{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T10:28:45Z","timestamp":1756636125706},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,9]]},"DOI":"10.1093\/humrep\/14.9.2286","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T22:22:29Z","timestamp":1027722149000},"page":"2286-2292","source":"Crossref","is-referenced-by-count":19,"title":["Absence of testicular DAZ gene expression in idiopathic severe testiculopathies"],"prefix":"10.1093","volume":"14","author":[{"given":"A.","family":"Ferlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Moro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Onisto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Toscano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bettella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Foresta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,9,1]]},"reference":[{"key":"key\n\t\t\t\t20170411104657_BROWN-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Brown, G.M., Furlong, R.A., Sargent, C.A. et al. (1998) Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene. Hum. Mol. Genet., 7, 97\u2013107.","DOI":"10.1093\/hmg\/7.1.97"},{"key":"key\n\t\t\t\t20170411104657_CHAI-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Chai, N.N., Salido, E.C. and Yen, P.H. (1997) Multiple functional copies of the RBM gene family, a spermatogenesis candidate on the human Y chromosome. Genomics, 45, 355\u2013361.","DOI":"10.1006\/geno.1997.4944"},{"key":"key\n\t\t\t\t20170411104657_CHAI-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Chai, N.N., Zhou, H., Hernandez, J. et al. (1998) Structure and organization of the RBMY genes on the human Y chromosome: translocation and amplification of an ancestral autosomal hnRNPG gene. Genomics, 49, 283\u2013289.","DOI":"10.1006\/geno.1998.5255"},{"key":"key\n\t\t\t\t20170411104657_CLEPET-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Clepet, C. Schafer, A.J., Sinclair, A.H. et al. (1993) The human SRY transcript. Hum. Mol. Genet., 2, 2007\u201312.","DOI":"10.1093\/hmg\/2.12.2007"},{"key":"key\n\t\t\t\t20170411104657_COOKE-AND-ELLIOTT-1997","doi-asserted-by":"crossref","unstructured":"Cooke, H. and Elliott, D.J. (1997) RNA-binding proteins and human male infertility. Trends Genet., 13, 87\u201389.","DOI":"10.1016\/S0168-9525(97)01066-4"},{"key":"key\n\t\t\t\t20170411104657_EBERHART-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Eberhart, C.G., Maines, J.Z. and Wasserman, S.A. (1996) Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia. Nature, 381, 783\u2013785.","DOI":"10.1038\/381783a0"},{"key":"key\n\t\t\t\t20170411104657_ELLIOTT-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Elliott, D.J., Millar, M.R., Oghene, K. et al. (1997) Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm. Proc. Natl. Acad. Sci. USA, 94, 3848\u20133853.","DOI":"10.1073\/pnas.94.8.3848"},{"key":"key\n\t\t\t\t20170411104657_ELLIOTT-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Elliott, D.J., Oghrene, K., Makarov, G. et al. (1998) Dynamic changes in the subnuclear organisation of pre-mRNA splicing proteins and RBM during human germ cell development. J. Cell. Sci., 111, 1255\u20131265.","DOI":"10.1242\/jcs.111.9.1255"},{"key":"key\n\t\t\t\t20170411104657_EDWARDS-AND-BISHOP-1997","doi-asserted-by":"crossref","unstructured":"Edwards, R.G. and Bishop, C.E. (1997) On the origin and frequency of Y chromosome deletions responsible for severe male infertility. Mol. Hum. Reprod., 3, 