{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T23:10:48Z","timestamp":1776553848887,"version":"3.51.2"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["GNT1176437"],"award-info":[{"award-number":["GNT1176437"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ectopic pregnancy is a risk of both spontaneous and assisted reproduction pregnancies. The majority of ectopic pregnancies abnormally implant within a fallopian tube (extrauterine pregnancies). In haemodynamically stable women, medical or expectant treatment can be offered. Currently accepted medical treatment is using a drug called methotrexate. However, methotrexate has potential adverse effects, and a significant proportion of women will still require emergency surgery (up to 30%) to remove the ectopic pregnancy. Mifepristone (RU-486) has anti-progesterone effects and has a role in managing intrauterine pregnancy loss and termination of pregnancy. On reviewing the literature and given progesterone\u2019s pivotal role in sustaining pregnancy, we propose that we may have overlooked the role of mifepristone in the medical management of tubal ectopic pregnancy in haemodynamically stable women.<\/jats:p>","DOI":"10.1093\/humrep\/dead116","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T01:36:59Z","timestamp":1686361019000},"page":"1445-1448","source":"Crossref","is-referenced-by-count":6,"title":["Have we overlooked the role of mifepristone for the medical management of tubal ectopic pregnancy?"],"prefix":"10.1093","volume":"38","author":[{"given":"Julia","family":"Oltman","sequence":"first","affiliation":[{"name":"Aberdeen Centre for Women\u2019s Health Research, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen , Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjana","family":"Balachander","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences at Monash Health, Monash University , Clayton, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8337-550X","authenticated-orcid":false,"given":"Ben W","family":"Mol","sequence":"additional","affiliation":[{"name":"Aberdeen Centre for Women\u2019s Health Research, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen , Aberdeen, UK"},{"name":"Monash Medical Centre Clayton, Obstetrics and Gynaecology, Monash Medical Centre , Clayton, Victoria, Australia"},{"name":"Monash University , Clayton, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5320-9540","authenticated-orcid":false,"given":"Andrea M F","family":"Woolner","sequence":"additional","affiliation":[{"name":"Aberdeen Centre for Women\u2019s Health Research, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen , Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"2023080108204575500_dead116-B1","doi-asserted-by":"crossref","first-page":"423708","DOI":"10.1155\/2014\/423708","article-title":"Predictors of success of different treatment modalities for management of ectopic pregnancy","volume":"2014","author":"Avcio\u011flu","year":"2014","journal-title":"Obstet Gynecol Int"},{"key":"2023080108204575500_dead116-B14"},{"key":"2023080108204575500_dead116-B2","author":"British National Formulary (BNF)","year":"2023"},{"key":"2023080108204575500_dead116-B3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0140-6736(20)31788-8","article-title":"Mifepristone 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