{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:31:25Z","timestamp":1791811885306,"version":"4.3.4"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Swedish government"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>STUDY QUESTION<\/jats:title><jats:p>Is preimplantation genetic testing (PGT) associated with adverse perinatal outcome and early childhood health?<\/jats:p><\/jats:sec><jats:sec><jats:title>SUMMARY ANSWER<\/jats:title><jats:p>Children born after PGT had comparable perinatal outcomes to children born after IVF\/ICSI and comparable findings regarding early childhood health.<\/jats:p><\/jats:sec><jats:sec><jats:title>WHAT IS KNOWN ALREADY<\/jats:title><jats:p>PGT is offered to couples affected by monogenic disorders (PGT-M) or inherited chromosomal aberrations (PGT-SR), limiting the risk of transferring the disorder to the offspring. PGT, an invasive technique, requires genetic analysis of one or up to ten cells from the embryo and is combined with IVF or ICSI. Several studies, most of them small, have shown comparable results after PGT and IVF\/ICSI concerning perinatal outcome. Only a few studies with limited samples have been published on PGT and childhood health.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title><jats:p>We performed a register-based study including all singletons born after PGT (n\u2009=\u2009390) in Sweden during 1 January 1996\u201330 September 2019. Singletons born after PGT were compared with all singletons born after IVF\/ICSI (n\u2009=\u200961\u00a0060) born during the same period of time and with a matched sample of singletons (n\u2009=\u200942\u00a0034) born after spontaneous conception selected from the Medical Birth Register. Perinatal outcomes, early childhood health, and maternal outcomes were compared between pregnancies after PGT and IVF\/ICSI as well as between pregnancies after PGT and spontaneous conception. Primary outcomes were preterm birth (PTB) and low birthweight (LBW) whereas childhood morbidity was the secondary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title><jats:p>Data on women who went through PGT and gave birth were obtained from the local databases at the two PGT centres in Sweden, whereas data on IVF treatment for the IVF\/ICSI group were obtained from the national IVF registers. These data were then cross-linked to national health registers; the Medical Birth Register, the Patient Register, and the Cause of Death Register. Logistic multivariable regression analysis and Cox proportional hazards models were performed with adjustment for relevant confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title><jats:p>The mean follow-up time was 4.6\u2009years for children born after PGT and 5.1\u2009years for children born after spontaneous conception, whereas the mean follow-up time was 9.0\u2009years for children born after IVF\/ICSI. For perinatal outcomes, PTB occurred in 7.7% of children after PGT and in 7.3% of children after IVF\/ICSI, whereas the rates were 4.9% and 5.2% for LBW (adjusted odds ratio (AOR) 1.22, 95% CI 0.82\u20131.81 and AOR 1.17, 95% CI 0.71\u20131.91, respectively). No differences were observed for birth defects. In comparison to spontaneous conception, children born after PGT had a higher risk for PTB (AOR 1.73, 95% CI 1.17\u20132.58). Regarding early childhood health, the absolute risk of asthma was 38\/390 (9.7%) in children born after PGT and 6980\/61\u00a0060 (11.4%) in children born after in IVF\/ICSI, whereas the corresponding numbers were 34\/390 (8.7%) and 7505\/61\u00a0060 (12.3%) for allergic disorders. Following Cox proportional hazards models, no significant differences were found for these outcomes. Sepsis, hypothyroidism, attention deficit hyperactivity disorder, autism spectrum disorders, mental retardation, cerebral palsy, and epilepsy were diagnosed in a maximum of three PGT children. No PGT children died during the follow-up period. Regarding maternal outcomes, the rates of placenta praevia and caesarean delivery were significantly higher after PGT in comparison to spontaneous conception (AOR 6.46, 95% CI 3.38\u201312.37 and AOR 1.52, 95% CI 1.20\u20131.92, respectively), whereas no differences were seen comparing pregnancies after PGT and IVF\/ICSI.<\/jats:p><\/jats:sec><jats:sec><jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title><jats:p>The rather small sample size of children born after PGT made it impossible to adjust for all relevant confounders including fertilization method and culture duration. Moreover, the follow-up time was short for most of the children especially in the PGT group, probably lowering the absolute number of diagnoses in early childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title><jats:p>The results are reassuring and indicate that the embryo biopsy itself has no adverse effect on the perinatal, early childhood, or maternal outcomes. Although the results are comparable to IVF\/ICSI also regarding early childhood outcome, they should be taken with caution due to the low number of children with diagnoses and short follow-up time. Long-term follow-up studies on children born after PGT are scarce and should be conducted considering the invasiveness of the technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title><jats:p>The study was financed by grants from the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (LUA\/ALF 70940), the Board of National Specialised Medical Care at Sahlgrenska University Hospital and Hjalmar Svensson Research Foundation. There are no conflicts of interest to declare.<\/jats:p><\/jats:sec><jats:sec><jats:title>TRIAL REGISTRATION NUMBER<\/jats:title><jats:p>N\/A.