549\u2013554.","DOI":"10.1093\/molehr\/3.7.549"},{"key":"key\n\t\t\t\t20170411104657_FERLIN-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Ferlin, A., Moro, E., Garolla, A. and Foresta, C. (1999) Human male infertility and Y chromosome deletions: role of the AZF-candidate gene DAZ, RBM and DFFRY. Hum. Reprod, 14, 1710\u20131716.","DOI":"10.1093\/humrep\/14.7.1710"},{"key":"key\n\t\t\t\t20170411104657_FORESTA-AND-VAROTTO-1992","doi-asserted-by":"crossref","unstructured":"Foresta, C. and Varotto, A. (1992) Assessment of testicular cytology by fine needle aspiration as a diagnostic parameter in the evaluation of the oligozoospermic subject. Fertil. Steril., 58, 1028\u20131033.","DOI":"10.1016\/S0015-0282(16)55455-7"},{"key":"key\n\t\t\t\t20170411104657_FORESTA-ETAL-1992","doi-asserted-by":"crossref","unstructured":"Foresta, C., Varotto, A. and Scandellari, C. (1992) Assessment of testicular cytology by fine needle aspiration as a diagnostic parameter in the evaluation of the azoospermic subject. Fertil. Steril., 57, 858\u2013865.","DOI":"10.1016\/S0015-0282(16)54971-1"},{"key":"key\n\t\t\t\t20170411104657_FORESTA-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Foresta, C., Ferlin, A., Bettella, A. et al. (1995) Diagnostic and clinical features in azoospermia. Clin. Endocrinol., 43, 537\u2013543.","DOI":"10.1111\/j.1365-2265.1995.tb02917.x"},{"key":"key\n\t\t\t\t20170411104657_FORESTA-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Foresta, C., Ferlin, A., Garolla, A. et al. (1997) Y-chromosome deletions in idiopathic severe testiculopathies. J. Clin. Endocrinol. Metab., 82, 1075\u201380.","DOI":"10.1210\/jcem.82.4.3798"},{"key":"key\n\t\t\t\t20170411104657_FORESTA-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Foresta, C., Ferlin, A., Garolla, A. et al. (1998) High frequency of well-defined Y-chromosome deletions in idiopathic Sertoli cell-only syndrome. Hum. Reprod., 13, 302\u2013307.","DOI":"10.1093\/humrep\/13.2.302"},{"key":"key\n\t\t\t\t20170411104657_GIRARDI-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Girardi, S.K., Mielnik, A. and Schlegel, P.N. (1997) Submicroscopic deletions in the Y chromosome of infertile men. Hum. Reprod., 12, 1635\u20131641.","DOI":"10.1093\/humrep\/12.8.1635"},{"key":"key\n\t\t\t\t20170411104657_GLASER-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Gla\u0308ser, B., Herl, T., Taylor, K. et al. (1997) High resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin. Chrom. Res., 5, 23\u201330.","DOI":"10.1023\/A:1018437301461"},{"key":"key\n\t\t\t\t20170411104657_GLASER-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Gla\u0308ser, B, Yen, P.H. and Schempp, W. (1998) Fibre-fluorescence in situ hybridization unravels apparently seven DAZ genes or pseudogenes clustered within a Y-chromosome region frequently deleted in azoospermic males. Chromosome Res., 6, 481\u2013486.","DOI":"10.1023\/A:1009256613348"},{"key":"key\n\t\t\t\t20170411104657_GRIMALDI-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Grimaldi, P., Scarponi, C., Rossi, P. et al. (1998) Analysis of Yq microdeletions in infertile males by PCR and DNA hybridization techniques. Mol. Hum. Reprod., 4, 1116\u20131121.","DOI":"10.1093\/molehr\/4.12.1116"},{"key":"key\n\t\t\t\t20170411104657_HABERMANN-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Habermann, B., Mi, H.F., Edelmann, A. et al. (1998) DAZ (Deleted in Azoospermia) genes encode proteins located in human late spermatids and in sperm tails. Hum. Reprod., 13, 363\u2013368.","DOI":"10.1093\/humrep\/13.2.363"},{"key":"key\n\t\t\t\t20170411104657_KENT-FIRST-ETAL-1996A","doi-asserted-by":"crossref","unstructured":"Kent-First, M.G., Kol, S., Muallem, A. et