{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:11:22Z","timestamp":1768515082516,"version":"3.49.0"},"reference-count":102,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071623"],"award-info":[{"award-number":["82071623"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2017ZZ01016"],"award-info":[{"award-number":["2017ZZ01016"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Endometriosis-associated pain can be managed by either surgery or hormonal therapy. The final decision as to which treatment modality to take is based on efficacy and possible complications of different treatment modalities, risk of recurrence, and the patient\u2019s wishes and preferences. But in the thicket of fears, doubts, and murky facts, the choice may ultimately be the trade-off between irrational fears and ignorance versus scientific evidence. We elaborate some pros and cons of the two treatment modalities and highlight some notable downsides of hormonal therapy, in particular the possible yet unquantified risk of long-term hormonal therapy for malignant transformation, perhaps with the only exception of combined oral contraceptives. Thus, when discussing with patients, we advocate the approach of discussing the advantages and disadvantages of all treatment options in detail, accounting for the known pros and cons with a full understanding of the predictive irrationality of human beings. For endometriosis-associated pain, surgery is definitely not a failure of medicine but, rather, a viable option, especially given the recently surfaced undercurrent of wariness and dissatisfaction with the current hormonal drugs among patients with endometriosis. Above all, there is a pressing need to fill the knowledge gap of perioperative interventions intended to reduce the risk of recurrence and to fulfill the demand for the development of safe and efficacious non-hormonal therapeutics.<\/jats:p>","DOI":"10.1093\/humrep\/dead061","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T21:29:12Z","timestamp":1680816552000},"page":"1245-1252","source":"Crossref","is-referenced-by-count":8,"title":["In the thicket of fears, doubts, and murky facts: some reflections on treatment modalities for endometriosis-associated pain"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-7811","authenticated-orcid":false,"given":"Michel","family":"Canis","sequence":"first","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Medicine, CHU Clermont Ferrand , Clermont Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8511-7624","authenticated-orcid":false,"given":"Sun-Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Research Institute, Shanghai Obstetrics and Gynecology Hospital, Fudan University , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"2023070507330656500_dead061-B1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.fertnstert.2004.03.046","article-title":"Laparoscopic excision of endometriosis: a randomized, placebo-controlled trial","volume":"82","author":"Abbott","year":"2004","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/AOG.0b013e3181cb50b5","article-title":"ACOG Practice Bulletin No. 110: noncontraceptive uses of hormonal contraceptives","volume":"115","author":"ACOG","year":"2010","journal-title":"Obstet Gynecol"},{"key":"2023070507330656500_dead061-B3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12905-020-01139-7","article-title":"Real-world characteristics of women with endometriosis-related pain entering a multidisciplinary endometriosis program","volume":"21","author":"Agarwal","year":"2021","journal-title":"BMC Womens Health"},{"key":"2023070507330656500_dead061-B4","doi-asserted-by":"crossref","first-page":"978326","DOI":"10.3389\/fsurg.2022.978326","article-title":"Colorectal endometriosis: diagnosis, surgical strategies and post-operative complications","volume":"9","author":"Alborzi","year":"2022","journal-title":"Front Surg"},{"key":"2023070507330656500_dead061-B5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1055\/s-0040-1718943","article-title":"Interdisciplinary teams in endometriosis care","volume":"38","author":"Allaire","year":"2020","journal-title":"Semin Reprod Med"},{"key":"2023070507330656500_dead061-B6","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1093\/humrep\/17.7.1895","article-title":"Hyperalgesia, nerve infiltration and nerve growth factor expression in deep adenomyotic nodules, peritoneal and ovarian endometriosis","volume":"17","author":"Anaf","year":"2002","journal-title":"Hum Reprod"},{"key":"2023070507330656500_dead061-B7","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1056\/NEJMoa1614814","article-title":"Cancer-associated mutations in endometriosis without cancer","volume":"376","author":"Anglesio","year":"2017","journal-title":"N