{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:12:11Z","timestamp":1789621931312,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"IVI-RMA Valencia","award":["1706-VLC-051-EL"],"award-info":[{"award-number":["1706-VLC-051-EL"]}]},{"name":"Conseller\u00eda d\u2019Educaci\u00f3, Investigaci\u00f3, Cultura, i esport Generalitat Valenciana","award":["GV\/2018\/\/151"],"award-info":[{"award-number":["GV\/2018\/\/151"]}]},{"name":"Almudena Devesa-Peiro","award":["FPU\/15\/01398"],"award-info":[{"award-number":["FPU\/15\/01398"]}]},{"name":"Cristina Rodriguez-Varela","award":["FPU18\/01657"],"award-info":[{"award-number":["FPU18\/01657"]}]},{"DOI":"10.13039\/100014440","name":"Ministry of Science, Innovation and Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>Is there a relationship between serum and endometrial progesterone (P4) levels, including P4 and metabolites (oestrone, oestradiol and 17\u03b1-hydroxyprogesterone), and endometrial receptivity?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>Serum P4 levels were not correlated with endometrial P4, nor associated with endometrial receptivity as determined by the ERA\u00ae test; however, endometrial P4 and 17\u03b1-hydroxyprogesterone levels were positively correlated and related to endometrial receptivity by ERA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>Acquisition of endometrial receptivity is governed by P4, which induces secretory transformation. A close relationship between serum P4 and pregnancy outcome is reported for hormone replacement therapy (HRT) cycles. However, the relationship between serum and uterine P4 levels has not been described, and it is unknown whether uterine receptivity depends more on serum or uterine P4 levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>A prospective cohort study was performed during March 2018\u20132019 in 85 IVF patients undergoing an evaluation-only HRT cycle with oestradiol valerate (6\u2009mg\/day) and micronised vaginal progesterone (400\u2009mg\/12 h).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>Patients were under 50\u2009years of age, had undergone at least one failed IVF cycle, had no uterine pathology, and had adequate endometrial thickness (&amp;gt; 6.5\u2009mm). The study was conducted at IVI Valencia and IVI Foundation. An endometrial biopsy and a blood sample were collected after 5\u2009days of P4 vaginal treatment. Measures included serum P4 levels, ERA\u00ae-based evaluation of endometrial receptivity, and endometrial P4 levels along with metabolites (oestrone, oestradiol and 17\u03b1-hydroxyprogesterone) measured by ultra-performance liquid chromatography\u2013tandem mass spectrometry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>Seventy-nine women were included (mean age: 39.9\u2009\u00b1\u20094.6, BMI: 24.2\u2009\u00b1\u20093.9\u2009kg\/m2, endometrial thickness: 8.2\u2009\u00b1\u20091.4\u2009mm). The percentage of endometria indicated as receptive by ERA\u00ae was 40.5%. When comparing receptive versus non-receptive groups, no differences were observed in baseline characteristics nor in steroid hormones levels in serum or endometrium. No association between serum P4 and endometrial steroid levels or ERA result was found (P\u2009&amp;lt;\u20090.05). When the population was stratified according to metabolite concentration levels, endometrial P4 and 17\u03b1-hydroxyprogesterone were significantly associated with endometrial receptivity (P\u2009&amp;lt;\u20090.05). A higher proportion of receptive endometria by ERA was observed when endometrial P4 levels were higher than 40.07\u2009\u00b5g\/ml (relative maximum) and a lower proportion of receptive endometria was associated with endometrial 17\u03b1-hydroxyprogesterone lower than 0.35\u2009ng\/ml (first quartile). A positive correlation R2\u2009=\u20090.67, P\u2009&amp;lt;\u20090.001 was observed between endometrial P4 and 17\u03b1-hydroxyprogesterone levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>This study did not analyse pregnancy outcomes. Further, the findings can only be extrapolated to HRT cycles with micronised vaginal progesterone for luteal phase support.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>Our findings suggest that the combined benefits of different routes of progesterone administration for luteal phase support could be leveraged to ensure an adequate concentration of progesterone both in the uterus and in the bloodstream. Further studies will confirm whether this method can optimise both endometrial receptivity and live birth rate. Additionally, targeted treatment to increase P4 endometrial levels may normalise the timing of the window of implantation without needing to modify the progesterone administration day.