{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:38:27Z","timestamp":1790818707044,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:00:00Z","timestamp":1608768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Resources and Services Administration of the U.S. Department of Health and Human Services"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HD086013"],"award-info":[{"award-number":["R01HD086013"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["2R01HD041702"],"award-info":[{"award-number":["2R01HD041702"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HD098232"],"award-info":[{"award-number":["R01HD098232"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01ES031272"],"award-info":[{"award-number":["R01ES031272"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"S. Department of Health and Human Services","doi-asserted-by":"crossref","award":["UJ2MC31074"],"award-info":[{"award-number":["UJ2MC31074"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000016","name":"S. Department of Health and Human Services","doi-asserted-by":"crossref","award":["R03ES029594"],"award-info":[{"award-number":["R03ES029594"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>Is in utero exposure to mercury associated with the risk of precocious puberty?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>Prenatal exposure to high levels of mercury was associated with increased risk of precocious puberty, which was strengthened by concomitant maternal cardiometabolic conditions and adverse birth outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>The developing fetus is sensitive to mercury, a well-known endocrine disruptor which impacts the endocrine and reproductive system.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>This study included 1512 mother\u2013child pairs from the Boston Birth Cohort, a longitudinal cohort which recruited at birth and followed prospectively up to 21\u2009years of age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>Mother\u2013child pairs, from a predominantly urban minority population, were enrolled from 2002 to 2013. Prenatal exposure was assessed by maternal mercury concentration in red blood cells (RBCs) collected at 1\u20133\u2009days after delivery. Precocious puberty was defined based on International Classification of Disease codes. Cox proportional hazards models were applied to the association between maternal mercury concentrations and the risk of precocious puberty.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>The median (interquartile range) of maternal mercury concentrations among children with and without precocious puberty were 3.4 (1.9\u20134.6) \u00b5g\/l and 2.0 (1.0\u20133.7) \u00b5g\/l, respectively. Compared to those in the lowest tertile for mercury, the highest tertile was associated with increased risk of precocious puberty, with an adjusted hazard ratio (HR) of 2.41, 95% CI: 1.16\u20135.03. In addition, concomitant maternal cardiometabolic conditions and adverse birth outcomes strengthened the effects of mercury on the risk of precocious puberty. The highest risk of precocious puberty was observed among children who had adverse birth outcomes and whose mothers had high RBC-mercury concentrations along with cardiometabolic conditions, with an HR of 4.76 (95% CI: 1.66\u201313.60) compared to children with favorable profiles of all three risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>Precocious puberty was defined based on medical records, not on a direct assessment, which may have led to underdiagnosis and the inability to make a subclassification. The study included a predominately urban, low-income, minority population and as such our findings may not be widely generalizable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>Prenatal Hg exposure was associated with an increased risk of precocious puberty. This risk was strengthened by concomitant maternal cardiometabolic conditions during pregnancy and adverse birth outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>This study was funded by the NIH\/National Institute of Environmental Health Sciences, NIH\/Eunice Kennedy Shriver National Institute of Child Health and Human Development and the Health Resources and Services Administration of the U.S. Department of Health and Human Services. The authors declare no conflicts of interest.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>N\/A.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/deaa315","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T20:13:38Z","timestamp":1603829618000},"page":"712-720","source":"Crossref","is-referenced-by-count":24,"title":["Prenatal exposure to mercury and precocious puberty: a prospective birth cohort study"],"prefix":"10.1093","volume":"36","author":[{"given":"Guoying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Yee","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA"},{"name":"Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkai","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA"},{"name":"Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,24]]},"reference":[{"key":"2021021818582418600_deaa315-B1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S2213-8587(15)00418-0","article-title":"Pubertal development and regulation","volume":"4","author":"Abreu","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2021021818582418600_deaa315-B2","doi-asserted-by":"crossref","first-page":"E59","DOI":"10.1542\/peds.107.4.e59","article-title":"Size at birth predicts age at menarche","volume":"107","author":"Adair","year":"2001","journal-title":"Pediatrics"},{"key":"2021021818582418600_deaa315-B3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.chemosphere.2007.01.003","article-title":"Mercury in hair and blood from residents of Phnom Penh (Cambodia) and possible effect on serum hormone levels","volume":"68","author":"Agusa","year":"2007","journal-title":"Chemosphere"},{"key":"2021021818582418600_deaa315-B4","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1542\/peds.111.4.844","article-title":"Relative weight and race influence average age at menarche: results from