{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:56:15Z","timestamp":1781013375949,"version":"3.54.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"Abstract<\/jats:title>\n \n STUDY QUESTION<\/jats:title>\n What is the impact of a late follicular phase progesterone elevation (LFPE) during controlled ovarian hyperstimulation (COH) on embryonic competence and reproductive potential in thaw cycles of preimplantation genetic testing for aneuploidy (PGT-A) screened embryos?<\/jats:p>\n <\/jats:sec>\n \n SUMMARY ANSWER<\/jats:title>\n Our study findings suggest that LFPE, utilizing a progesterone cutoff value of 2.0 ng\/ml, is neither associated with impaired embryonic development, increased rate of embryonic aneuploidy, nor compromised implantation and pregnancy outcomes following a euploid frozen embryo transfer (FET) cycle.<\/jats:p>\n <\/jats:sec>\n \n WHAT IS KNOWN ALREADY<\/jats:title>\n Premature progesterone elevation during COH has been associated with lower pregnancy rates due to altered endometrial receptivity in fresh IVF cycles. Also, increased levels of progesterone (P) have been suggested to be a marker for ovarian dysfunction, with some evidence to show an association between LFPE and suboptimal embryonic development. However, the effect of LFPE on embryonic competence is still controversial.<\/jats:p>\n <\/jats:sec>\n \n STUDY DESIGN, SIZE, DURATION<\/jats:title>\n Retrospective cohort analysis in a single, academic ART center from September 2016 to March 2020. In total, 5244 COH cycles for IVF\/PGT-A were analyzed, of those 5141 were included in the analysis. A total of 23\u00a0991 blastocysts underwent trophectoderm biopsy and PGT analysis. Additionally, the clinical IVF outcomes of 5806 single euploid FET cycles were evaluated.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n Cohorts were separated in two groups: Group 1: oocytes retrieved from cycles with normal P levels during ovulation trigger (P\u2009\u2264\u20092.0 ng\/ml); Group 2: oocytes retrieved after cycles in which LFPE was noted (P\u2009&gt;\u20092.0 ng\/ml). Extended culture and PGT-A was performed. Secondly, IVF outcomes after a single euploid FET were evaluated for each cohort.<\/jats:p>\n <\/jats:sec>\n \n MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n Four thousand nine hundred and twenty-five cycles in Group 1 were compared with 216 cycles on Group 2. Oocyte maturity rates, fertilization rates and blastulation rates were comparable among groups. A 65.3% (n\u2009=\u200922\u00a0654) rate of utilizable blastocysts was found in patients with normal P levels and were comparable to the 62.4% (n\u2009=\u20091337) observed in those with LFPE (P\u2009=\u20090.19). The euploidy rates were 52.8% (n\u2009=\u200911\u00a0964) and 53.4% (n\u2009=\u2009714), respectively, albeit this difference was not statistically significant (P\u2009=\u20090.81). Our multivariate analysis was fitted with a generalized estimating equation (GEE) and no association was found with LFPE and an increased odds of embryo aneuploidy (adjusted odds ratio 1.04 95% CI 0.86\u20131.27, P\u2009=\u20090.62). A sub-analysis of subsequent 5806 euploid FET cycles (normal P: n\u2009=\u20095617 cycles and elevated P: n\u2009=\u2009189 cycles) showed no differences among groups in patient\u2019s BMI, Anti-M\u00fcllerian hormone (AMH), endometrial thickness at FET and number of prior IVF cycles. However, a significant difference was found in patient\u2019s age and oocyte age. The number of good quality embryos transferred, implantation rate, clinical pregnancy rate, ongoing pregnancy rate, multiple pregnancy rate and clinical pregnancy loss rates were comparable among groups. Of the registered live births (normal P group: n\u2009=\u20092198; elevated P group: n\u2009=\u200952), there were no significant differences in gestational age weeks (39.0\u2009\u00b1\u20091.89 versus 39.24\u2009\u00b1\u20091.53, P\u2009=\u20090.25) and birth weight (3317\u2009\u00b1\u2009571.9 versus 3 266\u2009\u00b1\u2009455.8 g, P\u2009=\u20090.26) at delivery, respectively.<\/jats:p>\n <\/jats:sec>\n \n LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n The retrospective nature of the study and probable variability in the study center\u2019s laboratory protocol(s), selected progesterone cutoff value and progesterone assay techniques compared to other ART centers may limit the external validity of our findings.<\/jats:p>\n <\/jats:sec>\n \n WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n Based on robust sequencing data from a large cohort of embryos, we conclude that premature P elevation during IVF stimulation does not predict embryonic competence. Our study results show that LFPE is neither associated with impaired embryonic development nor increased rates of aneuploidy. Embryos obtained from cycles with LFPE can be selected for transfer, and patients can be reassured that the odds of achieving a healthy pregnancy are similar to the embryos exposed during COH cycles to physiologically normal P levels.<\/jats:p>\n <\/jats:sec>\n \n STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n No funding was received for the realization of this study. Dr A.B.C. is advisor and\/or board member of Sema 4 (Stakeholder in data), Progyny and Celmatix. The other authors have no conflicts of interest to declare.