{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:51:36Z","timestamp":1753876296214,"version":"3.41.2"},"reference-count":31,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>What is the effect of salpingectomy for ectopic pregnancy or hydrosalpinx at a young age on ovarian cancer risk compared to no salpingectomy for any reason?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>We found no significant reduction in ovarian cancer risk after salpingectomy for ectopic pregnancy or hydrosalpinx.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>Salpingectomy may reduce ovarian cancer incidence, although the lag-time between intervention and therapeutic effect remains to be elucidated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>This nationwide population-based database study uses the Dutch pathology database to identify all women who underwent salpingectomy for ectopic pregnancy or hydrosalpinx between January 1990 and December 2012 and compared ovarian cancer incidence to a control group of women who had a benign dermal nevus removed, matched for age at the time and year of procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>After selection and manual control of intervention and control group, ovarian cancer incidence was recorded. Hazard ratios (HRs) with 95% CI for the development of ovarian cancer were calculated with Cox regression analyses, both unadjusted and adjusted for age. Subgroup analyses were performed to investigate lag-time between intervention and protective effect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>In all, 18\u00a0961 women were included in the intervention group; 17\u00a0106 women had a unilateral salpingectomy and 1855 had a bilateral salpingectomy. The control group consisted of 23\u00a0686 women. With 14 ovarian cancer cases in the intervention group, the incidence rate (IR) of ovarian cancer was 5.4 (95% CI 3.1\u20138.9) per 100\u00a0000 person-years. In the control group, there were 24 ovarian cancer cases, resulting in an IR of 7.1 (95% CI 4.7\u201310.5) per 100\u00a0000 person-years (P\u2009=\u20090.34). The age-adjusted HR for ovarian cancer was 0.76 (95% CI 0.39\u20131.47) after salpingectomy. Unilateral salpingectomy resulted in an age-adjusted HR of 0.81 (95% CI 0.41\u20131.59) and bilateral salpingectomy resulted in an age-adjusted HR of 0.43 (95% CI 0.06\u20133.16) based on one case. None of our subgroup analysis for lag-time resulted in a significant difference in ovarian cancer incidence between intervention and control group. The difference in ovarian cancer incidence appeared largest in women with at least 8 years of follow-up (P\u2009=\u20090.08).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>Due to the young population, ovarian cancer incidence is low, even at the end of follow-up. Furthermore, due to the anonymous nature of the pathology registry, we were unable to adjust for confounding factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>Although results did not reach statistical significance, they add to the available data on ovarian cancer incidence after salpingectomy. Our subgroup analysis suggests there may be no benefit in the first years following salpingectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>None.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>N\/A.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/deaa264","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T03:50:03Z","timestamp":1600314603000},"source":"Crossref","is-referenced-by-count":5,"title":["Ovarian cancer risk after salpingectomy for ectopic pregnancy or hydrosalpinx: results of the OCASE nationwide population-based database study"],"prefix":"10.1093","author":[{"given":"L A M","family":"van Lieshout","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M J","family":"Piek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Verwijmeren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Catharina Cancer Institute, Catharina Hospital, Eindhoven 5623EJ, The Netherlands"},{"name":"Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht 6200MD, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Houterman","sequence":"additional","affiliation":[{"name":"Department of Education and Research, Catharina Hospital, Eindhoven 5623EJ, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A G","family":"Siebers","sequence":"additional","affiliation":[{"name":"PALGA, Houten 3991SZ, The Netherlands"},{"name":"Department of Pathology, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"de Hullu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R L M","family":"Bekkers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Catharina Cancer Institute, Catharina Hospital, Eindhoven 5623EJ, The Netherlands"},{"name":"GROW school for Oncology and Developmental Biology, Maastricht University, Maastricht 6229ER, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"2020110717311168300_deaa264-B1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/jrms.JRMS_81_17","article-title":"Evaluation of ovarian function after hysterectomy with or without salpingectomy: a feasible study","volume":"22","author":"Behnamfar","year":"2017","journal-title":"J Res Med Sci"},{"key":"2020110717311168300_deaa264-B2","doi-asserted-by":"crossref","first-page":"e1000114","DOI":"10.1371\/journal.pmed.1000114","article-title":"The preclinical natural history of serous ovarian cancer: defining the target for early detection","volume":"6","author":"Brown","year":"2009","journal-title":"PLoS Med"},{"key":"2020110717311168300_deaa264-B3","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1056\/NEJMra1411426","article-title":"Pelvic inflammatory disease","volume":"372","author":"Brunham","year":"2015","journal-title":"N Engl J Med"},{"key":"2020110717311168300_deaa264-B4","article-title":"Ovarian carcinoma: recent developments in classification of tumour histological subtype","volume":"3","author":"Clarke","year":"2011","journal-title":"Can J P Athol"},{"key":"2020110717311168300_deaa264-B6822286","doi-asserted-by":"crossref","first-page":"85.e1","DOI":"10.1016\/j.ajog.2018.10.016","article-title":"Menopausal symptoms and surgical complications after opportunistic bilateral salpingectomy, a register-based cohort study","volume":"220","author":"Collins","year":"2019","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2020110717311168300_deaa264-B5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00404-013-3041-3","article-title":"Revisiting the pathogenesis of ovarian cancer: the central role of the fallopian tube","volume":"289","author":"Dietl","year":"2014","journal-title":"Arch Gynecol Obstet"},{"key":"2020110717311168300_deaa264-B6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jmig.2017.01.001","article-title":"The role of opportunistic bilateral salpingectomy vs tubal occlusion or ligation for ovarian cancer prophylaxis","volume":"24","author":"Ely","year":"2017","journal-title":"J