{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:32:31Z","timestamp":1761154351345},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,9]]},"DOI":"10.1093\/humrep\/14.9.2216","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:22:29Z","timestamp":1027707749000},"page":"2216-2222","source":"Crossref","is-referenced-by-count":10,"title":["Adipocyte insulin action following ovulation in polycystic ovarian syndrome"],"prefix":"10.1093","volume":"14","author":[{"given":"Philippa","family":"J.Marsden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison P.","family":"Murdoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,9,1]]},"reference":[{"key":"key\n\t\t\t\t20170411104619_ADAMS-ETAL-1986","doi-asserted-by":"crossref","unstructured":"Adams, J., Polson, D.W. and Franks, S. (1986) Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br. Med. J., 293, 355\u2013359.","DOI":"10.1136\/bmj.293.6543.355"},{"key":"key\n\t\t\t\t20170411104619_BAIRD-ETAL-1977","doi-asserted-by":"crossref","unstructured":"Baird, D.T., Corker, C.S., Davidson, D.W. et al. (1977) Pituitary\u2013ovarian relationships in polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 45, 798\u2013809.","DOI":"10.1210\/jcem-45-4-798"},{"key":"key\n\t\t\t\t20170411104619_BARBIERI-ETAL-1984","doi-asserted-by":"crossref","unstructured":"Barbieri, R.L., Makris, A. and Ryan, K.J. (1984) Insulin stimulates androgen accumulation in incubations of human ovarian stroma and theca. Obstet. Gynaecol., 64, 73S\u201380S.","DOI":"10.1097\/00006250-198409001-00019"},{"key":"key\n\t\t\t\t20170411104619_BLANKSTEIN-ETAL-1987","doi-asserted-by":"crossref","unstructured":"Blankstein, J., Rabinovici, J., Goldenberg, M. et al. (1987) Changing pituitary reactivity to follicle stimulating hormone and luteinising hormone releasing hormone after induced ovulatory cycles and after anovulation in patients with polycystic ovarian disease. J. Clin. Endocrinol. Metab., 65, 1164\u20131167.","DOI":"10.1210\/jcem-65-6-1164"},{"key":"key\n\t\t\t\t20170411104619_CHANG-ETAL-1980","doi-asserted-by":"crossref","unstructured":"Chang, R.J., Nakamura, R.M., Judd, H.L. et al. (1980) Insulin resistance in non-obese patients with polycystic ovarian disease. J. Clin. Endocrinol. Metab., 57, 356\u2013359.","DOI":"10.1210\/jcem-57-2-356"},{"key":"key\n\t\t\t\t20170411104619_CIAMPELLI-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Ciampelli, M, Fulghescu, A.M., Cucinelli, F. et al. (1997) Heterogeneity in beta cell activity, hepatic insulin clearance and peripheral insulin sensitivity in women with polycystic ovary syndrome. Hum. Reprod., 12, 1897\u20131901.","DOI":"10.1093\/humrep\/12.9.1897"},{"key":"key\n\t\t\t\t20170411104619_CIARALDI-ETAL-1992","unstructured":"Ciaraldi, T.P., El-Roeiy, A., Madar, Z. et al. (1992) Cellular mechanisms of insulin resistance in polycystic ovarian syndrome. J. Clin. Endocrinol. Metab., 75, 577\u2013583."},{"key":"key\n\t\t\t\t20170411104619_CIARALDI-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Ciaraldi, T.P., Morales, A.J., Hickman, M.G. et al. (1997) Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity. J. Clin. Endocrinol. Metab., 82, 1421\u20131425.","DOI":"10.1210\/jc.82.5.1421"},{"key":"key\n\t\t\t\t20170411104619_CONWAY-1990","unstructured":"Conway, G.S. (1990) Insulin resistance and polycystic ovary syndrome. Contemp. Rev. Obstet. Gynaecol., 2, 4\u201339."