<\/jats:p>\n <\/jats:sec>\n \n TRIAL REGISTRATION NUMBER<\/jats:title>\n NA<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humrep\/deaa123","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T19:17:20Z","timestamp":1588792640000},"page":"1889-1899","source":"Crossref","is-referenced-by-count":34,"title":["Late follicular phase progesterone elevation during ovarian stimulation is not associated with decreased implantation of chromosomally screened embryos in thaw cycles"],"prefix":"10.1093","volume":"35","author":[{"given":"Carlos","family":"Hernandez-Nieto","sequence":"first","affiliation":[{"name":"Reproductive Medicine Associates of New York, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A","family":"Lee","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Associates of New York, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Alkon-Meadows","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Associates of New York, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Luna-Rojas","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Associates of New York, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmoy","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Associates of New York, New York, NY, USA"},{"name":"Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan B","family":"Copperman","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Associates of New York, New York, NY, USA"},{"name":"Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Sandler","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Associates of New York, New York, NY, USA"},{"name":"Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"2020080315204265500_deaa123-B1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1477-7827-12-128","article-title":"Human steroidogenesis: implications for controlled ovarian stimulation with exogenous gonadotropins","volume":"12","author":"Andersen","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"key":"2020080315204265500_deaa123-B2","first-page":"e91","article-title":"High progesterone levels on the day of HCG administration do not affect the embryo quality and the reproductive outcomes of frozen embryo transfers","volume":"169","author":"Baldini","year":"2018","journal-title":"Clin Ter"},{"key":"2020080315204265500_deaa123-B3","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1093\/humrep\/deq125","article-title":"Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles","volume":"25","author":"Bosch","year":"2010","journal-title":"Hum Reprod"},{"key":"2020080315204265500_deaa123-B4","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.fertnstert.2003.07.002","article-title":"Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome","volume":"80","author":"Bosch","year":"2003","journal-title":"Fertil Steril"},{"key":"2020080315204265500_deaa123-B5"},{"key":"2020080315204265500_deaa123-B6","year":"2007"},{"key":"2020080315204265500_deaa123-B82228885","article-title":"level progesterone\/estradiolratio on the day of hCG administration: detrimental cutoff levels new treatmentstrategy","volume":"95","author":"Progesterone","year":"2011","journal-title":"Fertil Steril"},{"key":"2020080315204265500_deaa123-B7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/humupd\/dmn019","article-title":"Progesterone elevation on the day of hCG: methodological issues","volume":"14","author":"Fleming","year":"2008","journal-title":"Hum Reprod Update"},{"key":"2020080315204265500_deaa123-B8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s10815-017-0927-1","article-title":"DHEA supplementation can result in assay changes which may impact clinical decisions in IVF","volume":"34","author":"Franasiak","year":"2017","journal-title":"J Assist Reprod Genet"},{"key":"2020080315204265500_deaa123-B9","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/humrep\/dez091","article-title":"Clinically significant intra-day variability of serum progesterone levels during the final day of oocyte maturation: a prospective study with repeated measurements","volume":"34","author":"Gonz\u00e1lez-Foruria","year":"2019","journal-title":"Hum Reprod"},{"key":"2020080315204265500_deaa123-B10","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.fertnstert.2013.08.045","article-title":"Progesterone elevation does not compromise pregnancy rates in high responders: a pooled analysis of in vitro fertilization patients treated with recombinant follicle-stimulating hormone\/gonadotropin-releasing hormone antagonist in six trials","volume":"100","author":"Griesinger","year":"2013","journal-title":"Fertil Steril"},{"key":"2020080315204265500_deaa123-B11","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1093\/humrep\/dez129","article-title":"What is the reproductive potential of day 7 euploid embryos?","volume":"34","author":"Hernandez-Nieto","year":"2019","journal-title":"Hum Reprod"},{"key":"2020080315204265500_deaa123-B12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/humupd\/dml046","article-title":"Wide genomic analysis of human endometrial receptivity: new times, new opportunities","volume":"13","author":"Horcajadas","year":"2007","journal-title":"Hum Reprod Update"},{"key":"2020080315204265500_deaa123-B13","doi-asserted-by":"crossref","first-page":"e0145895","DOI":"10.1371\/journal.pone.0145895","article-title":"Elevated progesterone levels on the day of oocyte maturation may affect top quality embryo IVF