al. (1996a) Infertility in intracytoplasmic sperm injection derived sons. Lancet, 348, 332.","DOI":"10.1016\/S0140-6736(05)64498-4"},{"key":"key\n\t\t\t\t20170411104657_KENT-FIRST-ETAL-1996B","doi-asserted-by":"crossref","unstructured":"Kent-First, M.G., Kol, S., Muallem, A. et al. (1996b) The incidence and possible relevance of Y-linked microdeletions in babies born after intracytoplasmic sperm injection and their infertile fathers. Mol. Hum. Reprod., 2, 943\u2013950.","DOI":"10.1093\/molehr\/2.12.943"},{"key":"key\n\t\t\t\t20170411104657_KLEIMAN-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Kleiman, S.E., Yogev, L., Gamzu, R. et al. (1999) Genetic evaluation of infertile men. Hum. Reprod., 14, 33\u201338.","DOI":"10.1093\/humrep\/14.1.33"},{"key":"key\n\t\t\t\t20170411104657_KOBAYASHI-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Kobayashi, K., Mizumo, K., Hida, A. et al. (1995) PCR analysis of the Y chromosome long arm in azoospermic patients: evidence for a second locus required for spermatogenesis. Hum. Mol. Genet., 3, 1965\u20131967.","DOI":"10.1093\/hmg\/3.11.1965"},{"key":"key\n\t\t\t\t20170411104657_LAHN-AND-PAGE-1997","doi-asserted-by":"crossref","unstructured":"Lahn, B.T. and Page, D.C. (1997) Functional coherence of the human Y chromosome. Science, 278, 675\u2013680.","DOI":"10.1126\/science.278.5338.675"},{"key":"key\n\t\t\t\t20170411104657_LEE-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Lee, J.H., Lee, D.R., Yoon, S.J. et al. (1998) Expression of DAZ (deleted in azoospermia), DAZL1 (DAZ-like) and protamine-2 in testis and its application for diagnosis of spermatogenesis in non-obstructive azoospermia. Mol. Hum. Reprod., 4, 827\u2013834.","DOI":"10.1093\/molehr\/4.9.827"},{"key":"key\n\t\t\t\t20170411104657_LIOW-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Liow, S.L., Ghadessy, F.J., Ng, S.C. et al. (1998) Y chromosome microdeletions, in azoospermic or near-azoospermic subjects, are located in the AZFc (DAZ) subregion. Mol. Hum. Reprod., 4, 763\u2013768.","DOI":"10.1093\/molehr\/4.8.763"},{"key":"key\n\t\t\t\t20170411104657_MA-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Ma, K., Inglis, J.D., Sharkey, A. et al. (1993) A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. Cell, 75, 1287\u20131295.","DOI":"10.1016\/0092-8674(93)90616-X"},{"key":"key\n\t\t\t\t20170411104657_MAZEYRAT-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Mazeyrat, S., Sant, N., Sargent, C.A. et al. (1998) The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region. Hum. Mol. Genet., 7, 1713\u20131724.","DOI":"10.1093\/hmg\/7.11.1713"},{"key":"key\n\t\t\t\t20170411104657_MCLACHLAN-ETAL-1998","doi-asserted-by":"crossref","unstructured":"McLachlan, R.I., Mallidis, C., Ma, K. et al. (1998) Genetic disorders and spermatogenesis. Reprod. Fertil. Dev., 10, 97\u2013104.","DOI":"10.1071\/R98029"},{"key":"key\n\t\t\t\t20170411104657_MENKE-ETAL-1997","unstructured":"Menke, D.B., Mutter, G.L. and Page, D.C. (1997) Expression of DAZ, an Azoospermia factor candidate, in human spermatogonia. Am. J. Hum. Genet., 60, 237\u2013240."