{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:26Z","timestamp":1792785926552,"version":"4.5.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022291","name":"Tommy\u2019s National Centre for Miscarriage Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022291","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIHR Efficacy and Mechanism Evaluation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The human endometrium is a dynamic entity that plays a pivotal role in mediating the complex interplay between the mother and developing embryo. Endometrial disruption can lead to pregnancy loss, impacting both maternal physical and psychological health. Recent research suggests that the endometrial microbiota may play a role in this, although the exact mechanisms are still being explored, aided by recent technological advancements and our growing understanding of host immune responses. Suboptimal or dysbiotic vaginal microbiota, characterized by increased microbial diversity and reduced Lactobacillus dominance, has been associated with various adverse reproductive events, including miscarriage. However, the mechanisms linking the lower reproductive tract microbiota with pregnancy loss remain unclear. Recent observational studies implicate a potential microbial continuum between the vaginal and endometrial niche in patients with pregnancy loss; however, transcervical sampling of the low biomass endometrium is highly prone to cross-contamination, which is often not controlled for. In this review, we explore emerging evidence supporting the theory that a dysbiotic endometrial microbiota may modulate key inflammatory pathways required for successful embryo implantation and pregnancy development. We also highlight that a greater understanding of the endometrial microbiota, its relationship with the local endometrial microenvironment, and potential interventions remain a focus for future research.<\/jats:p>","DOI":"10.1093\/humrep\/dead274","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:31:34Z","timestamp":1703183494000},"page":"638-646","source":"Crossref","is-referenced-by-count":71,"title":["The endometrial microbiota and early pregnancy loss"],"prefix":"10.1093","volume":"39","author":[{"given":"Joshua","family":"Odendaal","sequence":"first","affiliation":[{"name":"Division of Biomedical Sciences, Clinical Sciences Research Laboratories, Warwick Medical School, Tommy's National Centre for Miscarriage Research, University of Warwick , Coventry, UK"},{"name":"University Hospitals Coventry & Warwickshire , Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Black","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, Clinical Sciences Research Laboratories, Warwick Medical School, Tommy's National Centre for Miscarriage Research, University of Warwick , Coventry, UK"},{"name":"University Hospitals Coventry & Warwickshire , Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip R","family":"Bennett","sequence":"additional","affiliation":[{"name":"Tommy\u2019s National Centre for Miscarriage Research, Imperial College London , London, UK"},{"name":"March of Dimes Prematurity Research Centre at Imperial College London , London, UK"},{"name":"Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London , London, 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