{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:22:50Z","timestamp":1793283770298,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["GNT1176437"],"award-info":[{"award-number":["GNT1176437"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["GNT1159536"],"award-info":[{"award-number":["GNT1159536"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003122","name":"Ferring Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["GTN2016729"],"award-info":[{"award-number":["GTN2016729"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["GNT2009767"],"award-info":[{"award-number":["GNT2009767"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IVF is the backbone of infertility treatment, but due to its costs, it is not affordable for everyone. The cost of IVF is further escalated by interventions added to the routine treatment, which are claimed to boost pregnancy rates, so-called add-ons. Consequently, it is critical to offset the increased costs of an intervention against a potentially higher benefit. Here, we propose using a simplified framework considering the cost of a standard IVF procedure to create one live-born baby as a benchmark for the cost-effectiveness of other fertility treatments, add-ons inclusive. This framework is a simplified approach to a formal economic evaluation, enabling a rapid assessment of cost effectiveness in clinical settings. For a 30-year-old woman, assuming a 44.6% cumulative live birth rate and a cost of $12\u00a0000 per complete cycle, the cost to create one live-born baby would be \u223c$27\u00a0000 (i.e. willingness to pay). Under this concept, the decision whether to accept or reject a new treatment depends from an economic perspective on the incremental cost per additional live birth from the new treatment\/add-on, with the $27\u00a0000 per live-born baby as a reference threshold. This threshold can vary with women\u2019s age, and other factors such as the economic perspective and risk of side effects can play a role. If a new add-on or treatment costs &amp;gt;$27\u00a0000 per live birth, it might be more rational to invest in a new IVF cycle rather than spending on the add-on. With the increasing number of novel technologies in IVF and the lack of a rapid approach to evaluate their cost-effectiveness, this simplified framework will help with a more objective assessment of the cost-effectiveness of infertility treatments, including add-ons.<\/jats:p>","DOI":"10.1093\/humrep\/dead265","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T01:11:22Z","timestamp":1703639482000},"page":"448-453","source":"Crossref","is-referenced-by-count":8,"title":["Applying a simplified economic evaluation approach to evaluate infertility treatments in clinical practice"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3321-6660","authenticated-orcid":false,"given":"Qian","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Monash University , Clayton, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8980-0909","authenticated-orcid":false,"given":"Wentao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Monash University , Clayton, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J","family":"Callander","sequence":"additional","affiliation":[{"name":"Discipline for Health Services Management, School of Public Health, University of Technology Sydney , Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6622-8134","authenticated-orcid":false,"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Monash University , Clayton, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben W","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Monash University , Clayton, VIC, Australia"},{"name":"Aberdeen Centre for Women's Health Research, School of Medicine, University of Aberdeen , Aberdeen, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"2024030111171822600_dead265-B1","doi-asserted-by":"crossref","first-page":"hoab004","DOI":"10.1093\/hropen\/hoab004","article-title":"Clinical efficacy of hyaluronate-containing embryo transfer medium in IVF\/ICSI treatment cycles: a cohort study","volume":"2021","author":"Adeniyi","year":"2021","journal-title":"Hum Reprod Open"},{"key":"2024030111171822600_dead265-B2","first-page":"CD009452","article-title":"Heparin for assisted reproduction","author":"Akhtar","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2024030111171822600_dead265-B3","author":"American Society 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The ethics and regulation of in vitro fertility add-ons","volume":"112","author":"Wilkinson","year":"2019","journal-title":"Fertil Steril"},{"key":"2024030111171822600_dead265-B37","doi-asserted-by":"crossref","first-page":"101363","DOI":"10.1016\/j.eclinm.2022.101363","article-title":"Ethiodized poppyseed oil-based contrast medium is superior to water-based contrast medium during hysterosalpingography regarding image quality improvement and fertility enhancement: a multicentric, randomized and controlled trial","volume":"46","author":"Zhang","year":"2022","journal-title":"EClinicalMedicine"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/39\/3\/448\/56808297\/dead265.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/39\/3\/448\/56808297\/dead265.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T11:19:57Z","timestamp":1709291997000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/39\/3\/448\/7499708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,26]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,12,26]]},"published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dead265","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3,1]]},"published":{"date-parts":[[2023,12,26]]}}}