Minim Invasive Gynecol"},{"key":"2020110717311168300_deaa264-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jnci\/dju410","article-title":"Ovarian cancer risk after salpingectomy: a nationwide population-based study","volume":"107","author":"Falconer","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"2020110717311168300_deaa264-B8","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.fertnstert.2013.07.1997","article-title":"Short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve: a pilot randomized controlled trial","volume":"100","author":"Findley","year":"2013","journal-title":"Fertil Steril"},{"year":"2012","author":"IKNL","key":"2020110717311168300_deaa264-B9"},{"year":"2018","key":"2020110717311168300_deaa264-B10"},{"key":"2020110717311168300_deaa264-B11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1136\/mp.55.5.305","article-title":"Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer","volume":"55","author":"Jongsma","year":"2002","journal-title":"Mol Pathol"},{"key":"2020110717311168300_deaa264-B13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ygyno.2014.10.005","article-title":"Effect of tubal sterilization technique on risk of serous epithelial ovarian and primary peritoneal carcinoma","volume":"135","author":"Lessard-Anderson","year":"2014","journal-title":"Gynecol Oncol"},{"key":"2020110717311168300_deaa264-B14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/aogs.12516","article-title":"Tubal ligation and salpingectomy and the risk of epithelial ovarian cancer and borderline ovarian tumors: a nationwide case-control study","volume":"94","author":"Madsen","year":"2015","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2020110717311168300_deaa264-B15","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1093\/annonc\/mdw306","article-title":"Global trends and predictions in ovarian cancer mortality","volume":"27","author":"Malvezzi","year":"2016","journal-title":"Ann Oncol"},{"key":"2020110717311168300_deaa264-B16","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1097\/AOG.0000000000002580","article-title":"Ovarian cancer prevention and screening","volume":"131","author":"Menon","year":"2018","journal-title":"Obstet Gynecol"},{"key":"2020110717311168300_deaa264-B17","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1093\/humrep\/des466","article-title":"Reproductive characteristics in relation to ovarian cancer risk by histologic pathways","volume":"28","author":"Merritt","year":"2013","journal-title":"Hum Reprod"},{"key":"2020110717311168300_deaa264-B18","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/modpathol.2016.238","article-title":"Serous tubal intraepithelial neoplasia: the concept and its application","volume":"30","author":"Meserve","year":"2017","journal-title":"Mod Pathol"},{"year":"2015","author":"Oncoline","key":"2020110717311168300_deaa264-B20"},{"key":"2020110717311168300_deaa264-B21","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0140-6736(01)05992-X","article-title":"Tubal ligation and risk of ovarian cancer","volume":"358","author":"Piek","year":"2001","journal-title":"Lancet"},{"key":"2020110717311168300_deaa264-B22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1000","article-title":"Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer","volume":"195","author":"Piek","year":"2001","journal-title":"J Pathol"},{"key":"2020110717311168300_deaa264-B23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1701-2163(15)30659-9","article-title":"The fallopian tube as the origin of high grade serous ovarian cancer: review of a paradigm shift","volume":"36","author":"Reade","year":"2014","journal-title":"J Obstet Gynaecol Canada"},{"key":"2020110717311168300_deaa264-B24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ygyno.2010.06.003","article-title":"SGO white paper on ovarian cancer: etiology, screening and surveillance","volume":"119","author":"Schorge","year":"2010","journal-title":"Gynecol Oncol"},{"key":"2020110717311168300_deaa264-B25","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1447-0756.2007.00669.x","article-title":"salpingectomy during abdominal hysterectomy: effects on ovarian reserve and ovarian stromal blood flow","volume":"33","author":"Sezik","year":"2007","journal-title":"J Obstet Gynaecol Res"},{"key":"2020110717311168300_deaa264-B26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21387","article-title":"Cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"2020110717311168300_deaa264-B27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/1471-0528.14182","article-title":"Impact of opportunistic salpingectomy on anti-M\u00fcllerian hormone in patients undergoing laparoscopic hysterectomy: a multicentre randomised controlled trial","volume":"124","author":"Song","year":"2017","journal-title":"BJOG"},{"key":"2020110717311168300_deaa264-B28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ygyno.2018.11.033","article-title":"The fallopian tube, \u201cprecursor escape\u201d and narrowing the knowledge gap to the origins of high-grade serous carcinoma","volume":"152","author":"Soong","year":"2019","journal-title":"Gynecol Oncol"},{"key":"2020110717311168300_deaa264-B29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s10397-017-1019-z","article-title":"Effects of salpingectomy during abdominal hysterectomy on ovarian reserve: a randomized controlled trial","volume":"14","author":"Tehranian","year":"2017","journal-title":"Gynecol Surg"},{"key":"2020110717311168300_deaa264-B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.maturitas.2017.09.012","article-title":"Opportunistic salpingectomy in women undergoing hysterectomy: results from the HYSTUB randomised controlled trial","volume":"107","author":"van Lieshout","year":"2018","journal-title":"Maturitas"},{"key":"2020110717311168300_deaa264-B300"},{"key":"2020110717311168300_deaa264-B31","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1093\/annonc\/mdw411","article-title":"Ovarian cancer mortality trends: which factors are involved?","volume":"27","author":"Weiderpass","year":"2016","journal-title":"Ann Oncol"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/advance-article-pdf\/doi\/10.1093\/humrep\/deaa264\/34160871\/deaa264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/humrep\/advance-article-pdf\/doi\/10.1093\/humrep\/deaa264\/34160871\/deaa264.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T22:31:24Z","timestamp":1604788284000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/advance-article\/doi\/10.1093\/humrep\/deaa264\/5959820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,6]]},"references-count":31,"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaa264","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"type":"print","value":"0268-1161"},{"type":"electronic","value":"1460-2350"}],"subject":[],"published":{"date-parts":[[2020,11,6]]},"article-number":"deaa264"}}