Engl J Med"},{"key":"2023070507330656500_dead061-B8","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jmig.2015.04.001","article-title":"Adolescent endometriosis: report of a series of 55 cases with a focus on clinical presentation and long-term issues","volume":"22","author":"Audebert","year":"2015","journal-title":"J Minim Invasive Gynecol"},{"key":"2023070507330656500_dead061-B9","doi-asserted-by":"crossref","first-page":"hoac009","DOI":"10.1093\/hropen\/hoac009","article-title":"ESHRE guideline: endometriosis","volume":"2022","author":"Becker","year":"2022","journal-title":"Hum Reprod Open"},{"key":"2023070507330656500_dead061-B10","doi-asserted-by":"crossref","first-page":"e12438","DOI":"10.1002\/rmb2.12438","article-title":"Age-dependent phenotypes of ovarian endometriomas","volume":"21","author":"Benagiano","year":"2022","journal-title":"Reprod Med Biol"},{"key":"2023070507330656500_dead061-B11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jmig.2019.09.791","article-title":"Recurrence after surgery for colorectal endometriosis: a systematic review and meta-analysis","volume":"27","author":"Bendifallah","year":"2020","journal-title":"J Minim Invasive Gynecol"},{"key":"2023070507330656500_dead061-B12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejogrb.2016.07.513","article-title":"Surgery versus hormonal therapy for deep endometriosis: is it a choice of the physician?","volume":"209","author":"Berlanda","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2023070507330656500_dead061-B13","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S1701-2163(16)30054-8","article-title":"Canadian contraception consensus (part 2 of 4)","volume":"37","author":"Black","year":"2015","journal-title":"J Obstet Gynaecol Can"},{"key":"2023070507330656500_dead061-B14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/aogs.13260","article-title":"Long-term evaluation of painful symptoms and fertility after surgery for large rectovaginal endometriosis nodule: a retrospective study","volume":"97","author":"Bourdel","year":"2018","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2023070507330656500_dead061-B15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0002-9378(97)70482-4","article-title":"Endometriosis\u2013a disease because it is characterized by bleeding","volume":"176","author":"Brosens","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"2023070507330656500_dead061-B16","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10654-020-00705-5","article-title":"Oral contraceptive use by formulation and endometrial cancer risk among women born in 1947-1964: The Nurses' Health Study II, a prospective cohort study","volume":"36","author":"Burchardt","year":"2021","journal-title":"Eur J Epidemiol"},{"key":"2023070507330656500_dead061-B17","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ejogrb.2021.05.040","article-title":"Popularity of endocrine endometriosis drugs and limited alternatives in the present and foreseeable future: a survey among 1420 affected women","volume":"262","author":"Burla","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2023070507330656500_dead061-B18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/humrep\/deg012","article-title":"The ovarian endometrioma: why is it so poorly managed? Laparoscopic treatment of large ovarian endometrioma: why such a long learning curve?","volume":"18","author":"Canis","year":"2003","journal-title":"Hum Reprod"},{"key":"2023070507330656500_dead061-B19","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.fertnstert.2008.07.1738","article-title":"Does the learning curve of conservative laparoscopic surgery in women with rectovaginal endometriosis impair the recurrence rate?","volume":"92","author":"Carmona","year":"2009","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B20","first-page":"153","article-title":"Clinical uses of gonadotropin-releasing hormone analogues","volume":"144","author":"Casper","year":"1991","journal-title":"CMAJ"},{"key":"2023070507330656500_dead061-B21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.fertnstert.2017.01.008","article-title":"Introduction: A focus on the medical management of endometriosis","volume":"107","author":"Casper","year":"2017","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.fertnstert.2017.01.003","article-title":"Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills","volume":"107","author":"Casper","year":"2017","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B23","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1093\/humrep\/der156","article-title":"Oral contraceptives and endometriosis: the past use of oral contraceptives for treating severe primary dysmenorrhea is associated with endometriosis, especially