{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:20:06Z","timestamp":1791624006273,"version":"4.3.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>What are the effects of male anxiety and depression on IVF outcomes?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>Men with anxiety had lower final total motile sperm counts (fTMSC) during IVF compared to men without anxiety; however, there were no differences in live birth rates (LBRs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>Studies have shown that male anxiety causes low sperm motility, worse sperm morphology, and increased DNA fragmentation, which are known to be influential factors on fertilization rates and embryo quality during IVF. However, data are lacking on whether there is a direct association between male anxiety and\/or depression and IVF outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>This was a survey-based, retrospective cohort study completed at a single, large hospital-affiliated fertility center with 222 respondents who underwent IVF with or without ICSI. The study was conducted between 6 September 2018 and 27 December 2022.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>Male partners of couples who underwent IVF or IVF\/ICSI completed a Hospital Anxiety and Depression Scale (HADS) questionnaire. They were separated into two groups for both anxiety (HADS-A\u2009\u2265\u20098 or HADS-A\u2009&amp;lt;\u20098) and depression (HADS-D\u2009\u2265\u20098 or HADS-D\u2009&amp;lt;\u20098). Men with an elevated HADS-A or HADS-D score \u22658 were considered to have anxiety or depression, respectively. The primary outcome was LBR. Secondary outcomes included semen parameters at the time of IVF, cycle outcomes, pregnancy outcomes, and prevalence of erectile dysfunction and low libido.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>There were a total of 222 respondents, of whom 22.5% had a HADS-A\u2009\u2265\u20098 and 6.5% had a HADS-D\u2009\u2265\u20098. The average age of respondents was 37.38\u2009\u00b1\u20094.90\u2009years old. Antidepressant use was higher in the respondents with a HADS-A or HADS-D\u2009\u2265\u20098 (P\u2009&amp;lt;\u20090.05). Smoking use was similar between groups for both HADS-A and HADS-D (P\u2009&amp;gt;\u20090.05). When adjusted for male BMI, antidepressant use and smoking, men with a HADS-A or HADS-D\u2009\u2265\u20098 had similar rates of erectile dysfunction (adjusted relative risk (aRR)\u2009=\u20091.12 (95% CI 0.60, 2.06)) and low libido (aRR\u2009=\u20091.70 (95% CI 0.91, 3.15)) compared to those with a HADS-A or HADS-D\u2009\u2264\u20098. Men with a HADS-A\u2009\u2265\u20098 were more likely to have a lower fTMSC on the day of oocyte retrieval (11.8\u2009\u2265\u20098 vs 20.1\u2009&amp;lt;\u20098, adjusted \u00df = \u22120.66 (95% CI \u22121.22, \u22120.10)). However, the LBR per embryo transfer (ET) was similar between the HADS-A groups (43.2% \u22658 vs 45.1% &amp;lt;8, adjusted relative risk = 0.90 (95% CI 0.65, 1.06)). Although depression was uncommon in the entire cohort, the HADS-D groups were clinically similar for fTMSC (18.7\u2009\u2265\u20098 vs 16.0\u2009&amp;lt;\u20098) and LBR per ET (46.7% \u22658 vs 45.4% &amp;lt;8).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>Limitations of our study are the survey-based design, the lack of sperm morphology assessment at the time of IVF, our inability to fully assess the HADS-D\u2009\u2265\u20098 cohort due to the small sample size and the large Caucasian demographic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>Couples undergoing IVF have an increased likelihood of suffering from anxiety and\/or depression. There is currently a debate on whether or not men should be treated with antidepressants while attempting to conceive due to potential detrimental effects on sperm quality. Our study shows that, regardless of antidepressant use, couples with men who did or did not report anxiety and\/or depression have similar LBRs when undergoing IVF. Therefore, it is important to assess both partners for mental health and to not withhold treatment due to a concern about a potential impact of antidepressants or anxiety\/depression on sperm quality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>There was no funding to report for this study. Z.W. is a contributing author for UptoDate. S.S.S. is on the advisory board for Ferring Pharmaceuticals. E.G. was a medical consultant for Hall-Matson Esq, Teladoc, and CRICO and is a contributing author for UptoDate. The remaining authors have nothing to report.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>N\/A.