},{"key":"key\n\t\t\t\t20170411104619_DAHLGREN-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Dahlgren E., Landin K., Krotkiewski M. et al. (1998) Effects of two antiandrogen treatments on hirsutism and insulin sensitivity in women with polycystic ovary syndrome. Hum. Reprod., 13, 2706\u20132711","DOI":"10.1093\/humrep\/13.10.2706"},{"key":"key\n\t\t\t\t20170411104619_DUNAIF-1997","doi-asserted-by":"crossref","unstructured":"Dunaif, A. (1997) Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr. Rev., 18, 774\u2013800.","DOI":"10.1210\/er.18.6.774"},{"key":"key\n\t\t\t\t20170411104619_DUNAIF-ETAL-1989","doi-asserted-by":"crossref","unstructured":"Dunaif, A., Segal, K.R., Futterweit, W. et al. (1989) Profound peripheral insulin resistance independent of obesity, in polycystic ovary syndrome. Diabetes, 38, 1165\u20131174.","DOI":"10.2337\/diab.38.9.1165"},{"key":"key\n\t\t\t\t20170411104619_DUNAIF-ETAL-1992","doi-asserted-by":"crossref","unstructured":"Dunaif, A,, Segal, K.R., Shelley, D.R. et al. (1992) Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes, 41, 1257\u20131266.","DOI":"10.2337\/diab.41.10.1257"},{"key":"key\n\t\t\t\t20170411104619_EK-ETAL-1997","unstructured":"Ek, I., Arner, P., Bergqvist, A., et al. (1997) Impaired adipocyte lipolysis in nonobese women with the polycystic ovary syndrome: a possible link to insulin resistance. J. Clin. Endocrinol. Metab., 82, 1147\u20131153."},{"key":"key\n\t\t\t\t20170411104619_FALCONE-ETAL-1992","doi-asserted-by":"crossref","unstructured":"Falcone, T., Little, A.B. and Morris, D. (1992) Impaired glucose effectiveness in patients with polycystic ovary syndrome. Hum. Reprod., 7, 922\u2013925.","DOI":"10.1093\/oxfordjournals.humrep.a137771"},{"key":"key\n\t\t\t\t20170411104619_FERRIMAN-AND-GALLWEY-1961","doi-asserted-by":"crossref","unstructured":"Ferriman, D. and Gallwey, J. (1961) Clinical assessment of body hair growth in women. J. Clin. Endocrinol. Metab., 21, 1440\u20131445.","DOI":"10.1210\/jcem-21-11-1440"},{"key":"key\n\t\t\t\t20170411104619_FOX-ETAL-1991","doi-asserted-by":"crossref","unstructured":"Fox, R., Corrigan, E., Thomas, P.G. et al. (1991) Oestrogen and androgen states in oligo-amenorrhoeic women with polycystic ovaries. Br. J. Obstet. Gynaecol., 98, 294\u2013299.","DOI":"10.1111\/j.1471-0528.1991.tb13396.x"},{"key":"key\n\t\t\t\t20170411104619_FRANKS-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Franks, F., White, D., Gilling-Smith, C. et al. (1996) Hypersecretion of androgens by polycystic ovaries: the role of genetic factors in the regulation of cytochrome p450c17 alpha. Clin. Endocrinol. Metab., 10, 193\u2013203.","DOI":"10.1016\/S0950-351X(96)80057-7"},{"key":"key\n\t\t\t\t20170411104619_GADIR-ETAL-1990","doi-asserted-by":"crossref","unstructured":"Gadir, A.A., Khatim, M.S., Mowafi, R.S. et al. (1990) Hormonal changes in patients with polycystic ovarian disease after ovarian electrocautery or pituitary desensitisation. Clin. Endocrinol., 32, 749\u2013754.","DOI":"10.1111\/j.1365-2265.1990.tb00921.x"},{"key":"key\n\t\t\t\t20170411104619_HAGUE-ETAL-1988","doi-asserted-by":"crossref","unstructured":"Hague, W.M., Adams, J., Reeders, S.T. et al. (1988) Familial polycystic ovaries: a genetic disease? Clin. Endocrinol., 29, 593\u2013605.","DOI":"10.1111\/j.1365-2265.1988.tb03707.x"},{"key":"key\n\t\t\t\t20170411104619_JUDD-ETAL-1976","doi-asserted-by":"crossref","unstructured":"Judd, H.L., Rigg, L.A., Anderson, D.C. et al. (1976) The effects of ovarian wedge resection on circulating gonadotrophin and ovarian steroid levels in patients with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 43, 347\u2013355.","DOI":"10.1210\/jcem-43-2-347"},{"key":"key\n\t\t\t\t20170411104619_KASDORF-AND-KALKHOFF-1988","doi-asserted-by":"crossref","unstructured":"Kasdorf, G. and Kalkhoff, R.K. (1988) Prospective studies of insulin sensitivity in normal women receiving oral contraceptive agents. J. Clin. Endocrinol. Metab., 66, 846\u2013852.","DOI":"10.1210\/jcem-66-4-846"},{"key":"key\n\t\t\t\t20170411104619_KIDDY-ETAL-1992","doi-asserted-by":"crossref","unstructured":"Kiddy, D., Hamilton-Fairley, D., Bush, A. et al. (1992) Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin. Endocrinol., 36, 105\u2013111.","DOI":"10.1111\/j.1365-2265.1992.tb02909.x"},{"key":"key\n\t\t\t\t20170411104619_KORYTKOWSKI-ETAL-1995","unstructured":"Korytkowski, M.T., Mokan, M., Horwitz, M.J. et al. (1995) Metabolic effects of oral contraceptives in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 80, 3327\u20133334."