{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:02:06Z","timestamp":1791388926021,"version":"4.3.3"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["81571439"],"award-info":[{"award-number":["81571439"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Research & Development Program of China","award":["2016YFC1000206-5"],"award-info":[{"award-number":["2016YFC1000206-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>Do cumulative live birth rates (CLBRs) after one complete ART cycle differ between the three commonly used controlled ovarian stimulation (COS) protocols (GnRH antagonist, depot GnRHa (GnRH agonist) and long GnRHa) in normal responders undergoing IVF\/ICSI?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>There were similar CLBRs between the GnRH antagonist, depot GnRHa and long GnRHa protocols.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>There is no consensus on which COS protocol is the most optimal in women with normal ovarian response. The CLBR provides the final success rate after one complete ART cycle, including the fresh and all subsequent frozen\u2013thawed embryo transfer (ET) cycles. We suggest that the CLBR measure would allow for better comparisons between the different treatment protocols.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>A prospective controlled, randomized, open label trial was performed between May 2016 and May 2017. A total of 819 patients were allocated to the GnRH antagonist, depot GnRHa or long GnRHa protocol in a 1:1:1 ratio. The minimum follow-up time from the first IVF cycle was 2\u00a0years. To further investigate the potential effect of COS with the GnRH antagonist, depot GnRHa or long GnRHa protocol on endometrial receptivity, the expression of homeobox A10 (HOXA10), myeloid ecotropic viral integration site 1 (MEIS1) and leukemia inhibitory factor (LIF) endometrial receptivity markers was evaluated in endometrial tissue from patients treated with the different COS protocols.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>Infertile women with normal ovarian response (n\u2009=\u2009819) undergoing IVF\/ICSI treatment were randomized to the GnRH antagonist, depot GnRHa or long GnRHa protocol. Both IVF and ICSI cycles were included, and the sperm samples used were either fresh or frozen partner ejaculates or frozen donor ejaculates. The primary outcome was the live birth rate (LBR) per fresh ET cycle, and the CLBR after one complete ART cycle, until the birth of a first child (after 28\u00a0weeks) or until all frozen embryos were used, whichever occurred first. Pipelle endometrial biopsies from 34 female patients were obtained on Days 7\u20138 after oocyte retrieval or spontaneous ovulation in natural cycles, respectively, and HOXA10, MEIS1 and LIF mRNA and protein expression levels in the human endometrium was determined by quantitative real-time PCR and western blot, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>There were no significant differences in CLBRs between the GnRH antagonist, depot GnRHa or long GnRHa protocol (71.4 versus 75.5 versus 72.2%, respectively). However, there was a significantly higher LBR per fresh ET cycle in the depot GnRHa protocol than in the long GnRHa and GnRH antagonist protocols (62.6 versus 52.1% versus 45.6%, P\u2009&amp;lt;\u20090.05). Furthermore, HOXA10, MEIS1 and LIF mRNA and protein expression in endometrium all showed significantly higher in the depot GnRHa protocol than in the long GnRHa and GnRH antagonist protocols (P\u2009&amp;lt;\u20090.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>A limitation of our study was that both our clinicians and patients were not blinded to the randomization for the randomized controlled trial (RCT). An inclusion criterion for the current retrospective cohort study was based on the \u2018actual ovarian response\u2019 during COS treatment, while the included population for the RCT was \u2018expected normal responders\u2019 based on maternal age and ovarian reserve test. In addition, the analysis was restricted to patients under 40\u00a0years of age undergoing their first IVF cycle. Furthermore, the endometrial tissue was collected from patients who cancelled the fresh ET, which may include some patients at risk for ovarian hyperstimulation syndrome, however only patients with 4\u201319 oocytes retrieved were included in the molecular study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>The depot GnRH agonist protocol improves the live birth rate per fresh ET cycle, but not the cumulative live birth rate in normal responders. A possible explanation for the improved LBR after fresh ET in the depot GnRHa protocol could be molecular signalling at the level of endometrial receptivity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>This project was funded by Grant 81571439 from the National Natural Sciences Foundation of China and Grant 2016YFC1000206-5 from the National Key Research &amp; Development Program of China. The authors declare no conflict of interest.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>The RCT trial was registered at the Chinese Clinical Trial Registry, Study Number: ChiCTR-INR-16008220.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION DATE<\/jats:title>\n                  <jats:p>5 April 2016.