{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:19:40Z","timestamp":1754486380075,"version":"3.37.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["320656"],"award-info":[{"award-number":["320656"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,30]]},"abstract":"Abstract<\/jats:title>\n \n STUDY QUESTION<\/jats:title>\n Is parents\u2019 age at birth associated with daughters\u2019 fecundability?<\/jats:p>\n <\/jats:sec>\n \n SUMMARY ANSWER<\/jats:title>\n Daughters born to mothers &lt;25\u2009years or fathers \u226535\u2009years had slightly lower fecundability.<\/jats:p>\n <\/jats:sec>\n \n WHAT IS KNOWN ALREADY<\/jats:title>\n Two recent studies reported lower fecundability in women born to mothers &lt;20\u2009years, which may be partly due to daughters of young mothers being less likely to plan their pregnancies.<\/jats:p>\n <\/jats:sec>\n \n STUDY DESIGN, SIZE, DURATION<\/jats:title>\n A retrospective cohort study of 58\u00a0496 pregnancy planners (4290 of whom conceived with treatment) and 14\u00a0194 non-planners enrolled in the Norwegian Mother, Father and Child Cohort Study (MoBa) between 2000 and 2008, linked with the Medical Birth Registry of Norway.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n Participants were born in Norway between 1967 and 1990. We estimated fecundability ratios (FRs) and 95% CI as a function of both parents\u2019 (F1) age at the daughter\u2019s (F2) birth among non-treated planners and the relative risk of time to pregnancy (TTP) \u226512\u2009months or treatment among all planners. We explored whether daughters of young mothers were under-represented among planners, compared with the underlying population. Finally, we estimated FRs after adding non-planners, randomly assigned to conceiving in the first cycle with probabilities of 0.60 and 0.70.<\/jats:p>\n <\/jats:sec>\n \n MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n For both mother and father, the reference category was 25\u201329\u2009years. Fecundability was slightly lower among daughters of older fathers (FRs (95% CI): 0.95 (0.92, 0.98) for F1 father\u2019s age 35\u201339\u2009years and 0.93 (0.89, 0.97) for \u226540\u2009years) and daughters of young mothers (0.92 (0.89, 0.96) for F1 mother\u2019s age &lt;20\u2009years and 0.97 (0.95, 0.99) for 20\u201324\u2009years). Results were similar for the composite outcome TTP\u2009\u2265\u200912\u2009months or treatment, although driven by TTP\u2009\u2265\u200912. Compared with Norwegian-born women with \u22651 pregnancy, planners born to mothers &lt;20\u2009years were underrepresented. Including non-planners with very high fecundability weakened the association with mother\u2019s age &lt;20\u2009years.<\/jats:p>\n <\/jats:sec>\n \n LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n This was a pregnancy cohort with retrospectively reported information on planning and TTP. Selection bias appears unlikely to fully explain the association with mother\u2019s age &lt;20\u2009years.<\/jats:p>\n <\/jats:sec>\n \n WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n Daughters of young mothers or older fathers may have slightly lower fecundability. If corroborated, the finding about older paternal age is relevant, given the widespread tendency to delay childbearing.<\/jats:p>\n <\/jats:sec>\n \n STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n This work was partly funded by the Research Council of Norway (project no. 320656), and through its Centres of Excellence funding scheme (project no. 262700). M.C.M. has received funding from the European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation programme (grant agreement no. 947684). No competing interests.<\/jats:p>\n <\/jats:sec>\n \n TRIAL REGISTRATION NUMBER<\/jats:title>\n N\/A.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humrep\/deac086","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T11:15:09Z","timestamp":1649934909000},"page":"1896-1906","source":"Crossref","is-referenced-by-count":2,"title":["Parents\u2019 age at birth and daughters\u2019 time to pregnancy: a study within the Norwegian Mother, Father and Child Cohort"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9298-4921","authenticated-orcid":false,"given":"Olga","family":"Basso","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, McGill University Health Centre, Montreal, Canada"},{"name":"Department of Epidemiology, Biostatistics, and Occupational Health, McGill University , Montreal, Canada"},{"name":"Research Institute of the McGill University Health Centre , Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0568-3774","authenticated-orcid":false,"given":"Maria C","family":"Magnus","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health, Norwegian Institute of Public Health (NIPH) , Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4710-3221","authenticated-orcid":false,"given":"Lise A","family":"Arge","sequence":"additional","affiliation":[{"name":"Centre for Fertility and Health, Norwegian Institute of Public Health (NIPH) , Oslo, Norway"},{"name":"Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo , Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2199-5225","authenticated-orcid":false,"given":"Siri E","family":"H\u00e5berg","sequence":"additional","affiliation":[{"name":"Centre for Fertility 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