deep infiltrating endometriosis","volume":"26","author":"Chapron","year":"2011","journal-title":"Hum Reprod"},{"key":"2023070507330656500_dead061-B24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3349\/ymj.2022.0278","article-title":"Recurrence, reoperation, pregnancy rates, and risk factors for recurrence after ovarian endometrioma surgery: long-term follow-up of 756 women","volume":"64","author":"Choi","year":"2023","journal-title":"Yonsei Med J"},{"key":"2023070507330656500_dead061-B25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/humupd\/dmq022","article-title":"Hormonal contraception and risk of cancer","volume":"16","author":"Cibula","year":"2010","journal-title":"Hum Reprod Update"},{"key":"2023070507330656500_dead061-B26","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jmig.2018.08.005","article-title":"Patient quality of life and symptoms after surgical treatment for endometriosis","volume":"26","author":"Comptour","year":"2019","journal-title":"J Minim Invasive Gynecol"},{"key":"2023070507330656500_dead061-B27","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1152\/physrev.00031.2019","article-title":"Physiology of the endometrium and regulation of menstruation","volume":"100","author":"Critchley","year":"2020","journal-title":"Physiol Rev"},{"key":"2023070507330656500_dead061-B28","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3390\/diagnostics11040697","article-title":"What is new on ovarian carcinoma: integrated morphologic and molecular analysis following the new 2020 World Health Organization classification of female genital tumors","volume":"11","author":"De Leo","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"2023070507330656500_dead061-B29","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1177\/1933719118799195","article-title":"Further evidence for hypercoagulability in women with ovarian endometriomas","volume":"25","author":"Ding","year":"2018","journal-title":"Reprod Sci"},{"key":"2023070507330656500_dead061-B30","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgaa189","article-title":"Evidence in support for the progressive nature of ovarian endometriomas","volume":"105","author":"Ding","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"2023070507330656500_dead061-B31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12905-019-0860-9","article-title":"Is there a correlation between inflammatory markers and coagulation parameters in women with advanced ovarian endometriosis?","volume":"19","author":"Ding","year":"2019","journal-title":"BMC Womens Health"},{"key":"2023070507330656500_dead061-B32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1783\/147118910791749416","article-title":"Risk of venous thromboembolism and the use of dienogest- and drospirenone-containing oral contraceptives: results from a German case-control study","volume":"36","author":"Dinger","year":"2010","journal-title":"J Fam Plann Reprod Health Care"},{"key":"2023070507330656500_dead061-B33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2009.02.065","article-title":"Laparoscopic management of endometriomas using a combined technique of excisional (cystectomy) and ablative surgery","volume":"94","author":"Donnez","year":"2010","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B34","first-page":"CD011031","article-title":"Laparoscopic surgery for endometriosis","volume":"4","author":"Duffy","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"2023070507330656500_dead061-B35","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jpag.2017.01.014","article-title":"Dienogest 2 mg daily in the treatment of adolescents with clinically suspected endometriosis: the VISanne Study to Assess Safety in ADOlescents","volume":"30","author":"Ebert","year":"2017","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"2023070507330656500_dead061-B36","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1161\/STROKEAHA.122.039250","article-title":"Laparoscopically confirmed endometriosis and risk of incident stroke: a prospective cohort study","volume":"53","author":"Farland","year":"2022","journal-title":"Stroke"},{"key":"2023070507330656500_dead061-B37","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.ajog.2004.06.104","article-title":"Is rectovaginal endometriosis a progressive disease?","volume":"191","author":"Fedele","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"2023070507330656500_dead061-B38","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0015-0282(16)48132-X","article-title":"Microsurgery of endometriosis in infertile