{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:20:47Z","timestamp":1792185647119,"version":"4.4.0"},"reference-count":99,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility; however, whether women with PCOS and spontaneous or drug-induced ovulatory cycles have the same reproductive potential as non-PCOS controls is a matter of debate. In the present opinion paper, the author takes the opportunity to summarize the collective evidence supporting the hypothesis of reduced fertility potential in women with PCOS, regardless of ovulatory status, and speculate that reduced reproductive potential may be caused by altered oocytes, embryo and endometrial competence, and infertility-related co-morbidities as well as an increased risk of pregnancy complications.<\/jats:p>","DOI":"10.1093\/humrep\/deab181","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T11:37:19Z","timestamp":1626176239000},"page":"2421-2428","source":"Crossref","is-referenced-by-count":133,"title":["Is fertility reduced in ovulatory women with polycystic ovary syndrome? An opinion paper"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2767-8295","authenticated-orcid":false,"given":"Stefano","family":"Palomba","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology, University \u201cMagna Graecia\u201d of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,1]]},"reference":[{"key":"2021082017500950300_deab181-B1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/humrep\/dez272","article-title":"Harmonising research outcomes for polycystic ovary syndrome: an international multi-stakeholder core outcome set","volume":"35","author":"Al Wattar","year":"2020","journal-title":"Hum Reprod"},{"key":"2021082017500950300_deab181-B2","doi-asserted-by":"crossref","first-page":"6076274","DOI":"10.1155\/2020\/6076274","article-title":"Association of IL-1\u03b2, IL-6, TNF-\u03b1, and TGF\u03b21 gene polymorphisms with recurrent spontaneous abortion in polycystic ovary syndrome","volume":"2020","author":"Alkhuriji","year":"2020","journal-title":"Dis Markers"},{"key":"2021082017500950300_deab181-B3","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1210\/jc.2014-2086","article-title":"Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development","volume":"100","author":"Ambekar","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2021082017500950300_deab181-B4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.rbmo.2018.04.043","article-title":"Distinct changes in the proteome profile of endometrial tissues in polycystic ovary syndrome compared with healthy fertile women","volume":"37","author":"Amjadi","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"2021082017500950300_deab181-B5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12958-020-00617-9","article-title":"Non-esterified fatty acids in the ovary: friends or foes?","volume":"18","author":"Baddela","year":"2020","journal-title":"Reprod Biol Endocrinol"},{"key":"2021082017500950300_deab181-B6","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/obr.12832","article-title":"The role of maternal obesity in infant outcome in polycystic ovary syndrome \u2013 a systematic review, meta-analysis, and meta-regression","volume":"20","author":"Bahri Khomami","year":"2019","journal-title":"Obes Rev"},{"key":"2021082017500950300_deab181-B7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/obr.12829","article-title":"Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity \u2013 a systematic review, meta-analysis, and meta-regression","volume":"20","author":"Bahri Khomami","year":"2019","journal-title":"Obes Rev"},{"key":"2021082017500950300_deab181-B8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/humupd\/dmw025","article-title":"The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance","volume":"22","author":"Balen","year":"2016","journal-title":"Hum Reprod Update"},{"key":"2021082017500950300_deab181-B9","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0039-128X(03)00120-X","article-title":"A role for the androgen receptor in the endometrial antiproliferative effects of progesterone antagonists","volume":"68","author":"Brenner","year":"2003","journal-title":"Steroids"},{"key":"2021082017500950300_deab181-B10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.rbmo.2019.11.001","article-title":"Factors related to early spontaneous miscarriage during IVF\/ICSI treatment: an analysis of 21,485 clinical pregnancies","volume":"40","author":"Bu","year":"2020","journal-title":"Reprod Biomed Online"},{"key":"2021082017500950300_deab181-B11","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/humrep\/deaa192","article-title":"Association of polycystic ovary syndrome or anovulatory infertility with offspring psychiatric and mild neurodevelopmental disorders: a Finnish population-based cohort study","volume":"35","author":"Chen","year":"2020","journal-title":"Hum Reprod"},{"key":"2021082017500950300_deab181-B12","doi-asserted-by":"crossref","first-page":"hoy021","DOI":"10.1093\/hropen\/hoy021","article-title":"International PCOS Network. 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