},{"key":"key\n\t\t\t\t20170411104657_MULHALL-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Mulhall, J.P., Reijo, R., Alagappan, R. et al. (1997) Azoospermic men with deletion of the DAZ gene cluster are capable of completing spermatogenesis: fertilization, normal embryonic development and pregnancy occur when retrieved testicular spermatozoa are used for intracytoplasmic sperm injection. Hum. Reprod., 12, 503\u2013508.","DOI":"10.1093\/humrep\/12.3.503"},{"key":"key\n\t\t\t\t20170411104657_NAJMABADI-ETAL-1996","unstructured":"Najmabadi, H., Huang, V., Yen, P. et al. (1996) Substantial prevalence of microdeletions of the Y-chromosome in infertile men with idiopathic azoospermia and oligozoospermia detected using a sequence-tagged site-based mapping strategy. J. Clin. Endocrinol. Metab., 81, 1347\u20131352."},{"key":"key\n\t\t\t\t20170411104657_PROSSER-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Prosser, J., Inglis, J.D., Condie, A. et al (1996) Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene. Mamm. Genome, 7, 835\u2013842.","DOI":"10.1007\/s003359900246"},{"key":"key\n\t\t\t\t20170411104657_PRYOR-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Pryor, J.L., Kent-First, M., Muallem, A. et al. (1997) Microdeletions in the Y chromosome of infertile men. N. Engl. J. Med., 336, 534\u2013539.","DOI":"10.1056\/NEJM199702203360802"},{"key":"key\n\t\t\t\t20170411104657_QURESHI-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Qureshi, S.J., Ross, A.R., Ma, K. et al. (1996) Polymerase chain reaction screening for Y chromosome microdeletions: a first step towards the diagnosis of genetically-determined spermatogenic failure in men. Mol. Hum. Reprod., 2, 775\u2013779.","DOI":"10.1093\/molehr\/2.10.775"},{"key":"key\n\t\t\t\t20170411104657_REIJO-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Reijo, R., Lee, T., Salo, P. et al. (1995) Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nature Genet., 10, 383\u2013393.","DOI":"10.1038\/ng0895-383"},{"key":"key\n\t\t\t\t20170411104657_REIJO-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Reijo, R., Alagappan, R.K., Patrizio, P. et al. (1996) Severe oligozoospermia resulting from deletions of azoospermia factor gene on Y chromosome. Lancet, 347, 1290\u20131293.","DOI":"10.1016\/S0140-6736(96)90938-1"},{"key":"key\n\t\t\t\t20170411104657_ROSSATO-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Rossato, M., Ferlin, A., Garolla, A. et al. (1998) High fertilization rate in conventional in-vitro fertilization utilizing spermatozoa from an oligozoospermic subject presenting microdeletions of the Y chromosome long arm. Mol. Hum. Reprod., 4, 473\u2013476.","DOI":"10.1093\/molehr\/4.5.473"},{"key":"key\n\t\t\t\t20170411104657_SAXENA-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Saxena,R ., Brown, L., Hawkins, T. et al. (1996) The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. Nature Genet., 14, 292\u2013299.","DOI":"10.1038\/ng1196-292"},{"key":"key\n\t\t\t\t20170411104657_SILBER-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Silber, S.J., Alagappan, R., Brown, L.G. et al. (1998) Y chromosome deletions in azoospermic and severely oligozoospermic men undergoing intracytoplasmic sperm injection after testicular sperm extraction. Hum. Reprod., 13, 3332\u20133337.","DOI":"10.1093\/humrep\/13.12.3332"},{"key":"key\n\t\t\t\t20170411104657_SIMONI-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Simoni, M., Gromoll, J., Dworniczak, B. et al. (1997) Screening for deletions of the Y chromosome involving the DAZ (Deleted in AZoospermia) gene in azoospermia and severe oligozoospermia. Fertil. Steril., 67, 542\u2013547.","DOI":"10.1016\/S0015-0282(97)80083-0"},{"key":"key\n\t\t\t\t20170411104657_SINCLAIR-ETAL-1990","doi-asserted-by":"crossref","unstructured":"Sinclair, A.H., Berta, P., Palmer, M.S. et