<\/jats:p><\/jats:sec>","DOI":"10.1093\/humrep\/dead021","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T19:52:39Z","timestamp":1675799559000},"page":"739-750","source":"Crossref","is-referenced-by-count":25,"title":["Preimplantation genetic testing and child health: a national register-based study"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5008-5661","authenticated-orcid":false,"given":"Erica","family":"Ginstr\u00f6m Ernstad","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, East Hospital, Sahlgrenska University Hospital , Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Hanson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Reproductive Medicine, Sahlgrenska University Hospital , Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"W\u00e5nggren","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet , Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Thurin-Kjellberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Reproductive Medicine, Sahlgrenska University Hospital , Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Hulthe S\u00f6derberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Sahlgrenska University Hospital , Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Syk Lundberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Karolinska University Hospital , Stockholm, Sweden"},{"name":"Department of Molecular Medicine and Surgery, Centre for Molecular Medicine, Karolinska Institutet , Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Petzold","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla-Britt","family":"Wennerholm","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, East Hospital, Sahlgrenska University Hospital , Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Bergh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Reproductive Medicine, Sahlgrenska University Hospital , Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.fertnstert.2016.07.1092","article-title":"Preimplantation genetic diagnosis: a national multicenter obstetric and neonatal follow-up study","volume":"106","author":"Bay","year":"2016","journal-title":"Fertil Steril"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"hoy013","DOI":"10.1093\/hropen\/hoy013","article-title":"Body composition and blood pressure in 6-year-old singletons born after pre-implantation genetic testing for monogenic and structural chromosomal aberrations: a matched cohort study","volume":"2018","author":"Belva","year":"2018","journal-title":"Hum Reprod Open"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/humupd\/dmz001","article-title":"The health of children conceived by ART: \u2018the chicken or the egg?\u2019","volume":"25","author":"Berntsen","year":"2019","journal-title":"Hum Reprod Update"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s10654-017-0316-1","article-title":"The Swedish cause of death register","volume":"32","author":"Brooke","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"2023040319421413600_"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/140349489001800209","article-title":"A quality study of a medical birth registry","volume":"18","author":"Cnattingius","year":"1990","journal-title":"Scand J Soc Med"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"hoaa043","DOI":"10.1093\/hropen\/hoaa043","article-title":"ESHRE PGT Consortium data collection XVI-XVIII: cycles from 2013 to 2015","volume":"2020","author":"Coonen","year":"2020","journal-title":"Hum Reprod Open"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1093\/humrep\/dex265","article-title":"ESHRE PGD Consortium data collection XIV-XV: cycles from January 2011 to December 2012 with pregnancy follow-up to October 2013","volume":"32","author":"De Rycke","year":"2017","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.earlhumdev.2009.10.003","article-title":"Growth and health outcome of 102 2-year-old children conceived after preimplantation genetic diagnosis or screening","volume":"85","author":"Desmyttere","year":"2009","journal-title":"Early Hum Dev"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/humrep\/der360","article-title":"Neonatal follow-up of 995 consecutively born children after embryo biopsy for PGD","volume":"27","author":"Desmyttere","year":"2012","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.fertnstert.2020.08.1423","article-title":"Current evidence supporting a goal of singletons: a review of maternal and perinatal outcomes associated with twin versus singleton pregnancies after in vitro fertilization and intracytoplasmic sperm injection","volume":"114","author":"Eapen","year":"2020","journal-title":"Fertil Steril"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.fertnstert.2014.06.023","article-title":"Neonatal outcome after preimplantation genetic diagnosis","volume":"102","author":"Eldar-Geva","year":"2014","journal-title":"Fertil Steril"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/humrep\/17.4.929","article-title":"Hospital care utilization of infants born after IVF","volume":"17","author":"Ericson","year":"2002","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","author":"European Network of Publication-Based Registries for the Epidemiological Surveillance of Congenital Anomalies (EUROCAT)"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/jmf.13.3.175.190","article-title":"Etiology and risk factors for placenta previa: an overview and meta-analysis of observational studies","volume":"13","author":"Faiz","year":"2003","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"378.e1","DOI":"10.1016\/j.ajog.2015.12.040","article-title":"Neonatal and maternal outcome after blastocyst transfer: a population-based registry study","volume":"214","author":"Ginstr\u00f6m Ernstad","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"126.e121","DOI":"10.1016\/j.ajog.2019.03.010","article-title":"Neonatal and maternal outcome after frozen embryo transfer: increased risks in programmed cycles","volume":"221","author":"Ginstr\u00f6m