two nationally representative surveys of us girls studied 25 years apart","volume":"111","author":"Anderson","year":"2003","journal-title":"Pediatrics"},{"key":"2021021818582418600_deaa315-B5","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1542\/peds.2007-2329C","article-title":"Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report","volume":"120","author":"Barlow","year":"2007","journal-title":"Pediatrics"},{"key":"2021021818582418600_deaa315-B6","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/00039896.1963.10663449","article-title":"Accumulation and retention of mercury in the mouse. III. An autoradiographic comparison of methylmercuric dicyandiamide with inorganic mercury","volume":"6","author":"Berlin","year":"1963","journal-title":"Arch Environ Health"},{"key":"2021021818582418600_deaa315-B7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1590\/2359-3997000000144","article-title":"Central precocious puberty: revisiting the diagnosis and therapeutic management","volume":"60","author":"Brito","year":"2016","journal-title":"Arch Endocrinol Metab"},{"key":"2021021818582418600_deaa315-B8","doi-asserted-by":"crossref","first-page":"S192","DOI":"10.1542\/peds.1813E","article-title":"Environmental factors and puberty timing: expert panel research needs","volume":"121","author":"Buck Louis","year":"2008","journal-title":"Pediatrics"},{"key":"2021021818582418600_deaa315-B9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/jes.2014.26","article-title":"Placental transfer and concentrations of cadmium, mercury, lead, and selenium in mothers, newborns, and young children","volume":"24","author":"Chen","year":"2014","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"2021021818582418600_deaa315-B10","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/10408440600845619","article-title":"The toxicology of mercury and its chemical compounds","volume":"36","author":"Clarkson","year":"2006","journal-title":"Crit Rev Toxicol"},{"key":"2021021818582418600_deaa315-B11","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2471\/BLT.07.043497","article-title":"Development of a who growth reference for school-aged children and adolescents","volume":"85","author":"de Onis","year":"2007","journal-title":"Bull World Health Organ"},{"key":"2021021818582418600_deaa315-B12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/enrs.2000.4116","article-title":"Mercury, selenium, and cadmium in human autopsy samples from Idrija residents and mercury mine workers","volume":"84","author":"Falnoga","year":"2000","journal-title":"Environ Res"},{"key":"2021021818582418600_deaa315-B13","first-page":"500","article-title":"Thimerosal exposure & increasing trends of premature puberty in the vaccine safety datalink","volume":"131","author":"Geier","year":"2010","journal-title":"Indian J Med Res"},{"key":"2021021818582418600_deaa315-B14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/toxics6040067","article-title":"Premature puberty and thimerosal-containing hepatitis B vaccination: a case-control study in the vaccine safety datalink","volume":"6","author":"Geier","year":"2018","journal-title":"Toxics"},{"key":"2021021818582418600_deaa315-B15","doi-asserted-by":"crossref","first-page":"S218","DOI":"10.1542\/peds.2007-1813G","article-title":"Public health implications of altered puberty timing","volume":"121","author":"Golub","year":"2008","journal-title":"Pediatrics"},{"key":"2021021818582418600_deaa315-B16","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/01.chi.0000120022.14101.11","article-title":"Is pubertal timing associated with psychopathology in young adulthood","volume":"43","author":"Graber","year":"2004","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"2021021818582418600_deaa315-B17","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-3462-1","volume-title":"Regression Modelling Strategies with Applications to Linear Models, Logistic Regression, and Survival Analysis","author":"Harrell","year":"2001"},{"key":"2021021818582418600_deaa315-B18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.reprotox.2019.02.012","article-title":"Exposure to mercury and human reproductive health: a systematic review","volume":"85","author":"Henriques","year":"2019","journal-title":"Reprod Toxicol"},{"key":"2021021818582418600_deaa315-B19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1542\/peds.99.4.505","article-title":"Secondary sexual characteristics and menses in young girls seen in office practice: a study from the pediatric research in office settings network","volume":"99","author":"Herman-Giddens","year":"1997","journal-title":"Pediatrics"},{"key":"2021021818582418600_deaa315-B20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jpeds.2018.10.053","article-title":"Exposure to diabetes in utero is associated with earlier pubertal timing and faster pubertal growth in the offspring: the epoch study","volume":"206","author":"Hockett","year":"2019","journal-title":"J Pediatr"},{"key":"2021021818582418600_deaa315-B21","first-page":"671","article-title":"Premature adrenarche\u2013normal variant or forerunner of adult disease?","volume":"21","author":"Ib\u00e1\u00f1ez","year":"2000","journal-title":"Endocr Rev"},{"key":"2021021818582418600_deaa315-B22","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/humrep\/dez015","article-title":"Variations in reproductive events across life: a pooled analysis of data from 505 147 women across 10 countries","volume":"34","author":"Inter","year":"2019","journal-title":"Hum Reprod"},{"key":"2021021818582418600_deaa315-B23","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1542\/peds.104.4.936","article-title":"Reexamination of the age limit for defining when puberty is precocious in girls in the United States: implications for evaluation and treatment. Drug and therapeutics and executive committees of the Lawson Wilkins pediatric endocrine society","volume":"104","author":"Kaplowitz","year":"1999","journal-title":"Pediatrics"},{"key":"2021021818582418600_deaa315-B24","doi-asserted-by":"crossref","first-page":"e0141844","DOI":"10.1371\/journal.pone.0141844","article-title":"A significant