{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:11:35Z","timestamp":1784232695826,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>To date, vaginal\/cervical clear cell adenocarcinoma (CCAC) has not been reported in the granddaughters of women treated with diethylstilbestrol (DES) during pregnancy. We present an 8-year-old girl with a history of severe vaginal bleeding who was diagnosed with cervical CCAC. She underwent fertility-sparing surgery and radiotherapy. No sign of recurrence was detected throughout a 10-year follow-up. Her grandmother had received DES therapy during pregnancy with the patient\u2019s mother. Although no direct causal link is demonstrated, this case raises for the first time, the hypothesis of multigenerational effects of DES in girls and strongly suggests the need to follow the granddaughters of DES-treated women.<\/jats:p>","DOI":"10.1093\/humrep\/deaa267","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T13:37:24Z","timestamp":1600349844000},"source":"Crossref","is-referenced-by-count":7,"title":["Diethylstilbestrol exposure during pregnancy with primary clear cell carcinoma of the cervix in an 8-year-old granddaughter: a multigenerational effect of endocrine disruptors?"],"prefix":"10.1093","author":[{"given":"Laura","family":"Gaspari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Paris","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Endocrinologie-Gyn\u00e9cologie P\u00e9diatrique, Service de P\u00e9diatrie, H\u00f4pital Arnaud-de-Villeneuve, CHU Montpellier et Universit\u00e9 Montpellier, Montpellier, France"},{"name":"Centre de R\u00e9f\u00e9rence Maladies Rares du D\u00e9veloppement G\u00e9nital, Constitutif Sud, H\u00f4pital Lapeyronie, CHU Montpellier et Universit\u00e9 Montpellier, Montpellier, France"},{"name":"INSERM U 1203, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Cassel-Knipping","sequence":"additional","affiliation":[{"name":"Polyclinique Urbain V, Avignon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Villeret","sequence":"additional","affiliation":[{"name":"H\u00f4pital Henri Duffaut, Service de Pathologie, Avignon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnauld","family":"Verschuur","sequence":"additional","affiliation":[{"name":"H\u00f4pital d\u2019Enfants de la Timone, Centre de Canc\u00e9rologie P\u00e9diatrique, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Soyer-Gobillard","sequence":"additional","affiliation":[{"name":"CNRS, Universit\u00e9 Sorbonne, Association Hhorages-France, F-Asni\u00e8res-sur-Oise, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Carcopino-Tusoli","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Gyn\u00e9cologie, H\u00f4pital Nord Marseille, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Hamamah","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biologie de La Reproduction et DPI (ART\/PGD), H\u00f4pital A. de Villeneuve, CHU Montpellier et Universit\u00e9, Montpellier, France"},{"name":"INSERM U 1203, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Kalfa","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Maladies Rares du D\u00e9veloppement G\u00e9nital, Constitutif Sud, H\u00f4pital Lapeyronie, CHU Montpellier et Universit\u00e9 Montpellier, Montpellier, France"},{"name":"D\u00e9partement de Chirurgie P\u00e9diatrique, H\u00f4pital Lapeyronie, CHU Montpellier et Universit\u00e9 Montpellier 1, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Sultan","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Endocrinologie-Gyn\u00e9cologie P\u00e9diatrique, Service de P\u00e9diatrie, H\u00f4pital Arnaud-de-Villeneuve, CHU Montpellier et Universit\u00e9 Montpellier, Montpellier, France"},{"name":"Centre de R\u00e9f\u00e9rence Maladies Rares du D\u00e9veloppement G\u00e9nital, Constitutif Sud, H\u00f4pital Lapeyronie, CHU Montpellier et Universit\u00e9 Montpellier, Montpellier, 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