{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:35:49Z","timestamp":1791920149238,"version":"4.3.4"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100020309","name":"KARL STORZ SE & Co. KG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020309","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,5]]},"abstract":"Abstract<\/jats:title>\n \n STUDY QUESTION<\/jats:title>\n Is interleukin-10 (IL-10) anti-fibrotic in endometriosis?<\/jats:p>\n <\/jats:sec>\n \n SUMMARY ANSWER<\/jats:title>\n IL-10 is not anti-fibrotic but pro-fibrotic in endometriosis, because IL-10 treatment of endometriotic stromal cells in vitro promotes myofibroblast proliferation and collagen type I protein expression.<\/jats:p>\n <\/jats:sec>\n \n WHAT IS KNOWN ALREADY<\/jats:title>\n We previously showed that persistent activation of signal transducer and activator of transcription 3 (STAT3) via IL-6 trans-signaling promotes fibrosis of endometriosis. Studies showed marked anti-fibrotic effects of IL-10 via the STAT3 signaling pathway, which is generally considered to be anti-inflammatory, in various organs.<\/jats:p>\n <\/jats:sec>\n \n STUDY DESIGN, SIZE, DURATION<\/jats:title>\n Endometrial and\/or endometriotic samples of 54 patients who had histological evidence of deep endometriosis, and endometrial samples from 30 healthy fertile women were analyzed.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n The effects of IL-10\/STAT3 signaling as well as inhibition of STAT3 activation by knockdown of STAT3 gene on the pro-fibrotic phenotype in endometrial and endometriotic stromal cells in vitro were investigated. Then, the effects of various time points of IL-10 treatment in combination with transforming growth factor (TGF)-\u03b21 and\/or IL-6\/soluble IL-6 receptor (sIL-6R) on the profibrotic phenotype of endometrial and endometriotic stromal cells were investigated.<\/jats:p>\n <\/jats:sec>\n \n MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n IL-10 induced pro-fibrotic phenotype (cell proliferation, collagen type I synthesis, \u03b1-smooth muscle actin positive stress fibers and collagen gel contraction) of endometriotic stromal cells. Knockdown of STAT3 gene decreased the IL-10 induced pro-fibrotic phenotype of endometriotic stromal cells. In contrast, IL-10 had no significant effects on pro-fibrotic phenotype of endometrial stromal cells of healthy women. Sequential IL-10 treatment with or without TGF-\u03b21 and\/or IL-6\/sIL-6R induced persistent activation of STAT3 and significantly increased proliferation of myofibroblasts (cells with \u03b1-smooth muscle actin positive stress fibers) and protein expression of collagen type I in endometriotic stromal cells. TGF-\u03b21 and\/or IL-6\/sIL6RIL-6\/sIL6R treatment significantly increased tissue inhibitor of metalloproteinase 1 (TIMP1) protein expression, whereas IL-10 had no significant effects. Knockdown of STAT3 gene significantly decreased the TGF-\u03b21 and\/or IL-6\/sIL6R induced TIMP1 protein expression. In contrast, pre-treatment with IL-10 before TGF-\u03b21 and\/or IL-6\/sIL-6R treatment and sequential IL-10 treatment with or without TGF-\u03b21 and\/or IL-6\/sIL-6R significantly decreased proliferation of fibroblasts (cells without \u03b1-smooth muscle actin positive stress fibers) and collagen type I protein expression in endometrial stromal cells of healthy women.<\/jats:p>\n <\/jats:sec>\n \n LARGE SCALE DATA<\/jats:title>\n N\/A.<\/jats:p>\n <\/jats:sec>\n \n LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n Given the large number of complex interactions and signaling pathways of pro- and anti-inflammatory mediators that are involved in the pathophysiology of endometriosis, the present study investigated only a very small portion of the whole. Further in vivo studies are required to validate the present findings.<\/jats:p>\n <\/jats:sec>\n \n WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n Inflammatory mediators in the pathophysiology of endometriosis have been extensively investigated as potential therapeutic targets. However, the present study showed that anti-inflammatory signals of IL-10 and IL-6 through persistent STAT3 activation may promote endometriosis fibrosis. Therapeutic strategies, such as suppression of \u2018inflammation\u2019, might dysregulate the cross-regulation of \u2018pro- and anti-inflammatory mediators\u2019, leading to detrimental effects in patients with endometriosis, such as fibrosis. To develop new, but not deleterious, therapeutic strategies, studies are required to investigate whether, how and what \u2018anti-inflammatory mediators\u2019 along with pro-inflammatory mediators are involved in individual patients with endometriosis.<\/jats:p>\n <\/jats:sec>\n \n STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n This study was supported in part by KARL STORZ SE & Co. KG (Tuttlingen, Germany). The authors have no conflict of interest to disclose.