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/dead179","type":"journal-article","created":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T18:59:51Z","timestamp":1694372391000},"page":"2119-2127","source":"Crossref","is-referenced-by-count":12,"title":["The effects of male anxiety and depression on IVF outcomes"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9761-8901","authenticated-orcid":false,"given":"Zachary","family":"Walker","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Brigham & Women\u2019s Hospital , Boston, MA, USA"},{"name":"Harvard Medical School , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ernandez","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA, USA"},{"name":"Division of Urology, Brigham & Women\u2019s Hospital , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lanes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Brigham & Women\u2019s Hospital , Boston, MA, USA"},{"name":"Harvard Medical School , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serene S","family":"Srouji","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Brigham & Women\u2019s Hospital , Boston, MA, USA"},{"name":"Harvard Medical School , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Ginsburg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Brigham & Women\u2019s Hospital , Boston, MA, USA"},{"name":"Harvard Medical School , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kathrins","sequence":"additional","affiliation":[{"name":"Harvard Medical School , Boston, MA, USA"},{"name":"Division of Urology, Brigham & Women\u2019s Hospital , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,10]]},"reference":[{"key":"2023110708011131400_dead179-B1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"2023110708011131400_dead179-B2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/iju.14126","article-title":"Editorial Comment to Effect of antidepressant medications on semen parameters and male fertility","volume":"27","author":"Amano","year":"2020","journal-title":"Int J Urol"},{"key":"2023110708011131400_dead179-B3","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1093\/humrep\/16.12.2710","article-title":"Sperm morphological defects related to environment, lifestyle and medical history of 1001 male partners of pregnant women from four European cities","volume":"16","author":"Auger","year":"2001","journal-title":"Hum Reprod"},{"key":"2023110708011131400_dead179-B4","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.fertnstert.2016.12.031","article-title":"Male factor infertility and lack of openness about infertility as risk factors for depressive symptoms in males undergoing assisted reproductive technology treatment in Italy","volume":"107","author":"Babore","year":"2017","journal-title":"Fertil Steril"},{"key":"2023110708011131400_dead179-B5","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1007\/s10815-019-01580-0","article-title":"Association between blastocyst morphology and pregnancy and perinatal outcomes following fresh and cryopreserved embryo transfer","volume":"36","author":"Bakkensen","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"2023110708011131400_dead179-B6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/iju.14111","article-title":"Effect of antidepressant medications on semen parameters and male fertility","volume":"27","author":"Beeder","year":"2020","journal-title":"Int J Urol"},{"key":"2023110708011131400_dead179-B7","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/and.12268","article-title":"Effect of psychological stress on fertility hormones and seminal quality in male partners of infertile couples","volume":"47","author":"Bhongade","year":"2015","journal-title":"Andrologia"},{"key":"2023110708011131400_dead179-B8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0022-3999(01)00296-3","article-title":"The validity of the Hospital Anxiety and Depression Scale: an updated literature review","volume":"52","author":"Bjelland","year":"2002","journal-title":"J Psychosom Res"},{"key":"2023110708011131400_dead179-B9","first-page":"227","article-title":"\u2018How to count sperm properly\u2019: checklist for acceptability of studies based on human semen analysis","volume":"31","author":"Bj\u00f6rndahl","year":"2016","journal-title":"Hum Reprod"},{"key":"2023110708011131400_dead179-B10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/aogs.13280","article-title":"A prospective investigation of perceived stress, infertility-related stress, and cortisol levels in women undergoing in vitro fertilization: influence on embryo quality and clinical pregnancy rate","volume":"97","author":"Cesta","year":"2018","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2023110708011131400_dead179-B11","doi-asserted-by":"crossref","first-page":"e0165125","DOI":"10.1371\/journal.pone.0165125","article-title":"Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: a systematic review and meta-analysis","volume":"11","author":"Cissen","year":"2016","journal-title":"PLoS One"},{"key":"2023110708011131400_dead179-B38","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/humrep\/14.3.753","article-title":"Relationship between psychological stress and semen quality among in-vitro fertilization patients","volume":"14","author":"Clarke","year":"1999","journal-title":"Hum Reprod"},{"key":"2023110708011131400_dead179-B12","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s10815-018-1304-4","article-title":"Paternal factors contributing to embryo quality","volume":"35","author":"Colaco","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"2023110708011131400_dead179-B13","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3390\/nu10091162","article-title":"Dietary patterns and poor semen quality risk in men: a cross-sectional study","volume":"10","author":"Danielewicz","year":"2018","journal-title":"Nutrients"},{"key":"2023110708011131400_dead179-B14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s43032-020-00408-y","article-title":"Current insights and