Ernstad","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/344768a0","article-title":"Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification","volume":"344","author":"Handyside","year":"1990","journal-title":"Nature"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1034\/j.1600-0412.2001.080004331.x","article-title":"Preimplantation genetic diagnosis (PGD): the Gothenburg experience","volume":"80","author":"Hanson","year":"2001","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1093\/humrep\/den217","article-title":"Preimplantation genetic screening in women of advanced maternal age caused a decrease in clinical pregnancy rate: a randomized controlled trial","volume":"23","author":"Hardarson","year":"2008","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/humrep\/deq231","article-title":"ESHRE PGD consortium best practice guidelines for amplification-based PGD","volume":"26","author":"Harton","year":"2011","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.rbmo.2017.05.003","article-title":"Obstetric and neonatal outcomes of pregnancies conceived after preimplantation genetic diagnosis: cohort study and meta-analysis","volume":"35","author":"Hasson","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.fertnstert.2019.01.035","article-title":"Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis","volume":"111","author":"Heijligers","year":"2019","journal-title":"Fertil Steril"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1093\/humrep\/dey302","article-title":"The cognitive and socio-emotional development of 5-year-old children born after PGD","volume":"33","author":"Heijligers","year":"2018","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.fertnstert.2021.06.040","article-title":"Impact of preimplantation genetic testing on obstetric and neonatal outcomes: a systematic review and meta-analysis","volume":"116","author":"Hou","year":"2021","journal-title":"Fertil Steril"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/jech.2009.093823","article-title":"Risk of autism spectrum disorders in children born after assisted conception: a population-based follow-up study","volume":"65","author":"Hvidtjorn","year":"2011","journal-title":"J Epidemiol Community Health"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.fertnstert.2013.09.025","article-title":"Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan","volume":"101","author":"Ishihara","year":"2014","journal-title":"Fertil Steril"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1080\/14767058.2017.1332035","article-title":"The association of placenta previa and assisted reproductive techniques: a meta-analysis","volume":"31","author":"Karami","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/humrep\/dex337","article-title":"Developmental outcome of 9-year-old children born after PGS: follow-up of a randomized trial","volume":"33","author":"Kuiper","year":"2018","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ejpn.2010.12.004","article-title":"Is there an increased risk for drug treated attention deficit\/hyperactivity disorder in children born after in vitro fertilization?","volume":"15","author":"K\u00e4ll\u00e9n","year":"2011","journal-title":"Eur J Paediatr Neurol"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ejpn.2010.03.007","article-title":"Cerebral palsy in children born after in vitro fertilization. Is the risk decreasing?","volume":"14","author":"K\u00e4ll\u00e9n","year":"2010","journal-title":"Eur J Paediatr Neurol"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.fertnstert.2005.03.035","article-title":"In vitro fertilization in Sweden: child morbidity including cancer risk","volume":"84","author":"K\u00e4ll\u00e9n","year":"2005","journal-title":"Fertil Steril"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.rbmo.2020.11.014","article-title":"Child health after preimplantation genetic testing","volume":"42","author":"Lewis","year":"2021","journal-title":"Reprod Biomed Online"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/humrep\/dep298","article-title":"Report on a consecutive series of 581 children born after blastomere biopsy for preimplantation genetic diagnosis","volume":"25","author":"Liebaers","year":"2010","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"46207","DOI":"10.1038\/srep46207","article-title":"Association between assisted reproductive technology and the risk of autism spectrum disorders in the offspring: a meta-analysis","volume":"7","author":"Liu","year":"2017","journal-title":"Sci Rep"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1186\/1471-2458-11-450","article-title":"External review and validation of the Swedish National Inpatient Register","volume":"11","author":"Ludvigsson","year":"2011","journal-title":"BMC Public Health"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.fertnstert.2013.08.044","article-title":"Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of blastocyst-stage versus cleavage-stage embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis","volume":"100","author":"Maheshwari","year":"2013","journal-title":"Fertil Steril"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/humupd\/dmx031","article-title":"Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer?","volume":"24","author":"Maheshwari","year":"2018","journal-title":"Hum Reprod Update"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1651-2227.1996.tb14164.x","article-title":"Intrauterine growth curves based on ultrasonically estimated foetal weights","volume":"85","author":"Marsal","year":"1996","journal-title":"Acta Paediatr"},{"key":"2023040319421413600_","author":"National Registry of Assisted Reproduction"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s12519-018-0172-4","article-title":"Pregnancy and child developmental outcomes after preimplantation genetic screening: a meta-analytic and systematic review","volume":"14","author":"Natsuaki","year":"2018","journal-title":"World J