{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:43:25Z","timestamp":1791240205401,"version":"4.1.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Key Research and Development Projects of China","award":["2021YFD1600201"],"award-info":[{"award-number":["2021YFD1600201"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ovarian aging, a natural process in women and various other female mammals as they age, is characterized by a decline in ovarian function and fertility due to a reduction in oocyte reserve and quality. This phenomenon is believed to result from a combination of genetic, hormonal, and environmental factors. While these factors collectively contribute to the shaping of ovarian aging, the substantial impact and intricate interplay of chronic inflammation in this process have been somewhat overlooked in discussions. Chronic inflammation, a prolonged and sustained inflammatory response persisting over an extended period, can exert detrimental effects on tissues and organs. This review delves into the novel hallmark of aging\u2014chronic inflammation\u2014to further emphasize the primary characteristics of ovarian aging. It endeavors to explore not only the clinical symptoms but also the underlying mechanisms associated with this complex process. By shining a spotlight on chronic inflammation, the aim is to broaden our understanding of the multifaceted aspects of ovarian aging and its potential clinical implications.<\/jats:p>","DOI":"10.1093\/humrep\/deae132","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T19:42:13Z","timestamp":1717184533000},"page":"1599-1607","source":"Crossref","is-referenced-by-count":50,"title":["Unveiling the role of chronic inflammation in ovarian aging: insights into mechanisms and clinical implications"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8951-5638","authenticated-orcid":false,"given":"Yutian","family":"Zeng","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University , Chengdu Campus, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University , Chengdu Campus, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiting","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University , Chengdu Campus, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Shan","sequence":"additional","affiliation":[{"name":"Genital Medicine Center, The Third People\u2019s Hospital of Cheng , Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Qian","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Sichuan Jinxin Xinan Woman & Children Hospital , Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-128X","authenticated-orcid":false,"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University , Chengdu Campus, Chengdu, China"},{"name":"Key Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China"},{"name":"Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University , Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"2024080105583697700_deae132-B1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ni.3772","article-title":"Limiting 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