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DATE OF FIRST PATIENT\u2019S ENROLLMENT<\/jats:title>\n                  <jats:p>12 May 2016<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/deaa086","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T11:22:14Z","timestamp":1585740134000},"page":"1306-1318","source":"Crossref","is-referenced-by-count":96,"title":["The depot GnRH agonist protocol improves the live birth rate per fresh embryo transfer cycle, but not the cumulative live birth rate in normal responders: a randomized controlled trial and molecular mechanism study"],"prefix":"10.1093","volume":"35","author":[{"given":"Bei","family":"Xu","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, 1095 JieFang Avenue, Wuhan 430030, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Geerts","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Amsterdam University Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiao","family":"Hu","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, 1095 JieFang Avenue, Wuhan 430030, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yue","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, 1095 JieFang Avenue, Wuhan 430030, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Li","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, 1095 JieFang Avenue, Wuhan 430030, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijin","family":"Zhu","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, 1095 JieFang Avenue, Wuhan 430030, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, 1095 JieFang Avenue, Wuhan 430030, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"2020062517040836800_ref1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1196\/annals.1335.020","article-title":"Leukemia inhibitory factor and human embryo implantation","volume":"1034","author":"Aghajanova","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"2020062517040836800_ref2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/GCO.0b013e32833848e5","article-title":"Update on the role of leukemia inhibitory factor in assisted reproduction","volume":"22","author":"Aghajanova","year":"2010","journal-title":"Curr Opin Obstet Gynecol"},{"key":"2020062517040836800_ref3","first-page":"CD002808","article-title":"Depot versus daily administration of gonadotrophin-releasing hormone agonist protocols for pituitary down regulation in assisted reproduction cycles","volume":"1","author":"Albuquerque","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2020062517040836800_ref4","first-page":"CD001750","article-title":"Gonadotrophin-releasing hormone antagonists for assisted reproductive technology","volume":"5","author":"Al-Inany","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"2020062517040836800_ref4a","first-page":"CD001750","article-title":"Gonadotrophin-releasing hormone antagonists for assisted reproductive technology","volume":"29","author":"Al-Inany","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2020062517040836800_ref5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1472-6483(10)60426-9","article-title":"Frozen-thawed cleavage-stage embryo transfer cycles after previous GnRHa or antagonist stimulation","volume":"18","author":"Bahceci","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"2020062517040836800_ref6","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1096\/fasebj.14.9.1101","article-title":"In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing m\u0171llerian system","volume":"14","author":"Block","year":"2000","journal-title":"FASEB J"},{"key":"2020062517040836800_ref7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/09513599209015549","article-title":"Pituitary and ovarian suppression after early follicular and mid-luteal administration of a LHRH agonist in a depot formulation: Decapeptyl CR","volume":"6","author":"Broekmans","year":"1992","journal-title":"Gynecol Endocrinol"},{"key":"2020062517040836800_ref8","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1210\/endo.141.12.7855","article-title":"Leukemia inhibitory factor can substitute for nidatory estrogen and is essential to inducing a receptive uterus for implantation but is not essential for subsequent embryogenesis","volume":"141","author":"Chen","year":"2000","journal-title":"Endocrinology"},{"key":"2020062517040836800_ref10","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.fertnstert.2012.07.1107","article-title":"Outcomes of vitrified early cleavage-stage and blastocyst-stage embryos in a cryopreservation program: evaluation of 3,150 warming cycles","volume":"98","author":"Cobo","year":"2012","journal-title":"Fertil Steril"},{"key":"2020062517040836800_ref11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/humrep\/dev270","article-title":"How do cumulative live birth rates and cumulative multiple live birth rates over complete courses of assisted technology treatment per woman compare among registries?","volume":"31","author":"De Neubourg","year":"2016","journal-title":"Hum Reprod"},{"key":"2020062517040836800_ref12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1477-7827-10-26","article-title":"GnRHa versus GnRH antagonist in in vitro fertilization and embryo transfer (IVF\/ET)","volume":"10","author":"Depalo","year":"2012","journal-title":"Reprod Biol Endocrinol"},{"key":"2020062517040836800_ref13","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0140-6736(10)60490-4","article-title":"Endometriosis and infertility: pathophysiology and management","volume":"376","author":"Ziegler","year":"2010","journal-title":"Lancet"},{"key":"2020062517040836800_ref14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2174\/138920309789630561","article-title":"Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: class-I cytokines involved in the neuroendocrine regulation of the reproductive function","volume":"10","author":"Dozio","year":"2009","journal-title":"Curr Protein Pept Sci"},{"key":"2020062517040836800_ref15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1472-6483(10)60781-X","article-title":"Similar outcome for cryopreserved embryo transfer following GnRH-antagonist\/GnRH-agonist, GnRH-antagonist\/HCG or long protocol ovarian stimulation","volume":"14","author":"Eldar-Geva","year":"2007","journal-title":"Reprod Biomed Online"},{"key":"2020062517040836800_ref16","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0015-0282(00)00518-5","article-title":"Blastocyst