{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:22:00Z","timestamp":1773210120573,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701406"],"award-info":[{"award-number":["81701406"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>Should women with X chromosome abnormalities (XCAs) be recommended to have embryos selected by both morphological and cytogenetic assessment through preimplantation genetic testing (PGT) rather than morphological assessment only in conventional IVF\/ICSI treatment?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>PGT is not a preferred recommendation for women with XCAs in the absence of other PGT indications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>XCAs are the most frequent sort of chromosomal aberrations in infertile women. Patients with a complete or partial absence of one X chromosome, diagnosed as Turner Syndrome (TS), demonstrate low spontaneous pregnancy rates (5\u20137%) and high miscarriage rates (22.8\u201330.8%), as well as high chances of birth defects (20%). PGT is known to improve pregnancy rates and decrease the incidence of miscarriage in couples with chromosomal aberrations such as Robertsonian and reciprocal translocations and Klinefelter Syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>A retrospective cohort study was conducted with 394 women with XCAs and undergoing their first oocyte retrieval and first embryo transfer cycle from June 2011 to August 2019 in the Reproductive Hospital Affiliated to Shandong University.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>Pregnancy outcomes were compared between the conventional IVF\/ICSI group (n\u2009=\u2009284) and the PGT group (n\u2009=\u2009110) in the first fresh or frozen embryo transfer cycle for each woman with XCAs. Three platforms were applied in PGT: fluorescence in situ hybridisation (FISH, n\u2009=\u200934), array comparative genomic hybridisation (aCGH, n\u2009=\u200924) and next-generation sequencing (NGS, n\u2009=\u200951). The embryo aneuploidy rate and distribution of embryonic chromosomal aberrations revealed by aCGH or NGS were analysed and stratified by maternal age and type of XCAs to assess the effect of maternal XCAs on embryo karyotypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULT AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>The live birth rate (LBR) per embryo transfer was similar between the PGT group and IVF\/ICSI group both in the first cycle of fresh or frozen embryo transfer respectively (39.13% in PGTFISH vs 42.58% in IVF\/ICSI, Padj=0.558; 66.67% in PGTFISH vs 52.08% in PGTaCGH\/NGS vs 53.06% in IVF\/ICSI, Padj=0.756), as was the clinical pregnancy rate (60.87% in PGTFISH vs 50.97% in IVF\/ICSI, Padj =0.672; 88.89% in PGTFISH vs 58.33% in PGTaCGH\/NGS vs 69.39% in IVF\/ICSI, Padj =0.480) and the pregnancy loss rate (35.71% in PGTFISH vs 16.46% in IVF\/ICSI, Padj =0.136; 12.50% in PGTFISH vs 10.71% in PGTaCGH\/NGS vs 23.53% in IVF\/ICSI, Padj =0.352). The rates of maternal and neonatal complications were also comparable between the PGT and IVF\/ICSI groups with fresh and frozen transfers respectively (10.00% vs 8.85%, P\u2009=\u20091.000; 21.74% vs 14.55%, P\u2009=\u20090.272). Intriguingly, the distribution of embryonic chromosome abnormalities was more frequent on autosomes 22 (20.39%), 21 (18.45%) and 16 (17.47%), compared with the X chromosome (8.73%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>Selection bias is an inherent drawback of a retrospective study. First, our participants hosted 4.84% X chromosome mosaicism with few typical somatic anomalies of TS. Second, the incidences of history of recurrent miscarriage and abnormal offspring in the PGT group were higher than in IVF\/ICSI group although binary logistic regression analysis was performed to attenuate the modifying effect of confounding factors. Third, FISH performed in this study only used X\/Y probes and lacked the reference of autosome, which might have resulted in misdiagnosis and bias. Finally, intrinsic disadvantages could not be totally avoided due to the retrospective nature of this study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATION OF THE FINDINGS<\/jats:title>\n                  <jats:p>In the current study, comparable pregnancy outcomes were revealed among a large cohort of women with XCAs undergoing their first cycles of PGT or conventional IVF\/ICSI treatment. Moreover, the X chromosome abnormality was illustrated to cause no higher frequency of aberrations in embryos. Our data provided perspectives for genetic and reproductive counselling to XCAs individuals and their families.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>This work was supported by National Research and Development Plan (2016YFC1000604 and 2017YFC1001100), the National Natural Science Foundation of China (81701406), Shandong Science Fund for Distinguished Young Scholars (JQ201720), Taishan Scholars Program for Young Experts of Shandong Province (tsqn20161069) and Projects of Medical and Health Technology Development Program in Shandong Province (202005010520, 202005010523 and 2016WS0368). There is no conflict of interest to declare.