{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:49:33Z","timestamp":1785498573817,"version":"3.56.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T00:00:00Z","timestamp":1600473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Elective \u2018freeze all\u2019, also called \u2018freeze only\u2019, refers to an IVF cycle where all embryos are frozen for later embryo transfer in a non-stimulated cycle, with the promise of increased success rates and prevention of ovarian hyperstimulation syndrome (OHSS) in most patients. However, \u2018freeze all\u2019 is associated with significantly higher perinatal complications including eclampsia, preeclampsia, chronic hypertension and large-for-gestational-age infants, without the demonstrated advantages of providing better results, except for a decrease in the incidence of OHSS, which should matter to women with polycystic ovary syndrome (PCOS) and high responders to ovarian stimulation but not to all patients. \u2018Freeze all\u2019 is also suggested for all simulated IVF cycles, due to the alleged \u2018faulty endometrium\u2019 caused by ovarian stimulation. However, there is no direct evidence that asynchronous endometrium exists, and only if preovulatory progesterone level increase, can \u2018freeze all\u2019 confer an advantage. We conclude that an alleged diagnosis of \u2018faulty endometrium\u2019 should not be used as an indication for \u2018freeze all\u2019. To offset the risk of OHSS more simply, less costly and less risky solutions such as mild ovarian stimulation, to dampen the number of oocytes and to aim for transfer of a single blastocyst, should be the preferred solution to treat women with PCOS and high responders for oocyte retrieval.<\/jats:p>","DOI":"10.1093\/humrep\/deaa204","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T11:29:01Z","timestamp":1596194941000},"page":"2179-2184","source":"Crossref","is-referenced-by-count":11,"title":["Should we still offer elective freezing of all embryos in all IVF cycles?"],"prefix":"10.1093","volume":"35","author":[{"given":"Zion","family":"Ben Rafael","sequence":"first","affiliation":[{"name":"COGI Congress, Department of OB\/GYN, Laniado Medical Center, Netanya, Israel, affiliated with the Rappaport Faculty of Medicine, Technion, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,19]]},"reference":[{"key":"2020092514450215100_deaa204-B1","first-page":"33","article-title":"Symposium: update on prediction and management of OHSS","volume":"19","author":"Aboulghar","year":"2009","journal-title":"RBMO"},{"key":"2020092514450215100_deaa204-B2","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.fertnstert.2018.05.024","article-title":"Freezing of all embryos in in vitro fertilization is beneficial in high responders, but not intermediate and low responders: an analysis of 82,935 cycles from the Society for Assisted Reproductive Technology registry","volume":"11","author":"Acharya","year":"2018","journal-title":"Fertil Steril"},{"key":"2020092514450215100_deaa204-B3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.rbmo.2017.01.010","article-title":"Ovarian stimulation protocols for IVF: is more better than less?","volume":"34","author":"Alper","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"2020092514450215100_deaa204-B4","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.fertnstert.2014.08.013","article-title":"Ovarian response to recombinant human follicle-stimulating hormone: a randomized, antim\u00fcllerian hormone-stratified, dose-response trial in women undergoing in vitro fertilization\/intracytoplasmic sperm injection","volume":"102","author":"Arce","year":"2014","journal-title":"Fertil Steril"},{"key":"2020092514450215100_deaa204-B5","first-page":"40","article-title":"Extended analyses of the German IVF Registry (DIR): andrological aspects, medical-economical assumptions related to the shift from IVF to ICSI and stimulation with","volume":"7","author":"Bals-Pratsch","year":"2010","journal-title":"gonadotropins. 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