score affects implantation and pregnancy outcome","volume":"73","author":"Gardner","year":"2000","journal-title":"Fertil Steril"},{"key":"2020062517040836800_ref17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/09513590.2018.1528221","article-title":"GnRH antagonist versus follicular-phase single-dose GnRHa protocol in patients of normal ovarian response during controlled ovarian stimulation","volume":"35","author":"Geng","year":"2019","journal-title":"Gynecol Endocrinol"},{"key":"2020062517040836800_ref18","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1093\/humrep\/der178","article-title":"Final ART success rates: a 10 years survey","volume":"26","author":"Gnoth","year":"2011","journal-title":"Hum Reprod"},{"key":"2020062517040836800_ref19","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.fertnstert.2014.05.036","article-title":"Regulation of myeloid ecotropic viral integration site 1 and its expression in normal and abnormal endometrium","volume":"102","author":"Hu","year":"2014","journal-title":"Fertil Steril"},{"key":"2020062517040836800_ref20","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/humupd\/dmx017","article-title":"GnRH antagonist versus long agonist protocols in IVF: a systematic review and meta-analysis accounting for patient type","volume":"23","author":"Lambalk","year":"2017","journal-title":"Hum Reprod Update"},{"key":"2020062517040836800_ref21","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.fertnstert.2007.01.013","article-title":"Cryopreserved blastocyst transfer: impact of gonadotropin-releasing hormone agonist versus antagonist in the previous oocyte retrieval cycles","volume":"88","author":"Lee","year":"2007","journal-title":"Fertil Steril"},{"key":"2020062517040836800_ref22","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.fertnstert.2013.07.1976","article-title":"Dual trigger with combination of gonadotropin-releasing hormone agonist and human chorionic gonadotropin significantly improves the live-birth rate for normal responders in GnRH-antagonist cycles","volume":"100","author":"Lin","year":"2013","journal-title":"Fertil Steril"},{"key":"2020062517040836800_ref23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2020062517040836800_ref24","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1056\/NEJMoa1110238","article-title":"Cumulative birth rates with linked assisted reproductive technology cycles","volume":"366","author":"Luke","year":"2012","journal-title":"N Engl J Med"},{"key":"2020062517040836800_ref25","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1210\/me.2006-0270","article-title":"Leukemia inhibitory factor induces the chemomigration of immortalized gonadotropin-releasing hormone neurons through the independent activation of the Janus kinase\/signal transducer and activator of transcription 3, mitogen-activated protein kinase\/extracellularly regulated kinase 1\/2, and phosphatidylinositol 3-kinase\/Akt signaling pathways","volume":"21","author":"Magni","year":"2007","journal-title":"Mol Endocrinol"},{"key":"2020062517040836800_ref26","first-page":"2703","article-title":"Cumulative live birth rate: time for a consensus?","volume":"30","author":"Maheshwari","year":"2015","journal-title":"Hum Reprod"},{"key":"2020062517040836800_ref27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5114\/aoms.2014.40743","article-title":"Comparisons of the effects of long-acting and short-acting GnRHas on embryo quality, endometrial thickness and pregnancy rate in human in vitro fertilization","volume":"10","author":"Mao","year":"2014","journal-title":"Arch Med Sci"},{"key":"2020062517040836800_ref28","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/humrep\/dev336","article-title":"Cumulative live birth rates after one or more complete cycles of IVF: a population-based study of linked cycle data from 178,898 women","volume":"31","author":"McLernon","year":"2016","journal-title":"Hum Reprod"},{"key":"2020062517040836800_ref29","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0015-0282(16)55188-7","article-title":"Ovarian hyperstimulation syndrome in novel reproductive technologies: prevention and treatment","volume":"58","author":"Navot","year":"1992","journal-title":"Fertil Steril"},{"key":"2020062517040836800_ref30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1477-7827-8-107","article-title":"Administration of single-dose GnRHa in the luteal phase in ICSI cycles: a meta-analysis","volume":"8","author":"Oliveira","year":"2010","journal-title":"Reprod Biol Endocrinol"},{"key":"2020062517040836800_ref31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.fertnstert.2014.03.030","article-title":"Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?","volume":"102","author":"Ren","year":"2014","journal-title":"Fertil Steril"},{"key":"2020062517040836800_ref32","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1093\/humrep\/del215","article-title":"Ovarian stimulation with GnRHa, but not GnRH antagonist, partially restores the expression of endometrial integrin beta3 and leukaemia-inhibitory factor and improves uterine receptivity in mice","volume":"21","author":"Ruan","year":"2006","journal-title":"Hum Reprod"},{"key":"2020062517040836800_ref33","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/374460a0","article-title":"Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice","volume":"374","author":"Satokata","year":"1995","journal-title":"Nature"},{"key":"2020062517040836800_ref34","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1210\/jc.2004-0817","article-title":"HOXA10, Pbx2, and Meis1 protein expression in the human endometrium: formation of multimeric complexes on HOXA10 target genes","volume":"90","author":"Sarno","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2020062517040836800_ref35","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.fertnstert.2007.07.1316","article-title":"Can