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>N\/A.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/deab177","type":"journal-article","created":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T11:06:49Z","timestamp":1625396809000},"page":"2612-2621","source":"Crossref","is-referenced-by-count":7,"title":["Preimplantation genetic testing is not a preferred recommendation for patients with X chromosome abnormalities"],"prefix":"10.1093","volume":"36","author":[{"given":"Chenxi","family":"Li","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University , Jinan, Shandong, China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan, Shandong, China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan, Shandong, China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan, Shandong, China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Dang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University , Jinan, Shandong, China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan, Shandong, China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan, Shandong, China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan, Shandong, China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University , Jinan, Shandong, China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan, Shandong, China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan, Shandong, China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan, Shandong, China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongchang","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University , Jinan, Shandong, China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan, Shandong, China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan, Shandong, China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan, Shandong, China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University , Jinan, Shandong, China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan, Shandong, China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan, Shandong, China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan, Shandong, China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-1075","authenticated-orcid":false,"given":"Yingying","family":"Qin","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University , Jinan, Shandong, China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan, Shandong, China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan, Shandong, China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan, Shandong, China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"2023042621462926200_deab177-B1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/humrep\/dew012","article-title":"Spontaneous fertility and pregnancy outcomes amongst 480 women with Turner syndrome","volume":"31","author":"Bernard","year":"2016","journal-title":"Hum Reprod"},{"key":"2023042621462926200_deab177-B2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejogrb.2018.08.005","article-title":"Pregnancy outcome in Turner syndrome: a French multi-center study after the 2009 guidelines","volume":"229","author":"Cadoret","year":"2018","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2023042621462926200_deab177-B3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1513873","article-title":"Fresh versus frozen embryos for infertility in the polycystic ovary syndrome","volume":"375","author":"Chen","year":"2016","journal-title":"N Engl J Med"},{"key":"2023042621462926200_deab177-B4","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.fertnstert.2016.01.025","article-title":"Effects of maternal age on euploidy rates in a large cohort of embryos analyzed with 24-chromosome single-nucleotide polymorphism-based preimplantation genetic screening","volume":"105","author":"Demko","year":"2016","journal-title":"Fertil Steril"},{"key":"2023042621462926200_deab177-B5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12958-015-0055-7","article-title":"Reproductive and obstetric outcomes in mosaic Turner's Syndrome: a cross-sectional study and review of the literature","volume":"13","author":"Do\u011fer","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"2023042621462926200_deab177-B6","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00439-013-1309-0","article-title":"The origin and impact of embryonic aneuploidy","volume":"132","author":"Fragouli","year":"2013","journal-title":"Hum Genet"},{"key":"2023042621462926200_deab177-B7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/humupd\/dmy036","article-title":"The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies","volume":"25","author":"Fragouli","year":"2019","journal-title":"Hum Reprod Update"},{"key":"2023042621462926200_deab177-B8","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0015-0282(00)00518-5","article-title":"Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer","volume":"73","author":"Gardner","year":"2000","journal-title":"Fertil