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humrep\/deac248","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T14:27:04Z","timestamp":1669127224000},"page":"14-29","source":"Crossref","is-referenced-by-count":23,"title":["IL-10 is not anti-fibrotic but pro-fibrotic in endometriosis: IL-10 treatment of endometriotic stromal cells in vitro<\/i> promotes myofibroblast proliferation and collagen type I protein expression"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9297-6515","authenticated-orcid":false,"given":"Sachiko","family":"Matsuzaki","sequence":"first","affiliation":[{"name":"CHU Clermont-Ferrand, Chirurgie Gyn\u00e9cologique , Clermont-Ferrand, France"},{"name":"Universit\u00e9 Clermont Auvergne, Institut Pascal, UMR6602, CNRS\/UCA\/SIGMA , Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Pouly","sequence":"additional","affiliation":[{"name":"CHU Clermont-Ferrand, Chirurgie Gyn\u00e9cologique , Clermont-Ferrand, France"},{"name":"Universit\u00e9 Clermont Auvergne, Institut Pascal, UMR6602, CNRS\/UCA\/SIGMA , Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Canis","sequence":"additional","affiliation":[{"name":"CHU Clermont-Ferrand, Chirurgie Gyn\u00e9cologique , Clermont-Ferrand, France"},{"name":"Universit\u00e9 Clermont Auvergne, Institut Pascal, UMR6602, CNRS\/UCA\/SIGMA , Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"2023010801273477700_deac248-B1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/humupd\/dmv003","article-title":"Deep endometriosis infiltrating the recto-sigmoid: critical factors to consider before management","volume":"21","author":"Abr\u00e3o","year":"2015","journal-title":"Hum Reprod Update"},{"key":"2023010801273477700_deac248-B2","first-page":"e4620","article-title":"Recommendations for anti-inflammatory treatments in Alzheimer\u2019s disease: a comprehensive review of the literature","volume":"11","author":"Ali","year":"2019","journal-title":"Cureus"},{"key":"2023010801273477700_deac248-B3","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1074\/jbc.M112.386573","article-title":"Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation","volume":"288","author":"Braun","year":"2013","journal-title":"J Biol Chem"},{"key":"2023010801273477700_deac248-B4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbamcr.2010.01.003","article-title":"The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity","volume":"1803","author":"Brew","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"2023010801273477700_deac248-B5","doi-asserted-by":"crossref","first-page":"e2666","DOI":"10.1038\/cddis.2017.95","article-title":"IL-27 triggers IL-10 production in Th17 cells via a c-Maf\/ROR\u03b3t\/Blimp-1 signal to promote the progression of endometriosis","volume":"8","author":"Chang","year":"2017","journal-title":"Cell Death Dis"},{"key":"2023010801273477700_deac248-B6","doi-asserted-by":"crossref","first-page":"e202001000","DOI":"10.26508\/lsa.202001000","article-title":"IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection","volume":"4","author":"Chenery","year":"2021","journal-title":"Life Sci Alliance"},{"key":"2023010801273477700_deac248-B7","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/humrep\/deh290","article-title":"Evidence for an increased release of proteolytic activity by the eutopic endometrial tissue in women with endometriosis and for involvement of matrix metalloproteinase-9","volume":"19","author":"Collette","year":"2004","journal-title":"Hum Reprod"},{"key":"2023010801273477700_deac248-B8","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1093\/humrep\/del297","article-title":"Increased expression of matrix metalloproteinase-9 in the eutopic endometrial tissue of women with endometriosis","volume":"21","author":"Collette","year":"2006","journal-title":"Hum Reprod"},{"key":"2023010801273477700_deac248-B9","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1111\/bph.12856","article-title":"Experimental design and analysis and their reporting: new guidance for publication in BJP","volume":"172","author":"Curtis","year":"2015","journal-title":"Br J Pharmacol"},{"key":"2023010801273477700_deac248-B10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bbrc.2011.02.009","article-title":"Silencing tissue inhibitors of metalloproteinases (TIMPs) with short interfering RNA reveals a role for TIMP-1 in hepatic stellate cell proliferation","volume":"407","author":"Fowell","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"2023010801273477700_deac248-B11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri.2017.90","article-title":"Type 2 immunity in tissue repair and fibrosis","volume":"18","author":"Gieseck","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"2023010801273477700_deac248-B12","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1093\/humrep\/deg300","article-title":"Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis","volume":"18","author":"Gilabert-Estell\u00e9s","year":"2003","journal-title":"Hum