{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:39:16Z","timestamp":1785523156021,"version":"3.56.0"},"reference-count":89,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National de la Recherche Scientifique de Belgique"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Since the first description of adenomyosis more than 150\u2009years ago, multiple hypotheses have attempted to explain its pathogenesis. Indeed, research over recent years has greatly enhanced our knowledge of the underlying causes. This has opened up avenues for the development of strategies for both disease prevention and treatment of its main symptoms, such as pelvic pain, heavy menstrual bleeding, and infertility. However, the current means are still largely ineffective, so it is vital that we shed light on the pathways involved. Dysregulated mechanisms and aberrant protein expression have been identified as contributing factors in interactions between endometrial epithelial and stromal cells, ultimately leading to the growth of adenomyotic lesions. These include collective cell migration, epithelial-to-mesenchymal transition, hormonal influence, and signaling from non-coding RNAs and extracellular vesicles. We provide a concise summary of the latest insights into the crosstalk between glands and stroma in ectopic adenomyotic lesion formation. While there is an abundance of literature on similarities between adenomyosis and deep endometriosis, there are insufficient data on the cytochemical, molecular, and pathogenetic mechanisms of these two disorders. However, various shared features, including alterations of cell adhesion molecules, abnormal hormone regulation, and the presence of cancer-driving mutations and epigenetic modifications, have been identified. Nevertheless, the pathogenic mechanisms that contribute to the cause and development of these enigmatic diseases have not been fully elucidated yet.<\/jats:p>","DOI":"10.1093\/humrep\/deae116","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:09:17Z","timestamp":1718669357000},"page":"1608-1617","source":"Crossref","is-referenced-by-count":14,"title":["Overview of crosstalk between stromal and epithelial cells in the pathogenesis of adenomyosis and shared features with deep endometriotic nodules"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3092-8029","authenticated-orcid":false,"given":"Margherita","family":"Zipponi","sequence":"first","affiliation":[{"name":"P\u00f4le de Gyn\u00e9cologie, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain , Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6738-289X","authenticated-orcid":false,"given":"Luciana","family":"Cacciottola","sequence":"additional","affiliation":[{"name":"P\u00f4le de Gyn\u00e9cologie, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain , Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6331-3026","authenticated-orcid":false,"given":"Marie-Madeleine","family":"Dolmans","sequence":"additional","affiliation":[{"name":"P\u00f4le de Gyn\u00e9cologie, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain , Brussels, Belgium"},{"name":"Gynecology Department, Cliniques Universitaires St-Luc , Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"2024080106373226100_deae116-B1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/ijgo.14609","article-title":"Transvaginal ultrasound versus magnetic resonance imaging for diagnosing adenomyosis: a systematic review and head-to-head meta-analysis","volume":"161","author":"Alc\u00e1zar","year":"2023","journal-title":"Int J Gynaecol Obstet"},{"key":"2024080106373226100_deae116-B2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1055\/s-0040-1718922","article-title":"Pathology and pathogenesis of adenomyosis","volume":"38","author":"Antero","year":"2020","journal-title":"Semin Reprod Med"},{"key":"2024080106373226100_deae116-B3","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.3390\/cells12121566","article-title":"Horizontal transfer of malignant traits and the involvement of extracellular vesicles in 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