cycles","volume":"11","author":"Huang","year":"2016","journal-title":"PLoS One"},{"key":"2020080315204265500_deaa123-B14","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s10815-019-01598-4","article-title":"Revisiting debates of premature luteinization and its effect on assisted reproductive technology outcome","volume":"36","author":"Hussein","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"2020080315204265500_deaa123-B15","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s10815-018-1264-8","article-title":"The curious case of premature luteinization","volume":"35","author":"Kaponis","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"2020080315204265500_deaa123-B16","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s10815-016-0752-y","article-title":"Is it the egg or the endometrium? Elevated progesterone on day of trigger is not associated with embryo ploidy nor decreased success rates in subsequent embryo transfer cycles","volume":"33","author":"Kofinas","year":"2016","journal-title":"J Assist Reprod Genet"},{"key":"2020080315204265500_deaa123-B17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.fertnstert.2004.01.027","article-title":"Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists","volume":"82","author":"Kolibianakis","year":"2004","journal-title":"Fertil Steril"},{"key":"2020080315204265500_deaa123-B18","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.rbmo.2014.08.009","article-title":"Double stimulation during the follicular and luteal phases of poor responders in IVF\/ICSI programmes (Shanghai protocol)","volume":"29","author":"Kuang","year":"2014","journal-title":"Reprod Biomed Online"},{"key":"2020080315204265500_deaa123-B19","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.fertnstert.2011.08.029","article-title":"Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial","volume":"96","author":"Kyrou","year":"2011","journal-title":"Fertil Steril"},{"key":"2020080315204265500_deaa123-B20","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1093\/humrep\/der126","article-title":"Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis","volume":"26","author":"Labarta","year":"2011","journal-title":"Hum Reprod"},{"key":"2020080315204265500_deaa123-B21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00404-011-2045-0","article-title":"Elevated progesterone in GnRH agonist down regulated in vitro fertilization (IVFICSI) cycles reduces live birth rates but not embryo quality","volume":"285","author":"Lahoud","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"2020080315204265500_deaa123-B22","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.rbmo.2017.01.011","article-title":"Effect of progesterone elevation in follicular phase of IVF-cycles on the endometrial receptivity","volume":"34","author":"Lawrenz","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"2020080315204265500_deaa123-B23","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.fertnstert.2018.02.128","article-title":"Premature progesterone elevation: targets and rescue strategies","volume":"109","author":"Lawrenz","year":"2018","journal-title":"Fertil Steril"},{"key":"2020080315204265500_deaa123-B24","doi-asserted-by":"crossref","first-page":"e0206098","DOI":"10.1371\/journal.pone.0206098","article-title":"Inter-assay variation and reproducibility of progesterone measurements during ovarian stimulation for IVF","volume":"13","author":"Lawrenz","year":"2018","journal-title":"PLoS One"},{"key":"2020080315204265500_deaa123-B25","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/jez.1402660208","article-title":"Effect of follicle cells and steroidogenesis on maturation and fertilization in vitro of pig oocytes","volume":"266","author":"Nagai","year":"1993","journal-title":"J Exp Zool"},{"key":"2020080315204265500_deaa123-B26","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/humrep\/dex010","article-title":"FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization","volume":"32","author":"Oktem","year":"2017","journal-title":"Hum Reprod"},{"key":"2020080315204265500_deaa123-B27","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.rbmo.2017.06.002","article-title":"Random-start ovarian stimulation in women desiring elective cryopreservation of oocytes","volume":"35","author":"Pereira","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"2020080315204265500_deaa123-B6671020","volume":"35","author":"Racca","year":"2020","journal-title":"Hum\u00a0 Reprod"},{"key":"2020080315204265500_deaa123-B28","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/humrep\/dey031","article-title":"Impact of late-follicular phase elevated serum progesterone on cumulative live birth rates: is there a deleterious effect on embryo quality?","volume":"33","author":"Racca","year":"2018","journal-title":"Hum Reprod"},{"key":"2020080315204265500_deaa123-B29","first-page":"3319","article-title":"Dynamic changes in the intrafollicular inhibin\/activin\/follistatin axis during human follicular development: relationship to circulating hormone concentrations","volume":"85","author":"Schneyer","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2020080315204265500_deaa123-B30","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.fertnstert.2019.02.024","article-title":"Endometrial preparation before the transfer of single, vitrified-warmed, euploid blastocysts: does