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>This research was supported by the IVI-RMA Valencia (1706-VLC-051-EL) and Conseller\u00eda d\u2019Educaci\u00f3, Investigaci\u00f3, Cultura, i esport Generalitat Valenciana (Valencian Government, Spain, GV\/2018\/\/151). Almudena Devesa-Peiro (FPU\/15\/01398) and Cristina Rodriguez-Varela (FPU18\/01657) were supported by the FPU program fellowship from the Ministry of Science, Innovation and Universities (Spanish Government). P.D.-G. is co-inventor on the ERA patent, with non-economic benefits. The other authors have no competing interests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>NCT03456375.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/deab184","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T19:11:49Z","timestamp":1628104309000},"page":"2861-2870","source":"Crossref","is-referenced-by-count":79,"title":["Analysis of serum and endometrial progesterone in determining endometrial receptivity"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3048-9447","authenticated-orcid":false,"given":"E","family":"Labarta","sequence":"first","affiliation":[{"name":"Reproductive Medicine, IVI RMA Valencia, Valencia, Spain"},{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Sebastian-Leon","sequence":"additional","affiliation":[{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5540-3032","authenticated-orcid":false,"given":"A","family":"Devesa-Peiro","sequence":"additional","affiliation":[{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"},{"name":"Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Celada","sequence":"additional","affiliation":[{"name":"Reproductive Medicine, IVI RMA Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Vidal","sequence":"additional","affiliation":[{"name":"Reproductive Medicine, IVI RMA Valencia, Valencia, Spain"},{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Giles","sequence":"additional","affiliation":[{"name":"Reproductive Medicine, IVI RMA Valencia, Valencia, Spain"},{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4273-4120","authenticated-orcid":false,"given":"C","family":"Rodriguez-Varela","sequence":"additional","affiliation":[{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Bosch","sequence":"additional","affiliation":[{"name":"Reproductive Medicine, IVI RMA Valencia, Valencia, Spain"},{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-7545","authenticated-orcid":false,"given":"P","family":"Diaz-Gimeno","sequence":"additional","affiliation":[{"name":"IVI Foundation, Instituto de Investigaci\u00f3n Sanitaria La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"2021111806391669900_deab184-B1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/humupd\/dmt048","article-title":"Guidelines for the design, analysis and interpretation of \u201comics\u201d data: focus on human endometrium","volume":"20","author":"Altm\u00e4e","year":"2014","journal-title":"Hum Reprod Update"},{"key":"2021111806391669900_deab184-B2","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s10815-018-1190-9","article-title":"Does the endometrial receptivity array really provide personalized embryo transfer?","volume":"35","author":"Bassil","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"2021111806391669900_deab184-B3","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/humrep\/12.5.1073","article-title":"Targeted drug delivery in gynaecology: the first uterine pass effect","volume":"12","author":"Bulletti","year":"1997","journal-title":"Hum Reprod"},{"key":"2021111806391669900_deab184-B4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/978-1-4684-5101-6_21","article-title":"Progesterone resistance","volume":"196","author":"Chrousos","year":"1986","journal-title":"Adv Exp Med Biol"},{"key":"2021111806391669900_deab184-B5","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.fertnstert.2004.03.069","article-title":"Histological dating of timed endometrial biopsy tissue is not related to fertility status","volume":"82","author":"Coutifaris","year":"2004","journal-title":"Fertil Steril"},{"key":"2021111806391669900_deab184-B6","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1007\/s10815-020-01948-7","article-title":"Evaluation of the endometrial receptivity assay and the preimplantation genetic test for aneuploidy in overcoming recurrent implantation failure","volume":"37","author":"Cozzolino","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"2021111806391669900_deab184-B7","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/humupd\/dmy044","article-title":"Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis","volume":"25","author":"Craciunas","year":"2019","journal-title":"Hum Reprod Update"},{"key":"2021111806391669900_deab184-B8","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1016\/j.fertnstert.2018.07.026","article-title":"Three-arm RCT: vaginal only progesterone is inferior, but vaginal plus intramuscular (IM) progesterone every third day is equivalent, to daily IM progesterone for