},{"key":"key\n\t\t\t\t20170411104619_KUSTIN-ETAL-1987","doi-asserted-by":"crossref","unstructured":"Kustin, J., Kazer, R.R., Hoffman, D.I. et al. (1987) Insulin resistance and abnormal ovarian responses to human chorionic gonadotrophin in chronically anovulatory women. Am. J. Obstet. Gynaecol., 157, 1468\u20131473.","DOI":"10.1016\/S0002-9378(87)80246-6"},{"key":"key\n\t\t\t\t20170411104619_LANZONE-ETAL-1990","doi-asserted-by":"crossref","unstructured":"Lanzone, A., Fulghescu, A.M., Andreani, C.L. et al. (1990) Insulin secretion in polycystic ovarian disease: effect of ovarian suppression by GnRH agonist. Hum. Reprod., 5, 143\u2013149.","DOI":"10.1093\/oxfordjournals.humrep.a137058"},{"key":"key\n\t\t\t\t20170411104619_LLOYD-ETAL-1978","unstructured":"Lloyd, B., Burrin, J., Smythe, P. et al. (1978) Enzymatic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol and hydroxybutyrate. Clin. Chem., 34, 1724\u20131729."},{"key":"key\n\t\t\t\t20170411104619_MARSDEN-ETAL-1994","doi-asserted-by":"crossref","unstructured":"Marsden, P.J., Murdoch, A. and Taylor, R. (1994) Severe impairment of insulin action in adipocytes from amenorrhoeic subjects with polycystic ovary syndrome. Metabolism, 43, 1536\u20131542","DOI":"10.1016\/0026-0495(94)90013-2"},{"key":"key\n\t\t\t\t20170411104619_MARSDEN-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Marsden, P.J., Murdoch, A. and Taylor, R. (1996) Adipocyte insulin action during the normal menstrual cycle. Hum. Reprod., 11, 968\u2013974.","DOI":"10.1093\/oxfordjournals.humrep.a019333"},{"key":"key\n\t\t\t\t20170411104619_MURDOCH-ETAL-1986","doi-asserted-by":"crossref","unstructured":"Murdoch, A.P., Dunlop, W. and Kendall-Taylor, P. (1986) Studies of prolactin secretion in polycystic ovary syndrome. Clin. Endocrinol., 24, 165\u2013175.","DOI":"10.1111\/j.1365-2265.1986.tb00759.x"},{"key":"key\n\t\t\t\t20170411104619_PEDERSEN-AND-GLIEMANN-1981","doi-asserted-by":"crossref","unstructured":"Pedersen, O. and Gliemann, J. (1981) Hexose transport in human adipocytes: factors influencing the response to insulin and kinetics of methylglucose and glucose transport. Diabetologia, 20, 630\u2013635.","DOI":"10.1007\/BF00257432"},{"key":"key\n\t\t\t\t20170411104619_PEDERSEN-AND-HJOLLUND-1982","doi-asserted-by":"crossref","unstructured":"Pedersen, O. and Hjollund, E. (1982) Insulin receptor binding to fat and blood cells and insulin action in fat cells from insulin dependent diabetics. Diabetologia, 31, 706\u2013715.","DOI":"10.2337\/diab.31.8.706"},{"key":"key\n\t\t\t\t20170411104619_PEDERSEN-ETAL-1981","doi-asserted-by":"crossref","unstructured":"Pedersen, O., Hjollund, E., Beck-Neilsen, H. et al. (1981) Insulin receptor binding and receptor-mediated insulin degradation in human adipocytes. Diabetologia, 20, 636\u2013641.","DOI":"10.1007\/BF00257433"},{"key":"key\n\t\t\t\t20170411104619_PORETSKY-AND-KALIN-1987","doi-asserted-by":"crossref","unstructured":"Poretsky, L. and Kalin, M.F. (1987) The gonadotrophic function of insulin. Endocr. Rev., 8, 132\u2013141.","DOI":"10.1210\/edrv-8-2-132"},{"key":"key\n\t\t\t\t20170411104619_PORETSKY-ETAL-1985","doi-asserted-by":"crossref","unstructured":"Poretsky, L., Grigorescu, F., Siebel, M. et al. (1985) Distribution and characterisation of insulin and insulin-like growth factor I receptors in normal human ovary. J. Clin. Endocrinol. Metab., 61, 728\u2013734.","DOI":"10.1210\/jcem-61-4-728"},{"key":"key\n\t\t\t\t20170411104619_RITTMASTER-ETAL-1993","unstructured":"Rittmaster, R.S., Deshwal, N. and Lehman, L. (1993) The role of adrenal hyperandrogenism, insulin resistance and obesity in the pathogenesis of polycystic ovarian syndrome. J. Clin. Endocrinol. Metab., 76, 1295\u20131300."