{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:13:27Z","timestamp":1784841207662,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006197","name":"A.P. M\u00f8ller Foundation for the Advancement of Medical Science","doi-asserted-by":"crossref","award":["17-L-0236"],"award-info":[{"award-number":["17-L-0236"]}],"id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Else and Mogens Wedell-Wedellborgs Fund","award":["102-5949"],"award-info":[{"award-number":["102-5949"]}]},{"name":"Direkt\u00f8r Emil C. 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Follow-up histology and cytology diagnoses were registered during the 5\u2009years after baseline. Adjusted relative risks (aRR) and 95% CI were calculated for precancerous cervical lesions in HIUD users compared with CIUD and OC users.<\/jats:p>\n <\/jats:sec>\n \n MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n Women with normal cytology at baseline: at follow-up HIUD users had the same risk of CIN3 or higher (3+) as CIUD users; aRR 1.08 (95% CI 0.94\u20131.22). For the HIUD and CIUD groups compared with OCs, the risks of CIN3+ were lower: aRR 0.63 (95% CI 0.57\u20130.69) and aRR 0.58 (95% CI 0.52\u20130.65), respectively. The same was observed for CIN2 risks: aRR 0.86 (95% CI 0.76\u20130.96) and aRR 0.68 (95% CI 0.58\u20130.79) for HIUD and CIUD groups, respectively. Women with abnormal diagnosis at baseline: a lower progression risk, except for CIN2+ at baseline, was observed in HIUD users compared with OC users. Similar progression risks were found in HIUD and CIUD users. There were no differences between the three contraceptive groups in persistence or regression of present lesions.<\/jats:p>\n <\/jats:sec>\n \n LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n We adjusted for age, education, and region of residence as a proxy for socio-economic factors. Data on smoking and sexual behavior were not available thus we cannot exclude some differences between the three user groups.<\/jats:p>\n <\/jats:sec>\n \n WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n These findings suggest that women may safely use HIUDs.<\/jats:p>\n <\/jats:sec>\n \n STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n A.P. M\u00f8ller Foundation for the Advancement of Medical Science, Else and Mogens Wedell-Wedellborgs Fund, Direkt\u00f8r Emil C. Hertz og Hustru Inger Hertz Fund, and the Fund for Development of Evidence Based Medicine in Private Specialized Practices. EL is principle investigator for a study with HPV-test-kits provided by Roche. The other authors have nothing to declare.<\/jats:p>\n <\/jats:sec>\n \n TRIAL REGISTRATION NUMBER<\/jats:title>\n N\/A.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humrep\/deab066","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T12:12:21Z","timestamp":1614859941000},"page":"1796-1807","source":"Crossref","is-referenced-by-count":13,"title":["Risk of precancerous cervical lesions in women using a hormone-containing intrauterine device and other contraceptives: a register-based cohort study from Denmark"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-9783","authenticated-orcid":false,"given":"Malene","family":"Skorstengaard","sequence":"first","affiliation":[{"name":"Department of Public Health, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsebeth","family":"Lynge","sequence":"additional","affiliation":[{"name":"Centre for Epidemiological 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