latest updates in sperm motility and associated applications in assisted reproduction","volume":"29","author":"Dcunha","year":"2022","journal-title":"Reprod Sci"},{"key":"2023110708011131400_dead179-B15","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1093\/humrep\/dei062","article-title":"Glutathione and free sulphydryl content of seminal plasma in healthy medical students during and after exam stress","volume":"20","author":"Eskiocak","year":"2005","journal-title":"Hum Reprod"},{"key":"2023110708011131400_dead179-B16","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.fertnstert.2018.01.029","article-title":"Major depression, antidepressant use, and male and female fertility","volume":"109","author":"Evans-Hoeker","year":"2018","journal-title":"Fertil Steril"},{"key":"2023110708011131400_dead179-B17","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1111\/jsm.12207","article-title":"Relationship between sexual dysfunction and psychological burden in men with infertility: a large observational study in China","volume":"10","author":"Gao","year":"2013","journal-title":"J Sex Med"},{"key":"2023110708011131400_dead179-B18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejogrb.2020.03.006","article-title":"Stress and the impact on the outcome of medically assisted reproduction","volume":"248","author":"Geisler","year":"2020","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2023110708011131400_dead179-B19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0015-0282(16)59663-0","article-title":"Effects of stress and characteristic adaptability on semen quality in healthy men","volume":"49","author":"Giblin","year":"1988","journal-title":"Fertil Steril"},{"key":"2023110708011131400_dead179-B20","first-page":"1025","article-title":"Sperm oxidative stress during in vitro manipulation and its effects on sperm function and embryo development","volume":"10","author":"Gualtieri","year":"2021","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"2023110708011131400_dead179-B21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/aje\/kwv135","article-title":"Association between use of marijuana and male reproductive hormones and semen quality: a study among 1,215 healthy young men","volume":"182","author":"Gundersen","year":"2015","journal-title":"Am J Epidemiol"},{"key":"2023110708011131400_dead179-B22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.5534\/wjmh.2015.33.3.143","article-title":"Smoking and male infertility: an evidence-based review","volume":"33","author":"Harlev","year":"2015","journal-title":"World J Mens Health"},{"key":"2023110708011131400_dead179-B23","author":"How much physical activity do adults need?","year":"2022"},{"key":"2023110708011131400_dead179-B24","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.fertnstert.2014.04.021","article-title":"Effects of work and life stress on semen quality","volume":"102","author":"Janevic","year":"2014","journal-title":"Fertil Steril"},{"key":"2023110708011131400_dead179-B25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3109\/03014460.2013.849755","article-title":"Occupational, life stress and family functioning: does it affect semen quality?","volume":"41","author":"Jurewicz","year":"2014","journal-title":"Ann Hum Biol"},{"key":"2023110708011131400_dead179-B26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2147\/NDT.S287198","article-title":"The analysis of anxiety and depression in different stages of in vitro fertilization-embryo transfer in couples in China","volume":"17","author":"Liu","year":"2021","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2023110708011131400_dead179-B27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.rbmo.2019.01.012","article-title":"Does stress affect IVF outcomes? A prospective study of physiological and psychological stress in women undergoing IVF","volume":"39","author":"Miller","year":"2019","journal-title":"Reprod Biomed Online"},{"key":"2023110708011131400_dead179-B28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/13651501.2021.1872647","article-title":"The effects of selective serotonin reuptake inhibitors on male and female fertility: a brief literature review","volume":"26","author":"Milosavljevi\u0107","year":"2022","journal-title":"Int J Psychiatry Clin Pract"},{"key":"2023110708011131400_dead179-B29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrurol.2015.112","article-title":"Effects of psychological stress on male fertility","volume":"12","author":"Nargund","year":"2015","journal-title":"Nat Rev Urol"},{"key":"2023110708011131400_dead179-B30","doi-asserted-by":"crossref","first-page":"e14449","DOI":"10.1111\/and.14449","article-title":"Association between generalized anxiety symptoms and semen quality in infertile men: a multicentre study in North China","volume":"54","author":"Pan","year":"2022","journal-title":"Andrologia"},{"key":"2023110708011131400_dead179-B31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/0167482X.2017.1289369","article-title":"Whose fault is it? Blame predicting psychological adjustment and couple satisfaction in couples seeking fertility treatment","volume":"39","author":"P\u00e9loquin","year":"2018","journal-title":"J Psychosom Obstet Gynaecol"},{"key":"2023110708011131400_dead179-B32","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.fertnstert.2017.01.025","article-title":"Performing