al. (1990) A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature, 346, 240\u2013244.","DOI":"10.1038\/346240a0"},{"key":"key\n\t\t\t\t20170411104657_STUPPIA-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Stuppia, L., Mastroprimiano, G., Calabrese, G. et al. (1996) Microdeletions in interval 6 of the human Y chromosome detected by STS-PCR in 6 of 33 patients with idiopathic oligo-azoospermia. Cytogenet. Cell. Genet., 72, 155\u2013158.","DOI":"10.1159\/000134174"},{"key":"key\n\t\t\t\t20170411104657_STUPPIA-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Stuppia, L., Gatta, V., Mastroprimiano, G. et al. (1997) Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene. J. Med. Genet., 34, 881\u2013883.","DOI":"10.1136\/jmg.34.11.881"},{"key":"key\n\t\t\t\t20170411104657_TRICOLI-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Tricoli, J.V., Yoo, J.L., D'Souza, S.A. et al. (1993) Detection of sex-region Y (SRY) transcripts in human prostate adenocarcinoma and benign prostate hypertrophy. Genes Chromosomes Cancer, 8, 28\u201333.","DOI":"10.1002\/gcc.2870080106"},{"key":"key\n\t\t\t\t20170411104657_VEREB-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Vereb, M., Agulnik, A.I., Houston, J.T. et al. (1997) Absence of DAZ gene mutations in cases of non-obstructed azoospermia. Mol. Hum. Reprod., 3, 55\u201359.","DOI":"10.1093\/molehr\/3.1.55"},{"key":"key\n\t\t\t\t20170411104657_VOGT-1998","doi-asserted-by":"crossref","unstructured":"Vogt, P.H. (1998) Human chromosome deletions in Yq11, AZF candidate genes and male infertility: history and update. Mol. Hum. Reprod., 4, 739\u2013744.","DOI":"10.1093\/molehr\/4.8.739"},{"key":"key\n\t\t\t\t20170411104657_VOGT-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Vogt, P.H., Edelmann, A., Kirsch, S. et al. (1996) Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. Hum. Mol. Genet., 5, 933\u2013943.","DOI":"10.1093\/hmg\/5.7.933"},{"key":"key\n\t\t\t\t20170411104657_VOGT-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Vogt, P.H., Affara, N., Davey, P. et al. (1997) Report of the third international workshop on Y chromosome mapping 1997. Cytogenet. Cell. Genet., 79, 1\u201320.","DOI":"10.1159\/000134680"},{"key":"key\n\t\t\t\t20170411104657_VOLLRATH-ETAL-1992","doi-asserted-by":"crossref","unstructured":"Vollrath, D., Foote, S., Hilton, A. et al. (1992) The human Y chromosome: a 43-interval map based on naturally occurring deletions. Science, 258, 52\u201359.","DOI":"10.1126\/science.1439769"},{"key":"key\n\t\t\t\t20170411104657_YEN-1998","doi-asserted-by":"crossref","unstructured":"Yen, P.H. (1998) A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males. Genomics, 54, 5\u201312.","DOI":"10.1006\/geno.1998.5526"},{"key":"key\n\t\t\t\t20170411104657_YEN-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Yen, P.H., Chai, N.N. and Salido, E.C. (1997) The human DAZ genes, a putative male infertility factor on the Y chromosome, are highly polymorphic in the DAZ repeat regions. Mamm. Genome, 8, 756\u2013759.","DOI":"10.1007\/s003359900560"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/14\/9\/2286\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T03:32:32Z","timestamp":1682220752000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article-lookup\/doi\/10.1093\/humrep\/14.9.2286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1999,9,1]]},"published-print":{"date-parts":[[1999,9]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/14.9.2286","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published":{"date-parts":[[1999,9]]}}}