increase in the incidence of central precocious puberty among Korean girls from 2004 to 2010","volume":"10","author":"Kim","year":"2015","journal-title":"PLoS One"},{"key":"2021021818582418600_deaa315-B25","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1095\/biolreprod11.2.180","article-title":"Localization, accumulation, and toxic effects of mercuric chloride on the reproductive axis of the female hamster","volume":"11","author":"Lamperti","year":"1974","journal-title":"Biol Reprod"},{"key":"2021021818582418600_deaa315-B26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.envres.2018.10.007","article-title":"Associations of environmental exposures to methylmercury and selenium with female infertility: a case-control study","volume":"168","author":"Maeda","year":"2019","journal-title":"Environ Res"},{"key":"2021021818582418600_deaa315-B27","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1210\/en.2002-221054","article-title":"Estrogen-like activity of metals in mcf-7 breast cancer cells","volume":"144","author":"Martin","year":"2003","journal-title":"Endocrinology"},{"key":"2021021818582418600_deaa315-B28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF02899039","article-title":"Accumulation of mercury in the anterior pituitary of rats following oral or intraperitoneal administration of methyl mercury","volume":"51","author":"Moller-Madsen","year":"1986","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"2021021818582418600_deaa315-B29","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/aje\/kwn034","article-title":"Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a us cohort","volume":"167","author":"Oken","year":"2008","journal-title":"Am J Epidemiol"},{"key":"2021021818582418600_deaa315-B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4274\/jcrpe.v3i1.01","article-title":"Effects of environmental endocrine disruptors on pubertal development","volume":"3","author":"Ozen","year":"2011","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"2021021818582418600_deaa315-B32","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1542\/peds.106.3.622","article-title":"Current age of onset of puberty","volume":"106","author":"Rosenfield","year":"2000","journal-title":"Pediatrics"},{"key":"2021021818582418600_deaa315-B33","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1021\/es034983m","article-title":"Maternal and fetal mercury and n-3 polyunsaturated fatty acids as a risk and benefit of fish consumption to fetus","volume":"38","author":"Sakamoto","year":"2004","journal-title":"Environ Sci Technol"},{"key":"2021021818582418600_deaa315-B34","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1001\/jama.289.13.1667","article-title":"Blood mercury levels in us children and women of childbearing age, 1999-2000","volume":"289","author":"Schober","year":"2003","journal-title":"JAMA"},{"key":"2021021818582418600_deaa315-B35","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/oxfordjournals.epirev.a036205","article-title":"The effects of exogenous female hormones on the fetus","volume":"1","author":"Shapiro","year":"1979","journal-title":"Epidemiol Rev"},{"key":"2021021818582418600_deaa315-B36","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/humrep\/deq316","article-title":"Smoking and alcohol use during pregnancy and age of menarche in daughters","volume":"26","author":"Shrestha","year":"2011","journal-title":"Hum Reprod"},{"key":"2021021818582418600_deaa315-B37","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1093\/humrep\/dey287","article-title":"Maternal age at menarche and pubertal development in sons and daughters: a nationwide cohort study","volume":"33","author":"Sorensen","year":"2018","journal-title":"Hum Reprod"},{"key":"2021021818582418600_deaa315-B38","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/10408440802233259","article-title":"The endocrine effects of mercury in humans and wildlife","volume":"39","author":"Tan","year":"2009","journal-title":"Crit Rev Toxicol"},{"key":"2021021818582418600_deaa315-B39","first-page":"111","article-title":"Neurobiological mechanisms of the onset of puberty in primates","volume":"22","author":"Terasawa","year":"2001","journal-title":"Endocr Rev"},{"key":"2021021818582418600_deaa315-B40","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/jama.287.2.195","article-title":"Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight","volume":"287","author":"Wang","year":"2002","journal-title":"JAMA"},{"key":"2021021818582418600_deaa315-B41","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s12916-019-1442-2","article-title":"In utero exposure to mercury and childhood overweight or obesity: counteracting effect of maternal folate status","volume":"17","author":"Wang","year":"2019","journal-title":"BMC Med"},{"key":"2021021818582418600_deaa315-B42","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1001\/jama.2014.1","article-title":"Preterm birth and random plasma insulin levels at birth and in early childhood","volume":"311","author":"Wang","year":"2014","journal-title":"JAMA"},{"key":"2021021818582418600_deaa315-B43","volume-title":"Who Multicentre Growth Reference Study Group","author":"WHO.","year":"2006"},{"key":"2021021818582418600_deaa315-B44","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1210\/endo-128-5-2457","article-title":"Prenatal androgens time neuroendocrine sexual maturation","volume":"128","author":"Wood","year":"1991","journal-title":"Endocrinology"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/36\/3\/712\/36317788\/deaa315.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/36\/3\/712\/36317788\/deaa315.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T01:37:57Z","timestamp":1613871477000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/36\/3\/712\/6046541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,24]]},"references-count":43,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,12,24]]},"published-print":{"date-parts":[[2021,2,18]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaa315","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,1]]},"published":{"date-parts":[[2020,12,24]]}}}