Steril"},{"key":"2023042621462926200_deab177-B9","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.fertnstert.2020.04.003","article-title":"Preimplantation genetic testing for aneuploidy in patients with partial X monosomy using their own oocytes: Is this a suitable indication?","volume":"114","author":"Giles","year":"2020","journal-title":"Fertil Steril"},{"key":"2023042621462926200_deab177-B10","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-17-0430","article-title":"Clinical practice guidelines for the care of girls and women with Turner syndrome: Proceedings from the 2016 Cincinnati International Turner Syndrome Meeting","volume":"177","author":"Gravholt","year":"2017","journal-title":"Eur J Endocrinol"},{"key":"2023042621462926200_deab177-B11","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41574-019-0224-4","article-title":"Turner syndrome: mechanisms and management","volume":"15","author":"Gravholt","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"2023042621462926200_deab177-B12","doi-asserted-by":"crossref","first-page":"hoaa017","DOI":"10.1093\/hropen\/hoaa017","article-title":"ESHRE PGT Consortium good practice recommendations for the detection of structural and numerical chromosomal aberrations","volume":"2020","author":"Group","year":"2020","journal-title":"Hum Reprod Open"},{"key":"2023042621462926200_deab177-B13","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/MOP.0b013e328332c6ab","article-title":"Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew","volume":"21","author":"Hassold","year":"2009","journal-title":"Curr Opin Pediatr"},{"key":"2023042621462926200_deab177-B14","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1530\/EJE-09-0750","article-title":"45,X\/46,XX mosaicism below 30% of aneuploidy: clinical implications in adult women from a reproductive medicine unit","volume":"162","author":"Homer","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"2023042621462926200_deab177-B15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.rbmo.2018.04.039","article-title":"Low anti-Mullerian hormone concentration is associated with increased risk of embryonic aneuploidy in women of advanced age","volume":"37","author":"Jiang","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"2023042621462926200_deab177-B16","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1089\/thy.2018.0657","article-title":"Impact of thyroid autoimmunity on ovarian reserve, pregnancy outcomes, and offspring health in euthyroid women following in vitro fertilization\/intracytoplasmic sperm injection","volume":"30","author":"Ke","year":"2020","journal-title":"Thyroid"},{"key":"2023042621462926200_deab177-B17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.rbmo.2010.11.005","article-title":"Anti-Mullerian hormone-based prediction model for a live birth in assisted reproduction","volume":"22","author":"La Marca","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"2023042621462926200_deab177-B18","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.xfre.2020.09.003","article-title":"Transfers of lower quality embryos based on morphological appearance result in appreciable live birth rates: a Canadian center\u2019s experience","volume":"1","author":"Lai","year":"2020","journal-title":"F&S Reports"},{"key":"2023042621462926200_deab177-B19","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tjog.2020.05.005","article-title":"Could PGT-A pick up true abnormalities that have clinical relevance? Retrospective analysis of 1043 embryos","volume":"59","author":"Liu","year":"2020","journal-title":"Taiwan J Obstet Gynecol"},{"key":"2023042621462926200_deab177-B20","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/humrep\/12.10.2129","article-title":"Utilization of retrieved oocytes as an index of the efficiency of superovulation strategies for in-vitro fertilization treatment","volume":"12","author":"Meniru","year":"1997","journal-title":"Hum Reprod"},{"key":"2023042621462926200_deab177-B21","doi-asserted-by":"crossref","first-page":"108320","DOI":"10.1016\/j.mrrev.2020.108320","article-title":"Mechanisms of oocyte aneuploidy associated with advanced maternal age","volume":"785","author":"Mikwar","year":"2020","journal-title":"Mutat Res"},{"key":"2023042621462926200_deab177-B22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/humrep\/dex031","article-title":"Euploidy rates in donor egg cycles significantly differ between fertility centers","volume":"32","author":"Munne","year":"2017","journal-title":"Hum Reprod"},{"key":"2023042621462926200_deab177-B23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/humrep\/dey346","article-title":"To test or not to test? A framework for counselling patients on preimplantation genetic testing for aneuploidy (PGT-A)","volume":"34","author":"Murphy","year":"2019","journal-title":"Hum Reprod"},{"key":"2023042621462926200_deab177-B24","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.fertnstert.2018.01.011","article-title":"Frequencies of chromosome-specific mosaicisms in trophoectoderm biopsies detected by next-generation sequencing","volume":"109","author":"Nakhuda","year":"2018","journal-title":"Fertil