Reprod"},{"key":"2023010801273477700_deac248-B13","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"2023010801273477700_deac248-B14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0002-9378(97)70553-2","article-title":"Increased interleukin-6 levels in peritoneal fluid of infertile patients with active endometriosis","volume":"176","author":"Harada","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"2023010801273477700_deac248-B15","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.it.2019.08.003","article-title":"Rebalancing immune homeostasis to treat autoimmune diseases","volume":"40","author":"Horwitz","year":"2019","journal-title":"Trends Immunol"},{"key":"2023010801273477700_deac248-B16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1165\/ajrcmb.20.4.3342","article-title":"Lung fibrosis induced by silica particles in NMRI mice is associated with an upregulation of the p40 subunit of interleukin-12 and Th-2 manifestations","volume":"20","author":"Huaux","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2023010801273477700_deac248-B17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1165\/ajrcmb.18.1.2911","article-title":"Role of interleukin-10 in the lung response to silica in mice","volume":"18","author":"Huaux","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2023010801273477700_deac248-B18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1084\/jem.20171274","article-title":"Cardiac macrophages promote diastolic dysfunction","volume":"215","author":"Hulsmans","year":"2018","journal-title":"J Exp Med"},{"key":"2023010801273477700_deac248-B19","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1056\/NEJMoa1113354","article-title":"Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis","volume":"366","author":"Idiopathic Pulmonary Fibrosis Clinical Research Network;","year":"2012","journal-title":"N Engl J Med"},{"key":"2023010801273477700_deac248-B20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","article-title":"Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease","volume":"32","author":"Iyer","year":"2012","journal-title":"Crit Rev Immunol"},{"key":"2023010801273477700_deac248-B21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/1523-1747.ep12286457","article-title":"Tissue inhibitor of metalloproteinase 1 (TIMP-1) may be an autocrine growth factor in scleroderma fibroblasts","volume":"108","author":"Kikuchi","year":"1997","journal-title":"J Invest Dermatol"},{"key":"2023010801273477700_deac248-B22","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.fertnstert.2012.07.1061","article-title":"Deep endometriosis: definition, diagnosis, and treatment","volume":"98","author":"Koninckx","year":"2012","journal-title":"Fertil Steril"},{"key":"2023010801273477700_deac248-B23","first-page":"263","article-title":"Correction: heterogeneity of endometriosis lesions requires individualisation of diagnosis and treatment and a different approach to research and evidence based medicine","volume":"11","author":"Koninckx","year":"2020","journal-title":"Facts Views Vis Obgyn"},{"key":"2023010801273477700_deac248-B24","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1007\/s00018-016-2268-0","article-title":"Transition from inflammation to proliferation: a critical step during wound healing","volume":"73","author":"Land\u00e9n","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"2023010801273477700_deac248-B25","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.4049\/jimmunol.165.5.2783","article-title":"Proinflammatory effects of IL-10 during human endotoxemia","volume":"165","author":"Lauw","year":"2000","journal-title":"J Immunol"},{"key":"2023010801273477700_deac248-B26","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3389\/fphar.2017.00460","article-title":"Drugs for autoimmune inflammatory diseases: from small molecule compounds to anti-TNF biologics","volume":"8","author":"Li","year":"2017","journal-title":"Front Pharmacol"},{"key":"2023010801273477700_deac248-B27","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.3390\/ijms21082840","article-title":"Expression of matrix metalloproteinases and their inhibitors in endometrium: high levels in endometriotic lesions","volume":"21","author":"Luddi","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2023010801273477700_deac248-B28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/biomedicines9010054","article-title":"Inflammatory mediators and pain in endometriosis: a systematic review","volume":"9","author":"Machairiotis","year":"2021","journal-title":"Biomedicines"},{"key":"2023010801273477700_deac248-B29","doi-asserted-by":"crossref","first-page":"668","DOI":"10.4103\/1735-1995.166215","article-title":"Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis","volume":"20","author":"M\u0103lu\u0163an","year":"2015","journal-title":"J Res Med