patients","volume":"42","author":"Gordts","year":"1984","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B39","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.fertnstert.2015.08.006","article-title":"Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery","volume":"104","author":"Guo","year":"2015","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/humrep\/dey015","article-title":"Fibrogenesis resulting from cyclic bleeding: the Holy Grail of the natural history of ectopic endometrium","volume":"33","author":"Guo","year":"2018","journal-title":"Hum Reprod"},{"key":"2023070507330656500_dead061-B41","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/humupd\/dmz047","article-title":"Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology","volume":"26","author":"Guo","year":"2020","journal-title":"Hum Reprod Update"},{"key":"2023070507330656500_dead061-B42","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/humupd\/dmy020","article-title":"Is it time for a paradigm shift in drug research and development in endometriosis\/adenomyosis?","volume":"24","author":"Guo","year":"2018","journal-title":"Hum Reprod Update"},{"key":"2023070507330656500_dead061-B43","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1093\/humrep\/dez187","article-title":"The perioperative period: a critical yet neglected time window for reducing the recurrence risk of endometriosis?","volume":"34","author":"Guo","year":"2019","journal-title":"Hum Reprod"},{"key":"2023070507330656500_dead061-B44","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.rbmo.2016.11.012","article-title":"Social psychogenic stress promotes the development of endometriosis in mouse","volume":"34","author":"Guo","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"2023070507330656500_dead061-B45","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab259","article-title":"Estrogen and progesterone therapy and meningiomas","volume":"163","author":"Hage","year":"2022","journal-title":"Endocrinology"},{"key":"2023070507330656500_dead061-B46","doi-asserted-by":"crossref","first-page":"c927","DOI":"10.1136\/bmj.c927","article-title":"Mortality among contraceptive pill users: cohort evidence from Royal College of General Practitioners' Oral Contraception Study","volume":"340","author":"Hannaford","year":"2010","journal-title":"BMJ"},{"key":"2023070507330656500_dead061-B47","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.fertnstert.2016.07.1077","article-title":"Development of ovarian cancer after excision of endometrioma","volume":"106","author":"Haraguchi","year":"2016","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B48","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1177\/1933719110381927","article-title":"Generalized hyperalgesia in women with endometriosis and its resolution following a successful surgery","volume":"17","author":"He","year":"2010","journal-title":"Reprod Sci"},{"key":"2023070507330656500_dead061-B49","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3109\/09513590.2014.926882","article-title":"Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study","volume":"30","author":"Hirata","year":"2014","journal-title":"Gynecol Endocrinol"},{"key":"2023070507330656500_dead061-B50","article-title":"Changing prostaglandin E2 (PGE2) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE2 receptor EP2 and EP4","volume":"21","author":"Huang","year":"2021","journal-title":"Reprod Med Biol"},{"key":"2023070507330656500_dead061-B51","doi-asserted-by":"crossref","first-page":"e12423","DOI":"10.1002\/rmb2.12423","article-title":"Higher fibrotic content of endometriotic lesions is associated with diminished prostaglandin E2 signaling","volume":"21","author":"Huang","year":"2022","journal-title":"Reprod Med Biol"},{"key":"2023070507330656500_dead061-B52","doi-asserted-by":"crossref","first-page":"580.e581","DOI":"10.1016\/j.ajog.2017.02.002","article-title":"Lifetime cancer risk and combined oral contraceptives: the Royal College of General Practitioners' Oral Contraception Study","volume":"216","author":"Iversen","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"2023070507330656500_dead061-B53","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.3390\/healthcare10122515","article-title":"Clinical diagnosis and early medical management for endometriosis: consensus from asian expert group","volume":"10","author":"Kim","year":"2022","journal-title":"Healthcare (Basel)"},{"key":"2023070507330656500_dead061-B54","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejogrb.2017.02.015","article-title":"Dienogest and deep infiltrating endometriosis: The remission of symptoms is not related to endometriosis nodule remission","volume":"211","author":"Leonardo-Pinto","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2023070507330656500_dead061-B55","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000127419","article-title":"Patterns of and factors potentially influencing the age at