vitrified-warmed blastocyst transfer in terms of live birth","volume":"110","author":"Devine","year":"2018","journal-title":"Fertil Steril"},{"key":"2021111806391669900_deab184-B9","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.fertnstert.2010.04.063","article-title":"A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature","volume":"95","author":"D\u00edaz-Gimeno","year":"2011","journal-title":"Fertil Steril"},{"key":"2021111806391669900_deab184-B10","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.fertnstert.2012.09.046","article-title":"The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity","volume":"99","author":"D\u00edaz-Gimeno","year":"2013","journal-title":"Fertil Steril"},{"key":"2021111806391669900_deab184-B11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.fertnstert.2017.07.007","article-title":"Window of implantation transcriptomic stratification reveals different endometrial subsignatures associated with live birth and biochemical pregnancy","volume":"108","author":"D\u00edaz-Gimeno","year":"2017","journal-title":"Fertil Steril"},{"key":"2021111806391669900_deab184-B12","author":"Erguler","year":"2016"},{"key":"2021111806391669900_deab184-B13","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.3390\/ijms19103276","article-title":"Endometrial intracrinology: oestrogens, androgens and endometrial disorders","volume":"19","author":"Gibson","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2021111806391669900_deab184-B14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0010-7824(75)90028-1","article-title":"Unconjugated steroids in the human endometrium","volume":"11","author":"Guerrero","year":"1975","journal-title":"Contraception"},{"key":"2021111806391669900_deab184-B15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jpba.2018.01.034","article-title":"Analysis by LC\u2013MS\/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue","volume":"152","author":"H\u00e4kkinen","year":"2018","journal-title":"J Pharm Biomed Anal"},{"key":"2021111806391669900_deab184-B16","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/humupd\/dmz042","article-title":"Identifying biomarkers for predicting successful embryo implantation: applying single to multi-OMICs to improve reproductive outcomes","volume":"26","author":"Hern\u00e1ndez-Vargas","year":"2020","journal-title":"Hum Reprod Update"},{"key":"2021111806391669900_deab184-B17","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s10815-021-02074-8","article-title":"Prospective analysis of progesterone exposure in programmed single thawed euploid embryo transfer cycles and outcomes","volume":"38","author":"Hirschberg","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"2021111806391669900_deab184-B18","doi-asserted-by":"crossref","first-page":"E2188","DOI":"10.1210\/jc.2014-1913","article-title":"Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions","volume":"99","author":"Huhtinen","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2021111806391669900_deab184-B19","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1093\/humrep\/dex316","article-title":"Low serum progesterone on the day of embryo transfer is associated with a diminished ongoing pregnancy rate in oocyte donation cycles after artificial endometrial preparation: a prospective study","volume":"32","author":"Labarta","year":"2017","journal-title":"Hum Reprod"},{"key":"2021111806391669900_deab184-B20","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/humrep\/deaa322","article-title":"Impact of low serum progesterone levels on the day of embryo transfer on pregnancy outcome: a prospective cohort study in artificial cycles with vaginal progesterone","volume":"36","author":"Labarta","year":"2021","journal-title":"Hum Reprod"},{"key":"2021111806391669900_deab184-B21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.rbmo.2020.09.027","article-title":"Comments on the methodology of an endometrial receptivity array trial","volume":"42","author":"Lensen","year":"2021","journal-title":"Reprod Biomed Online"},{"key":"2021111806391669900_deab184-B22","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.3390\/ijms20153822","article-title":"Progesterone and estrogen signaling in the endometrium: What goes wrong in endometriosis?","volume":"20","author":"Marquardt","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2021111806391669900_deab184-B23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0015-0282(16)56935-0","article-title":"Pharmacokinetics and endometrial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study","volume":"62","author":"Miles","year":"1994","journal-title":"Fertil Steril"},{"key":"2021111806391669900_deab184-B24","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.fertnstert.2019.04.021","article-title":"Evaluation of progestogen supplementation for luteal phase support in fresh in vitro fertilization