Sci"},{"key":"2023010801273477700_deac248-B30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000010094","article-title":"Fibrogenesis in peritoneal endometriosis. A semi-quantitative analysis of type-I collagen","volume":"47","author":"Matsuzaki","year":"1999","journal-title":"Gynecol Obstet Invest"},{"key":"2023010801273477700_deac248-B31","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1111\/bph.14170","article-title":"In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: autophagy may be required for regrowth of endometriosis","volume":"175","author":"Matsuzaki","year":"2018","journal-title":"Br J Pharmacol"},{"key":"2023010801273477700_deac248-B32","doi-asserted-by":"crossref","first-page":"9467","DOI":"10.1038\/s41598-020-66298-x","article-title":"Dose-dependent pro- or anti-fibrotic responses of endometriotic stromal cells to interleukin-1\u03b2 and tumor necrosis factor \u03b1","volume":"10","author":"Matsuzaki","year":"2020","journal-title":"Sci Rep"},{"key":"2023010801273477700_deac248-B33","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/humrep\/deac098","article-title":"Persistent activation of signal transducer and activator of transcription 3 via interleukin-6 trans-signaling is involved in fibrosis of endometriosis","volume":"37","author":"Matsuzaki","year":"2022","journal-title":"Hum Reprod"},{"key":"2023010801273477700_deac248-B34","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/ni1539","article-title":"TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology","volume":"8","author":"McGeachy","year":"2007","journal-title":"Nat Immunol"},{"key":"2023010801273477700_deac248-B35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0024-3205(02)01641-7","article-title":"Expression of matrix metalloproteinases in ovarian endometriomas: immunohistochemical study and enzyme immunoassay","volume":"71","author":"Mizumoto","year":"2002","journal-title":"Life Sci"},{"key":"2023010801273477700_deac248-B36","doi-asserted-by":"crossref","first-page":"1600189","DOI":"10.1002\/pmic.201600189","article-title":"Tubulin or not tubulin: heading toward total protein staining as loading control in western blots","volume":"17","author":"Moritz","year":"2017","journal-title":"Proteomics"},{"key":"2023010801273477700_deac248-B37","doi-asserted-by":"crossref","first-page":"11069","DOI":"10.1074\/jbc.M111490200","article-title":"Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis","volume":"277","author":"Murphy","year":"2002","journal-title":"J Biol Chem"},{"key":"2023010801273477700_deac248-B38","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.4049\/jimmunol.170.6.3263","article-title":"Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3","volume":"170","author":"Niemand","year":"2003","journal-title":"J Immunol"},{"key":"2023010801273477700_deac248-B39","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0015-0282(97)00191-X","article-title":"Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities","volume":"68","author":"Nisolle","year":"1997","journal-title":"Fertil Steril"},{"key":"2023010801273477700_deac248-B40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0015-0282(16)30062-0","article-title":"Dating the endometrial biopsy","volume":"1","author":"Noyes","year":"1950","journal-title":"Fertil Steril"},{"key":"2023010801273477700_deac248-B41","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/intimm\/dxy054","article-title":"Macrophages in inflammation, repair and regeneration","volume":"30","author":"Oishi","year":"2018","journal-title":"Int Immunol"},{"key":"2023010801273477700_deac248-B42","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.3748\/wjg.14.1885","article-title":"Effect of infliximab on small bowel stenoses in patients with Crohn\u2019s disease","volume":"14","author":"Pallotta","year":"2008","journal-title":"World J Gastroenterol"},{"key":"2023010801273477700_deac248-B43","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.tips.2015.07.007","article-title":"Resolution pharmacology: opportunities for therapeutic innovation in inflammation","volume":"36","author":"Perretti","year":"2015","journal-title":"Trends Pharmacol Sci"},{"key":"2023010801273477700_deac248-B44","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3390\/biom10071017","article-title":"The regulatory role of IL-10 in neurodegenerative diseases","volume":"10","author":"Porro","year":"2020","journal-title":"Biomolecules"},{"key":"2023010801273477700_deac248-B45","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejogrb.2011.12.011","article-title":"Expression and possible role of interleukin-10 receptors in patients with adenomyosis","volume":"161","author":"Qin","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2023010801273477700_deac248-B46","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1530\/REP-19-0411","article-title":"IL-2 and IL-27 synergistically promote growth and invasion of endometriotic stromal cells by