the embryo transfer: a guideline","volume":"107","author":"Penzias","year":"2017","journal-title":"Fertil Steril"},{"key":"2023110708011131400_dead179-B33","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/humrep\/deh167","article-title":"Is infertility a risk factor for impaired male fertility?","volume":"19","author":"Pook","year":"2004","journal-title":"Hum Reprod"},{"key":"2023110708011131400_dead179-B34","doi-asserted-by":"crossref","first-page":"e14207","DOI":"10.1111\/and.14207","article-title":"Impact of duloxetine on male fertility: a randomised controlled clinical trial","volume":"53","author":"Punjani","year":"2021","journal-title":"Andrologia"},{"key":"2023110708011131400_dead179-B35","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.fertnstert.2010.05.042","article-title":"Standardization of grading embryo morphology","volume":"94","author":"Racowsky","year":"2010","journal-title":"Fertil Steril"},{"key":"2023110708011131400_dead179-B36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejogrb.2013.07.034","article-title":"Psychological impact of single and multiple courses of assisted reproductive treatments in couples: a comparative study","volume":"171","author":"Reis","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2023110708011131400_dead179-B37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.rbmo.2016.09.012","article-title":"Semen quality and alcohol intake: a systematic review and meta-analysis","volume":"34","author":"Ricci","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"2023110708011131400_dead179-B39","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.fertnstert.2020.11.015","article-title":"Diagnosis and treatment of infertility in men: AUA\/ASRM guideline part I","volume":"115","author":"Schlegel","year":"2021","journal-title":"Fertil Steril"},{"key":"2023110708011131400_dead179-B40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/humupd\/dms050","article-title":"BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis","volume":"19","author":"Sermondade","year":"2013","journal-title":"Hum Reprod Update"},{"key":"2023110708011131400_dead179-B41","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/oxfordjournals.humrep.a138191","article-title":"Higher success rate by intracytoplasmic sperm injection than by subzonal insemination. report of a second series of 300 consecutive treatment cycles","volume":"8","author":"Steirteghem","year":"1993","journal-title":"Hum Reprod"},{"key":"2023110708011131400_dead179-B42","doi-asserted-by":"crossref","first-page":"300060520932403","DOI":"10.1177\/0300060520932403","article-title":"Psychological aspects of infertility. A systematic review","volume":"48","author":"Szkodziak","year":"2020","journal-title":"J Int Med Res"},{"key":"2023110708011131400_dead179-B43","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.fertnstert.2009.04.039","article-title":"Adverse effect of paroxetine on sperm","volume":"94","author":"Tanrikut","year":"2010","journal-title":"Fertil Steril"},{"key":"2023110708011131400_dead179-B44","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.fertnstert.2013.01.098","article-title":"Association of state and trait anxiety to semen quality of in vitro fertilization patients: a controlled study","volume":"99","author":"Vellani","year":"2013","journal-title":"Fertil Steril"},{"key":"2023110708011131400_dead179-B45","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1093\/humrep\/den154","article-title":"Prevalence of psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment","volume":"23","author":"Volgsten","year":"2008","journal-title":"Hum Reprod"},{"key":"2023110708011131400_dead179-B46","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/1557988317695901","article-title":"Assessment on occurrences of depression and anxiety and associated risk factors in the infertile chinese men","volume":"11","author":"Yang","year":"2017","journal-title":"Am J Mens Health"},{"key":"2023110708011131400_dead179-B47","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.fertnstert.2021.09.013","article-title":"Associations between depression, oxidative stress, and semen quality among 1,000 healthy men screened as potential sperm donors","volume":"117","author":"Ye","year":"2022","journal-title":"Fertil Steril"},{"key":"2023110708011131400_dead179-B48","doi-asserted-by":"crossref","first-page":"39051","DOI":"10.1038\/srep39051","article-title":"Semen preparation methods and sperm telomere length: density gradient centrifugation versus the swim up procedure","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci Rep"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/38\/11\/2119\/52726886\/dead179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/38\/11\/2119\/52726886\/dead179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:02:01Z","timestamp":1699344121000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/38\/11\/2119\/7266784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,10]]},"references-count":48,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,9,10]]},"published-print":{"date-parts":[[2023,11,2]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dead179","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11,1]]},"published":{"date-parts":[[2023,9,10]]}}}