cycles","volume":"112","author":"Mohammed","year":"2019","journal-title":"Fertil Steril"},{"key":"2021111806391669900_deab184-B25","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.fertnstert.2003.11.030","article-title":"A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women","volume":"81","author":"Murray","year":"2004","journal-title":"Fertil Steril"},{"key":"2021111806391669900_deab184-B26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4103\/jhrs.JHRS_74_18","article-title":"Personalized embryo transfer helps in improving In vitro fertilization\/ICSI outcomes in patients with recurrent implantation failure","volume":"12","author":"Patel","year":"2019","journal-title":"J Hum Reprod Sci"},{"key":"2021111806391669900_deab184-B27","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1210\/jc.2013-3937","article-title":"Progesterone pharmacokinetics and pharmacodynamics with 3 dosages and 2 regimens of an effervescent micronized progesterone vaginal insert","volume":"99","author":"Paulson","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2021111806391669900_deab184-B28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.fertnstert.2020.07.002","article-title":"Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers","volume":"115","author":"Pirtea","year":"2021","journal-title":"Fertil Steril"},{"key":"2021111806391669900_deab184-B29","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2016"},{"key":"2021111806391669900_deab184-B30","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.fertnstert.2013.05.004","article-title":"The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure","volume":"100","author":"Ruiz-Alonso","year":"2013","journal-title":"Fertil Steril"},{"key":"2021111806391669900_deab184-B31","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/humrep\/deu070","article-title":"What a difference two days make: personalized embryo transfer (pET) paradigm: a case report and pilot study","volume":"29","author":"Ruiz-Alonso","year":"2014","journal-title":"Hum Reprod"},{"key":"2021111806391669900_deab184-B32","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/humrep\/dey023","article-title":"Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure","volume":"33","author":"Sebastian-Leon","year":"2018","journal-title":"Hum Reprod"},{"key":"2021111806391669900_deab184-B33","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fendo.2019.00198","article-title":"Progesterone-related immune modulation of pregnancy and labor","volume":"10","author":"Shah","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2021111806391669900_deab184-B34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.rbmo.2020.06.002","article-title":"A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF","volume":"41","author":"Sim\u00f3n","year":"2020","journal-title":"Reprod Biomed Online"},{"key":"2021111806391669900_deab184-B35","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.rbmo.2017.09.012","article-title":"Repeated implantation failure at the crossroad between statistics, clinics and over-diagnosis","volume":"36","author":"Somigliana","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"2021111806391669900_deab184-B36","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.rbmo.2013.06.010","article-title":"Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity","volume":"27","author":"Young","year":"2013","journal-title":"Reprod Biomed Online"},{"key":"2021111806391669900_deab184-B37","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/humrep\/dex252","article-title":"Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression","volume":"32","author":"Young","year":"2017","journal-title":"Hum Reprod"},{"key":"2021111806391669900_deab184-B38","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.rbmo.2015.05.005","article-title":"Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement","volume":"31","author":"Yovich","year":"2015","journal-title":"Reprod Biomed Online"},{"key":"2021111806391669900_deab184-B39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1749-6632.1997.tb48550.x","article-title":"The first uterine pass effect","volume":"828","author":"Ziegler","year":"1997","journal-title":"Ann N Y Acad Sci"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/36\/11\/2861\/41165260\/deab184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/36\/11\/2861\/41165260\/deab184.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T09:34:20Z","timestamp":1637228060000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/36\/11\/2861\/6348476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,12]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,8,12]]},"published-print":{"date-parts":[[2021,10,18]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deab184","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11,1]]},"published":{"date-parts":[[2021,8,12]]}}}