first surgery for women with ovarian endometriomas","volume":"66","author":"Liu","year":"2008","journal-title":"Gynecol Obstet Invest"},{"key":"2023070507330656500_dead061-B56","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1093\/humrep\/dew237","article-title":"Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor beta2","volume":"31","author":"Long","year":"2016","journal-title":"Hum Reprod"},{"key":"2023070507330656500_dead061-B57","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/s43032-022-01066-y","article-title":"Decreased glycolysis at menstruation is associated with increased menstrual blood loss","volume":"30","author":"Mao","year":"2022","journal-title":"Reprod Sci"},{"key":"2023070507330656500_dead061-B58","first-page":"43","article-title":"Histology of chocolate cysts","volume":"6","author":"Martin","year":"1990","journal-title":"J Gyecol Surg"},{"key":"2023070507330656500_dead061-B59","doi-asserted-by":"crossref","first-page":"17654","DOI":"10.1038\/s41598-019-54096-z","article-title":"Subtype I (intrinsic) adenomyosis is an independent risk factor for dienogest-related serious unpredictable bleeding in patients with symptomatic adenomyosis","volume":"9","author":"Matsubara","year":"2019","journal-title":"Sci Rep"},{"key":"2023070507330656500_dead061-B60","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1093\/humrep\/dep043","article-title":"Analysis of risk factors for the removal of normal ovarian tissue during laparoscopic cystectomy for ovarian endometriosis","volume":"24","author":"Matsuzaki","year":"2009","journal-title":"Hum Reprod"},{"key":"2023070507330656500_dead061-B61","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/aogs.12123","article-title":"Hormonal and surgical treatments for endometriosis and risk of epithelial ovarian cancer","volume":"92","author":"Melin","year":"2013","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2023070507330656500_dead061-B62","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/humupd\/dmq057","article-title":"Surgical treatment of deeply infiltrating endometriosis with colorectal involvement","volume":"17","author":"Meuleman","year":"2011","journal-title":"Hum Reprod Update"},{"key":"2023070507330656500_dead061-B63","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jmig.2016.04.008","article-title":"Continuous amenorrhea may be insufficient to stop the progression of colorectal endometriosis","volume":"23","author":"Millochau","year":"2016","journal-title":"J Minim Invasive Gynecol"},{"key":"2023070507330656500_dead061-B64","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ajog.2004.03.035","article-title":"Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis","volume":"191","author":"Modugno","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"2023070507330656500_dead061-B65","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejogrb.2020.05.049","article-title":"Risk of depression and anemia in users of hormonal endometriosis treatments: results from the VIPOS study","volume":"251","author":"Moehner","year":"2020","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2023070507330656500_dead061-B66","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.3390\/ijms19082332","article-title":"Clinically relevant anti-inflammatory agents for chemoprevention of colorectal cancer: new perspectives","volume":"19","author":"Mohammed","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2023070507330656500_dead061-B67","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.fertnstert.2015.11.047","article-title":"Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients","volume":"105","author":"Monsanto","year":"2016","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B68","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1080\/03007995.2020.1744120","article-title":"Use of dienogest in endometriosis: a narrative literature review and expert commentary","volume":"36","author":"Murji","year":"2020","journal-title":"Curr Med Res Opin"},{"key":"2023070507330656500_dead061-B69","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.fertnstert.2011.02.034","article-title":"Histologic analysis of specimens from laparoscopic endometrioma excision performed by different surgeons: does the surgeon matter?","volume":"95","author":"Muzii","year":"2011","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B70","author":"National Institute for Health and Care Excellence Guideline","year":"2017"},{"key":"2023070507330656500_dead061-B71","first-page":"2144","article-title":"Progression of deep infiltrating rectosigmoid endometriotic nodules","volume":"34","author":"Netter","year":"2019","journal-title":"Hum Reprod"},{"key":"2023070507330656500_dead061-B72","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.fertnstert.2017.07.021","article-title":"Evaluation