maintaining the balance of IFN-\u03b3 and IL-10 in endometriosis","volume":"159","author":"Qiu","year":"2020","journal-title":"Reproduction"},{"key":"2023010801273477700_deac248-B47","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1164\/rccm.200709-1446OC","article-title":"Treatment of idiopathic pulmonary fibrosis with etanercept: an exploratory, placebo-controlled trial","volume":"178","author":"Raghu","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"2023010801273477700_deac248-B48","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/path.4733","article-title":"Enhanced protection from fibrosis and inflammation in the combined absence of IL-13 and IFN-\u03b3","volume":"239","author":"Ramalingam","year":"2016","journal-title":"J Pathol"},{"key":"2023010801273477700_deac248-B49","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/humrep\/deh571","article-title":"mRNA analysis of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis using a real-time quantitative RT-PCR assay","volume":"20","author":"Ram\u00f3n","year":"2005","journal-title":"Hum Reprod"},{"key":"2023010801273477700_deac248-B50","first-page":"e23010","article-title":"STAT3 activation: a key factor in tumor immunoescape","volume":"2","author":"R\u00e9b\u00e9","year":"2013","journal-title":"JAKSTAT"},{"key":"2023010801273477700_deac248-B51","doi-asserted-by":"crossref","first-page":"fcaa109","DOI":"10.1093\/braincomms\/fcaa109","article-title":"Anti-inflammatories in Alzheimer\u2019s disease-potential therapy or spurious correlate?","volume":"2","author":"Rivers-Auty","year":"2020","journal-title":"Brain Commun"},{"key":"2023010801273477700_deac248-B52","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.3389\/fimmu.2020.02061","article-title":"Immune tolerance as the physiologic counterpart of chronic inflammation","volume":"11","author":"Rogovskii","year":"2020","journal-title":"Front Immunol"},{"key":"2023010801273477700_deac248-B53","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ab.2019.03.010","article-title":"Ponceau S waste: Ponceau S staining for total protein normalization","volume":"575","author":"Sander","year":"2019","journal-title":"Anal Biochem"},{"key":"2023010801273477700_deac248-B54","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1056\/NEJMoa030815","article-title":"Infliximab maintenance therapy for fistulizing Crohn\u2019s disease","volume":"350","author":"Sands","year":"2004","journal-title":"N Engl J Med"},{"key":"2023010801273477700_deac248-B55","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1039\/C7BM00286F","article-title":"Fibroblast fate regulation by time dependent TGF-\u03b21 and IL-10 stimulation in biomimetic 3D matrices","volume":"5","author":"Sapudom","year":"2017","journal-title":"Biomater Sci"},{"key":"2023010801273477700_deac248-B56","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/bbrc.1999.1455","article-title":"Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing","volume":"265","author":"Sato","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"2023010801273477700_deac248-B57","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","article-title":"Endometriosis: etiology, pathobiology, and therapeutic prospects","volume":"184","author":"Saunders","year":"2021","journal-title":"Cell"},{"key":"2023010801273477700_deac248-B58","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1038\/s41467-018-05800-6","article-title":"Resolution of chronic inflammatory disease: universal and tissue-specific concepts","volume":"9","author":"Schett","year":"2018","journal-title":"Nat Commun"},{"key":"2023010801273477700_deac248-B59","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1093\/humrep\/der195","article-title":"The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model","volume":"26","author":"Schwager","year":"2011","journal-title":"Hum Reprod"},{"key":"2023010801273477700_deac248-B60","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1096\/fj.201601222R","article-title":"Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms","volume":"31","author":"Serhan","year":"2017","journal-title":"FASEB J"},{"key":"2023010801273477700_deac248-B61","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0015-0282(98)00075-2","article-title":"Tissue inhibitor of metalloproteinase-1 concentrations are attenuated in peritoneal fluid and sera of women with endometriosis and restored in sera by gonadotropin-releasing hormone agonist therapy","volume":"69","author":"Sharpe-Timms","year":"1998","journal-title":"Fertil Steril"},{"key":"2023010801273477700_deac248-B62","first-page":"3784","article-title":"Partial purification and amino acid sequence analysis of endometriosis protein-II (ENDO-II) reveals homology with tissue inhibitor of metalloproteinases-1 (TIMP-1)","volume":"80","author":"Sharpe-Timms","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2023010801273477700_deac248-B63","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/wound.2019.1032","article-title":"The