Pediatr"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/humrep\/dev090","article-title":"Risk of hypertensive disorders in pregnancies following assisted reproductive technology: a cohort study from the CoNARTaS group","volume":"30","author":"Opdahl","year":"2015","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humupd\/dms044","article-title":"Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis","volume":"19","author":"Pinborg","year":"2013","journal-title":"Hum Reprod Update"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fertnstert.2015.09.007","article-title":"Assisted reproductive technology and the risk of pregnancy-related complications and adverse pregnancy outcomes in singleton pregnancies: a meta-analysis of cohort studies","volume":"105","author":"Qin","year":"2016","journal-title":"Fertil Steril"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1093\/humrep\/deu240","article-title":"Risk of placenta praevia is linked to endometrial thickness in a retrospective cohort study of 4537 singleton assisted reproduction technology births","volume":"29","author":"Rombauts","year":"2014","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.fertnstert.2022.01.010","article-title":"The neurodevelopmental morbidity of children born after assisted reproductive technology: a Nordic register study from the Committee of Nordic Assisted Reproductive Technology and Safety group","volume":"117","author":"R\u00f6n\u00f6","year":"2022","journal-title":"Fertil Steril"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/14647273.2017.1336259","article-title":"Reproductive outcome following pre-implantation genetic diagnosis (PGD) in the UK","volume":"21","author":"Sharpe","year":"2018","journal-title":"Hum Fertil (Camb)"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1093\/humrep\/deab122","article-title":"Cerebral palsy in ART children has declined substantially over time: a Nordic study from the CoNARTaS group","volume":"36","author":"Spangmose","year":"2021","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/humrep\/deaa032","article-title":"Obstetric and perinatal risks in 4601 singletons and 884 twins conceived after fresh blastocyst transfers: a Nordic study from the CoNARTaS group","volume":"35","author":"Spangmose","year":"2020","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0140-6736(02)07674-2","article-title":"Neurological sequelae in children born after in-vitro fertilisation: a population-based study","volume":"359","author":"Stromberg","year":"2002","journal-title":"Lancet"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/humrep\/dew317","article-title":"Pre-term birth and low birth weight following preimplantation genetic diagnosis: analysis of 88\u00a0010 singleton live births following PGD and IVF cycles","volume":"32","author":"Sunkara","year":"2017","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/humrep\/dev172","article-title":"Mental disorders in childhood and young adulthood among children born to women with fertility problems","volume":"30","author":"Svahn","year":"2015","journal-title":"Hum Reprod"},{"key":"2023040319421413600_","author":"Swedish National Board of Health and Welfare"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"hoab024","DOI":"10.1093\/hropen\/hoab024","article-title":"ESHRE PGT Consortium data collection XIX-XX: PGT analyses from 2016 to 2017(\u2020)","volume":"2021","author":"van Montfoort","year":"2021","journal-title":"Hum Reprod Open"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/1471-0528.15227","article-title":"Are singleton pregnancies after assisted reproduction technology (ART) associated with a higher risk of placental anomalies compared with non-ART singleton pregnancies? A systematic review and meta-analysis","volume":"126","author":"Vermey","year":"2019","journal-title":"BJOG"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1161\/HYPERTENSIONAHA.118.12043","article-title":"Increased preeclampsia risk and reduced aortic compliance with in vitro fertilization cycles in the absence of a corpus luteum","volume":"73","author":"von Versen-Hoynck","year":"2019","journal-title":"Hypertension"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s12519-021-00442-z","article-title":"Cerebral palsy in children born after assisted reproductive technology: a meta-analysis","volume":"17","author":"Wang","year":"2021","journal-title":"World J Pediatr"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/humupd\/dmab031","article-title":"Asthma and allergies in offspring conceived by ART: a systematic review and meta-analysis","volume":"28","author":"Wijs","year":"2021","journal-title":"Hum Reprod Update"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.fertnstert.2019.03.033","article-title":"Maternal and neonatal outcomes associated with trophectoderm biopsy","volume":"112","author":"Zhang","year":"2019","journal-title":"Fertil Steril"},{"key":"2023040319421413600_","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/humupd\/dmab027","article-title":"Obstetric and neonatal outcomes of pregnancies resulting from preimplantation genetic testing: a systematic review and meta-analysis","volume":"27","author":"Zheng","year":"2021","journal-title":"Hum Reprod Update"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/38\/4\/739\/49734506\/dead021.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/38\/4\/739\/49734506\/dead021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T16:58:40Z","timestamp":1701795520000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/38\/4\/739\/7030754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,7]]},"references-count":60,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2,7]]},"published-print":{"date-parts":[[2023,4,3]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dead021","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,4,1]]},"published":{"date-parts":[[2023,2,7]]}}}