the duration of estradiol treatment influence clinical outcome?","volume":"111","author":"Sekhon","year":"2019","journal-title":"Fertil Steril"},{"key":"2020080315204265500_deaa123-B31","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3389\/fendo.2019.00806","article-title":"Significant serum progesterone variations on the day of final oocyte maturation in stimulated IVF cycles","volume":"10","author":"Shanker","year":"2019","journal-title":"Front Endocrinol"},{"key":"2020080315204265500_deaa123-B32","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1210\/jc.2013-1528","article-title":"Intrafollicular endocrine milieu after addition of hCG to recombinant FSH during controlled ovarian stimulation for in vitro fertilization","volume":"99","author":"Thuesen","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2020080315204265500_deaa123-B33","first-page":"509","volume-title":"Clinical Guide to Laboratory Tests","author":"Tietz","year":"1995","edition":"3rd edn."},{"key":"2020080315204265500_deaa123-B34","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1093\/oxfordjournals.humrep.a135864","article-title":"Oocyte and embryo quality as well as pregnancy rate in intracytoplasmic sperm injection are not affected by high follicular phase serum progesterone","volume":"10","author":"Ubaldi","year":"1995","journal-title":"Hum.Reprod"},{"key":"2020080315204265500_deaa123-B8873343","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2016.03.002","volume":"105","author":"Ubaldi","year":"2016","journal-title":"Fertil Steril"},{"key":"2020080315204265500_deaa123-B35","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2019.09.012","article-title":"Luteal phase after conventional stimulation in the same ovarian cycle might improve the management of poor responder patients fulfilling the Bologna criteria: a case series","volume":"113","author":"Vaiarelli","year":"2020","journal-title":"Fertil Steril"},{"key":"2020080315204265500_deaa123-B36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.rbmo.2010.11.002","article-title":"Progesterone rise on hCG day in GnRH antagonist\/rFSH stimulated cycles affects endometrial gene expression","volume":"22","author":"Van Vaerenbergh","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"2020080315204265500_deaa123-B37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s40618-016-0531-8","article-title":"Are extremely high progesterone levels still an issue in IVF?","volume":"40","author":"Vanni","year":"2017","journal-title":"J Endocrinol Invest"},{"key":"2020080315204265500_deaa123-B38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176482","article-title":"Top quality blastocyst formation rates in relation to progesterone levels on the day of oocyte maturation in GnRH antagonist IVF\/ICSI cycles","volume":"12","author":"Vanni","year":"2017","journal-title":"PLoS One"},{"key":"2020080315204265500_deaa123-B39","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/humrep\/deu362","article-title":"Estimating the net effect of progesterone elevation on the day of hCG on live birth rates after IVF: a cohort analysis of 3296 IVF cycles","volume":"30","author":"Venetis","year":"2015","journal-title":"Hum Reprod"},{"key":"2020080315204265500_deaa123-B40","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/humupd\/dmt014","article-title":"Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60000 cycles","volume":"19","author":"Venetis","year":"2013","journal-title":"Hum Reprod Update"},{"key":"2020080315204265500_deaa123-B41","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.fertnstert.2017.05.007","article-title":"Yurttas Beim P. Freeze-only versus fresh embryo transfer in a multicenter matched cohort study: contribution of progesterone and maternal age to success rates","volume":"108","author":"Wang","year":"2017","journal-title":"Fertil Steril"},{"key":"2020080315204265500_deaa123-B42","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3109\/09513590.2011.569611","article-title":"Dehydroepiandrosterone supplementation increases baseline follicular phase progesterone levels","volume":"27","author":"Weissman","year":"2011","journal-title":"Gynecol Endocrinol"},{"key":"2020080315204265500_deaa123-B43","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1210\/jcem.74.4.1548349","article-title":"Hormonal regulation of the growth and steroidogenic function of human granulosa cells","volume":"74","author":"Yong","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"2020080315204265500_deaa123-B44","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1093\/humrep\/dex234","article-title":"The international glossary on infertility and fertility care, 2017","volume":"32","author":"Zegers-Hochschild","year":"2017","journal-title":"Hum Reprod"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/35\/8\/1889\/33560400\/deaa123.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/35\/8\/1889\/33560400\/deaa123.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T19:21:55Z","timestamp":1596482515000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/35\/8\/1889\/5869826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,10]]},"references-count":47,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,7,10]]},"published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaa123","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,7,10]]}}}