinol., 37, 558\u2013564.","DOI":"10.1111\/j.1365-2265.1992.tb01488.x"},{"key":"key\n\t\t\t\t20170410032425_RODGERS-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Rodgers, M., McLoughlin, J.D., Lambert, A. et al. (1995) Variability in the immunoreactive and bioactive follicle stimulating hormone content of human urinary menopausal gonadotrophin preparations. Hum. Reprod., 10, 1982\u20131986.","DOI":"10.1093\/oxfordjournals.humrep.a136220"},{"key":"key\n\t\t\t\t20170410032425_SCHOOT-ETAL-1992","unstructured":"Schoot, D.C., Coelingh Bennink, H.J.T., Mannaerts, B.M.J.L. et al. (1992) Human recombinant follicle stimulating hormone induces growth of preovulatory follicles without concomitant increase in androgen and oestrogen biosynthesis in a woman with isolated gonadotrophin deficiency. J. Clin. Endocrinol. Metab., 74, 1471\u20131473."},{"key":"key\n\t\t\t\t20170410032425_SHOHAM-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Shoham, Z., Mannaerts, B., Insler, V. et al. (1993) Induction of follicular growth using recombinant human follicle-stimulating hormone in two volunteer women with hypogonadotrophic hypogonadism. Fertil. Steril., 59, 738\u2013742.","DOI":"10.1016\/S0015-0282(16)55852-X"},{"key":"key\n\t\t\t\t20170410032425_TAYLOR-ETAL-1997","unstructured":"Taylor, A.E., McCourt, B., Martin, K.A. et al. (1997) Determinants of abnormal gonadotrophin secretion in clinically defined women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 82, 2248\u20132256."},{"key":"key\n\t\t\t\t20170410032425_THOMPSON-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Thompson, K.A., LaPolt, P.S., River, J. et al. (1995) Gonadotrophin requirements of the developing follicle. Fertil. Steril., 63, 273\u2013276.","DOI":"10.1016\/S0015-0282(16)57354-3"},{"key":"key\n\t\t\t\t20170410032425_VAN-DER-MEER-ETAL-1994","doi-asserted-by":"crossref","unstructured":"Van der Meer, M., Hompes, P.G.A., Scheele, F. et al. (1994) Follicle stimulating hormone (FSH) dynamics of low dose step-up ovulation induction with FSH in patients with polycystic ovary syndrome. Hum. Reprod., 9, 1612\u20131617.","DOI":"10.1093\/oxfordjournals.humrep.a138761"},{"key":"key\n\t\t\t\t20170410032425_WHITE-ETAL-1996","unstructured":"White, D.M., Polson, D.W., Kiddy, D. et al. (1996) Extensive personal experience: induction of ovulation with low-dose gonadotrophins in polycystic ovary syndrome: an analysis of 109 pregnancies in 225 women. J. Clin. Endocrinol. Metab., 81, 3821\u20133824."},{"key":"key\n\t\t\t\t20170410032425_WORLD-HEALTH-ORGANIZATION-1973","unstructured":"World Health Organization (1973) Agents stimulating gonadal function in the human. Report of a WHO specific group. World Health Org. Techn. Rep. Ser., 514, 1\u201328."}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","deposited":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T07:10:47Z","timestamp":1497510647000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article-lookup\/doi\/10.1093\/humrep\/14.12.2969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1999,12]]},"published-print":{"date-parts":[[1999,12]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/14.12.2969","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}