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However, the significance and the potential effect of endometrial microorganisms on reproductive functions remain to be fully elucidated. Analysing the endometrial microbiome, the microbes and their genetic material present in the endometrium, is an emerging area of study. The initial studies suggest it is associated with poor reproductive outcomes and with different gynaecological pathologies. Nevertheless, studying a low-biomass microbial niche as is endometrium, the challenge is to conduct well-designed and well-controlled experiments in order to avoid and adjust for the risk of contamination, especially from the lower genital tract. Herein, we aim to highlight methodological considerations and propose good practice recommendations for future endometrial microbiome studies.<\/jats:p>","DOI":"10.1093\/humrep\/deab009","type":"journal-article","created":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T18:43:58Z","timestamp":1610217838000},"page":"859-879","source":"Crossref","is-referenced-by-count":94,"title":["Analysing endometrial microbiome: methodological considerations and recommendations for good practice"],"prefix":"10.1093","volume":"36","author":[{"given":"Nerea M","family":"Molina","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada 18071, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada 18014, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Sola-Leyva","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada 18071, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada 18014, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Haahr","sequence":"additional","affiliation":[{"name":"The Fertility Clinic, Skive Regional Hospital, Skive 7800, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lusine","family":"Aghajanova","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford School of Medicine, Sunnyvale, CA 94087, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Laudanski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw 02-015, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Castilla","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada 18014, Spain"},{"name":"Unidad de Reproducci\u00f3n, UGC de Obstetricia y Ginecolog\u00eda, Hospital Universitario Virgen de las Nieves, Granada 18012, Spain"},{"name":"CEIFER Biobanco\u2014NextClinics, Granada 18004, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Altm\u00e4e","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada 18071, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada 18014, Spain"},{"name":"Competence Centre on Health Technologies, Tartu 50410, 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