},{"key":"key\n\t\t\t\t20170411104619_ROBINSON-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Robinson, S., Kiddy, D., Gelding, S.V. et al. (1993) The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clin. Endocrinol., 39, 351\u2013355.","DOI":"10.1111\/j.1365-2265.1993.tb02376.x"},{"key":"key\n\t\t\t\t20170411104619_ROSENBAUM-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Rosenbaum, D., Haber, R.S. and Dunaif, A. (1993) Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT-4 glucose transporters in adipocytes. Am. J. Physiol., 264, E197\u2013202.","DOI":"10.1152\/ajpendo.1993.264.2.E197"},{"key":"key\n\t\t\t\t20170411104619_RYAN-ETAL-1985","doi-asserted-by":"crossref","unstructured":"Ryan, E.A., O'Sullivan, M.J. and Sykler, J.S. (1985) Insulin action during pregnancy. Studies with the euglycaemic clamp technique. Diabetes., 34, 380\u2013389.","DOI":"10.2337\/diab.34.4.380"},{"key":"key\n\t\t\t\t20170411104619_SHARP-ETAL-1991","doi-asserted-by":"crossref","unstructured":"Sharp, P.S., Kiddy, D.S., Reed, M.J. et al. (1991) Correlation of plasma insulin and insulin-like growth factor-I with indices of androgen transport and metabolism in women with polycystic ovary syndrome. Clin. Endocrinol., 35, 253\u2013257.","DOI":"10.1111\/j.1365-2265.1991.tb03531.x"},{"key":"key\n\t\t\t\t20170411104619_STANLEY-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Stanley, K., Fraser, R. and Bruce, C. (1998) Physiological changes in insulin resistance in human pregnancy: longitudinal study with the hyperinsulinaemic euglycaemic clamp technique. Br. J. Obstet. Gynaecol., 105, 756\u2013759.","DOI":"10.1111\/j.1471-0528.1998.tb10207.x"},{"key":"key\n\t\t\t\t20170411104619_SWANSON-ETAL-1981","doi-asserted-by":"crossref","unstructured":"Swanson, M., Sauerbrei, E.E. and Cooperberg, P.L. (1981) Medical implications of ultrasonically detected polycystic ovaries. J. Clin. Ultrasound, 9, 219\u2013222.","DOI":"10.1002\/jcu.1870090504"},{"key":"key\n\t\t\t\t20170411104619_TAYLOR-ETAL-1985","doi-asserted-by":"crossref","unstructured":"Taylor, R., McCulloch, A.J., Zeuzem, S. et al. (1985) Insulin secretion, adipocyte insulin binding and insulin sensitivity in thyrotoxicosis. Acta Endocrinol., 109, 96\u2013103.","DOI":"10.1530\/acta.0.1090096"},{"key":"key\n\t\t\t\t20170411104619_ZHANG-ETAL-1984","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Stern, B. and Rebar, R. (1984) Endocrine comparison of obese menstruating and amenorrhoeic women. J. Clin. Endocrinol. Metab., 58, 1077\u20131083.","DOI":"10.1210\/jcem-58-6-1077"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/14\/9\/2216\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T03:20:00Z","timestamp":1583292000000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article-lookup\/doi\/10.1093\/humrep\/14.9.2216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9]]},"references-count":44,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1999,9,1]]},"published-print":{"date-parts":[[1999,9]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/14.9.2216","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published":{"date-parts":[[1999,9]]}}}