{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:27:19Z","timestamp":1740130039248,"version":"3.37.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,18]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Selective LH deficiency has been described in several men, but only in two women who presented normal pubertal development but secondary amenorrhoea due to anovulation. Despite its rarity, this condition represents a valuable model for studying the processes regulated by FSH or LH during late folliculogenesis and ovulation in humans. A woman previously diagnosed with selective LH deficiency due to a homozygous germline splice site mutation in LHB (IVS2\u2009+\u20091G\u2192C mutation) was submitted to an individualised ovarian induction protocol, first with recombinant LH and then with highly purified urinary hCG. Ovarian follicle growth and ovulation were achieved, and a healthy baby was born after an uneventful term pregnancy. The treatment described herein demonstrates that the clinical actions of exogenous LH or hCG in inducing late-stage follicular development in women with deficient LH production or performance might be interchangeable or inevitable, once FSH-dependent early follicular growth is assured.<\/jats:p>","DOI":"10.1093\/humrep\/deab213","type":"journal-article","created":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T19:09:46Z","timestamp":1631387386000},"page":"2916-2920","source":"Crossref","is-referenced-by-count":0,"title":["Successful pregnancy after ovulation induction with human chorionic gonadotropin in a woman with selective luteinising hormone deficiency"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-291X","authenticated-orcid":false,"given":"Lizandra Moura Paravidine","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Women's Health, University Hospital of Bras\u00edlia, Bras\u00edlia, Brazil"},{"name":"Department of Postgraduate Program in Medical Sciences, Faculty of Medicine, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Ramalho","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Women's Health, S\u00edrio Liban\u00eas Hospital, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelino Amaral","family":"Silva","sequence":"additional","affiliation":[{"name":"Genesis\u2014Human Reproduction Assistance Center, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Moreno","family":"Zaconeta","sequence":"additional","affiliation":[{"name":"Department of Women's Health, University Hospital of Bras\u00edlia, Bras\u00edlia, Brazil"},{"name":"Department of Gynecology and Obstetrics, Faculty of Medicine, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"da Silva Wanderley","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Faculty of Medicine, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Augusto Casulari Roxo","family":"da Motta","sequence":"additional","affiliation":[{"name":"Department of Postgraduate Program in Medical Sciences, Faculty of Medicine, University of Bras\u00edlia, Bras\u00edlia, Brazil"},{"name":"Department of Endocrinology and Metabolism, University Hospital of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Lofrano-Porto","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, University Hospital of Bras\u00edlia, Bras\u00edlia, Brazil"},{"name":"Department of Molecular Pharmacology Laboratory, Graduate Program in Health Sciences, University of Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,9,18]]},"reference":[{"key":"2021111806384927700_deab213-B1","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMoa0805792","article-title":"Normal spermatogenesis in a man with mutant luteinizing hormone","volume":"361","author":"Achard","year":"2009","journal-title":"N Engl J Med"},{"key":"2021111806384927700_deab213-B2","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/S1472-6483(11)60007-2","article-title":"Who needs LH in ovarian stimulation?","volume":"22(Suppl 1","author":"Alviggi","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"2021111806384927700_deab213-B3","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.fertnstert.2018.01.003","article-title":"Recombinant luteinizing hormone supplementation in assisted reproductive technology: 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