of the efficacy and safety of dienogest in the treatment of painful symptoms in patients with adenomyosis: a randomized, double-blind, multicenter, placebo-controlled study","volume":"108","author":"Osuga","year":"2017","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B73","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/jog.14209","article-title":"Long-term use of dienogest for the treatment of primary and secondary dysmenorrhea","volume":"46","author":"Osuga","year":"2020","journal-title":"J Obstet Gynaecol Res"},{"key":"2023070507330656500_dead061-B74","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/jog.13406","article-title":"Long-term use of dienogest in the treatment of painful symptoms in adenomyosis","volume":"43","author":"Osuga","year":"2017","journal-title":"J Obstet Gynaecol Res"},{"key":"2023070507330656500_dead061-B75","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1470-2045(11)70404-1","article-title":"Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies","volume":"13","author":"Pearce","year":"2012","journal-title":"Lancet Oncol"},{"key":"2023070507330656500_dead061-B76","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.fertnstert.2014.02.012","article-title":"Treatment of pelvic pain associated with endometriosis: a committee opinion","volume":"101","author":"Practice Committee of the American Society for Reproductive","year":"2014","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B77","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.fertnstert.2022.05.030","article-title":"Molecular analysis suggests oligoclonality and metastasis of endometriosis lesions across anatomically defined subtypes","volume":"118","author":"Praetorius","year":"2022","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B78","first-page":"577","article-title":"Treatment of ovarian endometriomas using laparoscopic surgical techniques","volume":"31","author":"Reich","year":"1986","journal-title":"J Reprod Med"},{"key":"2023070507330656500_dead061-B79","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/03007995.2022.2031940","article-title":"Surgery vs. hormone-based treatment for pain control in deep infiltrating endometriosis: a retrospective cohort study","volume":"38","author":"Rezende","year":"2022","journal-title":"Curr Med Res Opin"},{"key":"2023070507330656500_dead061-B80","first-page":"71","article-title":"Surgical excision versus ablation for superficial endometriosis-associated pain: a randomized controlled trial","volume":"21","author":"Riley","year":"2018","journal-title":"J Minim Invasive Gynecol"},{"key":"2023070507330656500_dead061-B81","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.maturitas.2012.01.018","article-title":"The pharmacology of dienogest","volume":"71","author":"Ruan","year":"2012","journal-title":"Maturitas"},{"key":"2023070507330656500_dead061-B82","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11060-022-04124-2","article-title":"Meningioma in patients exposed to progestin drugs: results from a real-life screening program","volume":"160","author":"Samoyeau","year":"2022","journal-title":"J Neurooncol"},{"key":"2023070507330656500_dead061-B83","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/0002-9378(78)90417-9","article-title":"Reoperation after initial treatment of endometriosis with conservative surgery","volume":"131","author":"Schenken","year":"1978","journal-title":"Am J Obstet Gynecol"},{"key":"2023070507330656500_dead061-B84","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0015-0282(16)45612-8","article-title":"Ultrastructural changes in endometriotic tissue during danazol treatment","volume":"36","author":"Schweppe","year":"1981","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B85","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0015-0282(02)03431-3","article-title":"Peritoneal defects and the development of endometriosis in relation to the timing of endoscopic surgery during the menstrual cycle","volume":"78","author":"Schweppe","year":"2002","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B86","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.jmig.2016.06.010","article-title":"Regarding \"continuous amenorrhea may be insufficient to stop the progression of colorectal endometriosis\"","volume":"23","author":"Scioscia","year":"2016","journal-title":"J Minim Invasive Gynecol"},{"key":"2023070507330656500_dead061-B87","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1210\/en.2017-00171","article-title":"Progressive fibrosis: a progesterone- and KLF11-mediated sexually dimorphic female