pregnancy rate be improved in gonadotropin-releasing hormone(GnRH) antagonist cycles by administering GnRHa before oocyte retrieval? A prospective, randomized study","volume":"90","author":"Schachter","year":"2008","journal-title":"Fertil Steril"},{"key":"2020062517040836800_ref36","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1128\/MCB.17.11.6448","article-title":"Abd-B-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins","volume":"17","author":"Shen","year":"1997","journal-title":"Mol Cell Biol"},{"key":"2020062517040836800_ref37","first-page":"CD006919","article-title":"Gonadotrophin-releasing hormone agonist protocols for pituitary suppression in assisted reproduction","volume":"11","author":"Siristatidis","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2020062517040836800_ref38","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118816835","article-title":"Endometrial but not ovarian response is associated with clinical outcomes and can be improved by prolonged pituitary downregulation in patients with thin and medium endometrium","author":"Song","year":"2018","journal-title":"Reprod Sci"},{"key":"2020062517040836800_ref39","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/359076a0","article-title":"Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor","volume":"359","author":"Stewart","year":"1992","journal-title":"Nature"},{"key":"2020062517040836800_ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6606a1","article-title":"Assisted reproductive technology surveillance - United States, 2014","volume":"66","author":"Sunderam","year":"2017","journal-title":"MMWR Surveill Summ"},{"key":"2020062517040836800_ref43","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1095\/biolreprod57.6.1338","article-title":"A conserved Hox axis in the mouse and human reproductive system: late establishment and persistent expression of the Hoxa cluster genes","volume":"57","author":"Taylor","year":"1997","journal-title":"Biol Reprod"},{"key":"2020062517040836800_ref44","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/humupd\/6.1.75","article-title":"The role of HOX genes in human implantation","volume":"6","author":"Taylor","year":"2000","journal-title":"Hum Reprod Update"},{"key":"2020062517040836800_ref45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1055\/s-2000-13478","article-title":"The role of HOX genes in the development and function of the female reproductive tract","volume":"18","author":"Taylor","year":"2000","journal-title":"Semin Reprod Med"},{"key":"2020062517040836800_ref46","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/humrep\/dew051","article-title":"Risk of severe ovarian hyperstimulation syndrome in GnRH antagonist versus GnRHa protocol: RCT including 1050 first IVF\/ICSI cycles","volume":"31","author":"Toftager","year":"2016","journal-title":"Hum Reprod"},{"key":"2020062517040836800_ref47","first-page":"556","article-title":"Cumulative live birth rates after one ART cycle including all subsequent frozen-thaw cycles in 1050 women: secondary outcome of an RCT comparing GnRH-antagonist and GnRH-agonist protocols","volume":"32","author":"Toftager","year":"2017","journal-title":"Hum Reprod"},{"key":"2020062517040836800_ref48","article-title":"Comparisons of GnRH antagonist protocol versus GnRHa long protocol in patients with normal ovarian reserve: a systematic review and meta-analysis","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"2020062517040836800_ref49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2014.05.027","article-title":"Cryopreservation of human embryos and its contribution to in vitro fertilization success rates","volume":"102","author":"Wong","year":"2014","journal-title":"Fertil Steril"},{"key":"2020062517040836800_ref50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106854","article-title":"Comparisons of GnRH antagonist versus GnRHa protocol in supposed normal ovarian responders undergoing IVF: a systematic review and meta-analysis","volume":"9","author":"Xiao","year":"2014","journal-title":"PLoS One"},{"key":"2020062517040836800_ref51","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/humrep\/den082","article-title":"Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation","volume":"23","author":"Xu","year":"2008","journal-title":"Hum Reprod"},{"key":"2020062517040836800_ref52","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/humrep\/deu004","article-title":"Regulation of endometrial receptivity by the highly expressed HOXA9, HOXA11 and HOXD10 HOX-class homeobox genes","volume":"29","author":"Xu","year":"2014","journal-title":"Hum Reprod"},{"key":"2020062517040836800_ref53","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.fertnstert.2012.03.014","article-title":"Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles","volume":"97","author":"Xu","year":"2012","journal-title":"Fertil Steril"},{"key":"2020062517040836800_ref54","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.fertnstert.2018.02.001","article-title":"Cumulative live birth rates in more than 3,000 patients with poor ovarian response: a 15-year survey of final in vitro fertilization outcome","volume":"109","author":"Xu","year":"2018","journal-title":"Fertil Steril"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/35\/6\/1306\/33428875\/deaa086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/35\/6\/1306\/33428875\/deaa086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T21:05:15Z","timestamp":1593119115000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/35\/6\/1306\/5849415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,1]]},"published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaa086","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,6]]},"published":{"date-parts":[[2020,6,1]]}}}