Steril"},{"key":"2023042621462926200_deab177-B25","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1042\/CS20160004","article-title":"Gender, aging and longevity in humans: an update of an intriguing\/neglected scenario paving the way to a gender-specific medicine","volume":"130","author":"Ostan","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"2023042621462926200_deab177-B26","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.fertnstert.2008.01.003","article-title":"From oocyte to baby: a clinical evaluation of the biological efficiency of in vitro fertilization","volume":"91","author":"Patrizio","year":"2009","journal-title":"Fertil Steril"},{"key":"2023042621462926200_deab177-B27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00439-002-0852-x","article-title":"Maternal aging and chromosomal abnormalities: new data drawn from in vitro unfertilized human oocytes","volume":"112","author":"Pellestor","year":"2003","journal-title":"Hum Genet"},{"key":"2023042621462926200_deab177-B28","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/oxfordjournals.humrep.a136618","article-title":"Embryo scoring as a prognostic tool in IVF treatment","volume":"2","author":"Puissant","year":"1987","journal-title":"Hum Reprod"},{"key":"2023042621462926200_deab177-B29","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.fertnstert.2017.03.011","article-title":"In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study","volume":"107","author":"Rubio","year":"2017","journal-title":"Fertil Steril"},{"key":"2023042621462926200_deab177-B30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000098184","article-title":"X chromosome loss and ageing","volume":"116","author":"Russell","year":"2007","journal-title":"Cytogenet Genome Res"},{"key":"2023042621462926200_deab177-B31","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1089\/gtmb.2017.0108","article-title":"Validation of next-generation sequencer for 24-chromosome aneuploidy screening in human embryos","volume":"21","author":"Sachdeva","year":"2017","journal-title":"Genet Test Mol Biomarkers"},{"key":"2023042621462926200_deab177-B32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/ajmg.a.30911","article-title":"Turner syndrome: four challenges across the lifespan","volume":"139A","author":"Sutton","year":"2005","journal-title":"Am J Med Genet A"},{"key":"2023042621462926200_deab177-B33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/09513599809024955","article-title":"Pregnancy in patients with turner's syndrome: six new cases and review of literature","volume":"12","author":"Tarani","year":"1998","journal-title":"Gynecol Endocrinol"},{"key":"2023042621462926200_deab177-B34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1210\/er.2016-1047","article-title":"Premature ovarian insufficiency: new perspectives on genetic cause and phenotypic spectrum","volume":"37","author":"Tucker","year":"2016","journal-title":"Endocr Rev"},{"key":"2023042621462926200_deab177-B35","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0140-6736(18)32843-5","article-title":"Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial","volume":"393","author":"Wei","year":"2019","journal-title":"The Lancet"},{"key":"2023042621462926200_deab177-B36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00404-014-3189-5","article-title":"Morphological good-quality embryo has higher nucleus spreading rate\/signal resolution rate in fluorescence in situ hybridization","volume":"290","author":"Wu","year":"2014","journal-title":"Arch Gynecol Obstet"},{"key":"2023042621462926200_deab177-B37","first-page":"1","article-title":"Cumulative live birth rate: an outmoded term. J Fertil: In Vitro \u2013 IVF-Worldwide Reprod Med","volume":"4","author":"Yovich","year":"2016","journal-title":"Genet Stem Cell Biol"},{"key":"2023042621462926200_deab177-B38","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.fertnstert.2018.01.012","article-title":"Association of birth defects with the mode of assisted reproductive technology in a Chinese data-linkage cohort","volume":"109","author":"Yu","year":"2018","journal-title":"Fertil Steril"},{"key":"2023042621462926200_deab177-B39","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.21873\/invivo.11925","article-title":"Low-level X chromosome mosaicism: a common finding in women undergoing IVF","volume":"34","author":"Zachaki","year":"2020","journal-title":"In Vivo"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/36\/9\/2612\/50104079\/deab177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/36\/9\/2612\/50104079\/deab177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T21:47:14Z","timestamp":1682545634000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/36\/9\/2612\/6330569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,27]]},"references-count":39,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,7,27]]},"published-print":{"date-parts":[[2021,8,18]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deab177","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9,1]]},"published":{"date-parts":[[2021,7,27]]}}}