{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T05:11:56Z","timestamp":1774156316100,"version":"3.50.1"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>For some years, the prospect of precise and personalized timing of the endometrial cycle for optimal embryo replacement has been held out as a potential solution to low implantation rates. It is envisaged that a receptive state can be defined and reached at a predictable time, and embryo replacement performed in synchrony. In the last century, morphological changes characteristic of the mid secretory phase were defined in precisely timed cycles in women of proven fertility, but when deviations from this standardized schedule occur, their significance for implantation has remained uncertain. \u2018Omics technologies have been widely advocated for staging the endometrial cycle and defining a set of biochemical requirements for implantation, but after two decades of research, improvements to pregnancy rates have not followed, and there is a striking lack of agreement regarding the molecular characterization of the receptive state. Some of the rationale underlying these problems is now emerging with the application of higher-level computational and biological methodology. Here, we consider the challenges of defining an endometrial phenotype that can support implantation and continuing pregnancy. Receptivity may be an emergent trait depending on contributions from multiple proteins that have low pathway connectivity. We recommend that authors choose language which rigorously avoids the implication that protocols for molecular staging of the mid secretory phase inherently identify a state of receptivity to the implanting blastocyst.<\/jats:p>","DOI":"10.1093\/humrep\/deac022","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T20:13:10Z","timestamp":1644351190000},"page":"644-650","source":"Crossref","is-referenced-by-count":19,"title":["Use of \u2018omics for endometrial timing: the cycle moves on"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8777-9261","authenticated-orcid":false,"given":"John D","family":"Aplin","sequence":"first","affiliation":[{"name":"Maternal and Fetal Health Centre, Manchester Academic Health Sciences Centre, University of Manchester, St Mary\u2019s Hospital, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1950-7325","authenticated-orcid":false,"given":"Adam","family":"Stevens","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Centre, Manchester Academic Health Sciences Centre, University of Manchester, St Mary\u2019s Hospital, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"2022040313214834100_deac022-B1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/humupd\/dmt048","article-title":"Guidelines for the design, analysis and interpretation of \u2018omics\u2019 data: focus on human endometrium","volume":"20","author":"Altmae","year":"2014","journal-title":"Hum Reprod Update"},{"key":"2022040313214834100_deac022-B2","doi-asserted-by":"crossref","first-page":"10077","DOI":"10.1038\/s41598-017-10098-3","article-title":"Meta-signature of human 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