response","volume":"158","author":"Shenoy","year":"2017","journal-title":"Endocrinology"},{"key":"2023070507330656500_dead061-B88","doi-asserted-by":"crossref","first-page":"529.e521","DOI":"10.1016\/j.ajog.2011.01.053","article-title":"Recurrent endometrioma and ovarian reserve: biological connection or surgical paradox?","volume":"204","author":"Somigliana","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"2023070507330656500_dead061-B89","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.celrep.2018.07.037","article-title":"Clonal expansion and diversification of cancer-associated mutations in endometriosis and normal endometrium","volume":"24","author":"Suda","year":"2018","journal-title":"Cell Rep"},{"key":"2023070507330656500_dead061-B90","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0015-0282(16)56990-8","article-title":"Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis","volume":"62","author":"Sutton","year":"1994","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B91","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/AOG.0b013e31825ec2ee","article-title":"Effect of long-term combined oral contraceptive pill use on endometrial thickness","volume":"120","author":"Talukdar","year":"2012","journal-title":"Obstet Gynecol"},{"key":"2023070507330656500_dead061-B92","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"2023070507330656500_dead061-B93","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3138\/ptc-2020-0124-gee","article-title":"The revised IASP definition of pain and accompanying notes: considerations for the physiotherapy profession","volume":"73","author":"Vader","year":"2021","journal-title":"Physiother Can"},{"key":"2023070507330656500_dead061-B94","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.fertnstert.2018.02.124","article-title":"Surgery for deep endometriosis without involvement of digestive or urinary tracts: do not worry the patients!","volume":"109","author":"Vallee","year":"2018","journal-title":"Fertil Steril"},{"key":"2023070507330656500_dead061-B95","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11154-021-09666-w","article-title":"Hormonal treatments for endometriosis: the endocrine background","volume":"23","author":"Vannuccini","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"key":"2023070507330656500_dead061-B96","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humrep\/deq302","article-title":"\u2018Waiting for Godot\u2019: a commonsense approach to the medical treatment of endometriosis","volume":"26","author":"Vercellini","year":"2011","journal-title":"Hum Reprod"},{"key":"2023070507330656500_dead061-B97","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"2023070507330656500_dead061-B98","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.contraception.2010.04.006","article-title":"Factors affecting mortality in a large cohort study with special reference to oral contraceptive use","volume":"82","author":"Vessey","year":"2010","journal-title":"Contraception"},{"key":"2023070507330656500_dead061-B99","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/09513590.2020.1725965","article-title":"Effect of Dienogest therapy on the size of the endometrioma","volume":"36","author":"Vignali","year":"2020","journal-title":"Gynecol Endocrinol"},{"key":"2023070507330656500_dead061-B100","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.jmig.2014.05.002","article-title":"Long-term fertility after laparoscopy for endometriosis-associated pelvic pain in young adult women","volume":"21","author":"Wilson-Harris","year":"2014","journal-title":"J Minim Invasive Gynecol"},{"key":"2023070507330656500_dead061-B101","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1177\/1933719115572478","article-title":"Evidence for a hypercoagulable state in women with ovarian endometriomas","volume":"22","author":"Wu","year":"2015","journal-title":"Reprod Sci"},{"key":"2023070507330656500_dead061-B102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2018.03.001","article-title":"The presence of KRAS, PPP2R1A and ARID1A mutations in 101 Chinese samples with ovarian endometriosis","volume":"809","author":"Zou","year":"2018","journal-title":"Mutat Res"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/38\/7\/1245\/50785396\/dead061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/38\/7\/1245\/50785396\/dead061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T16:49:01Z","timestamp":1688575741000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/38\/7\/1245\/7110225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,6]]},"references-count":102,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4,6]]},"published-print":{"date-parts":[[2023,7,5]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dead061","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7,1]]},"published":{"date-parts":[[2023,4,6]]}}}