role of the anti-inflammatory cytokine interleukin-10 in tissue fibrosis","volume":"9","author":"Steen","year":"2020","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"2023010801273477700_deac248-B64","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ajpath.2013.10.023","article-title":"Serum level of IL-10 is increased in patients with endometriosis, and IL-10 promotes the growth of lesions in a murine model","volume":"184","author":"Suen","year":"2014","journal-title":"Am J Pathol"},{"key":"2023010801273477700_deac248-B65","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/path.5339","article-title":"IL-10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis","volume":"249","author":"Suen","year":"2019","journal-title":"J Pathol"},{"key":"2023010801273477700_deac248-B66","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/humrep\/17.2.284","article-title":"Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1: a possible role in the pathogenesis of endometriosis","volume":"17","author":"Szamatowicz","year":"2002","journal-title":"Hum Reprod"},{"key":"2023010801273477700_deac248-B67","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"2023010801273477700_deac248-B68","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/gut.50.2.191","article-title":"Treatment of Crohn\u2019s disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma","volume":"50","author":"Tilg","year":"2002","journal-title":"Gut"},{"key":"2023010801273477700_deac248-B69","first-page":"1118","article-title":"Interleukin-6 secretion in vitro is up-regulated in ectopic and eutopic endometrial stromal cells from women with endometriosis","volume":"81","author":"Tseng","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2023010801273477700_deac248-B70","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0015-0282(99)00496-3","article-title":"Altered gene expression and secretion of interleukin-6 in stromal cells derived from endometriotic tissues","volume":"73","author":"Tsudo","year":"2000","journal-title":"Fertil Steril"},{"key":"2023010801273477700_deac248-B71","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00428-004-1117-y","article-title":"Eutopic endometrium and peritoneal, ovarian and bowel endometriotic tissues express a different profile of matrix metalloproteinases-2, -3 and -11, and of tissue inhibitor metalloproteinases-1 and -2","volume":"445","author":"Uzan","year":"2004","journal-title":"Virchows Arch"},{"key":"2023010801273477700_deac248-B72","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1074\/jbc.M609101200","article-title":"Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages","volume":"282","author":"Williams","year":"2007","journal-title":"J Biol Chem"},{"key":"2023010801273477700_deac248-B73","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"2023010801273477700_deac248-B74","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1530\/REP-17-0342","article-title":"The crosstalk between endometrial stromal cells and macrophages impairs cytotoxicity of NK cells in endometriosis by secreting IL-10 and TGF-\u03b2","volume":"154","author":"Yang","year":"2017","journal-title":"Reproduction"},{"key":"2023010801273477700_deac248-B75","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ni938","article-title":"IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages","volume":"4","author":"Yasukawa","year":"2003","journal-title":"Nat Immunol"},{"key":"2023010801273477700_deac248-B76","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/humupd\/dmx016","article-title":"The role of TGF-\u03b2 in the pathophysiology of peritoneal endometriosis","volume":"23","author":"Young","year":"2017","journal-title":"Hum Reprod Update"},{"key":"2023010801273477700_deac248-B77","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nri1995","article-title":"Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment","volume":"7","author":"Yu","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"2023010801273477700_deac248-B78","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1007\/s00018-019-03056-x","article-title":"Anti-inflammatory cytokines in endometriosis","volume":"76","author":"Zhou","year":"2019","journal-title":"Cell Mol Life Sci"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/38\/1\/14\/48445607\/deac248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/38\/1\/14\/48445607\/deac248.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T01:28:40Z","timestamp":1673141320000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/38\/1\/14\/6839851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,22]]},"references-count":78,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,11,22]]},"published-print":{"date-parts":[[2023,1,5]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deac248","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,11,22]]}}}